Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WNT7A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway . Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes . Required for normal neural stem cell proliferation in the hippocampus dentate gyrus . Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation . Promotes formation of synapses via its interaction with FZD5 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
109 Ala Thr Fuhrmannsyndrome(FUHRS) -
292 Arg Cys Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -
222 Arg Trp Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -
72 Glu Lys Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WNT7A_HUMAN
GO:0043169 cation binding 52.9412 4 no
GO:0046872 metal ion binding 52.9412 5 no
GO:0043168 anion binding 29.4118 4 no
GO:0000166 nucleotide binding 23.5294 4 no
GO:0017076 purine nucleotide binding 23.5294 5 no
GO:0032555 purine ribonucleotide binding 23.5294 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 no
GO:0005509 calcium ion binding 23.5294 6 no
GO:0001664 G protein-coupled receptor binding 17.6471 4 yes
GO:0005109 frizzled binding 17.6471 5 yes
GO:0005125 cytokine activity 11.7647 5 yes
GO:0048018 receptor ligand activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WNT7A_HUMAN
GO:0008104 protein localization 58.8235 4 yes
GO:0010646 regulation of cell communication 52.9412 4 yes
GO:0048522 positive regulation of cellular process 52.9412 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 yes
GO:0006996 organelle organization 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 yes
GO:0051128 regulation of cellular component organization 47.0588 4 yes
GO:0051246 regulation of protein metabolic process 47.0588 5 yes
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 yes
GO:0080090 regulation of primary metabolic process 47.0588 4 yes
GO:0009893 positive regulation of metabolic process 41.1765 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.1765 5 yes
GO:0022607 cellular component assembly 41.1765 4 yes
GO:0030030 cell projection organization 41.1765 4 yes
GO:1902531 regulation of intracellular signal transduction 35.2941 5 yes
GO:0048585 negative regulation of response to stimulus 35.2941 4 no
GO:0015031 protein transport 35.2941 4 no
GO:0071702 organic substance transport 35.2941 4 no
GO:0071705 nitrogen compound transport 35.2941 4 no
GO:0009889 regulation of biosynthetic process 35.2941 4 yes
GO:0010468 regulation of gene expression 35.2941 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 yes
GO:0016055 Wnt signaling pathway 35.2941 4 yes
GO:0031323 regulation of cellular metabolic process 35.2941 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.2941 5 yes
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 yes
GO:0051130 positive regulation of cellular component organization 35.2941 5 yes
GO:0051247 positive regulation of protein metabolic process 35.2941 6 yes
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 yes
GO:2001141 regulation of RNA biosynthetic process 29.4118 6 yes
GO:0007010 cytoskeleton organization 29.4118 5 no
GO:0009968 negative regulation of signal transduction 29.4118 5 no
GO:0010038 response to metal ion 29.4118 4 no
GO:0010648 negative regulation of cell communication 29.4118 5 no
GO:0023057 negative regulation of signaling 29.4118 4 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0006355 regulation of DNA-templated transcription 29.4118 7 yes
GO:0006915 apoptotic process 29.4118 4 yes
GO:0009891 positive regulation of biosynthetic process 29.4118 5 yes
GO:0009967 positive regulation of signal transduction 29.4118 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 29.4118 6 yes
GO:0010647 positive regulation of cell communication 29.4118 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 yes
GO:0023056 positive regulation of signaling 29.4118 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 29.4118 6 yes
GO:0032880 regulation of protein localization 29.4118 5 yes
GO:0042981 regulation of apoptotic process 29.4118 5 yes
GO:0043067 regulation of programmed cell death 29.4118 4 yes
GO:0044087 regulation of cellular component biogenesis 29.4118 4 yes
GO:0045595 regulation of cell differentiation 29.4118 4 yes
GO:0046903 secretion 29.4118 4 yes
GO:0048584 positive regulation of response to stimulus 29.4118 4 yes
GO:0051049 regulation of transport 29.4118 4 yes
GO:0051252 regulation of RNA metabolic process 29.4118 5 yes
GO:0060341 regulation of cellular localization 29.4118 4 yes
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.5294 4 yes
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 yes
GO:1903829 positive regulation of protein localization 23.5294 5 yes
GO:2000145 regulation of cell motility 23.5294 4 yes
GO:2000147 positive regulation of cell motility 23.5294 5 yes
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 no
GO:0030111 regulation of Wnt signaling pathway 23.5294 5 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0006886 intracellular protein transport 23.5294 4 no
GO:0071241 cellular response to inorganic substance 23.5294 4 no
GO:0071248 cellular response to metal ion 23.5294 5 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0034097 response to cytokine 23.5294 4 no
GO:0006357 regulation of transcription by RNA polymerase II 23.5294 8 yes
GO:0010628 positive regulation of gene expression 23.5294 7 yes
GO:0023061 signal release 23.5294 4 yes
GO:0030334 regulation of cell migration 23.5294 5 yes
GO:0030335 positive regulation of cell migration 23.5294 6 yes
GO:0031175 neuron projection development 23.5294 6 yes
GO:0034330 cell junction organization 23.5294 4 yes
GO:0040017 positive regulation of locomotion 23.5294 4 yes
GO:0042127 regulation of cell population proliferation 23.5294 4 yes
GO:0045596 negative regulation of cell differentiation 23.5294 5 yes
GO:0048812 neuron projection morphogenesis 23.5294 5 yes
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 yes
GO:0050807 regulation of synapse organization 23.5294 5 yes
GO:0050808 synapse organization 23.5294 5 yes
GO:0051093 negative regulation of developmental process 23.5294 4 yes
GO:0051094 positive regulation of developmental process 23.5294 4 yes
GO:0051241 negative regulation of multicellular organismal process 23.5294 4 yes
GO:0060627 regulation of vesicle-mediated transport 23.5294 4 yes
GO:0099054 presynapse assembly 17.6471 5 yes
GO:0099172 presynapse organization 17.6471 4 yes
GO:0099173 postsynapse organization 17.6471 4 yes
GO:0099175 regulation of postsynapse organization 17.6471 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 17.6471 6 yes
GO:1902473 regulation of protein localization to synapse 17.6471 6 yes
GO:1902474 positive regulation of protein localization to synapse 17.6471 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 17.6471 7 yes
GO:1903530 regulation of secretion by cell 17.6471 4 yes
GO:0008284 positive regulation of cell population proliferation 17.6471 5 yes
GO:0010594 regulation of endothelial cell migration 17.6471 5 yes
GO:0010595 positive regulation of endothelial cell migration 17.6471 6 yes
GO:0010632 regulation of epithelial cell migration 17.6471 4 yes
GO:0010634 positive regulation of epithelial cell migration 17.6471 5 yes
GO:0010975 regulation of neuron projection development 17.6471 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.6471 4 yes
GO:0030182 neuron differentiation 17.6471 4 yes
GO:0031344 regulation of cell projection organization 17.6471 5 yes
GO:0033993 response to lipid 17.6471 4 yes
GO:0035567 non-canonical Wnt signaling pathway 17.6471 5 yes
GO:0043066 negative regulation of apoptotic process 17.6471 6 yes
GO:0043069 negative regulation of programmed cell death 17.6471 5 yes
GO:0045893 positive regulation of DNA-templated transcription 17.6471 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 17.6471 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 17.6471 9 yes
GO:0051046 regulation of secretion 17.6471 5 yes
GO:0051254 positive regulation of RNA metabolic process 17.6471 6 yes
GO:0060070 canonical Wnt signaling pathway 17.6471 5 yes
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 17.6471 6 yes
GO:0099068 postsynapse assembly 11.7647 5 yes
GO:0099643 signal release from synapse 11.7647 5 yes
GO:0106027 neuron projection organization 11.7647 6 yes
GO:1901888 regulation of cell junction assembly 11.7647 5 yes
GO:1903305 regulation of regulated secretory pathway 11.7647 6 yes
GO:1904861 excitatory synapse assembly 11.7647 7 yes
GO:1905384 regulation of protein localization to presynapse 11.7647 7 yes
GO:1905386 positive regulation of protein localization to presynapse 11.7647 7 yes
GO:2000026 regulation of multicellular organismal development 11.7647 4 yes
GO:2000300 regulation of synaptic vesicle exocytosis 11.7647 6 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 11.7647 5 yes
GO:0000578 embryonic axis specification 11.7647 4 yes
GO:0002064 epithelial cell development 11.7647 4 yes
GO:0006836 neurotransmitter transport 11.7647 4 yes
GO:0007269 neurotransmitter secretion 11.7647 4 yes
GO:0007409 axonogenesis 11.7647 6 yes
GO:0007416 synapse assembly 11.7647 6 yes
GO:0010721 negative regulation of cell development 11.7647 6 yes
GO:0014070 response to organic cyclic compound 11.7647 4 yes
GO:0017157 regulation of exocytosis 11.7647 5 yes
GO:0031644 regulation of nervous system process 11.7647 5 yes
GO:0032355 response to estradiol 11.7647 4 yes
GO:0032535 regulation of cellular component size 11.7647 4 yes
GO:0034329 cell junction assembly 11.7647 5 yes
GO:0042733 embryonic digit morphogenesis 11.7647 4 yes
GO:0043408 regulation of MAPK cascade 11.7647 6 yes
GO:0043410 positive regulation of MAPK cascade 11.7647 7 yes
GO:0044057 regulation of system process 11.7647 4 yes
GO:0044089 positive regulation of cellular component biogenesis 11.7647 5 yes
GO:0046328 regulation of JNK cascade 11.7647 7 yes
GO:0046330 positive regulation of JNK cascade 11.7647 8 yes
GO:0046928 regulation of neurotransmitter secretion 11.7647 5 yes
GO:0050678 regulation of epithelial cell proliferation 11.7647 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 11.7647 6 yes
GO:0050767 regulation of neurogenesis 11.7647 6 yes
GO:0050768 negative regulation of neurogenesis 11.7647 6 yes
GO:0050770 regulation of axonogenesis 11.7647 5 yes
GO:0051240 positive regulation of multicellular organismal process 11.7647 4 yes
GO:0051588 regulation of neurotransmitter transport 11.7647 5 yes
GO:0051960 regulation of nervous system development 11.7647 5 yes
GO:0051961 negative regulation of nervous system development 11.7647 5 yes
GO:0051963 regulation of synapse assembly 11.7647 6 yes
GO:0060284 regulation of cell development 11.7647 5 yes
GO:0060997 dendritic spine morphogenesis 11.7647 6 yes
GO:0062009 secondary palate development 11.7647 4 yes
GO:0071363 cellular response to growth factor stimulus 11.7647 4 yes
GO:0071559 response to transforming growth factor beta 11.7647 4 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 11.7647 5 yes
GO:0097061 dendritic spine organization 11.7647 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALR_HUMAN [view entry] [view interactions] Low throughput yes yes
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
WIF1_HUMAN [view entry] [view interactions] Low throughput yes no
NOTUM_HUMAN [view interactions] Low throughput no no
RECK_HUMAN [view interactions] Low throughput no yes
FZD5_HUMAN [view interactions] Low throughput no yes
PORCN_HUMAN [view entry] [view interactions] Low throughput yes yes
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
DKK1_HUMAN [view interactions] Low throughput no no
FZD7_HUMAN [view interactions] Low throughput no yes
LDLR_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CO6A1_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
WNT7B_HUMAN [view interactions] High throughput no no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
FSTL1_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
2ABD_HUMAN [view interactions] High throughput no yes
BCAP_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
RSPRY_HUMAN [view interactions] High throughput no yes
TBB1_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
AFAM_HUMAN [view interactions] High throughput no no
CASP6_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
UBQL1_HUMAN [view interactions] High throughput no yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
MK09_HUMAN [view interactions] High throughput no yes
FBLN1_HUMAN [view interactions] High throughput no yes
CREL2_HUMAN [view interactions] High throughput no yes
FUT11_HUMAN [view interactions] High throughput no yes
PASK_HUMAN [view interactions] High throughput no yes
BORA_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
DKK3_HUMAN [view interactions] High throughput no yes
FBN2_HUMAN [view interactions] High throughput no no
DNJC3_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
MGRN1_HUMAN [view interactions] High throughput no yes
KREM2_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
WNT16_HUMAN [view interactions] High throughput no no
EFNA3_HUMAN [view interactions] High throughput no yes
SH3B4_HUMAN [view interactions] High throughput no yes
PKD2_HUMAN [view interactions] High throughput no yes