Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WNT5A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression . Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed). Mediates motility of melanoma cells (PubMed). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
83 Cys Ser Robinowsyndrome,autosomaldominant1(DRS1) -
182 Cys Arg Robinowsyndrome,autosomaldominant1(DRS1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WNT5A_HUMAN
GO:0017076 purine nucleotide binding 30.7692 4 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0001664 G protein-coupled receptor binding 26.9231 4 yes
GO:0005524 ATP binding 26.9231 5 no
GO:0030554 adenyl nucleotide binding 26.9231 5 no
GO:0032559 adenyl ribonucleotide binding 26.9231 5 no
GO:0046872 metal ion binding 23.0769 4 no
GO:0019900 kinase binding 23.0769 4 no
GO:0019901 protein kinase binding 23.0769 5 no
GO:0005109 frizzled binding 19.2308 5 yes
GO:0048018 receptor ligand activity 15.3846 4 yes
GO:0005125 cytokine activity 11.5385 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WNT5A_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 yes
GO:0010646 regulation of cell communication 73.0769 4 yes
GO:0080090 regulation of primary metabolic process 69.2308 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 69.2308 4 yes
GO:0048523 negative regulation of cellular process 65.3846 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.3846 4 yes
GO:0048584 positive regulation of response to stimulus 61.5385 4 yes
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0051246 regulation of protein metabolic process 61.5385 5 yes
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 57.6923 5 yes
GO:0009893 positive regulation of metabolic process 57.6923 4 yes
GO:0010468 regulation of gene expression 57.6923 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 57.6923 5 yes
GO:0051049 regulation of transport 53.8462 4 yes
GO:0051247 positive regulation of protein metabolic process 53.8462 6 yes
GO:0010647 positive regulation of cell communication 53.8462 5 yes
GO:0023056 positive regulation of signaling 53.8462 4 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 46.1538 6 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 46.1538 4 yes
GO:0008104 protein localization 46.1538 4 yes
GO:0009889 regulation of biosynthetic process 46.1538 4 yes
GO:0051252 regulation of RNA metabolic process 46.1538 5 yes
GO:0009967 positive regulation of signal transduction 46.1538 5 yes
GO:0010941 regulation of cell death 46.1538 4 yes
GO:0016055 Wnt signaling pathway 46.1538 5 yes
GO:0031326 regulation of cellular biosynthetic process 46.1538 5 yes
GO:0031344 regulation of cell projection organization 46.1538 5 yes
GO:0031401 positive regulation of protein modification process 46.1538 7 yes
GO:0042981 regulation of apoptotic process 42.3077 6 yes
GO:0043067 regulation of programmed cell death 42.3077 5 yes
GO:0044087 regulation of cellular component biogenesis 42.3077 4 yes
GO:0045595 regulation of cell differentiation 42.3077 4 yes
GO:0051130 positive regulation of cellular component organization 42.3077 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.3077 5 yes
GO:0060548 negative regulation of cell death 42.3077 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 42.3077 4 yes
GO:0043066 negative regulation of apoptotic process 38.4615 7 yes
GO:0043069 negative regulation of programmed cell death 38.4615 6 yes
GO:1902531 regulation of intracellular signal transduction 38.4615 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 38.4615 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 38.4615 6 yes
GO:2001141 regulation of RNA biosynthetic process 38.4615 6 yes
GO:0048585 negative regulation of response to stimulus 38.4615 4 yes
GO:0006355 regulation of DNA-templated transcription 38.4615 6 yes
GO:0009891 positive regulation of biosynthetic process 38.4615 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 38.4615 6 yes
GO:0010975 regulation of neuron projection development 38.4615 7 yes
GO:0030030 cell projection organization 38.4615 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 38.4615 6 yes
GO:0032101 regulation of response to external stimulus 38.4615 4 yes
GO:0080134 regulation of response to stress 34.6154 4 yes
GO:0032880 regulation of protein localization 34.6154 5 yes
GO:0033043 regulation of organelle organization 34.6154 5 yes
GO:0036211 protein modification process 34.6154 4 yes
GO:0042325 regulation of phosphorylation 34.6154 7 yes
GO:0042327 positive regulation of phosphorylation 34.6154 8 yes
GO:1902533 positive regulation of intracellular signal transduction 34.6154 6 yes
GO:0043412 macromolecule modification 34.6154 4 yes
GO:0045937 positive regulation of phosphate metabolic process 34.6154 7 yes
GO:0001932 regulation of protein phosphorylation 34.6154 7 yes
GO:0001934 positive regulation of protein phosphorylation 34.6154 8 yes
GO:0050804 modulation of chemical synaptic transmission 34.6154 5 no
GO:0099177 regulation of trans-synaptic signaling 34.6154 4 no
GO:0009892 negative regulation of metabolic process 34.6154 4 yes
GO:0051174 regulation of phosphorus metabolic process 34.6154 5 yes
GO:0051240 positive regulation of multicellular organismal process 34.6154 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 34.6154 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 34.6154 5 yes
GO:0019220 regulation of phosphate metabolic process 34.6154 6 yes
GO:0060341 regulation of cellular localization 34.6154 4 yes
GO:0022607 cellular component assembly 34.6154 4 yes
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 yes
GO:0042127 regulation of cell population proliferation 30.7692 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 30.7692 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 30.7692 8 yes
GO:2000026 regulation of multicellular organismal development 30.7692 4 yes
GO:0045893 positive regulation of DNA-templated transcription 30.7692 7 yes
GO:0002684 positive regulation of immune system process 30.7692 4 yes
GO:0045597 positive regulation of cell differentiation 30.7692 5 no
GO:0051129 negative regulation of cellular component organization 30.7692 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 30.7692 5 yes
GO:0051254 positive regulation of RNA metabolic process 30.7692 6 yes
GO:0010648 negative regulation of cell communication 30.7692 5 yes
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 yes
GO:0023057 negative regulation of signaling 30.7692 4 yes
GO:0030155 regulation of cell adhesion 30.7692 4 yes
GO:0031346 positive regulation of cell projection organization 30.7692 6 yes
GO:0071310 cellular response to organic substance 30.7692 4 yes
GO:0080135 regulation of cellular response to stress 26.9231 4 yes
GO:1901214 regulation of neuron death 26.9231 5 yes
GO:1901888 regulation of cell junction assembly 26.9231 5 yes
GO:0043408 regulation of MAPK cascade 26.9231 6 yes
GO:2000027 regulation of animal organ morphogenesis 26.9231 5 yes
GO:0045785 positive regulation of cell adhesion 26.9231 5 yes
GO:2000145 regulation of cell motility 26.9231 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 26.9231 8 yes
GO:0051248 negative regulation of protein metabolic process 26.9231 6 no
GO:0030162 regulation of proteolysis 26.9231 6 no
GO:0006996 organelle organization 26.9231 4 no
GO:0006357 regulation of transcription by RNA polymerase II 26.9231 7 yes
GO:0050865 regulation of cell activation 26.9231 4 yes
GO:0051050 positive regulation of transport 26.9231 4 yes
GO:0008284 positive regulation of cell population proliferation 26.9231 5 yes
GO:0009894 regulation of catabolic process 26.9231 4 yes
GO:0051241 negative regulation of multicellular organismal process 26.9231 4 yes
GO:0009968 negative regulation of signal transduction 26.9231 5 yes
GO:0010628 positive regulation of gene expression 26.9231 6 yes
GO:0060070 canonical Wnt signaling pathway 26.9231 6 yes
GO:0060284 regulation of cell development 26.9231 5 yes
GO:0030111 regulation of Wnt signaling pathway 26.9231 5 yes
GO:0030334 regulation of cell migration 26.9231 5 yes
GO:0031175 neuron projection development 26.9231 6 yes
GO:0034330 cell junction organization 23.0769 4 yes
GO:0035567 non-canonical Wnt signaling pathway 23.0769 6 yes
GO:0097485 neuron projection guidance 23.0769 7 yes
GO:0040017 positive regulation of locomotion 23.0769 4 yes
GO:0042176 regulation of protein catabolic process 23.0769 5 yes
GO:0043065 positive regulation of apoptotic process 23.0769 7 yes
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 yes
GO:0043068 positive regulation of programmed cell death 23.0769 6 yes
GO:0043085 positive regulation of catalytic activity 23.0769 4 yes
GO:0043410 positive regulation of MAPK cascade 23.0769 7 yes
GO:1903829 positive regulation of protein localization 23.0769 5 yes
GO:2000147 positive regulation of cell motility 23.0769 5 yes
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0051046 regulation of secretion 23.0769 5 no
GO:1903530 regulation of secretion by cell 23.0769 4 no
GO:0002694 regulation of leukocyte activation 23.0769 4 yes
GO:0050807 regulation of synapse organization 23.0769 5 yes
GO:0007411 axon guidance 23.0769 8 yes
GO:0051338 regulation of transferase activity 23.0769 4 yes
GO:0051963 regulation of synapse assembly 23.0769 6 yes
GO:0010942 positive regulation of cell death 23.0769 5 yes
GO:0022407 regulation of cell-cell adhesion 23.0769 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 23.0769 6 yes
GO:0030335 positive regulation of cell migration 23.0769 6 yes
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 yes
GO:0033993 response to lipid 19.2308 4 yes
GO:0090175 regulation of establishment of planar polarity 19.2308 6 yes
GO:0043549 regulation of kinase activity 19.2308 5 yes
GO:0045596 negative regulation of cell differentiation 19.2308 5 yes
GO:0001817 regulation of cytokine production 19.2308 4 yes
GO:0002009 morphogenesis of an epithelium 19.2308 4 yes
GO:0002696 positive regulation of leukocyte activation 19.2308 5 yes
GO:0050678 regulation of epithelial cell proliferation 19.2308 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 19.2308 6 yes
GO:0050767 regulation of neurogenesis 19.2308 6 yes
GO:0050768 negative regulation of neurogenesis 19.2308 6 yes
GO:0050808 synapse organization 19.2308 5 yes
GO:0050867 positive regulation of cell activation 19.2308 5 yes
GO:0051093 negative regulation of developmental process 19.2308 4 yes
GO:0051336 regulation of hydrolase activity 19.2308 4 yes
GO:0051347 positive regulation of transferase activity 19.2308 5 yes
GO:0051960 regulation of nervous system development 19.2308 5 yes
GO:0051961 negative regulation of nervous system development 19.2308 5 yes
GO:0010721 negative regulation of cell development 19.2308 6 yes
GO:0010976 positive regulation of neuron projection development 19.2308 7 yes
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 19.2308 7 yes
GO:0030100 regulation of endocytosis 19.2308 5 yes
GO:0030177 positive regulation of Wnt signaling pathway 19.2308 6 yes
GO:0030182 neuron differentiation 19.2308 4 yes
GO:0070848 response to growth factor 19.2308 4 yes
GO:0032102 negative regulation of response to external stimulus 19.2308 5 yes
GO:0071363 cellular response to growth factor stimulus 19.2308 5 yes
GO:0033674 positive regulation of kinase activity 15.3846 6 yes
GO:0034329 cell junction assembly 15.3846 5 yes
GO:0099054 presynapse assembly 15.3846 5 yes
GO:0099172 presynapse organization 15.3846 4 yes
GO:0099173 postsynapse organization 15.3846 4 yes
GO:0099175 regulation of postsynapse organization 15.3846 6 yes
GO:0042733 embryonic digit morphogenesis 15.3846 4 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 15.3846 6 yes
GO:0043393 regulation of protein binding 15.3846 4 yes
GO:0045807 positive regulation of endocytosis 15.3846 5 yes
GO:0045859 regulation of protein kinase activity 15.3846 6 yes
GO:2000177 regulation of neural precursor cell proliferation 15.3846 5 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 15.3846 6 yes
GO:0002831 regulation of response to biotic stimulus 15.3846 4 yes
GO:0050770 regulation of axonogenesis 15.3846 5 yes
GO:0050776 regulation of immune response 15.3846 4 yes
GO:0006796 phosphate-containing compound metabolic process 15.3846 4 yes
GO:0050920 regulation of chemotaxis 15.3846 4 yes
GO:0051099 positive regulation of binding 15.3846 4 yes
GO:0009890 negative regulation of biosynthetic process 15.3846 5 yes
GO:0051253 negative regulation of RNA metabolic process 15.3846 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 15.3846 6 yes
GO:0051726 regulation of cell cycle 15.3846 4 yes
GO:0010594 regulation of endothelial cell migration 15.3846 5 yes
GO:0010595 positive regulation of endothelial cell migration 15.3846 6 yes
GO:0010632 regulation of epithelial cell migration 15.3846 4 yes
GO:0010634 positive regulation of epithelial cell migration 15.3846 5 yes
GO:0010977 negative regulation of neuron projection development 15.3846 7 yes
GO:0016310 phosphorylation 15.3846 5 yes
GO:0022409 positive regulation of cell-cell adhesion 15.3846 6 yes
GO:0060562 epithelial tube morphogenesis 15.3846 4 yes
GO:0022604 regulation of cell morphogenesis 15.3846 5 yes
GO:0030178 negative regulation of Wnt signaling pathway 15.3846 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 15.3846 6 yes
GO:0031345 negative regulation of cell projection organization 15.3846 6 yes
GO:0071241 cellular response to inorganic substance 15.3846 4 yes
GO:0032103 positive regulation of response to external stimulus 15.3846 5 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 11.5385 8 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 11.5385 7 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 11.5385 9 yes
GO:0034097 response to cytokine 11.5385 4 yes
GO:0090287 regulation of cellular response to growth factor stimulus 11.5385 4 yes
GO:0040013 negative regulation of locomotion 11.5385 4 yes
GO:1901216 positive regulation of neuron death 11.5385 6 yes
GO:1901342 regulation of vasculature development 11.5385 5 yes
GO:1902473 regulation of protein localization to synapse 11.5385 6 yes
GO:1902474 positive regulation of protein localization to synapse 11.5385 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.5385 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 11.5385 8 yes
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 11.5385 6 yes
GO:0045598 regulation of fat cell differentiation 11.5385 5 yes
GO:0045732 positive regulation of protein catabolic process 11.5385 6 yes
GO:0045765 regulation of angiogenesis 11.5385 5 yes
GO:0000578 embryonic axis specification 11.5385 4 yes
GO:0045860 positive regulation of protein kinase activity 11.5385 7 yes
GO:0001558 regulation of cell growth 11.5385 4 yes
GO:0045892 negative regulation of DNA-templated transcription 11.5385 7 yes
GO:0045926 negative regulation of growth 11.5385 4 yes
GO:0001819 positive regulation of cytokine production 11.5385 5 yes
GO:0001837 epithelial to mesenchymal transition 11.5385 5 yes
GO:0048562 embryonic organ morphogenesis 11.5385 4 yes
GO:0048638 regulation of developmental growth 11.5385 4 yes
GO:0048640 negative regulation of developmental growth 11.5385 5 yes
GO:0048762 mesenchymal cell differentiation 11.5385 4 yes
GO:0002697 regulation of immune effector process 11.5385 4 yes
GO:0048806 genitalia development 11.5385 4 yes
GO:0048878 chemical homeostasis 11.5385 4 yes
GO:0002833 positive regulation of response to biotic stimulus 11.5385 5 yes
GO:0003156 regulation of animal organ formation 11.5385 6 yes
GO:0003306 Wnt signaling pathway involved in heart development 11.5385 5 yes
GO:0050771 negative regulation of axonogenesis 11.5385 6 yes
GO:0050778 positive regulation of immune response 11.5385 5 yes
GO:0006468 protein phosphorylation 11.5385 5 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 11.5385 4 yes
GO:0008285 negative regulation of cell population proliferation 11.5385 5 yes
GO:0009896 positive regulation of catabolic process 11.5385 5 yes
GO:0009913 epidermal cell differentiation 11.5385 5 yes
GO:0009948 anterior/posterior axis specification 11.5385 4 yes
GO:0010038 response to metal ion 11.5385 4 yes
GO:0051345 positive regulation of hydrolase activity 11.5385 5 yes
GO:0010638 positive regulation of organelle organization 11.5385 6 yes
GO:0030308 negative regulation of cell growth 11.5385 5 yes
GO:0061311 cell surface receptor signaling pathway involved in heart development 11.5385 4 yes
GO:0030855 epithelial cell differentiation 11.5385 4 yes
GO:0061387 regulation of extent of cell growth 11.5385 5 yes
GO:0062009 secondary palate development 11.5385 4 yes
GO:0031347 regulation of defense response 11.5385 5 yes
GO:0071248 cellular response to metal ion 11.5385 5 yes
GO:0071300 cellular response to retinoic acid 11.5385 5 yes
GO:0032526 response to retinoic acid 11.5385 4 yes
GO:0071396 cellular response to lipid 11.5385 5 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 11.5385 4 yes
GO:0032675 regulation of interleukin-6 production 11.5385 5 yes
GO:0072507 divalent inorganic cation homeostasis 7.6923 7 yes
GO:0032755 positive regulation of interleukin-6 production 7.6923 6 yes
GO:0032872 regulation of stress-activated MAPK cascade 7.6923 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 7.6923 7 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7.6923 5 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7.6923 6 yes
GO:0090103 cochlea morphogenesis 7.6923 4 yes
GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 7.6923 7 yes
GO:0090179 planar cell polarity pathway involved in neural tube closure 7.6923 8 yes
GO:0090381 regulation of heart induction 7.6923 4 yes
GO:0035282 segmentation 7.6923 4 yes
GO:0098771 inorganic ion homeostasis 7.6923 6 yes
GO:0099068 postsynapse assembly 7.6923 5 yes
GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 7.6923 9 yes
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 7.6923 5 yes
GO:0110110 positive regulation of animal organ morphogenesis 7.6923 5 yes
GO:0150011 regulation of neuron projection arborization 7.6923 6 yes
GO:0150012 positive regulation of neuron projection arborization 7.6923 5 yes
GO:1900019 regulation of protein kinase C activity 7.6923 8 yes
GO:1900020 positive regulation of protein kinase C activity 7.6923 9 yes
GO:0042659 regulation of cell fate specification 7.6923 5 yes
GO:0043030 regulation of macrophage activation 7.6923 5 yes
GO:0043032 positive regulation of macrophage activation 7.6923 6 yes
GO:1901889 negative regulation of cell junction assembly 7.6923 6 yes
GO:0043087 regulation of GTPase activity 7.6923 5 yes
GO:0043405 regulation of MAP kinase activity 7.6923 8 yes
GO:0043406 positive regulation of MAP kinase activity 7.6923 8 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 7.6923 5 yes
GO:0043506 regulation of JUN kinase activity 7.6923 9 yes
GO:0043507 positive regulation of JUN kinase activity 7.6923 9 yes
GO:1904018 positive regulation of vasculature development 7.6923 5 yes
GO:1904861 excitatory synapse assembly 7.6923 7 yes
GO:0045088 regulation of innate immune response 7.6923 5 yes
GO:1905330 regulation of morphogenesis of an epithelium 7.6923 5 yes
GO:0045599 negative regulation of fat cell differentiation 7.6923 6 yes
GO:1905809 negative regulation of synapse organization 7.6923 6 yes
GO:0045766 positive regulation of angiogenesis 7.6923 6 yes
GO:0045778 positive regulation of ossification 7.6923 5 yes
GO:2000047 regulation of cell-cell adhesion mediated by cadherin 7.6923 6 yes
GO:0045787 positive regulation of cell cycle 7.6923 5 yes
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 7.6923 7 yes
GO:0000165 MAPK cascade 7.6923 4 yes
GO:0001707 mesoderm formation 7.6923 4 yes
GO:2000243 positive regulation of reproductive process 7.6923 4 yes
GO:0046328 regulation of JNK cascade 7.6923 7 yes
GO:0046330 positive regulation of JNK cascade 7.6923 8 yes
GO:0001936 regulation of endothelial cell proliferation 7.6923 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 7.6923 7 yes
GO:2000826 regulation of heart morphogenesis 7.6923 6 yes
GO:0001947 heart looping 7.6923 5 yes
GO:0048145 regulation of fibroblast proliferation 7.6923 5 yes
GO:0002053 positive regulation of mesenchymal cell proliferation 7.6923 6 yes
GO:0002064 epithelial cell development 7.6923 4 yes
GO:0002685 regulation of leukocyte migration 7.6923 4 yes
GO:0002687 positive regulation of leukocyte migration 7.6923 5 yes
GO:0002688 regulation of leukocyte chemotaxis 7.6923 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 7.6923 6 yes
GO:0048754 branching morphogenesis of an epithelial tube 7.6923 4 yes
GO:0002699 positive regulation of immune effector process 7.6923 5 yes
GO:0048819 regulation of hair follicle maturation 7.6923 4 yes
GO:0048841 regulation of axon extension involved in axon guidance 7.6923 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 7.6923 6 yes
GO:0050727 regulation of inflammatory response 7.6923 5 yes
GO:0003143 embryonic heart tube morphogenesis 7.6923 4 yes
GO:0050801 ion homeostasis 7.6923 5 yes
GO:0006873 cellular ion homeostasis 7.6923 4 yes
GO:0006874 cellular calcium ion homeostasis 7.6923 7 yes
GO:0050919 negative chemotaxis 7.6923 4 yes
GO:0006875 cellular metal ion homeostasis 7.6923 6 yes
GO:0007223 Wnt signaling pathway, calcium modulating pathway 7.6923 7 yes
GO:0050921 positive regulation of chemotaxis 7.6923 5 yes
GO:0007254 JNK cascade 7.6923 6 yes
GO:0050922 negative regulation of chemotaxis 7.6923 5 yes
GO:0007416 synapse assembly 7.6923 6 yes
GO:0009952 anterior/posterior pattern specification 7.6923 4 yes
GO:0010453 regulation of cell fate commitment 7.6923 4 yes
GO:0010464 regulation of mesenchymal cell proliferation 7.6923 5 yes
GO:0051403 stress-activated MAPK cascade 7.6923 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 7.6923 8 yes
GO:0051592 response to calcium ion 7.6923 5 yes
GO:0010564 regulation of cell cycle process 7.6923 5 yes
GO:0051884 regulation of timing of anagen 7.6923 5 yes
GO:0051964 negative regulation of synapse assembly 7.6923 6 yes
GO:0055065 metal ion homeostasis 7.6923 7 yes
GO:0055074 calcium ion homeostasis 7.6923 8 yes
GO:0055080 cation homeostasis 7.6923 6 yes
GO:0060026 convergent extension 7.6923 5 yes
GO:0060029 convergent extension involved in organogenesis 7.6923 6 yes
GO:0030003 cellular cation homeostasis 7.6923 5 yes
GO:0060688 regulation of morphogenesis of a branching structure 7.6923 4 yes
GO:0030216 keratinocyte differentiation 7.6923 6 yes
GO:0030278 regulation of ossification 7.6923 4 yes
GO:0061035 regulation of cartilage development 7.6923 5 yes
GO:0030516 regulation of axon extension 7.6923 5 yes
GO:0030517 negative regulation of axon extension 7.6923 6 yes
GO:0031098 stress-activated protein kinase signaling cascade 7.6923 4 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 7.6923 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 7.6923 6 yes
GO:0032092 positive regulation of protein binding 7.6923 5 yes
GO:0071277 cellular response to calcium ion 7.6923 6 yes
GO:0071345 cellular response to cytokine stimulus 7.6923 5 yes
GO:0032649 regulation of interferon-gamma production 7.6923 5 yes
GO:0032651 regulation of interleukin-1 beta production 7.6923 6 yes
GO:0032652 regulation of interleukin-1 production 7.6923 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 7.6923 7 yes
GO:0032680 regulation of tumor necrosis factor production 7.6923 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 7.6923 8 yes
GO:0032729 positive regulation of interferon-gamma production 7.6923 6 yes
GO:0072503 cellular divalent inorganic cation homeostasis 7.6923 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in WNT5A_HUMAN
DOID:0080001 bone disease 7.6923 4 no
DOID:0080006 bone development disease 7.6923 5 no
DOID:65 connective tissue disease 7.6923 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLOT_HUMAN [view interactions] Low throughput no no
TIKI2_HUMAN [view interactions] Low throughput no yes
FZD1_HUMAN [view interactions] Low throughput no yes
ROR1_HUMAN [view interactions] Low throughput no no
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
FZD4_HUMAN [view interactions] Low throughput no yes
ROR2_HUMAN [view entry] [view interactions] Low throughput yes yes
WIF1_HUMAN [view entry] [view interactions] Low throughput yes no
LRP6_HUMAN [view interactions] Low throughput no yes
RYK_HUMAN [view interactions] Low throughput no no
PORCN_HUMAN [view entry] [view interactions] Low throughput yes yes
FZD2_HUMAN [view interactions] Low throughput no no
SFRP1_HUMAN [view interactions] Low throughput no no
LG3BP_HUMAN [view interactions] Low throughput no no
TBX1_HUMAN [view interactions] Low throughput no no
PITX2_HUMAN [view interactions] Low throughput no no
AFAM_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FZD5_HUMAN [view interactions] High throughput no yes
ANTR1_HUMAN [view interactions] High throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
WNT4_HUMAN [view interactions] High throughput no no
WNT5B_HUMAN [view interactions] High throughput no no
WNT7A_HUMAN [view entry] [view interactions] High throughput yes no
PA2GX_HUMAN [view interactions] High throughput no no
TECT2_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
LYPD1_HUMAN [view interactions] High throughput no no
WNT16_HUMAN [view interactions] High throughput no no
FSTL1_HUMAN [view interactions] High throughput no yes
DEF1_HUMAN [view interactions] High throughput no no
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
POTEF_HUMAN [view interactions] High throughput no no
PROC_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
MKRN2_HUMAN [view interactions] High throughput no yes
ACHB2_HUMAN [view entry] [view interactions] High throughput yes no
LCFC1_HUMAN [view interactions] High throughput no no
TPC2L_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
CD1A_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
MSMB_HUMAN [view interactions] High throughput no no
IGFL3_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
C1QA_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view interactions] High throughput no yes
CL12B_HUMAN [view interactions] High throughput no no
CL3L1_HUMAN [view interactions] High throughput no no
LRAD1_HUMAN [view interactions] High throughput no no
SNX8_HUMAN [view interactions] High throughput no yes
TM45A_HUMAN [view interactions] High throughput no no
LY6H_HUMAN [view entry] [view interactions] High throughput yes no
HEPS_HUMAN [view interactions] High throughput no yes
LCN6_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
KLRG2_HUMAN [view interactions] High throughput no no
GAS6_HUMAN [view interactions] High throughput no no
CO6A1_HUMAN [view interactions] High throughput no no
ASAH1_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
GGT7_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
CNNM4_HUMAN [view interactions] High throughput no yes
ZNT7_HUMAN [view interactions] High throughput no no
PROS_HUMAN [view interactions] High throughput no no
LMF1_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
GPC3_HUMAN [view interactions] Computational no no
DVL2_HUMAN [view interactions] Computational no yes
WNT8B_HUMAN [view interactions] Computational no no
WN10B_HUMAN [view interactions] Computational no yes
PAR6A_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
UBQL2_HUMAN [view interactions] Computational no yes
FZD9_HUMAN [view entry] [view interactions] Computational yes no
WN10A_HUMAN [view interactions] Computational no no
WNT3_HUMAN [view interactions] Computational no no
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
FZD3_HUMAN [view interactions] Computational no yes
WNT11_HUMAN [view interactions] Computational no no
RORA_HUMAN [view interactions] Computational no yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
WNT2B_HUMAN [view interactions] Computational no no
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
FLNA_HUMAN [view entry] [view interactions] Computational yes no
LRP5_HUMAN [view interactions] Computational no yes
MK08_HUMAN [view interactions] Computational no yes
SFRP3_HUMAN [view interactions] Computational no no
SFRP5_HUMAN [view interactions] Computational no no
WNT9B_HUMAN [view interactions] Computational no no
DAAM1_HUMAN [view entry] [view interactions] Computational yes yes
WNT1_HUMAN [view interactions] Computational no no
FZD10_HUMAN [view interactions] Computational no no
TMED5_HUMAN [view interactions] Computational no yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
DKK1_HUMAN [view interactions] Computational no no
WNT9A_HUMAN [view interactions] Computational no no
SFRP4_HUMAN [view interactions] Computational no no
MUC18_HUMAN [view interactions] Computational no yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
WNT3A_HUMAN [view entry] [view interactions] Computational yes no
AXIN1_HUMAN [view interactions] Computational no yes
WNT2_HUMAN [view interactions] Computational no no
SFRP2_HUMAN [view interactions] Computational no no
WNT7B_HUMAN [view interactions] Computational no no
DKK2_HUMAN [view interactions] Computational no no
VANG2_HUMAN [view interactions] Computational no no
FZD7_HUMAN [view interactions] Computational no yes
MK09_HUMAN [view interactions] Computational no yes
FZD8_HUMAN [view interactions] Computational no yes
WNT6_HUMAN [view interactions] Computational no yes
DVL3_HUMAN [view interactions] Computational no yes
FZD6_HUMAN [view interactions] Computational no yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes