Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PGAM1_HUMAN

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PGAM1_HUMAN
GO:0043169 cation binding 32.4675 4 no
GO:0046872 metal ion binding 32.4675 5 no
GO:0003723 RNA binding 28.5714 4 no
GO:0043168 anion binding 25.9740 4 no
GO:0000166 nucleotide binding 23.3766 4 no
GO:0019900 kinase binding 22.0779 4 yes
GO:0044389 ubiquitin-like protein ligase binding 22.0779 4 no
GO:0017076 purine nucleotide binding 22.0779 5 no
GO:0031625 ubiquitin protein ligase binding 20.7792 5 no
GO:0019901 protein kinase binding 19.4805 5 yes
GO:0004082 bisphosphoglycerate mutase activity 3.8961 5 yes
GO:0004619 phosphoglycerate mutase activity 3.8961 5 yes
GO:0016868 intramolecular phosphotransferase activity 3.8961 4 yes
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity 3.8961 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PGAM1_HUMAN
GO:0048522 positive regulation of cellular process 55.8442 4 no
GO:0031323 regulation of cellular metabolic process 53.2468 4 yes
GO:0080090 regulation of primary metabolic process 49.3506 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.0519 4 no
GO:0010646 regulation of cell communication 46.7532 4 no
GO:0048523 negative regulation of cellular process 46.7532 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0010468 regulation of gene expression 41.5584 6 no
GO:0010556 regulation of macromolecule biosynthetic process 41.5584 5 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0009893 positive regulation of metabolic process 35.0649 4 no
GO:0051246 regulation of protein metabolic process 35.0649 5 no
GO:0006796 phosphate-containing compound metabolic process 33.7662 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.7662 5 no
GO:1902531 regulation of intracellular signal transduction 33.7662 5 no
GO:0043412 macromolecule modification 32.4675 4 no
GO:0009892 negative regulation of metabolic process 32.4675 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.4675 5 no
GO:0031324 negative regulation of cellular metabolic process 32.4675 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.1688 5 yes
GO:0036211 protein modification process 31.1688 4 no
GO:0010647 positive regulation of cell communication 31.1688 5 no
GO:0023056 positive regulation of signaling 31.1688 4 no
GO:0031325 positive regulation of cellular metabolic process 31.1688 5 no
GO:0048584 positive regulation of response to stimulus 31.1688 4 no
GO:0009967 positive regulation of signal transduction 29.8701 5 no
GO:0042981 regulation of apoptotic process 29.8701 5 no
GO:0043067 regulation of programmed cell death 29.8701 4 no
GO:0051049 regulation of transport 27.2727 4 no
GO:0051247 positive regulation of protein metabolic process 27.2727 6 no
GO:0009890 negative regulation of biosynthetic process 25.9740 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.9740 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.9740 6 no
GO:0022607 cellular component assembly 25.9740 4 no
GO:0051252 regulation of RNA metabolic process 25.9740 5 no
GO:0006996 organelle organization 24.6753 4 no
GO:0009891 positive regulation of biosynthetic process 24.6753 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.6753 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.6753 6 no
GO:0051240 positive regulation of multicellular organismal process 24.6753 4 no
GO:0006355 regulation of DNA-templated transcription 24.6753 7 no
GO:2001141 regulation of RNA biosynthetic process 24.6753 6 no
GO:0006753 nucleoside phosphate metabolic process 22.0779 4 yes
GO:0009117 nucleotide metabolic process 22.0779 5 yes
GO:0019220 regulation of phosphate metabolic process 22.0779 6 yes
GO:0051174 regulation of phosphorus metabolic process 22.0779 5 yes
GO:1901565 organonitrogen compound catabolic process 22.0779 4 yes
GO:0010628 positive regulation of gene expression 22.0779 7 no
GO:0031399 regulation of protein modification process 22.0779 6 no
GO:0008104 protein localization 22.0779 4 no
GO:0006163 purine nucleotide metabolic process 20.7792 5 yes
GO:0019693 ribose phosphate metabolic process 20.7792 4 yes
GO:0019752 carboxylic acid metabolic process 20.7792 5 yes
GO:0043436 oxoacid metabolic process 20.7792 4 yes
GO:0072521 purine-containing compound metabolic process 20.7792 4 yes
GO:1902533 positive regulation of intracellular signal transduction 20.7792 6 no
GO:0051130 positive regulation of cellular component organization 20.7792 5 no
GO:0080134 regulation of response to stress 20.7792 4 no
GO:0033043 regulation of organelle organization 20.7792 5 no
GO:0009894 regulation of catabolic process 19.4805 4 yes
GO:0032787 monocarboxylic acid metabolic process 19.4805 6 yes
GO:0009150 purine ribonucleotide metabolic process 18.1818 6 yes
GO:0009259 ribonucleotide metabolic process 18.1818 5 yes
GO:0006006 glucose metabolic process 15.5844 5 yes
GO:0009141 nucleoside triphosphate metabolic process 15.5844 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 15.5844 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 15.5844 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 15.5844 7 yes
GO:0019318 hexose metabolic process 15.5844 4 yes
GO:0019362 pyridine nucleotide metabolic process 15.5844 5 yes
GO:0034655 nucleobase-containing compound catabolic process 15.5844 4 yes
GO:0046034 ATP metabolic process 15.5844 7 yes
GO:0046496 nicotinamide nucleotide metabolic process 15.5844 6 yes
GO:0072524 pyridine-containing compound metabolic process 15.5844 4 yes
GO:1901361 organic cyclic compound catabolic process 15.5844 4 yes
GO:0006090 pyruvate metabolic process 14.2857 7 yes
GO:0046434 organophosphate catabolic process 14.2857 4 yes
GO:0006096 glycolytic process 12.9870 4 yes
GO:0006195 purine nucleotide catabolic process 12.9870 6 yes
GO:0009132 nucleoside diphosphate metabolic process 12.9870 5 yes
GO:0009134 nucleoside diphosphate catabolic process 12.9870 6 yes
GO:0009135 purine nucleoside diphosphate metabolic process 12.9870 6 yes
GO:0009137 purine nucleoside diphosphate catabolic process 12.9870 7 yes
GO:0009154 purine ribonucleotide catabolic process 12.9870 6 yes
GO:0009166 nucleotide catabolic process 12.9870 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 12.9870 7 yes
GO:0009181 purine ribonucleoside diphosphate catabolic process 12.9870 8 yes
GO:0009185 ribonucleoside diphosphate metabolic process 12.9870 6 yes
GO:0009191 ribonucleoside diphosphate catabolic process 12.9870 7 yes
GO:0009261 ribonucleotide catabolic process 12.9870 5 yes
GO:0016051 carbohydrate biosynthetic process 12.9870 4 yes
GO:0016052 carbohydrate catabolic process 12.9870 4 yes
GO:0019364 pyridine nucleotide catabolic process 12.9870 6 yes
GO:0046031 ADP metabolic process 12.9870 7 yes
GO:0046032 ADP catabolic process 12.9870 7 yes
GO:0046364 monosaccharide biosynthetic process 12.9870 4 yes
GO:0072523 purine-containing compound catabolic process 12.9870 5 yes
GO:0072526 pyridine-containing compound catabolic process 12.9870 5 yes
GO:1901136 carbohydrate derivative catabolic process 12.9870 4 yes
GO:1901292 nucleoside phosphate catabolic process 12.9870 5 yes
GO:0006094 gluconeogenesis 11.6883 6 yes
GO:0019319 hexose biosynthetic process 11.6883 5 yes
GO:0006007 glucose catabolic process 10.3896 6 yes
GO:0006734 NADH metabolic process 10.3896 7 yes
GO:0006735 NADH regeneration 10.3896 8 yes
GO:0019320 hexose catabolic process 10.3896 5 yes
GO:0019674 NAD metabolic process 10.3896 6 yes
GO:0019677 NAD catabolic process 10.3896 7 yes
GO:0046365 monosaccharide catabolic process 10.3896 4 yes
GO:0061615 glycolytic process through fructose-6-phosphate 10.3896 5 yes
GO:0061620 glycolytic process through glucose-6-phosphate 10.3896 6 yes
GO:0061621 canonical glycolysis 10.3896 7 yes
GO:0061718 glucose catabolic process to pyruvate 10.3896 7 yes
GO:0062012 regulation of small molecule metabolic process 10.3896 4 yes
GO:0006109 regulation of carbohydrate metabolic process 6.4935 5 yes
GO:0006140 regulation of nucleotide metabolic process 6.4935 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 6.4935 5 yes
GO:1900542 regulation of purine nucleotide metabolic process 6.4935 6 yes
GO:1903578 regulation of ATP metabolic process 6.4935 7 yes
GO:0043470 regulation of carbohydrate catabolic process 5.1948 5 yes
GO:0006110 regulation of glycolytic process 3.8961 6 yes
GO:0030811 regulation of nucleotide catabolic process 3.8961 5 yes
GO:0033121 regulation of purine nucleotide catabolic process 3.8961 6 yes
GO:0034248 regulation of amide metabolic process 2.5974 4 yes
GO:0043456 regulation of pentose-phosphate shunt 2.5974 5 yes
GO:1902031 regulation of NADP metabolic process 2.5974 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP46_HUMAN [view entry] [view interactions] Low throughput yes yes
PGAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK13_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
PGAM2_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PCNA_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PHOP1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
UN5CL_HUMAN [view interactions] High throughput no no
ARL4D_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1A_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
CEBPA_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
AICDA_HUMAN [view interactions] High throughput no no
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
ASB9_HUMAN [view interactions] High throughput no no
ASB16_HUMAN [view interactions] High throughput no no
STB5L_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PCGF1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
HYPK_HUMAN [view interactions] High throughput no no
DS13A_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
PPARG_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP3_HUMAN [view interactions] High throughput no yes
AN32B_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
RBM8A_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
AN32A_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
NACAM_HUMAN [view interactions] High throughput no no
GLU2B_HUMAN [view interactions] High throughput no yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
ATIF1_HUMAN [view interactions] High throughput no yes
PRDX3_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
PMGE_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
CHPT1_HUMAN [view interactions] High throughput no yes
KDSR_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
RPAC2_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
S14L1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
KCTD9_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
TET5C_HUMAN [view interactions] High throughput no yes
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
PGAM4_HUMAN [view interactions] High throughput no no
ITA2B_HUMAN [view interactions] High throughput no no
ICLN_HUMAN [view interactions] High throughput no yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
TYSY_HUMAN [view interactions] High throughput no yes
ALDR_HUMAN [view interactions] High throughput no no
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
FABP5_HUMAN [view entry] [view interactions] High throughput yes no
LGUL_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
ENOB_HUMAN [view entry] [view interactions] High throughput yes no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
UMPS_HUMAN [view interactions] High throughput no no
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
PCP_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
ERO1A_HUMAN [view interactions] High throughput no yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
3HIDH_HUMAN [view interactions] High throughput no yes
MAPK2_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
NEUL_HUMAN [view interactions] High throughput no yes
ECHD1_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes