Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PKP4_HUMAN

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI003531 LIG_PDZ_Wminus1_1 LIG 1190 1192 -

Molecular function

Term Name % Distance from the top of the tree Annotated in PKP4_HUMAN
GO:0019900 kinase binding 39.6552 4 no
GO:0019901 protein kinase binding 39.6552 5 no
GO:0017076 purine nucleotide binding 37.9310 4 no
GO:0032555 purine ribonucleotide binding 37.9310 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.9310 4 no
GO:0003924 GTPase activity 25.8621 7 no
GO:0016462 pyrophosphatase activity 25.8621 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.8621 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.8621 6 no
GO:0005525 GTP binding 24.1379 5 no
GO:0019001 guanyl nucleotide binding 24.1379 5 no
GO:0032561 guanyl ribonucleotide binding 24.1379 5 no
GO:0045296 cadherin binding 17.2414 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PKP4_HUMAN
GO:0048522 positive regulation of cellular process 75.8621 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.6207 4 no
GO:0010646 regulation of cell communication 56.8966 4 no
GO:0009966 regulation of signal transduction 53.4483 4 no
GO:0048523 negative regulation of cellular process 53.4483 4 no
GO:0080090 regulation of primary metabolic process 53.4483 4 no
GO:0031323 regulation of cellular metabolic process 51.7241 4 no
GO:0051128 regulation of cellular component organization 51.7241 4 no
GO:0051171 regulation of nitrogen compound metabolic process 51.7241 4 no
GO:0022607 cellular component assembly 48.2759 4 yes
GO:0009893 positive regulation of metabolic process 44.8276 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.8276 5 no
GO:0008104 protein localization 44.8276 4 no
GO:0006996 organelle organization 43.1034 4 no
GO:0023056 positive regulation of signaling 43.1034 4 no
GO:1902531 regulation of intracellular signal transduction 43.1034 5 no
GO:0010468 regulation of gene expression 41.3793 5 no
GO:0051049 regulation of transport 41.3793 4 no
GO:0010647 positive regulation of cell communication 41.3793 5 no
GO:0048584 positive regulation of response to stimulus 41.3793 4 no
GO:0031325 positive regulation of cellular metabolic process 39.6552 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.6552 5 no
GO:0051246 regulation of protein metabolic process 37.9310 5 no
GO:0009967 positive regulation of signal transduction 36.2069 5 no
GO:0030030 cell projection organization 34.4828 4 no
GO:0043085 positive regulation of catalytic activity 32.7586 4 yes
GO:0019220 regulation of phosphate metabolic process 32.7586 6 no
GO:0022603 regulation of anatomical structure morphogenesis 32.7586 4 no
GO:0031344 regulation of cell projection organization 32.7586 5 no
GO:0031399 regulation of protein modification process 32.7586 6 no
GO:0042325 regulation of phosphorylation 32.7586 7 no
GO:0051130 positive regulation of cellular component organization 32.7586 5 no
GO:0051174 regulation of phosphorus metabolic process 32.7586 5 no
GO:0051247 positive regulation of protein metabolic process 32.7586 6 no
GO:0031401 positive regulation of protein modification process 31.0345 7 no
GO:0042127 regulation of cell population proliferation 31.0345 4 no
GO:0051094 positive regulation of developmental process 31.0345 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.0345 5 no
GO:2000145 regulation of cell motility 31.0345 4 no
GO:0009889 regulation of biosynthetic process 29.3103 4 no
GO:0016192 vesicle-mediated transport 29.3103 4 no
GO:0071702 organic substance transport 29.3103 4 no
GO:0071705 nitrogen compound transport 29.3103 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.3103 5 no
GO:0007010 cytoskeleton organization 29.3103 5 no
GO:0009892 negative regulation of metabolic process 29.3103 4 no
GO:0030334 regulation of cell migration 29.3103 5 no
GO:0071310 cellular response to organic substance 29.3103 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.3103 6 no
GO:1902533 positive regulation of intracellular signal transduction 29.3103 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.5862 5 no
GO:0032880 regulation of protein localization 27.5862 5 no
GO:0033043 regulation of organelle organization 27.5862 5 no
GO:0060341 regulation of cellular localization 27.5862 4 no
GO:0031326 regulation of cellular biosynthetic process 27.5862 5 no
GO:0032970 regulation of actin filament-based process 27.5862 4 no
GO:0010941 regulation of cell death 27.5862 4 no
GO:0030155 regulation of cell adhesion 27.5862 4 yes
GO:0034330 cell junction organization 27.5862 4 yes
GO:0001932 regulation of protein phosphorylation 27.5862 7 no
GO:0010562 positive regulation of phosphorus metabolic process 27.5862 6 no
GO:0031175 neuron projection development 27.5862 6 no
GO:0042327 positive regulation of phosphorylation 27.5862 8 no
GO:0045595 regulation of cell differentiation 27.5862 4 no
GO:0045937 positive regulation of phosphate metabolic process 27.5862 7 no
GO:0051252 regulation of RNA metabolic process 25.8621 5 no
GO:0043067 regulation of programmed cell death 25.8621 5 no
GO:0001934 positive regulation of protein phosphorylation 25.8621 8 no
GO:0010605 negative regulation of macromolecule metabolic process 25.8621 5 no
GO:0051240 positive regulation of multicellular organismal process 25.8621 4 no
GO:0051493 regulation of cytoskeleton organization 24.1379 6 no
GO:0051050 positive regulation of transport 24.1379 4 no
GO:0042981 regulation of apoptotic process 24.1379 6 no
GO:0044087 regulation of cellular component biogenesis 24.1379 4 no
GO:0051338 regulation of transferase activity 24.1379 4 no
GO:2000026 regulation of multicellular organismal development 24.1379 4 no
GO:0015031 protein transport 22.4138 4 no
GO:0006355 regulation of DNA-templated transcription 22.4138 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.4138 7 no
GO:2001141 regulation of RNA biosynthetic process 22.4138 6 no
GO:0032956 regulation of actin cytoskeleton organization 22.4138 5 no
GO:0045216 cell-cell junction organization 22.4138 5 yes
GO:0008284 positive regulation of cell population proliferation 22.4138 5 no
GO:0010648 negative regulation of cell communication 22.4138 5 no
GO:0023057 negative regulation of signaling 22.4138 4 no
GO:0036211 protein modification process 22.4138 4 no
GO:0043412 macromolecule modification 22.4138 4 no
GO:0043549 regulation of kinase activity 22.4138 5 no
GO:0051347 positive regulation of transferase activity 22.4138 5 no
GO:0097435 supramolecular fiber organization 20.6897 4 no
GO:0010628 positive regulation of gene expression 20.6897 6 no
GO:0051336 regulation of hydrolase activity 20.6897 4 yes
GO:0010243 response to organonitrogen compound 20.6897 4 no
GO:0031346 positive regulation of cell projection organization 20.6897 6 no
GO:0033674 positive regulation of kinase activity 20.6897 6 no
GO:0043408 regulation of MAPK cascade 20.6897 6 no
GO:0048585 negative regulation of response to stimulus 20.6897 4 no
GO:0050804 modulation of chemical synaptic transmission 20.6897 5 no
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 no
GO:0060284 regulation of cell development 20.6897 5 no
GO:0099177 regulation of trans-synaptic signaling 20.6897 4 no
GO:1901701 cellular response to oxygen-containing compound 20.6897 4 no
GO:0034329 cell junction assembly 18.9655 5 yes
GO:0051345 positive regulation of hydrolase activity 17.2414 5 yes
GO:0051726 regulation of cell cycle 17.2414 4 yes
GO:0007043 cell-cell junction assembly 15.5172 6 yes
GO:0010564 regulation of cell cycle process 12.0690 5 yes
GO:0043087 regulation of GTPase activity 12.0690 5 yes
GO:0043547 positive regulation of GTPase activity 10.3448 6 yes
GO:0032465 regulation of cytokinesis 6.8966 5 yes
GO:0045787 positive regulation of cell cycle 6.8966 5 yes
GO:0051302 regulation of cell division 6.8966 4 yes
GO:0090068 positive regulation of cell cycle process 6.8966 6 yes
GO:0032467 positive regulation of cytokinesis 5.1724 6 yes
GO:0051781 positive regulation of cell division 5.1724 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PKP4_HUMAN
DOID:0111962 combined immunodeficiency 3.4483 4 no
DOID:612 primary immunodeficiency disease 3.4483 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
ERBIN_HUMAN [view entry] [view interactions] Low throughput yes yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARMC8_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DESP_HUMAN [view entry] [view interactions] Low throughput yes no
DSC3_HUMAN [view interactions] Low throughput no no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CADH5_HUMAN [view interactions] Low throughput no yes
PDZD2_HUMAN [view interactions] Low throughput no yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
AKAP8_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
STK11_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
ATPF2_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
GBRAP_HUMAN [view interactions] High throughput no no
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
PTPRC_HUMAN [view interactions] High throughput no no
PTPRJ_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
SAV1_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
INADL_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
UBS3B_HUMAN [view interactions] High throughput no yes
VATB1_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
CLC11_HUMAN [view interactions] High throughput no no
PE2R3_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
NEST_HUMAN [view interactions] High throughput no no
RGAP1_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
URP2_HUMAN [view interactions] High throughput no no
EVPL_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
MD2L1_HUMAN [view interactions] High throughput no no
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
CADH8_HUMAN [view interactions] High throughput no no
CTNA3_HUMAN [view interactions] High throughput no no
APBA3_HUMAN [view interactions] High throughput no yes
TM52B_HUMAN [view interactions] High throughput no no
NK1R_HUMAN [view interactions] High throughput no no
HAVR2_HUMAN [view interactions] High throughput no no
KCNJ5_HUMAN [view interactions] High throughput no yes
FGFR2_HUMAN [view interactions] High throughput no yes
CP054_HUMAN [view interactions] High throughput no no
MRAP2_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ZBT10_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
BRPF3_HUMAN [view interactions] High throughput no yes
TRI66_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
CAD12_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
NK3R_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
CCD96_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view interactions] High throughput no no
CC85A_HUMAN [view interactions] High throughput no yes
CCL3_HUMAN [view interactions] High throughput no no
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
BACE2_HUMAN [view interactions] High throughput no yes
APBA1_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
FLRT1_HUMAN [view interactions] High throughput no no
PFD1_HUMAN [view interactions] High throughput no yes
AMHR2_HUMAN [view interactions] High throughput no no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOV_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
DAPLE_HUMAN [view interactions] High throughput no yes
CEP89_HUMAN [view interactions] High throughput no no
NCK5L_HUMAN [view interactions] High throughput no yes
PTPRK_HUMAN [view interactions] High throughput no no
KS6A2_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
DSC1_HUMAN [view interactions] Computational no no
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
DSG2_HUMAN [view interactions] Computational no no
DSG4_HUMAN [view interactions] Computational no no
DSG1_HUMAN [view entry] [view interactions] Computational yes no
DSG3_HUMAN [view interactions] Computational no no
DSC2_HUMAN [view interactions] Computational no no
FLCN_HUMAN [view interactions] Computational no yes