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WNT7A_HUMAN

GO
G2C
SynaptomeDB

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway . Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes . Required for normal neural stem cell proliferation in the hippocampus dentate gyrus . Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation . Promotes formation of synapses via its interaction with FZD5 . [View more on UniProt]

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No data found.

Position Amino acid Mutation Disease Overlap with binding region
109 Ala Thr Fuhrmannsyndrome(FUHRS) -
292 Arg Cys Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -
222 Arg Trp Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -
72 Glu Lys Limbpelvishypoplasiaaplasiasyndrome(LPHAS) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in WNT7A_HUMAN
GO:0046872 metal ion binding 26.3158 4 no
GO:0001664 G protein-coupled receptor binding 21.0526 4 yes
GO:0005109 frizzled binding 21.0526 5 yes
GO:0016462 pyrophosphatase activity 21.0526 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.0526 4 no
GO:0017076 purine nucleotide binding 21.0526 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.0526 6 no
GO:0032555 purine ribonucleotide binding 21.0526 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.0526 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0005125 cytokine activity 15.7895 5 yes
GO:0048018 receptor ligand activity 15.7895 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WNT7A_HUMAN
GO:0048522 positive regulation of cellular process 57.8947 4 yes
GO:0051128 regulation of cellular component organization 57.8947 4 yes
GO:0009966 regulation of signal transduction 57.8947 4 yes
GO:0010646 regulation of cell communication 57.8947 4 yes
GO:0048523 negative regulation of cellular process 52.6316 4 yes
GO:0008104 protein localization 52.6316 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 yes
GO:0051246 regulation of protein metabolic process 47.3684 5 yes
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 yes
GO:0080090 regulation of primary metabolic process 47.3684 4 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 47.3684 4 yes
GO:0016055 Wnt signaling pathway 47.3684 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 42.1053 5 yes
GO:0051247 positive regulation of protein metabolic process 42.1053 6 yes
GO:0060341 regulation of cellular localization 42.1053 4 yes
GO:0048585 negative regulation of response to stimulus 42.1053 4 no
GO:0009893 positive regulation of metabolic process 42.1053 4 yes
GO:0010468 regulation of gene expression 42.1053 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 yes
GO:0032880 regulation of protein localization 42.1053 5 yes
GO:0048584 positive regulation of response to stimulus 36.8421 4 yes
GO:0051049 regulation of transport 36.8421 4 yes
GO:0051094 positive regulation of developmental process 36.8421 4 yes
GO:0051130 positive regulation of cellular component organization 36.8421 5 yes
GO:0051252 regulation of RNA metabolic process 36.8421 5 yes
GO:0060070 canonical Wnt signaling pathway 36.8421 6 yes
GO:0071310 cellular response to organic substance 36.8421 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 36.8421 7 yes
GO:2001141 regulation of RNA biosynthetic process 36.8421 6 yes
GO:0030111 regulation of Wnt signaling pathway 36.8421 5 no
GO:0031399 regulation of protein modification process 36.8421 6 no
GO:0006996 organelle organization 36.8421 4 no
GO:0006355 regulation of DNA-templated transcription 36.8421 6 yes
GO:0009889 regulation of biosynthetic process 36.8421 4 yes
GO:0009967 positive regulation of signal transduction 36.8421 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.8421 5 yes
GO:0010647 positive regulation of cell communication 36.8421 5 yes
GO:0010941 regulation of cell death 36.8421 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 yes
GO:0023056 positive regulation of signaling 36.8421 4 yes
GO:0030030 cell projection organization 36.8421 4 yes
GO:0031323 regulation of cellular metabolic process 36.8421 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 yes
GO:0031326 regulation of cellular biosynthetic process 36.8421 5 yes
GO:0045893 positive regulation of DNA-templated transcription 31.5789 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 31.5789 6 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 31.5789 8 yes
GO:0051254 positive regulation of RNA metabolic process 31.5789 6 yes
GO:0060548 negative regulation of cell death 31.5789 5 yes
GO:0120036 plasma membrane bounded cell projection organization 31.5789 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 31.5789 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 31.5789 8 yes
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0031401 positive regulation of protein modification process 31.5789 7 no
GO:0033043 regulation of organelle organization 31.5789 5 no
GO:0006357 regulation of transcription by RNA polymerase II 31.5789 7 yes
GO:0009891 positive regulation of biosynthetic process 31.5789 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 31.5789 6 yes
GO:0022607 cellular component assembly 31.5789 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 31.5789 6 yes
GO:0042981 regulation of apoptotic process 31.5789 6 yes
GO:0043067 regulation of programmed cell death 31.5789 5 yes
GO:0044087 regulation of cellular component biogenesis 31.5789 4 yes
GO:0045595 regulation of cell differentiation 31.5789 4 yes
GO:0045596 negative regulation of cell differentiation 26.3158 5 yes
GO:0046903 secretion 26.3158 4 yes
GO:0050807 regulation of synapse organization 26.3158 5 yes
GO:0051093 negative regulation of developmental process 26.3158 4 yes
GO:0051240 positive regulation of multicellular organismal process 26.3158 4 yes
GO:0051241 negative regulation of multicellular organismal process 26.3158 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 yes
GO:1902531 regulation of intracellular signal transduction 26.3158 5 yes
GO:1903829 positive regulation of protein localization 26.3158 5 yes
GO:2000026 regulation of multicellular organismal development 26.3158 4 yes
GO:2000027 regulation of animal organ morphogenesis 26.3158 5 yes
GO:0036211 protein modification process 26.3158 4 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0043412 macromolecule modification 26.3158 4 no
GO:0051338 regulation of transferase activity 26.3158 4 no
GO:0060828 regulation of canonical Wnt signaling pathway 26.3158 6 no
GO:1901701 cellular response to oxygen-containing compound 26.3158 4 no
GO:0051129 negative regulation of cellular component organization 26.3158 5 no
GO:0008284 positive regulation of cell population proliferation 26.3158 5 yes
GO:0010628 positive regulation of gene expression 26.3158 6 yes
GO:0010975 regulation of neuron projection development 26.3158 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 yes
GO:0030182 neuron differentiation 26.3158 4 yes
GO:0031175 neuron projection development 26.3158 6 yes
GO:0031344 regulation of cell projection organization 26.3158 5 yes
GO:0042127 regulation of cell population proliferation 26.3158 4 yes
GO:0043066 negative regulation of apoptotic process 26.3158 7 yes
GO:0043069 negative regulation of programmed cell death 26.3158 6 yes
GO:0050678 regulation of epithelial cell proliferation 21.0526 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 21.0526 6 yes
GO:0050767 regulation of neurogenesis 21.0526 6 yes
GO:0050768 negative regulation of neurogenesis 21.0526 6 yes
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 yes
GO:0050808 synapse organization 21.0526 5 yes
GO:0051960 regulation of nervous system development 21.0526 5 yes
GO:0051961 negative regulation of nervous system development 21.0526 5 yes
GO:0051963 regulation of synapse assembly 21.0526 6 yes
GO:0060284 regulation of cell development 21.0526 5 yes
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 yes
GO:0070848 response to growth factor 21.0526 4 yes
GO:0071363 cellular response to growth factor stimulus 21.0526 5 yes
GO:0080134 regulation of response to stress 21.0526 4 yes
GO:0080135 regulation of cellular response to stress 21.0526 4 yes
GO:0099054 presynapse assembly 21.0526 5 yes
GO:0099172 presynapse organization 21.0526 4 yes
GO:0099173 postsynapse organization 21.0526 4 yes
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 yes
GO:1901888 regulation of cell junction assembly 21.0526 5 yes
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 yes
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0009892 negative regulation of metabolic process 21.0526 4 no
GO:0010038 response to metal ion 21.0526 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.0526 5 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0043393 regulation of protein binding 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:0051099 positive regulation of binding 21.0526 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.0526 5 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0015031 protein transport 21.0526 4 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0002009 morphogenesis of an epithelium 21.0526 4 no
GO:0006508 proteolysis 21.0526 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 21.0526 7 no
GO:0009057 macromolecule catabolic process 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010498 proteasomal protein catabolic process 21.0526 5 no
GO:0010942 positive regulation of cell death 21.0526 5 no
GO:0019941 modification-dependent protein catabolic process 21.0526 6 no
GO:0030163 protein catabolic process 21.0526 4 no
GO:0043065 positive regulation of apoptotic process 21.0526 7 no
GO:0043068 positive regulation of programmed cell death 21.0526 6 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 21.0526 6 no
GO:0043632 modification-dependent macromolecule catabolic process 21.0526 5 no
GO:0044265 cellular macromolecule catabolic process 21.0526 4 no
GO:0051603 proteolysis involved in protein catabolic process 21.0526 5 no
GO:1901214 regulation of neuron death 21.0526 5 no
GO:1901565 organonitrogen compound catabolic process 21.0526 4 no
GO:2000177 regulation of neural precursor cell proliferation 21.0526 5 no
GO:0007411 axon guidance 21.0526 8 no
GO:0031346 positive regulation of cell projection organization 21.0526 6 no
GO:0097485 neuron projection guidance 21.0526 7 no
GO:0030177 positive regulation of Wnt signaling pathway 21.0526 6 no
GO:0010721 negative regulation of cell development 21.0526 6 yes
GO:0023061 signal release 21.0526 4 yes
GO:0033993 response to lipid 21.0526 4 yes
GO:0034330 cell junction organization 21.0526 4 yes
GO:0048812 neuron projection morphogenesis 15.7895 7 yes
GO:0048858 cell projection morphogenesis 15.7895 5 yes
GO:0050770 regulation of axonogenesis 15.7895 5 yes
GO:0051046 regulation of secretion 15.7895 5 yes
GO:0051962 positive regulation of nervous system development 15.7895 5 yes
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 15.7895 7 yes
GO:0062009 secondary palate development 15.7895 4 yes
GO:0090175 regulation of establishment of planar polarity 15.7895 6 yes
GO:0099175 regulation of postsynapse organization 15.7895 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 15.7895 6 yes
GO:1902473 regulation of protein localization to synapse 15.7895 6 yes
GO:1902474 positive regulation of protein localization to synapse 15.7895 6 yes
GO:1903530 regulation of secretion by cell 15.7895 4 yes
GO:2000145 regulation of cell motility 15.7895 4 yes
GO:2000147 positive regulation of cell motility 15.7895 5 yes
GO:0000578 embryonic axis specification 15.7895 4 yes
GO:0014070 response to organic cyclic compound 15.7895 4 yes
GO:0030334 regulation of cell migration 15.7895 5 yes
GO:0030335 positive regulation of cell migration 15.7895 6 yes
GO:0031644 regulation of nervous system process 15.7895 5 yes
GO:0032990 cell part morphogenesis 15.7895 4 yes
GO:0034329 cell junction assembly 15.7895 5 yes
GO:0035567 non-canonical Wnt signaling pathway 15.7895 6 yes
GO:0040017 positive regulation of locomotion 15.7895 4 yes
GO:0042733 embryonic digit morphogenesis 15.7895 4 yes
GO:0043408 regulation of MAPK cascade 15.7895 6 yes
GO:0043410 positive regulation of MAPK cascade 15.7895 7 yes
GO:0044057 regulation of system process 15.7895 4 yes
GO:0046328 regulation of JNK cascade 10.5263 7 yes
GO:0046330 positive regulation of JNK cascade 10.5263 8 yes
GO:0046928 regulation of neurotransmitter secretion 10.5263 4 yes
GO:0048103 somatic stem cell division 10.5263 4 yes
GO:0051588 regulation of neurotransmitter transport 10.5263 5 yes
GO:0060066 oviduct development 10.5263 4 yes
GO:0060997 dendritic spine morphogenesis 10.5263 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 10.5263 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 10.5263 6 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 10.5263 4 yes
GO:0097061 dendritic spine organization 10.5263 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 10.5263 4 yes
GO:0099068 postsynapse assembly 10.5263 5 yes
GO:0099174 regulation of presynapse organization 10.5263 6 yes
GO:0099643 signal release from synapse 10.5263 5 yes
GO:0106027 neuron projection organization 10.5263 6 yes
GO:1903305 regulation of regulated secretory pathway 10.5263 6 yes
GO:1904861 excitatory synapse assembly 10.5263 7 yes
GO:1904889 regulation of excitatory synapse assembly 10.5263 7 yes
GO:1905384 regulation of protein localization to presynapse 10.5263 7 yes
GO:1905386 positive regulation of protein localization to presynapse 10.5263 7 yes
GO:1905606 regulation of presynapse assembly 10.5263 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 10.5263 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 10.5263 5 yes
GO:0001570 vasculogenesis 10.5263 4 yes
GO:0002064 epithelial cell development 10.5263 4 yes
GO:0006836 neurotransmitter transport 10.5263 4 yes
GO:0007269 neurotransmitter secretion 10.5263 4 yes
GO:0007409 axonogenesis 10.5263 8 yes
GO:0007416 synapse assembly 10.5263 6 yes
GO:0009953 dorsal/ventral pattern formation 10.5263 4 yes
GO:0010594 regulation of endothelial cell migration 10.5263 5 yes
GO:0010595 positive regulation of endothelial cell migration 10.5263 6 yes
GO:0010632 regulation of epithelial cell migration 10.5263 4 yes
GO:0010634 positive regulation of epithelial cell migration 10.5263 5 yes
GO:0017157 regulation of exocytosis 10.5263 5 yes
GO:0021846 cell proliferation in forebrain 10.5263 4 yes
GO:0021953 central nervous system neuron differentiation 10.5263 5 yes
GO:0022009 central nervous system vasculogenesis 10.5263 5 yes
GO:0030326 embryonic limb morphogenesis 10.5263 5 yes
GO:0032355 response to estradiol 10.5263 4 yes
GO:0032535 regulation of cellular component size 10.5263 4 yes
GO:0032872 regulation of stress-activated MAPK cascade 10.5263 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 10.5263 7 yes
GO:0035108 limb morphogenesis 10.5263 4 yes
GO:0035113 embryonic appendage morphogenesis 10.5263 4 yes
GO:0035115 embryonic forelimb morphogenesis 10.5263 6 yes
GO:0035116 embryonic hindlimb morphogenesis 10.5263 6 yes
GO:0035136 forelimb morphogenesis 10.5263 5 yes
GO:0035137 hindlimb morphogenesis 10.5263 5 yes
GO:0036465 synaptic vesicle recycling 10.5263 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
WIF1_HUMAN [view entry] [view interactions] Low throughput yes no
NOTUM_HUMAN [view interactions] Low throughput no no
RECK_HUMAN [view interactions] Low throughput no yes
FZD5_HUMAN [view interactions] Low throughput no yes
PORCN_HUMAN [view entry] [view interactions] Low throughput yes yes
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
DKK1_HUMAN [view interactions] Low throughput no no
FZD7_HUMAN [view interactions] Low throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
TBB1_HUMAN [view interactions] High throughput no yes
RSPRY_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
BCAP_HUMAN [view interactions] High throughput no no
2ABD_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
FSTL1_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
WNT7B_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
CO6A1_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
LDLR_HUMAN [view interactions] High throughput no yes
AFAM_HUMAN [view interactions] High throughput no no
CASP6_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
UBQL1_HUMAN [view interactions] High throughput no yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
MK09_HUMAN [view interactions] High throughput no yes
FBLN1_HUMAN [view interactions] High throughput no yes
CREL2_HUMAN [view interactions] High throughput no yes
FUT11_HUMAN [view interactions] High throughput no yes
PASK_HUMAN [view interactions] High throughput no yes
BORA_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
DKK3_HUMAN [view interactions] High throughput no yes
FBN2_HUMAN [view interactions] High throughput no no
DNJC3_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
MGRN1_HUMAN [view interactions] High throughput no yes
KREM2_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
WNT16_HUMAN [view interactions] High throughput no no
SH3B4_HUMAN [view interactions] High throughput no yes
PKD2_HUMAN [view interactions] High throughput no yes
WNT2_HUMAN [view interactions] Computational no no
WNT3_HUMAN [view interactions] Computational no no
FZD3_HUMAN [view interactions] Computational no yes
SFRP2_HUMAN [view interactions] Computational no no
WNT3A_HUMAN [view entry] [view interactions] Computational yes no
WN10A_HUMAN [view interactions] Computational no no
SFRP1_HUMAN [view interactions] Computational no no
FZD9_HUMAN [view entry] [view interactions] Computational yes no
LRP6_HUMAN [view interactions] Computational no yes
WN10B_HUMAN [view interactions] Computational no yes
WNT9A_HUMAN [view interactions] Computational no no
WNT8B_HUMAN [view interactions] Computational no no
AGRA2_HUMAN [view interactions] Computational no no
SFRP4_HUMAN [view interactions] Computational no no
TMED5_HUMAN [view interactions] Computational no yes
WNT6_HUMAN [view interactions] Computational no yes
SHH_HUMAN [view interactions] Computational no no
FZD6_HUMAN [view interactions] Computational no yes
FZD10_HUMAN [view interactions] Computational no no
FZD1_HUMAN [view interactions] Computational no yes
WNT1_HUMAN [view interactions] Computational no no
FZD8_HUMAN [view interactions] Computational no yes
WNT9B_HUMAN [view interactions] Computational no no
SFRP5_HUMAN [view interactions] Computational no no
WNT5B_HUMAN [view interactions] Computational no no
WNT4_HUMAN [view interactions] Computational no no
FZD2_HUMAN [view interactions] Computational no no
LRP5_HUMAN [view interactions] Computational no yes
WNT11_HUMAN [view interactions] Computational no no
WNT2B_HUMAN [view interactions] Computational no no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
FZD4_HUMAN [view interactions] Computational no yes