L2GL1_HUMAN
Evidence for PS localization
Functions
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in L2GL1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 52.4590 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 49.1803 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 49.1803 | 4 | no |
| GO:0019900 | kinase binding | 37.7049 | 4 | yes |
| GO:0019901 | protein kinase binding | 31.1475 | 5 | yes |
| GO:0005525 | GTP binding | 29.5082 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 29.5082 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.5082 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.5082 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 29.5082 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.5082 | 5 | no |
| GO:0003924 | GTPase activity | 27.8689 | 7 | no |
| GO:0030554 | adenyl nucleotide binding | 22.9508 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.3115 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.3115 | 4 | no |
| GO:0017022 | myosin binding | 4.9180 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in L2GL1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.4918 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.6557 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 59.0164 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.7377 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 54.0984 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.0984 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.4590 | 4 | no |
| GO:0006996 | organelle organization | 50.8197 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.1803 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 49.1803 | 4 | no |
| GO:0008104 | protein localization | 47.5410 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 47.5410 | 5 | no |
| GO:0009966 | regulation of signal transduction | 47.5410 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 44.2623 | 5 | no |
| GO:0022607 | cellular component assembly | 44.2623 | 4 | yes |
| GO:0051049 | regulation of transport | 40.9836 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.9836 | 5 | no |
| GO:0010468 | regulation of gene expression | 40.9836 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.3443 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 39.3443 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 37.7049 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0656 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.0656 | 4 | no |
| GO:0071702 | organic substance transport | 36.0656 | 4 | no |
| GO:0071705 | nitrogen compound transport | 36.0656 | 4 | no |
| GO:0010941 | regulation of cell death | 34.4262 | 4 | no |
| GO:0031399 | regulation of protein modification process | 34.4262 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 34.4262 | 6 | no |
| GO:0023056 | positive regulation of signaling | 34.4262 | 4 | no |
| GO:0007010 | cytoskeleton organization | 34.4262 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 34.4262 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.7869 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.7869 | 5 | no |
| GO:0030030 | cell projection organization | 32.7869 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 31.1475 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 31.1475 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.1475 | 5 | no |
| GO:0071310 | cellular response to organic substance | 31.1475 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 31.1475 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.1475 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.5082 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 29.5082 | 5 | no |
| GO:0051338 | regulation of transferase activity | 29.5082 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.5082 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.5082 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 29.5082 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.5082 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.5082 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.8689 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.8689 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.8689 | 4 | no |
| GO:0015031 | protein transport | 27.8689 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.2295 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 26.2295 | 4 | no |
| GO:0030334 | regulation of cell migration | 26.2295 | 5 | no |
| GO:2000145 | regulation of cell motility | 26.2295 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.5902 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.5902 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.5902 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.5902 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.5902 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.5902 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.5902 | 8 | no |
| GO:0043549 | regulation of kinase activity | 24.5902 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.5902 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 24.5902 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.5902 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.5902 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.5902 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 24.5902 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.5902 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.5902 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.5902 | 6 | no |
| GO:0051050 | positive regulation of transport | 24.5902 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 22.9508 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.9508 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.9508 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 22.9508 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 22.9508 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.9508 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.9508 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.3115 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.3115 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.3115 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 21.3115 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 21.3115 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.3115 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.3115 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 19.6721 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 19.6721 | 4 | yes |
| GO:0051223 | regulation of protein transport | 18.0328 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 18.0328 | 5 | yes |
| GO:0051046 | regulation of secretion | 14.7541 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 14.7541 | 4 | yes |
| GO:0030865 | cortical cytoskeleton organization | 14.7541 | 6 | yes |
| GO:0046903 | secretion | 13.1148 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 9.8361 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 9.8361 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 9.8361 | 6 | yes |
| GO:0032990 | cell part morphogenesis | 9.8361 | 4 | yes |
| GO:0048193 | Golgi vesicle transport | 8.1967 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 8.1967 | 4 | yes |
| GO:0006887 | exocytosis | 8.1967 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 6.5574 | 5 | yes |
| GO:0007409 | axonogenesis | 6.5574 | 8 | yes |
| GO:0051293 | establishment of spindle localization | 4.9180 | 4 | yes |
| GO:0051294 | establishment of spindle orientation | 4.9180 | 5 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 4.9180 | 4 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 3.2787 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in L2GL1_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 3.2787 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 3.2787 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYH10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | Low throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| PAR6B_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIB1_HUMAN | [view interactions] | High throughput | no | no |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAL1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1M_HUMAN | [view interactions] | High throughput | no | yes |
| ARL11_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| IRGQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG5_HUMAN | [view entry] [view interactions] | Computational | yes | no |