PKP4_HUMAN
Evidence for PS localization
Functions
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003531 | LIG_PDZ_Wminus1_1 | LIG | 1190 | 1192 | - |
| ELMI003531 | LIG_PDZ_Wminus1_1 | LIG | 1190 | 1192 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PKP4_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.5385 | 4 | no |
| GO:0000166 | nucleotide binding | 38.4615 | 4 | no |
| GO:0017076 | purine nucleotide binding | 38.4615 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 38.4615 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.4615 | 4 | no |
| GO:0019900 | kinase binding | 33.8462 | 4 | no |
| GO:0019901 | protein kinase binding | 30.7692 | 5 | no |
| GO:0003924 | GTPase activity | 23.0769 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | no |
| GO:0005525 | GTP binding | 21.5385 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 21.5385 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 21.5385 | 5 | no |
| GO:0045296 | cadherin binding | 15.3846 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PKP4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 73.8462 | 4 | yes |
| GO:0010646 | regulation of cell communication | 56.9231 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.9231 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.3846 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.8462 | 4 | no |
| GO:0009966 | regulation of signal transduction | 52.3077 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.3077 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.2308 | 4 | no |
| GO:0006996 | organelle organization | 46.1538 | 4 | no |
| GO:0022607 | cellular component assembly | 44.6154 | 4 | yes |
| GO:0008104 | protein localization | 44.6154 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.0769 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.0769 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 41.5385 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0010468 | regulation of gene expression | 36.9231 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 36.9231 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.9231 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.9231 | 5 | no |
| GO:0051049 | regulation of transport | 35.3846 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 33.8462 | 5 | no |
| GO:0031399 | regulation of protein modification process | 32.3077 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.3077 | 6 | no |
| GO:2000145 | regulation of cell motility | 32.3077 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.7692 | 5 | no |
| GO:0030334 | regulation of cell migration | 30.7692 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.2308 | 6 | no |
| GO:0030030 | cell projection organization | 29.2308 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 29.2308 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.2308 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.2308 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.2308 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.6923 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.6923 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 27.6923 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 27.6923 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.6923 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.6923 | 4 | no |
| GO:0034330 | cell junction organization | 26.1538 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 26.1538 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 26.1538 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 26.1538 | 5 | no |
| GO:0071702 | organic substance transport | 26.1538 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.1538 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.1538 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.1538 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.1538 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 24.6154 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 24.6154 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.6154 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.6154 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.6154 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.6154 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.6154 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.6154 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.6154 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.6154 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 24.6154 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.6154 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.6154 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.6154 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.6154 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.6154 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 23.0769 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.0769 | 5 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 23.0769 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.5385 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.5385 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.5385 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 21.5385 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5385 | 5 | no |
| GO:0045216 | cell-cell junction organization | 18.4615 | 5 | yes |
| GO:0034329 | cell junction assembly | 16.9231 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.9231 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 16.9231 | 4 | yes |
| GO:0007043 | cell-cell junction assembly | 13.8462 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.8462 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 10.7692 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 9.2308 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.6923 | 6 | yes |
| GO:0032465 | regulation of cytokinesis | 6.1538 | 5 | yes |
| GO:0045787 | positive regulation of cell cycle | 6.1538 | 5 | yes |
| GO:0051302 | regulation of cell division | 6.1538 | 4 | yes |
| GO:0090068 | positive regulation of cell cycle process | 6.1538 | 6 | yes |
| GO:0032467 | positive regulation of cytokinesis | 4.6154 | 6 | yes |
| GO:0051781 | positive regulation of cell division | 4.6154 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARMC8_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DSC3_HUMAN | [view interactions] | Low throughput | no | no |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CADH5_HUMAN | [view interactions] | Low throughput | no | yes |
| PDZD2_HUMAN | [view interactions] | Low throughput | no | yes |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| FLRT1_HUMAN | [view interactions] | High throughput | no | no |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| AMHR2_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPLE_HUMAN | [view interactions] | High throughput | no | yes |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP8_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CLC11_HUMAN | [view interactions] | High throughput | no | no |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| EVPL_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| CADH8_HUMAN | [view interactions] | High throughput | no | no |
| CTNA3_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| CP054_HUMAN | [view interactions] | High throughput | no | no |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT10_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CAD12_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |