Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANXA5_HUMAN

GO
G2C
SynGO

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ANXA5_HUMAN
GO:0046872 metal ion binding 30.4878 4 yes
GO:0003723 RNA binding 28.0488 4 no
GO:0017076 purine nucleotide binding 26.8293 4 no
GO:0019900 kinase binding 25.6098 4 no
GO:0019901 protein kinase binding 24.3902 5 no
GO:0032555 purine ribonucleotide binding 24.3902 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.3902 4 no
GO:0030554 adenyl nucleotide binding 21.9512 5 no
GO:0005509 calcium ion binding 15.8537 5 yes
GO:0004859 phospholipase inhibitor activity 4.8780 5 yes
GO:0005544 calcium-dependent phospholipid binding 4.8780 4 yes
GO:0055102 lipase inhibitor activity 4.8780 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANXA5_HUMAN
GO:0060255 regulation of macromolecule metabolic process 57.3171 4 no
GO:0080090 regulation of primary metabolic process 54.8780 4 no
GO:0048523 negative regulation of cellular process 53.6585 4 yes
GO:0048522 positive regulation of cellular process 53.6585 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.4390 4 no
GO:0031323 regulation of cellular metabolic process 51.2195 4 no
GO:0009893 positive regulation of metabolic process 47.5610 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.9024 5 no
GO:0010468 regulation of gene expression 43.9024 5 no
GO:0051246 regulation of protein metabolic process 42.6829 5 no
GO:0010646 regulation of cell communication 40.2439 4 no
GO:0009892 negative regulation of metabolic process 39.0244 4 no
GO:0051128 regulation of cellular component organization 39.0244 4 no
GO:0009966 regulation of signal transduction 37.8049 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.5854 5 no
GO:0010605 negative regulation of macromolecule metabolic process 35.3659 5 no
GO:0031325 positive regulation of cellular metabolic process 35.3659 5 no
GO:1902531 regulation of intracellular signal transduction 34.1463 5 no
GO:0009889 regulation of biosynthetic process 34.1463 4 no
GO:0031326 regulation of cellular biosynthetic process 32.9268 5 no
GO:0010941 regulation of cell death 31.7073 4 yes
GO:0031324 negative regulation of cellular metabolic process 31.7073 5 no
GO:0031399 regulation of protein modification process 30.4878 6 no
GO:0051247 positive regulation of protein metabolic process 30.4878 6 no
GO:0006996 organelle organization 30.4878 4 no
GO:0042981 regulation of apoptotic process 29.2683 6 yes
GO:0043067 regulation of programmed cell death 29.2683 5 yes
GO:0051049 regulation of transport 29.2683 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.2683 5 no
GO:0010556 regulation of macromolecule biosynthetic process 29.2683 5 no
GO:0048584 positive regulation of response to stimulus 29.2683 4 no
GO:0019220 regulation of phosphate metabolic process 28.0488 6 no
GO:0051174 regulation of phosphorus metabolic process 28.0488 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.0488 5 no
GO:0043412 macromolecule modification 26.8293 4 no
GO:0022607 cellular component assembly 25.6098 4 no
GO:0033043 regulation of organelle organization 25.6098 5 no
GO:0036211 protein modification process 25.6098 4 no
GO:0008104 protein localization 25.6098 4 no
GO:0042325 regulation of phosphorylation 24.3902 7 no
GO:0023056 positive regulation of signaling 24.3902 4 no
GO:0051130 positive regulation of cellular component organization 24.3902 5 no
GO:0031401 positive regulation of protein modification process 23.1707 7 no
GO:0051252 regulation of RNA metabolic process 23.1707 5 no
GO:0009967 positive regulation of signal transduction 23.1707 5 no
GO:0010647 positive regulation of cell communication 23.1707 5 no
GO:0080134 regulation of response to stress 23.1707 4 no
GO:0060548 negative regulation of cell death 21.9512 5 yes
GO:0001932 regulation of protein phosphorylation 21.9512 7 no
GO:0010562 positive regulation of phosphorus metabolic process 21.9512 6 no
GO:0043085 positive regulation of catalytic activity 21.9512 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.9512 7 no
GO:0006355 regulation of DNA-templated transcription 21.9512 6 no
GO:1903506 regulation of nucleic acid-templated transcription 21.9512 7 no
GO:2001141 regulation of RNA biosynthetic process 21.9512 6 no
GO:0006796 phosphate-containing compound metabolic process 21.9512 4 no
GO:0071310 cellular response to organic substance 21.9512 4 no
GO:0051336 regulation of hydrolase activity 20.7317 4 no
GO:0009894 regulation of catabolic process 20.7317 4 no
GO:0007010 cytoskeleton organization 20.7317 5 no
GO:0043066 negative regulation of apoptotic process 19.5122 7 yes
GO:0043069 negative regulation of programmed cell death 19.5122 6 yes
GO:0051241 negative regulation of multicellular organismal process 12.1951 4 yes
GO:0007599 hemostasis 3.6585 4 yes
GO:0050818 regulation of coagulation 2.4390 4 yes
GO:0050819 negative regulation of coagulation 2.4390 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ANXA5_HUMAN
DOID:114 heart disease 4.8780 3 no
DOID:0050700 cardiomyopathy 3.6585 4 no
DOID:0060036 intrinsic cardiomyopathy 3.6585 5 no
DOID:1289 neurodegenerative disease 3.6585 4 no
DOID:331 central nervous system disease 3.6585 3 no
DOID:2843 long QT syndrome 2.4390 6 no
DOID:0080001 bone disease 2.4390 4 no
DOID:0080006 bone development disease 2.4390 5 no
DOID:65 connective tissue disease 2.4390 3 no
DOID:231 motor neuron disease 2.4390 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] Low throughput yes no
VGFR2_HUMAN [view interactions] Low throughput no no
ITB5_HUMAN [view interactions] Low throughput no yes
TRI59_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CO2A1_HUMAN [view interactions] Low throughput no no
COAA1_HUMAN [view interactions] Low throughput no no
ANXA1_HUMAN [view entry] [view interactions] Low throughput yes no
ANXA5_HUMAN [view entry] [view interactions] Low throughput yes no
ATRX_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMT1_HUMAN [view interactions] Low throughput no no
IF2P_HUMAN [view interactions] Low throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
MYLK_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
SGK3_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
GSC2_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
FDFT_HUMAN [view interactions] High throughput no yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
SPT4H_HUMAN [view interactions] High throughput no no
PDS5A_HUMAN [view interactions] High throughput no yes
CK068_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
RPR1B_HUMAN [view interactions] High throughput no yes
TIF1A_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
LEG2_HUMAN [view interactions] High throughput no no
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
CPNE3_HUMAN [view interactions] High throughput no yes
HPRT_HUMAN [view interactions] High throughput no yes
PA2G4_HUMAN [view interactions] High throughput no yes
SIAS_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
RM12_HUMAN [view interactions] High throughput no yes
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
RU2B_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ZN207_HUMAN [view interactions] High throughput no yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
PYGL_HUMAN [view interactions] High throughput no yes
PLST_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A3_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A1_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
CRNN_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
ASB9_HUMAN [view interactions] High throughput no no
GCP3_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
LRC15_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PPP6_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
FBLN3_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
ARGAL_HUMAN [view interactions] High throughput no yes
DOCK9_HUMAN [view entry] [view interactions] High throughput yes yes
NMRL1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
AN32B_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
ATIF1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
AN32A_HUMAN [view interactions] High throughput no yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB2_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
OR1M1_HUMAN [view interactions] High throughput no no
TRI26_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
FBRL_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
HARS1_HUMAN [view interactions] High throughput no yes
PPT2_HUMAN [view interactions] High throughput no no
PUM1_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
UN13D_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
GCN1_HUMAN [view interactions] High throughput no yes
PDCD6_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes
PPA6_HUMAN [view interactions] High throughput no no
ECI1_HUMAN [view interactions] High throughput no yes
GABT_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
NEUM_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB2_HUMAN [view interactions] High throughput no no
ACSF2_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
HMCS1_HUMAN [view interactions] High throughput no yes
NNRE_HUMAN [view interactions] High throughput no yes
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
ABHDA_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] High throughput no no
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
PLGT3_HUMAN [view interactions] High throughput no no
NIT2_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CCS_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
LAMC3_HUMAN [view interactions] High throughput no no
2AAB_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
H2AX_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
KPCD1_HUMAN [view interactions] High throughput no yes
FGR_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
TBX3_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
TINF2_HUMAN [view interactions] High throughput no no
IRF2_HUMAN [view interactions] High throughput no yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
M3K7_HUMAN [view interactions] High throughput no yes
KPCD3_HUMAN [view interactions] High throughput no yes
S10AC_HUMAN [view interactions] Computational no no
MCL1_HUMAN [view interactions] Computational no yes
MANF_HUMAN [view interactions] Computational no yes
WDR1_HUMAN [view entry] [view interactions] Computational yes yes
ACTG_HUMAN [view entry] [view interactions] Computational yes yes
CCND1_HUMAN [view interactions] Computational no yes
VINC_HUMAN [view entry] [view interactions] Computational yes no
STXB2_HUMAN [view interactions] Computational no no
TDT_HUMAN [view interactions] Computational no no
CYC_HUMAN [view entry] [view interactions] Computational yes yes
ALBU_HUMAN [view interactions] Computational no no
P53_HUMAN [view interactions] Computational no no
TLN1_HUMAN [view entry] [view interactions] Computational yes no
FLNA_HUMAN [view entry] [view interactions] Computational yes no
G3P_HUMAN [view entry] [view interactions] Computational yes yes
PLEK_HUMAN [view entry] [view interactions] Computational yes no
HABP4_HUMAN [view interactions] Computational no yes
CASP3_HUMAN [view interactions] Computational no yes
TAGL2_HUMAN [view entry] [view interactions] Computational yes no
HEPN1_HUMAN [view interactions] Computational no no
ENDD1_HUMAN [view interactions] Computational no yes
S10A9_HUMAN [view entry] [view interactions] Computational yes no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
CD4_HUMAN [view interactions] Computational no no
BRPF3_HUMAN [view interactions] Computational no yes
CASP9_HUMAN [view interactions] Computational no yes
CASP8_HUMAN [view interactions] Computational no yes
TBA4A_HUMAN [view entry] [view interactions] Computational yes yes
B2CL1_HUMAN [view interactions] Computational no yes