ROR2_HUMAN
Evidence for PS localization
Functions
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development . Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 184 | Arg | Cys | Robinowsyndrome,autosomalrecessive1(RRS1) | - |
| 189 | Arg | Trp | Robinowsyndrome,autosomalrecessive1(RRS1) | - |
| 366 | Arg | Trp | Robinowsyndrome,autosomalrecessive1(RRS1) | - |
| 620 | Asn | Lys | Robinowsyndrome,autosomalrecessive1(RRS1) | - |
| 182 | Cys | Tyr | Robinowsyndrome,autosomalrecessive1(RRS1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ROR2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.6923 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.6923 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6923 | 4 | yes |
| GO:0019900 | kinase binding | 27.8846 | 4 | yes |
| GO:0019901 | protein kinase binding | 27.8846 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 21.1538 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.1538 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.1538 | 6 | no |
| GO:0005524 | ATP binding | 17.3077 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.3077 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.3077 | 5 | yes |
| GO:0046872 | metal ion binding | 15.3846 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 9.6154 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 9.6154 | 4 | yes |
| GO:0016301 | kinase activity | 9.6154 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 9.6154 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.7308 | 4 | yes |
| GO:0005109 | frizzled binding | 4.8077 | 5 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 3.8462 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 3.8462 | 4 | yes |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding | 2.8846 | 6 | yes |
| GO:0071936 | coreceptor activity involved in Wnt signaling pathway | 1.9231 | 4 | yes |
| GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | 1.9231 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ROR2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.3846 | 4 | yes |
| GO:0010646 | regulation of cell communication | 49.0385 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.0769 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 47.1154 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.1923 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.2308 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.2308 | 4 | yes |
| GO:0008104 | protein localization | 42.3077 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3462 | 4 | yes |
| GO:0051049 | regulation of transport | 41.3462 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.3846 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.4231 | 5 | yes |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.5769 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.5769 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | yes |
| GO:0006996 | organelle organization | 34.6154 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.6538 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 33.6538 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 32.6923 | 4 | yes |
| GO:0030030 | cell projection organization | 31.7308 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.7308 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.7308 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 30.7692 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.7692 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.7692 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 29.8077 | 5 | yes |
| GO:0071702 | organic substance transport | 28.8462 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.8846 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 27.8846 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 27.8846 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 26.9231 | 7 | yes |
| GO:0071705 | nitrogen compound transport | 26.9231 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.9231 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.9615 | 7 | yes |
| GO:0045595 | regulation of cell differentiation | 25.9615 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.9615 | 7 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.9615 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0385 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 24.0385 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 24.0385 | 8 | yes |
| GO:0043085 | positive regulation of catalytic activity | 24.0385 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.0385 | 7 | yes |
| GO:0051094 | positive regulation of developmental process | 24.0385 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.0385 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.0385 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.0385 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.0385 | 6 | yes |
| GO:0015031 | protein transport | 23.0769 | 4 | no |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.0769 | 8 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.1154 | 6 | yes |
| GO:2000145 | regulation of cell motility | 22.1154 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.1154 | 5 | no |
| GO:0043412 | macromolecule modification | 22.1154 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.1154 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.1154 | 5 | no |
| GO:0030334 | regulation of cell migration | 22.1154 | 5 | yes |
| GO:0036211 | protein modification process | 21.1538 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.1538 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.1538 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.1538 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.1923 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 20.1923 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 20.1923 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.1923 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.1923 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 20.1923 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 20.1923 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.1923 | 7 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.1923 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.1923 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 20.1923 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.1923 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.1923 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.1923 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.1923 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 20.1923 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.1923 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 20.1923 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 20.1923 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 19.2308 | 6 | yes |
| GO:0045859 | regulation of protein kinase activity | 18.2692 | 6 | yes |
| GO:0002684 | positive regulation of immune system process | 18.2692 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 17.3077 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 17.3077 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 16.3462 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 16.3462 | 6 | yes |
| GO:0033674 | positive regulation of kinase activity | 16.3462 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 16.3462 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 16.3462 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 16.3462 | 5 | yes |
| GO:2000147 | positive regulation of cell motility | 16.3462 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 15.3846 | 7 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 15.3846 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 15.3846 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 15.3846 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 15.3846 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 15.3846 | 8 | yes |
| GO:0010975 | regulation of neuron projection development | 15.3846 | 7 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 14.4231 | 7 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 13.4615 | 7 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 13.4615 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 12.5000 | 5 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 11.5385 | 4 | yes |
| GO:0016055 | Wnt signaling pathway | 11.5385 | 5 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 10.5769 | 7 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 10.5769 | 8 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 10.5769 | 5 | yes |
| GO:0043405 | regulation of MAP kinase activity | 9.6154 | 8 | yes |
| GO:0010976 | positive regulation of neuron projection development | 8.6538 | 7 | yes |
| GO:0035567 | non-canonical Wnt signaling pathway | 6.7308 | 6 | yes |
| GO:0000165 | MAPK cascade | 6.7308 | 4 | yes |
| GO:0043406 | positive regulation of MAP kinase activity | 5.7692 | 8 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 5.7692 | 6 | yes |
| GO:1902105 | regulation of leukocyte differentiation | 5.7692 | 5 | yes |
| GO:1903706 | regulation of hemopoiesis | 5.7692 | 4 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 5.7692 | 5 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 5.7692 | 6 | yes |
| GO:0043506 | regulation of JUN kinase activity | 4.8077 | 9 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 4.8077 | 5 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 4.8077 | 7 | yes |
| GO:0031098 | stress-activated protein kinase signaling cascade | 3.8462 | 4 | yes |
| GO:0042733 | embryonic digit morphogenesis | 3.8462 | 4 | yes |
| GO:0048806 | genitalia development | 3.8462 | 4 | yes |
| GO:1902107 | positive regulation of leukocyte differentiation | 3.8462 | 6 | yes |
| GO:1903708 | positive regulation of hemopoiesis | 3.8462 | 5 | yes |
| GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 3.8462 | 5 | yes |
| GO:0021782 | glial cell development | 3.8462 | 4 | yes |
| GO:0035282 | segmentation | 2.8846 | 4 | yes |
| GO:0042472 | inner ear morphogenesis | 2.8846 | 4 | yes |
| GO:0043507 | positive regulation of JUN kinase activity | 2.8846 | 9 | yes |
| GO:0045637 | regulation of myeloid cell differentiation | 2.8846 | 5 | yes |
| GO:0048562 | embryonic organ morphogenesis | 2.8846 | 4 | yes |
| GO:0051403 | stress-activated MAPK cascade | 2.8846 | 5 | yes |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 2.8846 | 7 | yes |
| GO:1900019 | regulation of protein kinase C activity | 2.8846 | 8 | yes |
| GO:1900020 | positive regulation of protein kinase C activity | 2.8846 | 9 | yes |
| GO:0002761 | regulation of myeloid leukocyte differentiation | 2.8846 | 6 | yes |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | 2.8846 | 7 | yes |
| GO:0007224 | smoothened signaling pathway | 2.8846 | 4 | yes |
| GO:0007254 | JNK cascade | 2.8846 | 6 | yes |
| GO:0009952 | anterior/posterior pattern specification | 2.8846 | 4 | yes |
| GO:0014002 | astrocyte development | 2.8846 | 5 | yes |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 2.8846 | 6 | yes |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 2.8846 | 7 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 2.8846 | 6 | yes |
| GO:0030509 | BMP signaling pathway | 1.9231 | 6 | yes |
| GO:0030538 | embryonic genitalia morphogenesis | 1.9231 | 4 | yes |
| GO:0030539 | male genitalia development | 1.9231 | 5 | yes |
| GO:0045639 | positive regulation of myeloid cell differentiation | 1.9231 | 6 | yes |
| GO:0045649 | regulation of macrophage differentiation | 1.9231 | 7 | yes |
| GO:0045651 | positive regulation of macrophage differentiation | 1.9231 | 8 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 1.9231 | 6 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 1.9231 | 6 | yes |
| GO:0061458 | reproductive system development | 1.9231 | 4 | yes |
| GO:1905517 | macrophage migration | 1.9231 | 4 | yes |
| GO:0002763 | positive regulation of myeloid leukocyte differentiation | 1.9231 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ROR2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.8077 | 3 | no |
| DOID:0050700 | cardiomyopathy | 3.8462 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.8462 | 5 | no |
| DOID:2843 | long QT syndrome | 2.8846 | 6 | no |
| DOID:0060764 | autosomal recessive Robinow syndrome | 1.9231 | 3 | yes |
| DOID:10273 | heart conduction disease | 1.9231 | 4 | no |
| DOID:0111962 | combined immunodeficiency | 1.9231 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 1.9231 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ROR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGD1_HUMAN | [view interactions] | Low throughput | no | no |
| WNT1_HUMAN | [view interactions] | Low throughput | no | no |
| WNT5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RNF43_HUMAN | [view interactions] | Low throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | Low throughput | no | no |
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA198_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKAL_HUMAN | [view interactions] | High throughput | no | no |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB10B_HUMAN | [view interactions] | High throughput | no | no |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| TM209_HUMAN | [view interactions] | High throughput | no | no |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| STIM2_HUMAN | [view interactions] | High throughput | no | yes |
| F1711_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM4_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| PR20E_HUMAN | [view interactions] | High throughput | no | no |
| PTN20_HUMAN | [view interactions] | High throughput | no | yes |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| ZEP1_HUMAN | [view interactions] | High throughput | no | yes |
| ALG13_HUMAN | [view interactions] | High throughput | no | yes |
| TET5A_HUMAN | [view interactions] | High throughput | no | yes |
| AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
| F168B_HUMAN | [view interactions] | High throughput | no | yes |
| CS054_HUMAN | [view interactions] | High throughput | no | no |
| ZNF34_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5B_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| UD17_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| OGFD3_HUMAN | [view interactions] | High throughput | no | no |
| ASIC1_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDA8_HUMAN | [view interactions] | High throughput | no | no |
| CD3E_HUMAN | [view interactions] | High throughput | no | no |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| B4GA1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK2_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| HLAE_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| CD1B_HUMAN | [view interactions] | High throughput | no | yes |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| ESPB1_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDN1_HUMAN | [view interactions] | High throughput | no | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGT1_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| PR20D_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRX_HUMAN | [view interactions] | High throughput | no | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| OBF1_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| SOX14_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FOSB_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| PITX1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| PA2GX_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LHX6_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STOX1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRA71_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC056_HUMAN | [view interactions] | High throughput | no | no |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| VENTX_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| ISX_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| CJ055_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS18_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| PTN7_HUMAN | [view interactions] | High throughput | no | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN6_HUMAN | [view interactions] | High throughput | no | no |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| ILKAP_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1F_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS21_HUMAN | [view interactions] | High throughput | no | no |
| DUS29_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR6_HUMAN | [view interactions] | High throughput | no | no |
| MTMR9_HUMAN | [view interactions] | High throughput | no | no |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR44_HUMAN | [view interactions] | High throughput | no | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| PHAR4_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT8_HUMAN | [view interactions] | High throughput | no | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| DIP2A_HUMAN | [view interactions] | High throughput | no | no |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FZD6_HUMAN | [view interactions] | Computational | no | yes |
| DVL3_HUMAN | [view interactions] | Computational | no | yes |
| MK09_HUMAN | [view interactions] | Computational | no | yes |
| FZD7_HUMAN | [view interactions] | Computational | no | yes |
| VANG2_HUMAN | [view interactions] | Computational | no | no |
| FZD8_HUMAN | [view interactions] | Computational | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DVL2_HUMAN | [view interactions] | Computational | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FZD9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FZD2_HUMAN | [view interactions] | Computational | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LRP5_HUMAN | [view interactions] | Computational | no | yes |
| FZD4_HUMAN | [view interactions] | Computational | no | yes |
| FZD10_HUMAN | [view interactions] | Computational | no | no |
| FZD1_HUMAN | [view interactions] | Computational | no | yes |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FZD5_HUMAN | [view interactions] | Computational | no | yes |
| WNT3A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTHR1_HUMAN | [view interactions] | Computational | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |