L2GL1_HUMAN
Evidence for PS localization
Functions
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in L2GL1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 47.6923 | 4 | no |
| GO:0000166 | nucleotide binding | 46.1538 | 4 | no |
| GO:0017076 | purine nucleotide binding | 46.1538 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 46.1538 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.1538 | 4 | no |
| GO:0019900 | kinase binding | 30.7692 | 4 | yes |
| GO:0005525 | GTP binding | 29.2308 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 29.2308 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.2308 | 5 | no |
| GO:0019901 | protein kinase binding | 27.6923 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 26.1538 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.1538 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.1538 | 6 | no |
| GO:0003924 | GTPase activity | 24.6154 | 7 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.5385 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.5385 | 4 | no |
| GO:0017022 | myosin binding | 4.6154 | 4 | yes |
| GO:0005096 | GTPase activator activity | 3.0769 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 3.0769 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in L2GL1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.2308 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.3846 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.3077 | 4 | no |
| GO:0006996 | organelle organization | 50.7692 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.7692 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.2308 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.6923 | 4 | no |
| GO:0008104 | protein localization | 47.6923 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.1538 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.6154 | 5 | no |
| GO:0022607 | cellular component assembly | 43.0769 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.0769 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.0769 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 43.0769 | 5 | no |
| GO:0010468 | regulation of gene expression | 41.5385 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.5385 | 5 | no |
| GO:0060341 | regulation of cellular localization | 40.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 38.4615 | 5 | yes |
| GO:0071702 | organic substance transport | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 36.9231 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 36.9231 | 5 | no |
| GO:0071705 | nitrogen compound transport | 36.9231 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.8462 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.8462 | 4 | no |
| GO:0031399 | regulation of protein modification process | 33.8462 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.8462 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 32.3077 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.7692 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:0008284 | positive regulation of cell population proliferation | 29.2308 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.2308 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.2308 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 29.2308 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.2308 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.2308 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.2308 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.6923 | 5 | no |
| GO:0030334 | regulation of cell migration | 27.6923 | 5 | no |
| GO:2000145 | regulation of cell motility | 27.6923 | 4 | no |
| GO:0015031 | protein transport | 27.6923 | 4 | no |
| GO:0030030 | cell projection organization | 26.1538 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.1538 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.1538 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 26.1538 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.1538 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 24.6154 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 24.6154 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 24.6154 | 7 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.6154 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 23.0769 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 23.0769 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 23.0769 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 23.0769 | 7 | no |
| GO:0043933 | protein-containing complex organization | 21.5385 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.5385 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.5385 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.5385 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.5385 | 4 | no |
| GO:0051046 | regulation of secretion | 20.0000 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 20.0000 | 4 | yes |
| GO:0051223 | regulation of protein transport | 18.4615 | 5 | yes |
| GO:0046903 | secretion | 13.8462 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 9.2308 | 5 | yes |
| GO:0030865 | cortical cytoskeleton organization | 7.6923 | 6 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 7.6923 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 7.6923 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 7.6923 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.6923 | 4 | yes |
| GO:0007409 | axonogenesis | 4.6154 | 6 | yes |
| GO:0051293 | establishment of spindle localization | 4.6154 | 4 | yes |
| GO:0051294 | establishment of spindle orientation | 4.6154 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 3.0769 | 4 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 3.0769 | 5 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 3.0769 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYH10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| PAR6B_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| TRIB1_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAL1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1M_HUMAN | [view interactions] | High throughput | no | yes |
| ARL11_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| IRGQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |