PKP4_HUMAN
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003531 | LIG_PDZ_Wminus1_1 | LIG | 1190 | 1192 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PKP4_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 39.6552 | 4 | no |
GO:0019901 | protein kinase binding | 39.6552 | 5 | no |
GO:0017076 | purine nucleotide binding | 37.9310 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 37.9310 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 37.9310 | 4 | no |
GO:0003924 | GTPase activity | 25.8621 | 7 | no |
GO:0016462 | pyrophosphatase activity | 25.8621 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.8621 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.8621 | 6 | no |
GO:0005525 | GTP binding | 24.1379 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 24.1379 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 24.1379 | 5 | no |
GO:0045296 | cadherin binding | 17.2414 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PKP4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 75.8621 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 58.6207 | 4 | no |
GO:0010646 | regulation of cell communication | 56.8966 | 4 | no |
GO:0009966 | regulation of signal transduction | 53.4483 | 4 | no |
GO:0048523 | negative regulation of cellular process | 53.4483 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 53.4483 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 51.7241 | 4 | no |
GO:0051128 | regulation of cellular component organization | 51.7241 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.7241 | 4 | no |
GO:0022607 | cellular component assembly | 48.2759 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 44.8276 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 44.8276 | 5 | no |
GO:0008104 | protein localization | 44.8276 | 4 | no |
GO:0006996 | organelle organization | 43.1034 | 4 | no |
GO:0023056 | positive regulation of signaling | 43.1034 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 43.1034 | 5 | no |
GO:0010468 | regulation of gene expression | 41.3793 | 5 | no |
GO:0051049 | regulation of transport | 41.3793 | 4 | no |
GO:0010647 | positive regulation of cell communication | 41.3793 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 41.3793 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 39.6552 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.6552 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 37.9310 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 36.2069 | 5 | no |
GO:0030030 | cell projection organization | 34.4828 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 32.7586 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 32.7586 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 32.7586 | 4 | no |
GO:0031344 | regulation of cell projection organization | 32.7586 | 5 | no |
GO:0031399 | regulation of protein modification process | 32.7586 | 6 | no |
GO:0042325 | regulation of phosphorylation | 32.7586 | 7 | no |
GO:0051130 | positive regulation of cellular component organization | 32.7586 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 32.7586 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 32.7586 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 31.0345 | 7 | no |
GO:0042127 | regulation of cell population proliferation | 31.0345 | 4 | no |
GO:0051094 | positive regulation of developmental process | 31.0345 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 31.0345 | 5 | no |
GO:2000145 | regulation of cell motility | 31.0345 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 29.3103 | 4 | no |
GO:0016192 | vesicle-mediated transport | 29.3103 | 4 | no |
GO:0071702 | organic substance transport | 29.3103 | 4 | no |
GO:0071705 | nitrogen compound transport | 29.3103 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.3103 | 5 | no |
GO:0007010 | cytoskeleton organization | 29.3103 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 29.3103 | 4 | no |
GO:0030334 | regulation of cell migration | 29.3103 | 5 | no |
GO:0071310 | cellular response to organic substance | 29.3103 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.3103 | 6 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 29.3103 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.5862 | 5 | no |
GO:0032880 | regulation of protein localization | 27.5862 | 5 | no |
GO:0033043 | regulation of organelle organization | 27.5862 | 5 | no |
GO:0060341 | regulation of cellular localization | 27.5862 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 27.5862 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 27.5862 | 4 | no |
GO:0010941 | regulation of cell death | 27.5862 | 4 | no |
GO:0030155 | regulation of cell adhesion | 27.5862 | 4 | yes |
GO:0034330 | cell junction organization | 27.5862 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 27.5862 | 7 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 27.5862 | 6 | no |
GO:0031175 | neuron projection development | 27.5862 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 27.5862 | 8 | no |
GO:0045595 | regulation of cell differentiation | 27.5862 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 27.5862 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 25.8621 | 5 | no |
GO:0043067 | regulation of programmed cell death | 25.8621 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.8621 | 8 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.8621 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.8621 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 24.1379 | 6 | no |
GO:0051050 | positive regulation of transport | 24.1379 | 4 | no |
GO:0042981 | regulation of apoptotic process | 24.1379 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 24.1379 | 4 | no |
GO:0051338 | regulation of transferase activity | 24.1379 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 24.1379 | 4 | no |
GO:0015031 | protein transport | 22.4138 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 22.4138 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 22.4138 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.4138 | 6 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 22.4138 | 5 | no |
GO:0045216 | cell-cell junction organization | 22.4138 | 5 | yes |
GO:0008284 | positive regulation of cell population proliferation | 22.4138 | 5 | no |
GO:0010648 | negative regulation of cell communication | 22.4138 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.4138 | 4 | no |
GO:0036211 | protein modification process | 22.4138 | 4 | no |
GO:0043412 | macromolecule modification | 22.4138 | 4 | no |
GO:0043549 | regulation of kinase activity | 22.4138 | 5 | no |
GO:0051347 | positive regulation of transferase activity | 22.4138 | 5 | no |
GO:0097435 | supramolecular fiber organization | 20.6897 | 4 | no |
GO:0010628 | positive regulation of gene expression | 20.6897 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 20.6897 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | no |
GO:0031346 | positive regulation of cell projection organization | 20.6897 | 6 | no |
GO:0033674 | positive regulation of kinase activity | 20.6897 | 6 | no |
GO:0043408 | regulation of MAPK cascade | 20.6897 | 6 | no |
GO:0048585 | negative regulation of response to stimulus | 20.6897 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 20.6897 | 5 | no |
GO:0051241 | negative regulation of multicellular organismal process | 20.6897 | 4 | no |
GO:0060284 | regulation of cell development | 20.6897 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 20.6897 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.6897 | 4 | no |
GO:0034329 | cell junction assembly | 18.9655 | 5 | yes |
GO:0051345 | positive regulation of hydrolase activity | 17.2414 | 5 | yes |
GO:0051726 | regulation of cell cycle | 17.2414 | 4 | yes |
GO:0007043 | cell-cell junction assembly | 15.5172 | 6 | yes |
GO:0010564 | regulation of cell cycle process | 12.0690 | 5 | yes |
GO:0043087 | regulation of GTPase activity | 12.0690 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 10.3448 | 6 | yes |
GO:0032465 | regulation of cytokinesis | 6.8966 | 5 | yes |
GO:0045787 | positive regulation of cell cycle | 6.8966 | 5 | yes |
GO:0051302 | regulation of cell division | 6.8966 | 4 | yes |
GO:0090068 | positive regulation of cell cycle process | 6.8966 | 6 | yes |
GO:0032467 | positive regulation of cytokinesis | 5.1724 | 6 | yes |
GO:0051781 | positive regulation of cell division | 5.1724 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PKP4_HUMAN |
---|---|---|---|---|
DOID:0111962 | combined immunodeficiency | 3.4483 | 4 | no |
DOID:612 | primary immunodeficiency disease | 3.4483 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARMC8_HUMAN | [view interactions] | Low throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DESP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DSC3_HUMAN | [view interactions] | Low throughput | no | no |
CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CADH5_HUMAN | [view interactions] | Low throughput | no | yes |
PDZD2_HUMAN | [view interactions] | Low throughput | no | yes |
GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
AKAP8_HUMAN | [view interactions] | High throughput | no | yes |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK11_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
GBRAP_HUMAN | [view interactions] | High throughput | no | no |
PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
PTPRC_HUMAN | [view interactions] | High throughput | no | no |
PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
LATS1_HUMAN | [view interactions] | High throughput | no | yes |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
SAV1_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INADL_HUMAN | [view interactions] | High throughput | no | no |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
PAXI1_HUMAN | [view interactions] | High throughput | no | no |
UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
VATB1_HUMAN | [view interactions] | High throughput | no | no |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
CLC11_HUMAN | [view interactions] | High throughput | no | no |
PE2R3_HUMAN | [view interactions] | High throughput | no | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEST_HUMAN | [view interactions] | High throughput | no | no |
RGAP1_HUMAN | [view interactions] | High throughput | no | no |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
URP2_HUMAN | [view interactions] | High throughput | no | no |
EVPL_HUMAN | [view interactions] | High throughput | no | yes |
KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MD2L1_HUMAN | [view interactions] | High throughput | no | no |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
CADH8_HUMAN | [view interactions] | High throughput | no | no |
CTNA3_HUMAN | [view interactions] | High throughput | no | no |
APBA3_HUMAN | [view interactions] | High throughput | no | yes |
TM52B_HUMAN | [view interactions] | High throughput | no | no |
NK1R_HUMAN | [view interactions] | High throughput | no | no |
HAVR2_HUMAN | [view interactions] | High throughput | no | no |
KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
CP054_HUMAN | [view interactions] | High throughput | no | no |
MRAP2_HUMAN | [view interactions] | High throughput | no | no |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
ZBT10_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
TRI66_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
CAD12_HUMAN | [view interactions] | High throughput | no | no |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
NK3R_HUMAN | [view interactions] | High throughput | no | no |
TX1B3_HUMAN | [view interactions] | High throughput | no | no |
CCD96_HUMAN | [view interactions] | High throughput | no | no |
ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
RYK_HUMAN | [view interactions] | High throughput | no | no |
CC85A_HUMAN | [view interactions] | High throughput | no | yes |
CCL3_HUMAN | [view interactions] | High throughput | no | no |
UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BACE2_HUMAN | [view interactions] | High throughput | no | yes |
APBA1_HUMAN | [view interactions] | High throughput | no | no |
CLC4A_HUMAN | [view interactions] | High throughput | no | no |
FLRT1_HUMAN | [view interactions] | High throughput | no | no |
PFD1_HUMAN | [view interactions] | High throughput | no | yes |
AMHR2_HUMAN | [view interactions] | High throughput | no | no |
GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAPLE_HUMAN | [view interactions] | High throughput | no | yes |
CEP89_HUMAN | [view interactions] | High throughput | no | no |
NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
PTPRK_HUMAN | [view interactions] | High throughput | no | no |
KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
NIN_HUMAN | [view interactions] | High throughput | no | no |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DSC1_HUMAN | [view interactions] | Computational | no | no |
PLAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DSG2_HUMAN | [view interactions] | Computational | no | no |
DSG4_HUMAN | [view interactions] | Computational | no | no |
DSG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DSG3_HUMAN | [view interactions] | Computational | no | no |
DSC2_HUMAN | [view interactions] | Computational | no | no |
FLCN_HUMAN | [view interactions] | Computational | no | yes |