Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEUM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEUM_HUMAN
GO:0043169 cation binding 48.2759 4 no
GO:0046872 metal ion binding 48.2759 5 no
GO:0019900 kinase binding 31.0345 4 no
GO:0043168 anion binding 24.1379 4 yes
GO:0019901 protein kinase binding 24.1379 5 no
GO:0005509 calcium ion binding 20.6897 6 no
GO:0035091 phosphatidylinositol binding 10.3448 4 yes
GO:1901981 phosphatidylinositol phosphate binding 10.3448 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEUM_HUMAN
GO:0048522 positive regulation of cellular process 68.9655 4 no
GO:0048523 negative regulation of cellular process 65.5172 4 no
GO:0060255 regulation of macromolecule metabolic process 58.6207 4 no
GO:0031323 regulation of cellular metabolic process 55.1724 4 no
GO:0080090 regulation of primary metabolic process 55.1724 4 no
GO:0010646 regulation of cell communication 55.1724 4 no
GO:0051246 regulation of protein metabolic process 51.7241 5 no
GO:0009966 regulation of signal transduction 51.7241 4 no
GO:0051128 regulation of cellular component organization 48.2759 4 yes
GO:0009893 positive regulation of metabolic process 44.8276 4 no
GO:0031325 positive regulation of cellular metabolic process 44.8276 5 no
GO:0051049 regulation of transport 44.8276 4 no
GO:0042325 regulation of phosphorylation 41.3793 7 no
GO:0051174 regulation of phosphorus metabolic process 41.3793 5 no
GO:0010604 positive regulation of macromolecule metabolic process 41.3793 5 no
GO:0022607 cellular component assembly 41.3793 4 no
GO:0051050 positive regulation of transport 41.3793 4 no
GO:0019220 regulation of phosphate metabolic process 41.3793 6 no
GO:0031399 regulation of protein modification process 41.3793 6 no
GO:0030030 cell projection organization 37.9310 4 yes
GO:0009892 negative regulation of metabolic process 37.9310 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.9310 5 no
GO:0034762 regulation of transmembrane transport 37.9310 4 no
GO:0001932 regulation of protein phosphorylation 37.9310 7 no
GO:0042327 positive regulation of phosphorylation 34.4828 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.4828 7 no
GO:0051247 positive regulation of protein metabolic process 34.4828 6 no
GO:0120036 plasma membrane bounded cell projection organization 34.4828 5 yes
GO:0008104 protein localization 34.4828 4 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0010562 positive regulation of phosphorus metabolic process 34.4828 6 no
GO:0031344 regulation of cell projection organization 31.0345 5 yes
GO:0044087 regulation of cellular component biogenesis 31.0345 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.0345 6 yes
GO:0009889 regulation of biosynthetic process 31.0345 4 no
GO:0010468 regulation of gene expression 31.0345 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.0345 5 no
GO:0031326 regulation of cellular biosynthetic process 31.0345 5 no
GO:0006996 organelle organization 31.0345 4 no
GO:0051248 negative regulation of protein metabolic process 31.0345 6 no
GO:0006915 apoptotic process 31.0345 4 no
GO:0050804 modulation of chemical synaptic transmission 31.0345 5 no
GO:0099177 regulation of trans-synaptic signaling 31.0345 4 no
GO:0023056 positive regulation of signaling 31.0345 4 no
GO:0032880 regulation of protein localization 31.0345 5 no
GO:0048584 positive regulation of response to stimulus 31.0345 4 no
GO:0060341 regulation of cellular localization 31.0345 4 no
GO:0001934 positive regulation of protein phosphorylation 31.0345 8 no
GO:0022898 regulation of transmembrane transporter activity 31.0345 4 no
GO:0031401 positive regulation of protein modification process 31.0345 7 no
GO:0034765 regulation of monoatomic ion transmembrane transport 27.5862 5 no
GO:0043085 positive regulation of catalytic activity 27.5862 4 no
GO:0043269 regulation of monoatomic ion transport 27.5862 5 no
GO:0043549 regulation of kinase activity 27.5862 5 no
GO:0051338 regulation of transferase activity 27.5862 4 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0031400 negative regulation of protein modification process 27.5862 7 no
GO:1902903 regulation of supramolecular fiber organization 27.5862 5 no
GO:0051130 positive regulation of cellular component organization 27.5862 5 no
GO:0034330 cell junction organization 27.5862 4 no
GO:0045595 regulation of cell differentiation 27.5862 4 no
GO:0051129 negative regulation of cellular component organization 27.5862 5 no
GO:0141124 intracellular signaling cassette 27.5862 4 no
GO:2000026 regulation of multicellular organismal development 27.5862 4 no
GO:0006796 phosphate-containing compound metabolic process 27.5862 4 no
GO:0010647 positive regulation of cell communication 27.5862 5 no
GO:0036211 protein modification process 27.5862 4 no
GO:0043412 macromolecule modification 27.5862 4 no
GO:0071310 cellular response to organic substance 27.5862 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 27.5862 5 no
GO:0034764 positive regulation of transmembrane transport 27.5862 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 24.1379 6 no
GO:0043270 positive regulation of monoatomic ion transport 24.1379 5 no
GO:0045859 regulation of protein kinase activity 24.1379 6 no
GO:0051347 positive regulation of transferase activity 24.1379 5 no
GO:0051924 regulation of calcium ion transport 24.1379 7 no
GO:1903169 regulation of calcium ion transmembrane transport 24.1379 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 24.1379 6 no
GO:0010563 negative regulation of phosphorus metabolic process 24.1379 6 no
GO:0042326 negative regulation of phosphorylation 24.1379 8 no
GO:0044057 regulation of system process 24.1379 4 no
GO:0045936 negative regulation of phosphate metabolic process 24.1379 7 no
GO:0031175 neuron projection development 24.1379 6 yes
GO:0033043 regulation of organelle organization 24.1379 5 yes
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0010243 response to organonitrogen compound 24.1379 4 no
GO:0010975 regulation of neuron projection development 24.1379 7 no
GO:0050890 cognition 24.1379 4 no
GO:0050808 synapse organization 24.1379 5 no
GO:0060284 regulation of cell development 24.1379 5 no
GO:0009967 positive regulation of signal transduction 24.1379 5 no
GO:0051051 negative regulation of transport 24.1379 4 no
GO:0071702 organic substance transport 24.1379 4 no
GO:1901701 cellular response to oxygen-containing compound 24.1379 4 no
GO:1903829 positive regulation of protein localization 24.1379 5 no
GO:0051282 regulation of sequestering of calcium ion 24.1379 4 no
GO:0010959 regulation of metal ion transport 24.1379 6 no
GO:0032411 positive regulation of transporter activity 24.1379 4 no
GO:0033674 positive regulation of kinase activity 24.1379 6 no
GO:0045860 positive regulation of protein kinase activity 20.6897 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 20.6897 7 no
GO:1904064 positive regulation of cation transmembrane transport 20.6897 7 no
GO:0001933 negative regulation of protein phosphorylation 20.6897 8 no
GO:0010038 response to metal ion 20.6897 4 no
GO:0010564 regulation of cell cycle process 20.6897 5 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 20.6897 5 no
GO:0051336 regulation of hydrolase activity 20.6897 4 no
GO:0051345 positive regulation of hydrolase activity 20.6897 5 no
GO:0051726 regulation of cell cycle 20.6897 4 no
GO:0051493 regulation of cytoskeleton organization 20.6897 6 no
GO:0009891 positive regulation of biosynthetic process 20.6897 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6897 6 no
GO:0051094 positive regulation of developmental process 20.6897 4 no
GO:0051252 regulation of RNA metabolic process 20.6897 5 no
GO:0042981 regulation of apoptotic process 20.6897 5 no
GO:0043066 negative regulation of apoptotic process 20.6897 6 no
GO:0043067 regulation of programmed cell death 20.6897 4 no
GO:0043069 negative regulation of programmed cell death 20.6897 5 no
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.6897 4 no
GO:0050767 regulation of neurogenesis 20.6897 6 no
GO:0051093 negative regulation of developmental process 20.6897 4 no
GO:0051960 regulation of nervous system development 20.6897 5 no
GO:0034763 negative regulation of transmembrane transport 20.6897 5 no
GO:0051240 positive regulation of multicellular organismal process 20.6897 4 no
GO:0070201 regulation of establishment of protein localization 20.6897 6 no
GO:0071705 nitrogen compound transport 20.6897 4 no
GO:0032410 negative regulation of transporter activity 20.6897 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 20.6897 5 no
GO:0051489 regulation of filopodium assembly 10.3448 7 yes
GO:0060491 regulation of cell projection assembly 10.3448 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 10.3448 6 yes
GO:0016198 axon choice point recognition 6.8966 4 yes
GO:0048678 response to axon injury 6.8966 4 yes
GO:0061564 axon development 6.8966 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
NICA_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCD1_HUMAN [view entry] [view interactions] Low throughput yes yes
RABE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
CCNL2_HUMAN [view interactions] High throughput no yes
BIRC2_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
PCDGK_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
MALD2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CUL4B_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
DRD4_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CP2S1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
MYH4_HUMAN [view interactions] High throughput no no
HORM2_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
DHRS3_HUMAN [view interactions] High throughput no yes
FBX34_HUMAN [view interactions] High throughput no no
T2R19_HUMAN [view interactions] High throughput no no
DCNL2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
CLPP_HUMAN [view interactions] High throughput no yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV4_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
MED21_HUMAN [view interactions] High throughput no yes
TIGD5_HUMAN [view interactions] High throughput no no
S1PR2_HUMAN [view entry] [view interactions] High throughput yes no
CXB7_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
GDE1_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes