Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPHA4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at Tyr-15 which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EPHA4_HUMAN
GO:0017076 purine nucleotide binding 35.0649 4 yes
GO:0032555 purine ribonucleotide binding 35.0649 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.7662 4 yes
GO:0019900 kinase binding 29.8701 4 yes
GO:0019901 protein kinase binding 29.8701 5 yes
GO:0030554 adenyl nucleotide binding 24.6753 5 yes
GO:0032559 adenyl ribonucleotide binding 24.6753 5 yes
GO:0005524 ATP binding 23.3766 5 yes
GO:0016301 kinase activity 20.7792 4 yes
GO:0045296 cadherin binding 20.7792 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 19.4805 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 18.1818 4 yes
GO:0004713 protein tyrosine kinase activity 16.8831 4 yes
GO:0046875 ephrin receptor binding 15.5844 4 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 7.7922 5 yes
GO:0019199 transmembrane receptor protein kinase activity 7.7922 4 yes
GO:1990782 protein tyrosine kinase binding 7.7922 6 yes
GO:0005003 ephrin receptor activity 6.4935 6 yes
GO:0005005 transmembrane-ephrin receptor activity 6.4935 7 yes
GO:0001540 amyloid-beta binding 3.8961 4 yes
GO:0005004 GPI-linked ephrin receptor activity 3.8961 7 yes
GO:0042731 PH domain binding 2.5974 4 yes
GO:0097161 DH domain binding 2.5974 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPHA4_HUMAN
GO:0048522 positive regulation of cellular process 68.8312 4 yes
GO:0048523 negative regulation of cellular process 64.9351 4 yes
GO:0010646 regulation of cell communication 62.3377 4 yes
GO:0009966 regulation of signal transduction 53.2468 4 yes
GO:0060255 regulation of macromolecule metabolic process 49.3506 4 yes
GO:0009893 positive regulation of metabolic process 48.0519 4 yes
GO:0031323 regulation of cellular metabolic process 48.0519 4 yes
GO:0080090 regulation of primary metabolic process 48.0519 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 46.7532 4 yes
GO:0051128 regulation of cellular component organization 45.4545 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 yes
GO:1902531 regulation of intracellular signal transduction 41.5584 5 yes
GO:0051049 regulation of transport 41.5584 4 no
GO:0031325 positive regulation of cellular metabolic process 40.2597 5 yes
GO:0051246 regulation of protein metabolic process 40.2597 5 yes
GO:0043085 positive regulation of catalytic activity 38.9610 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 37.6623 5 yes
GO:0019220 regulation of phosphate metabolic process 35.0649 6 yes
GO:0031399 regulation of protein modification process 35.0649 6 yes
GO:0042325 regulation of phosphorylation 35.0649 7 yes
GO:0048584 positive regulation of response to stimulus 35.0649 4 yes
GO:0051174 regulation of phosphorus metabolic process 35.0649 5 yes
GO:0010468 regulation of gene expression 33.7662 5 no
GO:0001932 regulation of protein phosphorylation 33.7662 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.7662 4 yes
GO:0022607 cellular component assembly 32.4675 4 no
GO:0009892 negative regulation of metabolic process 32.4675 4 yes
GO:0010647 positive regulation of cell communication 32.4675 5 yes
GO:0023056 positive regulation of signaling 32.4675 4 yes
GO:0030030 cell projection organization 32.4675 4 yes
GO:0048585 negative regulation of response to stimulus 32.4675 4 yes
GO:0051247 positive regulation of protein metabolic process 32.4675 6 yes
GO:0051336 regulation of hydrolase activity 32.4675 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 31.1688 6 yes
GO:0031344 regulation of cell projection organization 31.1688 5 yes
GO:0042127 regulation of cell population proliferation 31.1688 4 yes
GO:0042327 positive regulation of phosphorylation 31.1688 8 yes
GO:0045937 positive regulation of phosphate metabolic process 31.1688 7 yes
GO:0071310 cellular response to organic substance 31.1688 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.1688 6 yes
GO:0006996 organelle organization 29.8701 4 no
GO:0009967 positive regulation of signal transduction 29.8701 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.8701 5 yes
GO:0031401 positive regulation of protein modification process 29.8701 7 yes
GO:0043549 regulation of kinase activity 29.8701 5 yes
GO:0051338 regulation of transferase activity 29.8701 4 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0010941 regulation of cell death 28.5714 4 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 28.5714 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 28.5714 5 yes
GO:0010648 negative regulation of cell communication 28.5714 5 yes
GO:0023057 negative regulation of signaling 28.5714 4 yes
GO:0030155 regulation of cell adhesion 28.5714 4 yes
GO:0045595 regulation of cell differentiation 27.2727 4 yes
GO:0045859 regulation of protein kinase activity 27.2727 6 yes
GO:0008104 protein localization 25.9740 4 no
GO:0051050 positive regulation of transport 25.9740 4 no
GO:0006796 phosphate-containing compound metabolic process 25.9740 4 yes
GO:0010243 response to organonitrogen compound 25.9740 4 yes
GO:0010975 regulation of neuron projection development 25.9740 7 yes
GO:0033674 positive regulation of kinase activity 25.9740 6 yes
GO:0051130 positive regulation of cellular component organization 25.9740 5 yes
GO:0051241 negative regulation of multicellular organismal process 25.9740 4 yes
GO:0051345 positive regulation of hydrolase activity 25.9740 5 yes
GO:0051347 positive regulation of transferase activity 25.9740 5 yes
GO:2000145 regulation of cell motility 24.6753 4 yes
GO:0032880 regulation of protein localization 24.6753 5 no
GO:0042981 regulation of apoptotic process 24.6753 6 no
GO:0043067 regulation of programmed cell death 24.6753 5 no
GO:0060341 regulation of cellular localization 24.6753 4 no
GO:0034330 cell junction organization 24.6753 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 24.6753 5 yes
GO:1902533 positive regulation of intracellular signal transduction 23.3766 6 yes
GO:0002684 positive regulation of immune system process 23.3766 4 no
GO:0009889 regulation of biosynthetic process 23.3766 4 no
GO:0031326 regulation of cellular biosynthetic process 23.3766 5 no
GO:0009968 negative regulation of signal transduction 23.3766 5 yes
GO:0043412 macromolecule modification 23.3766 4 yes
GO:0050804 modulation of chemical synaptic transmission 23.3766 5 yes
GO:0051093 negative regulation of developmental process 23.3766 4 yes
GO:0080134 regulation of response to stress 23.3766 4 yes
GO:0099177 regulation of trans-synaptic signaling 23.3766 4 yes
GO:1901701 cellular response to oxygen-containing compound 23.3766 4 yes
GO:0016192 vesicle-mediated transport 22.0779 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.0779 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.0779 5 no
GO:0031324 negative regulation of cellular metabolic process 22.0779 5 no
GO:0050776 regulation of immune response 22.0779 4 no
GO:0044087 regulation of cellular component biogenesis 22.0779 4 no
GO:0030334 regulation of cell migration 22.0779 5 yes
GO:0032101 regulation of response to external stimulus 22.0779 4 yes
GO:0036211 protein modification process 22.0779 4 yes
GO:0051129 negative regulation of cellular component organization 22.0779 5 yes
GO:0051240 positive regulation of multicellular organismal process 22.0779 4 yes
GO:0120036 plasma membrane bounded cell projection organization 22.0779 5 yes
GO:0043269 regulation of ion transport 20.7792 5 no
GO:0033043 regulation of organelle organization 20.7792 5 no
GO:0007010 cytoskeleton organization 20.7792 5 no
GO:0045785 positive regulation of cell adhesion 20.7792 5 yes
GO:0045860 positive regulation of protein kinase activity 20.7792 7 yes
GO:0051248 negative regulation of protein metabolic process 20.7792 6 yes
GO:0016310 phosphorylation 19.4805 5 yes
GO:0032990 cell part morphogenesis 19.4805 4 yes
GO:0048858 cell projection morphogenesis 19.4805 5 yes
GO:0051094 positive regulation of developmental process 19.4805 4 yes
GO:0008284 positive regulation of cell population proliferation 18.1818 5 yes
GO:0043408 regulation of MAPK cascade 18.1818 6 yes
GO:0045216 cell-cell junction organization 18.1818 5 yes
GO:0050807 regulation of synapse organization 18.1818 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.1818 6 yes
GO:0006468 protein phosphorylation 16.8831 5 yes
GO:0030162 regulation of proteolysis 16.8831 6 yes
GO:0031346 positive regulation of cell projection organization 16.8831 6 yes
GO:0045596 negative regulation of cell differentiation 16.8831 5 yes
GO:0048812 neuron projection morphogenesis 16.8831 7 yes
GO:0071900 regulation of protein serine/threonine kinase activity 16.8831 7 yes
GO:1902532 negative regulation of intracellular signal transduction 15.5844 6 yes
GO:0002009 morphogenesis of an epithelium 15.5844 4 yes
GO:0018193 peptidyl-amino acid modification 15.5844 5 yes
GO:0031175 neuron projection development 15.5844 6 yes
GO:0031345 negative regulation of cell projection organization 15.5844 6 yes
GO:0045597 positive regulation of cell differentiation 15.5844 5 yes
GO:0048013 ephrin receptor signaling pathway 15.5844 6 yes
GO:0051960 regulation of nervous system development 15.5844 5 yes
GO:0060284 regulation of cell development 15.5844 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 15.5844 7 yes
GO:0071417 cellular response to organonitrogen compound 15.5844 4 yes
GO:1901699 cellular response to nitrogen compound 15.5844 4 yes
GO:2000147 positive regulation of cell motility 14.2857 5 yes
GO:0010977 negative regulation of neuron projection development 14.2857 7 yes
GO:0022604 regulation of cell morphogenesis 14.2857 5 yes
GO:0030335 positive regulation of cell migration 14.2857 6 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0040017 positive regulation of locomotion 14.2857 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 14.2857 8 yes
GO:0050767 regulation of neurogenesis 14.2857 6 yes
GO:0052547 regulation of peptidase activity 14.2857 5 yes
GO:0052548 regulation of endopeptidase activity 14.2857 6 yes
GO:1901652 response to peptide 14.2857 4 yes
GO:0007162 negative regulation of cell adhesion 12.9870 5 yes
GO:0007409 axonogenesis 12.9870 8 yes
GO:0018108 peptidyl-tyrosine phosphorylation 12.9870 6 yes
GO:0018212 peptidyl-tyrosine modification 12.9870 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 12.9870 8 yes
GO:0099175 regulation of postsynapse organization 12.9870 6 yes
GO:0007411 axon guidance 11.6883 8 yes
GO:0043087 regulation of GTPase activity 11.6883 5 yes
GO:0043410 positive regulation of MAPK cascade 11.6883 7 yes
GO:0045862 positive regulation of proteolysis 11.6883 7 yes
GO:0046777 protein autophosphorylation 11.6883 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 11.6883 9 yes
GO:0097485 neuron projection guidance 11.6883 7 yes
GO:0010950 positive regulation of endopeptidase activity 10.3896 7 yes
GO:0010952 positive regulation of peptidase activity 10.3896 6 yes
GO:0050770 regulation of axonogenesis 10.3896 5 yes
GO:0050808 synapse organization 10.3896 5 yes
GO:0050821 protein stabilization 10.3896 4 yes
GO:0051099 positive regulation of binding 10.3896 4 yes
GO:0080135 regulation of cellular response to stress 10.3896 4 yes
GO:2000146 negative regulation of cell motility 9.0909 5 yes
GO:0010720 positive regulation of cell development 9.0909 6 yes
GO:0040013 negative regulation of locomotion 9.0909 4 yes
GO:0043405 regulation of MAP kinase activity 9.0909 8 yes
GO:0061001 regulation of dendritic spine morphogenesis 9.0909 5 yes
GO:1901653 cellular response to peptide 9.0909 5 yes
GO:1903034 regulation of response to wounding 7.7922 5 yes
GO:1904645 response to amyloid-beta 7.7922 5 yes
GO:1904646 cellular response to amyloid-beta 7.7922 6 yes
GO:0030336 negative regulation of cell migration 7.7922 6 yes
GO:0043409 negative regulation of MAPK cascade 7.7922 7 yes
GO:0045861 negative regulation of proteolysis 7.7922 7 yes
GO:0050769 positive regulation of neurogenesis 7.7922 6 yes
GO:0050773 regulation of dendrite development 7.7922 4 yes
GO:0051962 positive regulation of nervous system development 7.7922 5 yes
GO:0060562 epithelial tube morphogenesis 7.7922 4 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 7.7922 8 yes
GO:1905244 regulation of modification of synaptic structure 6.4935 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 6.4935 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 6.4935 7 yes
GO:0021955 central nervous system neuron axonogenesis 6.4935 9 yes
GO:0034248 regulation of cellular amide metabolic process 6.4935 5 yes
GO:0034332 adherens junction organization 6.4935 6 yes
GO:0043406 positive regulation of MAP kinase activity 6.4935 8 yes
GO:0061097 regulation of protein tyrosine kinase activity 6.4935 7 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 5.1948 6 yes
GO:1903035 negative regulation of response to wounding 5.1948 5 yes
GO:0008045 motor neuron axon guidance 5.1948 9 yes
GO:0008344 adult locomotory behavior 5.1948 4 yes
GO:0034250 positive regulation of cellular amide metabolic process 5.1948 6 yes
GO:0048814 regulation of dendrite morphogenesis 5.1948 5 yes
GO:0050775 positive regulation of dendrite morphogenesis 5.1948 6 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 5.1948 8 yes
GO:0072178 nephric duct morphogenesis 5.1948 5 yes
GO:1900271 regulation of long-term synaptic potentiation 5.1948 4 yes
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3.8961 7 yes
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3.8961 8 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 3.8961 7 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 3.8961 7 yes
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 3.8961 8 yes
GO:1905245 regulation of aspartic-type peptidase activity 3.8961 6 yes
GO:1905247 positive regulation of aspartic-type peptidase activity 3.8961 7 yes
GO:0007413 axonal fasciculation 3.8961 4 yes
GO:0007628 adult walking behavior 3.8961 5 yes
GO:0021952 central nervous system projection neuron axonogenesis 3.8961 10 yes
GO:0022411 cellular component disassembly 3.8961 4 yes
GO:0090659 walking behavior 3.8961 4 yes
GO:0098883 synapse pruning 3.8961 6 yes
GO:0106030 neuron projection fasciculation 3.8961 7 yes
GO:0150146 cell junction disassembly 3.8961 5 yes
GO:1900272 negative regulation of long-term synaptic potentiation 3.8961 4 yes
GO:1902003 regulation of amyloid-beta formation 2.5974 6 yes
GO:1902004 positive regulation of amyloid-beta formation 2.5974 7 yes
GO:1904424 regulation of GTP binding 2.5974 4 yes
GO:1904426 positive regulation of GTP binding 2.5974 5 yes
GO:1905097 regulation of guanyl-nucleotide exchange factor activity 2.5974 5 yes
GO:1905099 positive regulation of guanyl-nucleotide exchange factor activity 2.5974 6 yes
GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity 2.5974 7 yes
GO:0008347 glial cell migration 2.5974 4 yes
GO:0010717 regulation of epithelial to mesenchymal transition 2.5974 5 yes
GO:0010719 negative regulation of epithelial to mesenchymal transition 2.5974 5 yes
GO:0021957 corticospinal tract morphogenesis 2.5974 11 yes
GO:0043506 regulation of JUN kinase activity 2.5974 9 yes
GO:0043507 positive regulation of JUN kinase activity 2.5974 9 yes
GO:0045685 regulation of glial cell differentiation 2.5974 5 yes
GO:0048679 regulation of axon regeneration 2.5974 5 yes
GO:0048681 negative regulation of axon regeneration 2.5974 6 yes
GO:0048710 regulation of astrocyte differentiation 2.5974 6 yes
GO:0070570 regulation of neuron projection regeneration 2.5974 4 yes
GO:0070571 negative regulation of neuron projection regeneration 2.5974 5 yes
GO:0097155 fasciculation of sensory neuron axon 2.5974 5 yes
GO:0097156 fasciculation of motor neuron axon 2.5974 5 yes
GO:1900037 regulation of cellular response to hypoxia 2.5974 5 yes
GO:1900038 negative regulation of cellular response to hypoxia 2.5974 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in EPHA4_HUMAN
DOID:0050686 organ system cancer 3.8961 3 no
DOID:0050700 cardiomyopathy 2.5974 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5974 5 no
DOID:114 heart disease 2.5974 3 no
DOID:2843 long QT syndrome 2.5974 6 no
DOID:193 reproductive organ cancer 2.5974 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CHIN_HUMAN [view interactions] Low throughput no no
EFNA2_HUMAN [view interactions] Low throughput no no
EFNA5_HUMAN [view interactions] Low throughput no yes
EFNA1_HUMAN [view interactions] Low throughput no no
EFNA4_HUMAN [view interactions] Low throughput no no
RIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHA2_HUMAN [view interactions] Low throughput no no
FRS2_HUMAN [view interactions] Low throughput no no
FGFR3_HUMAN [view interactions] Low throughput no yes
ARHGF_HUMAN [view entry] [view interactions] Low throughput yes no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
ANC2_HUMAN [view interactions] Low throughput no no
FZR1_HUMAN [view interactions] Low throughput no no
FGFR1_HUMAN [view interactions] Low throughput no yes
FGFR2_HUMAN [view interactions] Low throughput no yes
FGFR4_HUMAN [view interactions] Low throughput no no
SORL_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SLAP2_HUMAN [view interactions] Low throughput no no
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPB_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NGEF_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB3_HUMAN [view entry] [view interactions] Low throughput yes yes
RSP14_HUMAN [view interactions] High throughput no no
F118B_HUMAN [view interactions] High throughput no yes
GBP5_HUMAN [view interactions] High throughput no no
UMPS_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
TBB6_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
PDIP3_HUMAN [view interactions] High throughput no no
BAF_HUMAN [view entry] [view interactions] High throughput yes yes
FANCI_HUMAN [view interactions] High throughput no yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
EPHA3_HUMAN [view interactions] High throughput no yes
GPN3_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NTPCR_HUMAN [view interactions] High throughput no yes
RS29_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
NEMO_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
BET1_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
US6NL_HUMAN [view interactions] High throughput no yes
M21D2_HUMAN [view interactions] High throughput no yes
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
DSG2_HUMAN [view interactions] High throughput no no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
SC24B_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
ZFY16_HUMAN [view interactions] High throughput no yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
PTN13_HUMAN [view interactions] High throughput no yes
SC23B_HUMAN [view interactions] High throughput no yes
PKHA1_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
FERM2_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view interactions] High throughput no yes
FCHO2_HUMAN [view interactions] High throughput no yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
AAAT_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CPNE8_HUMAN [view interactions] High throughput no yes
SAHH3_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
F135A_HUMAN [view interactions] High throughput no yes
CNNM3_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
BI2L1_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
SNP29_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
S6A15_HUMAN [view interactions] High throughput no yes
ZFYV9_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
VANG1_HUMAN [view interactions] High throughput no no
DSC2_HUMAN [view interactions] High throughput no no
AGRL2_HUMAN [view entry] [view interactions] High throughput yes no
ACOT2_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
UNC5B_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
GAB1_HUMAN [view interactions] High throughput no yes
NISCH_HUMAN [view interactions] High throughput no yes
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
FETUA_HUMAN [view interactions] High throughput no no
ZNT1_HUMAN [view entry] [view interactions] High throughput yes no
BRK1_HUMAN [view interactions] High throughput no no
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
PKP2_HUMAN [view interactions] High throughput no yes
STAT_HUMAN [view interactions] High throughput no no
F1711_HUMAN [view entry] [view interactions] High throughput yes yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
STAM2_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
TRM7_HUMAN [view interactions] High throughput no yes
CBPD_HUMAN [view interactions] High throughput no yes
TRFL_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
DPA1_HUMAN [view interactions] High throughput no yes
CEA21_HUMAN [view interactions] High throughput no yes
GNAT2_HUMAN [view interactions] High throughput no no
RIPK3_HUMAN [view interactions] High throughput no no
TB22A_HUMAN [view interactions] High throughput no yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
HDA10_HUMAN [view interactions] High throughput no yes
ARMC6_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
TMEM9_HUMAN [view interactions] High throughput no no
NUBP2_HUMAN [view interactions] High throughput no yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
COPZ1_HUMAN [view interactions] High throughput no no
CFAB_HUMAN [view interactions] High throughput no no
CENPH_HUMAN [view interactions] High throughput no yes
CTLA4_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
LR74A_HUMAN [view interactions] High throughput no no
MAGA8_HUMAN [view interactions] High throughput no no
NHLC3_HUMAN [view interactions] High throughput no yes
ADA11_HUMAN [view entry] [view interactions] High throughput yes yes
NAGAB_HUMAN [view interactions] High throughput no yes
CIB2_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
KLRG2_HUMAN [view interactions] High throughput no no
TSN3_HUMAN [view interactions] High throughput no yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
OS9_HUMAN [view interactions] High throughput no yes
CBPA5_HUMAN [view interactions] High throughput no no
CP1A2_HUMAN [view interactions] High throughput no no
MMP26_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
RFC4_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
FABPL_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] Computational no yes
CBL_HUMAN [view interactions] Computational no yes
RASA1_HUMAN [view interactions] Computational no yes
FGR_HUMAN [view interactions] Computational no no
VAV2_HUMAN [view entry] [view interactions] Computational yes yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
EFNA3_HUMAN [view interactions] Computational no yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
BLK_HUMAN [view interactions] Computational no no
VAV3_HUMAN [view interactions] Computational no yes
EFNB1_HUMAN [view interactions] Computational no yes
CDK5_HUMAN [view entry] [view interactions] Computational yes yes