PGAM1_HUMAN
Evidence for PS localization
Functions
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PGAM1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.3030 | 4 | no |
| GO:0003723 | RNA binding | 24.2424 | 4 | no |
| GO:0019900 | kinase binding | 19.6970 | 4 | yes |
| GO:0019901 | protein kinase binding | 16.6667 | 5 | yes |
| GO:0004082 | bisphosphoglycerate mutase activity | 4.5455 | 5 | yes |
| GO:0004619 | phosphoglycerate mutase activity | 4.5455 | 5 | yes |
| GO:0016868 | intramolecular transferase activity, phosphotransferases | 4.5455 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PGAM1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.4848 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.9394 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.9394 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 39.3939 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.8485 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 31.8182 | 4 | no |
| GO:0010941 | regulation of cell death | 28.7879 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.7879 | 5 | no |
| GO:0043412 | macromolecule modification | 28.7879 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.2727 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 27.2727 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 27.2727 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0036211 | protein modification process | 27.2727 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 25.7576 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 25.7576 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 25.7576 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.7576 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.7576 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.7576 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.7576 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.7576 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.7576 | 5 | no |
| GO:0016310 | phosphorylation | 24.2424 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 24.2424 | 4 | yes |
| GO:0051049 | regulation of transport | 24.2424 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.2424 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.2424 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | yes |
| GO:0022607 | cellular component assembly | 22.7273 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.7273 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 21.2121 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 21.2121 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 21.2121 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 21.2121 | 4 | yes |
| GO:0006996 | organelle organization | 21.2121 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.2121 | 5 | no |
| GO:0006090 | pyruvate metabolic process | 19.6970 | 7 | yes |
| GO:0042325 | regulation of phosphorylation | 19.6970 | 7 | yes |
| GO:0006096 | glycolytic process | 18.1818 | 5 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 18.1818 | 6 | yes |
| GO:0006757 | ATP generation from ADP | 18.1818 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 18.1818 | 5 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 18.1818 | 6 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 18.1818 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 18.1818 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 18.1818 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 18.1818 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 18.1818 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 18.1818 | 7 | yes |
| GO:0016052 | carbohydrate catabolic process | 18.1818 | 4 | yes |
| GO:0046031 | ADP metabolic process | 18.1818 | 7 | yes |
| GO:0046034 | ATP metabolic process | 18.1818 | 7 | yes |
| GO:0046939 | nucleotide phosphorylation | 18.1818 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 15.1515 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 15.1515 | 5 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 12.1212 | 4 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 10.6061 | 5 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 7.5758 | 5 | yes |
| GO:0006140 | regulation of nucleotide metabolic process | 7.5758 | 5 | yes |
| GO:0043467 | regulation of generation of precursor metabolites and energy | 7.5758 | 5 | yes |
| GO:1900542 | regulation of purine nucleotide metabolic process | 7.5758 | 6 | yes |
| GO:1903578 | regulation of ATP metabolic process | 7.5758 | 7 | yes |
| GO:0010675 | regulation of cellular carbohydrate metabolic process | 6.0606 | 5 | yes |
| GO:0043470 | regulation of carbohydrate catabolic process | 6.0606 | 5 | yes |
| GO:0006110 | regulation of glycolytic process | 4.5455 | 6 | yes |
| GO:0043471 | regulation of cellular carbohydrate catabolic process | 4.5455 | 5 | yes |
| GO:0043456 | regulation of pentose-phosphate shunt | 3.0303 | 6 | yes |
| GO:1902031 | regulation of NADP metabolic process | 3.0303 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PGAM1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.5455 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.5455 | 5 | no |
| DOID:114 | heart disease | 4.5455 | 3 | no |
| DOID:1289 | neurodegenerative disease | 4.5455 | 4 | no |
| DOID:331 | central nervous system disease | 4.5455 | 3 | no |
| DOID:0080000 | muscular disease | 3.0303 | 3 | no |
| DOID:423 | myopathy | 3.0303 | 5 | no |
| DOID:66 | muscle tissue disease | 3.0303 | 4 | no |
| DOID:2843 | long QT syndrome | 3.0303 | 6 | no |
| DOID:574 | peripheral nervous system disease | 3.0303 | 3 | no |
| DOID:65 | connective tissue disease | 3.0303 | 3 | no |
| DOID:870 | neuropathy | 3.0303 | 4 | no |
| DOID:0050890 | synucleinopathy | 3.0303 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 3.0303 | 7 | no |
| DOID:14330 | Parkinsons disease | 3.0303 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB9_HUMAN | [view interactions] | High throughput | no | no |
| ASB16_HUMAN | [view interactions] | High throughput | no | no |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NACAM_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMGE_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CHPT1_HUMAN | [view interactions] | High throughput | no | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| S14L1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| UN5CL_HUMAN | [view interactions] | High throughput | no | no |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| A0A2U3TZM8_HUMAN | [view interactions] | Computational | no | no |
| DEOC_HUMAN | [view interactions] | Computational | no | no |
| PGAM4_HUMAN | [view interactions] | Computational | no | no |
| TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LDHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| G6PE_HUMAN | [view interactions] | Computational | no | yes |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| UBS3B_HUMAN | [view interactions] | Computational | no | yes |
| PGK2_HUMAN | [view interactions] | Computational | no | no |
| ENO4_HUMAN | [view interactions] | Computational | no | no |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MINP1_HUMAN | [view interactions] | Computational | no | yes |
| GLCTK_HUMAN | [view interactions] | Computational | no | yes |
| KPYM_HUMAN | [view interactions] | Computational | no | yes |