Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIP2B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIP2B_HUMAN
GO:0019900 kinase binding 35.2941 4 no
GO:0019901 protein kinase binding 32.3529 5 no
GO:0000166 nucleotide binding 32.3529 4 no
GO:0017076 purine nucleotide binding 32.3529 5 no
GO:0032555 purine ribonucleotide binding 32.3529 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.3529 4 no
GO:0043168 anion binding 32.3529 4 no
GO:0004713 protein tyrosine kinase activity 23.5294 4 no
GO:0005524 ATP binding 23.5294 5 no
GO:0016301 kinase activity 23.5294 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.5294 4 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0032559 adenyl ribonucleotide binding 23.5294 5 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 20.5882 5 no
GO:0019199 transmembrane receptor protein kinase activity 20.5882 4 no
GO:0015631 tubulin binding 17.6471 4 yes
GO:0043014 alpha-tubulin binding 5.8824 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DIP2B_HUMAN
GO:0048522 positive regulation of cellular process 82.3529 4 no
GO:0051128 regulation of cellular component organization 70.5882 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.6471 4 yes
GO:0010646 regulation of cell communication 64.7059 4 no
GO:0048523 negative regulation of cellular process 64.7059 4 yes
GO:0080090 regulation of primary metabolic process 64.7059 4 yes
GO:0009893 positive regulation of metabolic process 61.7647 4 yes
GO:0051246 regulation of protein metabolic process 61.7647 5 yes
GO:0031323 regulation of cellular metabolic process 58.8235 4 no
GO:0010604 positive regulation of macromolecule metabolic process 58.8235 5 yes
GO:0009966 regulation of signal transduction 55.8824 4 no
GO:0031325 positive regulation of cellular metabolic process 52.9412 5 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0030030 cell projection organization 47.0588 4 no
GO:0009889 regulation of biosynthetic process 47.0588 4 no
GO:0010468 regulation of gene expression 47.0588 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.0588 5 no
GO:0031326 regulation of cellular biosynthetic process 47.0588 5 no
GO:0006996 organelle organization 44.1176 4 no
GO:0008104 protein localization 44.1176 4 no
GO:0051094 positive regulation of developmental process 44.1176 4 no
GO:0010647 positive regulation of cell communication 44.1176 5 no
GO:0023056 positive regulation of signaling 44.1176 4 no
GO:0031399 regulation of protein modification process 44.1176 6 yes
GO:2000026 regulation of multicellular organismal development 41.1765 4 yes
GO:0001932 regulation of protein phosphorylation 41.1765 7 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 no
GO:0042325 regulation of phosphorylation 41.1765 7 no
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 no
GO:0051240 positive regulation of multicellular organismal process 41.1765 4 no
GO:0051049 regulation of transport 41.1765 4 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0031344 regulation of cell projection organization 41.1765 5 yes
GO:0045595 regulation of cell differentiation 41.1765 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.2353 6 yes
GO:0051130 positive regulation of cellular component organization 38.2353 5 no
GO:0120036 plasma membrane bounded cell projection organization 38.2353 5 no
GO:0050804 modulation of chemical synaptic transmission 38.2353 5 no
GO:0099177 regulation of trans-synaptic signaling 38.2353 4 no
GO:1902531 regulation of intracellular signal transduction 38.2353 5 no
GO:0022603 regulation of anatomical structure morphogenesis 38.2353 4 yes
GO:0009891 positive regulation of biosynthetic process 35.2941 5 no
GO:0031328 positive regulation of cellular biosynthetic process 35.2941 6 no
GO:0009967 positive regulation of signal transduction 35.2941 5 no
GO:0031401 positive regulation of protein modification process 35.2941 7 yes
GO:0001934 positive regulation of protein phosphorylation 32.3529 8 no
GO:0010557 positive regulation of macromolecule biosynthetic process 32.3529 6 no
GO:0010562 positive regulation of phosphorus metabolic process 32.3529 6 no
GO:0042327 positive regulation of phosphorylation 32.3529 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.3529 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 32.3529 4 no
GO:0010975 regulation of neuron projection development 32.3529 7 yes
GO:0060284 regulation of cell development 32.3529 5 yes
GO:0007010 cytoskeleton organization 29.4118 5 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0008284 positive regulation of cell population proliferation 29.4118 5 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0031324 negative regulation of cellular metabolic process 29.4118 5 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0045597 positive regulation of cell differentiation 29.4118 5 no
GO:0042981 regulation of apoptotic process 29.4118 5 no
GO:0043067 regulation of programmed cell death 29.4118 4 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 yes
GO:0031175 neuron projection development 26.4706 6 no
GO:0033043 regulation of organelle organization 26.4706 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.4706 5 no
GO:0051252 regulation of RNA metabolic process 26.4706 5 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 26.4706 5 no
GO:0030155 regulation of cell adhesion 26.4706 4 no
GO:0031346 positive regulation of cell projection organization 26.4706 6 no
GO:0009894 regulation of catabolic process 26.4706 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.4706 6 no
GO:0045596 negative regulation of cell differentiation 26.4706 5 yes
GO:0050767 regulation of neurogenesis 26.4706 6 yes
GO:0051093 negative regulation of developmental process 26.4706 4 yes
GO:0051241 negative regulation of multicellular organismal process 26.4706 4 yes
GO:0051960 regulation of nervous system development 26.4706 5 yes
GO:0033365 protein localization to organelle 23.5294 5 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0045859 regulation of protein kinase activity 23.5294 6 no
GO:0051338 regulation of transferase activity 23.5294 4 no
GO:0002009 morphogenesis of an epithelium 23.5294 4 no
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0010720 positive regulation of cell development 23.5294 6 no
GO:0030162 regulation of proteolysis 23.5294 6 no
GO:0030334 regulation of cell migration 23.5294 5 no
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0032101 regulation of response to external stimulus 23.5294 4 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:0043408 regulation of MAPK cascade 23.5294 6 no
GO:0048812 neuron projection morphogenesis 23.5294 5 no
GO:0050807 regulation of synapse organization 23.5294 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.5294 4 no
GO:2000145 regulation of cell motility 23.5294 4 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0060627 regulation of vesicle-mediated transport 23.5294 4 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0043933 protein-containing complex organization 20.5882 4 no
GO:0044089 positive regulation of cellular component biogenesis 20.5882 5 no
GO:0036211 protein modification process 20.5882 4 no
GO:0043412 macromolecule modification 20.5882 4 no
GO:0006355 regulation of DNA-templated transcription 20.5882 7 no
GO:2001141 regulation of RNA biosynthetic process 20.5882 6 no
GO:0009968 negative regulation of signal transduction 20.5882 5 no
GO:0010629 negative regulation of gene expression 20.5882 7 no
GO:0010648 negative regulation of cell communication 20.5882 5 no
GO:0016310 phosphorylation 20.5882 5 no
GO:0023057 negative regulation of signaling 20.5882 4 no
GO:0045785 positive regulation of cell adhesion 20.5882 5 no
GO:0048585 negative regulation of response to stimulus 20.5882 4 no
GO:0051248 negative regulation of protein metabolic process 20.5882 6 no
GO:0051336 regulation of hydrolase activity 20.5882 4 no
GO:0032880 regulation of protein localization 20.5882 5 no
GO:0060341 regulation of cellular localization 20.5882 4 no
GO:0010628 positive regulation of gene expression 20.5882 7 no
GO:0022898 regulation of transmembrane transporter activity 20.5882 4 no
GO:0034762 regulation of transmembrane transport 20.5882 4 no
GO:0031345 negative regulation of cell projection organization 20.5882 6 yes
GO:0010977 negative regulation of neuron projection development 17.6471 7 yes
GO:0048638 regulation of developmental growth 17.6471 4 yes
GO:0050770 regulation of axonogenesis 17.6471 5 yes
GO:0001558 regulation of cell growth 14.7059 4 yes
GO:0007399 nervous system development 14.7059 4 yes
GO:0010721 negative regulation of cell development 14.7059 6 yes
GO:0050768 negative regulation of neurogenesis 14.7059 6 yes
GO:0051961 negative regulation of nervous system development 14.7059 5 yes
GO:0050771 negative regulation of axonogenesis 11.7647 6 yes
GO:0061387 regulation of extent of cell growth 11.7647 5 yes
GO:0030308 negative regulation of cell growth 8.8235 5 yes
GO:0030516 regulation of axon extension 8.8235 5 yes
GO:0045926 negative regulation of growth 8.8235 4 yes
GO:0048640 negative regulation of developmental growth 8.8235 5 yes
GO:0030517 negative regulation of axon extension 5.8824 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARFG1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
ZBT7B_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
EIF1A_HUMAN [view interactions] High throughput no no
CD6_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
PRPS2_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
ABHDA_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
GSLG1_HUMAN [view entry] [view interactions] High throughput yes yes
L2GL1_HUMAN [view entry] [view interactions] High throughput yes yes
SYPM_HUMAN [view interactions] High throughput no yes
MICU1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CK052_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
HAVR2_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
LYAM2_HUMAN [view interactions] High throughput no no
CNKR3_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
SWAP1_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
RAD21_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes