Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEUM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEUM_HUMAN
GO:0046872 metal ion binding 54.1667 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005509 calcium ion binding 20.8333 5 no
GO:0035091 phosphatidylinositol binding 12.5000 4 yes
GO:1901981 phosphatidylinositol phosphate binding 12.5000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEUM_HUMAN
GO:0048523 negative regulation of cellular process 70.8333 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 54.1667 4 no
GO:0060255 regulation of macromolecule metabolic process 54.1667 4 no
GO:0080090 regulation of primary metabolic process 54.1667 4 no
GO:0031323 regulation of cellular metabolic process 54.1667 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051049 regulation of transport 45.8333 4 no
GO:0009966 regulation of signal transduction 45.8333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 41.6667 5 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0051050 positive regulation of transport 41.6667 4 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0036211 protein modification process 41.6667 4 no
GO:0043412 macromolecule modification 41.6667 4 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0034762 regulation of transmembrane transport 37.5000 4 no
GO:0031344 regulation of cell projection organization 37.5000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0030030 cell projection organization 33.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0060341 regulation of cellular localization 29.1667 4 no
GO:1902903 regulation of supramolecular fiber organization 29.1667 5 no
GO:0001934 positive regulation of protein phosphorylation 29.1667 8 no
GO:0022898 regulation of transmembrane transporter activity 29.1667 4 no
GO:0031401 positive regulation of protein modification process 29.1667 7 no
GO:0032412 regulation of ion transmembrane transporter activity 29.1667 5 no
GO:0045859 regulation of protein kinase activity 29.1667 6 no
GO:0045860 positive regulation of protein kinase activity 29.1667 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 29.1667 7 no
GO:1904062 regulation of cation transmembrane transport 29.1667 6 no
GO:0006796 phosphate-containing compound metabolic process 29.1667 4 no
GO:0009967 positive regulation of signal transduction 29.1667 5 no
GO:0010647 positive regulation of cell communication 29.1667 5 no
GO:0023056 positive regulation of signaling 29.1667 4 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 no
GO:0010243 response to organonitrogen compound 29.1667 4 no
GO:0033043 regulation of organelle organization 29.1667 5 yes
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 yes
GO:0010941 regulation of cell death 29.1667 4 no
GO:0008104 protein localization 29.1667 4 no
GO:0022607 cellular component assembly 29.1667 4 no
GO:0010468 regulation of gene expression 29.1667 5 no
GO:0031400 negative regulation of protein modification process 29.1667 7 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0051129 negative regulation of cellular component organization 29.1667 5 no
GO:0051130 positive regulation of cellular component organization 29.1667 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0032411 positive regulation of transporter activity 25.0000 4 no
GO:0034763 negative regulation of transmembrane transport 25.0000 5 no
GO:0034764 positive regulation of transmembrane transport 25.0000 5 no
GO:0034767 positive regulation of ion transmembrane transport 25.0000 6 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 25.0000 8 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:1903829 positive regulation of protein localization 20.8333 5 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:0001933 negative regulation of protein phosphorylation 20.8333 8 no
GO:0010564 regulation of cell cycle process 20.8333 5 no
GO:0010959 regulation of metal ion transport 20.8333 6 no
GO:0032410 negative regulation of transporter activity 20.8333 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 20.8333 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 20.8333 5 no
GO:0034766 negative regulation of ion transmembrane transport 20.8333 6 no
GO:0043271 negative regulation of ion transport 20.8333 5 no
GO:0044057 regulation of system process 20.8333 4 no
GO:0051099 positive regulation of binding 20.8333 4 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0051924 regulation of calcium ion transport 20.8333 7 no
GO:1903169 regulation of calcium ion transmembrane transport 20.8333 7 no
GO:1904063 negative regulation of cation transmembrane transport 20.8333 7 no
GO:1904064 positive regulation of cation transmembrane transport 20.8333 7 no
GO:0031345 negative regulation of cell projection organization 20.8333 6 no
GO:0002684 positive regulation of immune system process 20.8333 4 no
GO:0006468 protein phosphorylation 20.8333 5 no
GO:0016310 phosphorylation 20.8333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0050776 regulation of immune response 20.8333 4 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0043408 regulation of MAPK cascade 20.8333 6 no
GO:0051223 regulation of protein transport 20.8333 5 no
GO:0034248 regulation of cellular amide metabolic process 20.8333 5 no
GO:0014070 response to organic cyclic compound 20.8333 4 no
GO:0031175 neuron projection development 20.8333 6 yes
GO:0051241 negative regulation of multicellular organismal process 20.8333 4 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:0010639 negative regulation of organelle organization 20.8333 6 no
GO:0010942 positive regulation of cell death 20.8333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 20.8333 4 no
GO:0031329 regulation of cellular catabolic process 20.8333 5 no
GO:0034330 cell junction organization 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0050808 synapse organization 20.8333 5 no
GO:0050890 cognition 20.8333 4 no
GO:0051489 regulation of filopodium assembly 12.5000 7 yes
GO:0060491 regulation of cell projection assembly 12.5000 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 12.5000 6 yes
GO:0016198 axon choice point recognition 8.3333 4 yes
GO:0048678 response to axon injury 8.3333 4 yes
GO:0061564 axon development 8.3333 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in NEUM_HUMAN
DOID:0050700 cardiomyopathy 8.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 8.3333 5 no
DOID:114 heart disease 8.3333 3 no
DOID:2843 long QT syndrome 8.3333 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NICA_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCD1_HUMAN [view entry] [view interactions] Low throughput yes yes
RABE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
MED21_HUMAN [view interactions] High throughput no yes
TIGD5_HUMAN [view interactions] High throughput no no
S1PR2_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
GDE1_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
CCNL2_HUMAN [view interactions] High throughput no yes
BIRC2_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
PCDGK_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
MALD2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CUL4B_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
DRD4_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CP2S1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
MYH4_HUMAN [view interactions] High throughput no no
HORM2_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
DHRS3_HUMAN [view interactions] High throughput no yes
FBX34_HUMAN [view interactions] High throughput no no
T2R19_HUMAN [view interactions] High throughput no no
DCNL2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
CLPP_HUMAN [view interactions] High throughput no yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV4_HUMAN [view entry] [view interactions] High throughput yes yes
LYPA2_HUMAN [view interactions] Computational no no
NGF_HUMAN [view interactions] Computational no no