Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PORCN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
60 Gly Arg Focaldermalhypoplasia(FODH) -
365 Arg Gly Focaldermalhypoplasia(FODH) -
136 Ser Phe Focaldermalhypoplasia(FODH) -
168 Gly Arg Focaldermalhypoplasia(FODH) -
258 Val Glu Focaldermalhypoplasia(FODH) -
341 His Leu Focaldermalhypoplasia(FODH) -
365 Arg Gln Focaldermalhypoplasia(FODH) -
385 Cys Arg Focaldermalhypoplasia(FODH) -
439 Trp Arg Focaldermalhypoplasia(FODH) -
252 His Tyr Focaldermalhypoplasia(FODH) -
297 Ser Leu Focaldermalhypoplasia(FODH) -
331 Leu Arg Focaldermalhypoplasia(FODH) -
361 Glu Val Focaldermalhypoplasia(FODH) -
385 Cys Tyr Focaldermalhypoplasia(FODH) -
374 Ala Pro Focaldermalhypoplasia(FODH) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PORCN_HUMAN
GO:0001664 G protein-coupled receptor binding 50.0000 4 no
GO:0005109 frizzled binding 50.0000 5 no
GO:0005125 cytokine activity 50.0000 5 no
GO:0048018 receptor ligand activity 50.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PORCN_HUMAN
GO:0008104 protein localization 100.0000 4 yes
GO:0048522 positive regulation of cellular process 83.3333 4 no
GO:0051049 regulation of transport 83.3333 4 no
GO:0016055 Wnt signaling pathway 83.3333 5 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 83.3333 4 yes
GO:0010646 regulation of cell communication 83.3333 4 no
GO:0032880 regulation of protein localization 66.6667 5 no
GO:0048584 positive regulation of response to stimulus 66.6667 4 no
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0060341 regulation of cellular localization 66.6667 4 no
GO:0060627 regulation of vesicle-mediated transport 66.6667 4 no
GO:0071310 cellular response to organic substance 66.6667 4 no
GO:1903829 positive regulation of protein localization 66.6667 5 no
GO:0060070 canonical Wnt signaling pathway 66.6667 6 yes
GO:0009966 regulation of signal transduction 66.6667 4 no
GO:0009967 positive regulation of signal transduction 66.6667 5 no
GO:0010647 positive regulation of cell communication 66.6667 5 no
GO:0010941 regulation of cell death 66.6667 4 no
GO:0023056 positive regulation of signaling 66.6667 4 no
GO:0033043 regulation of organelle organization 50.0000 5 no
GO:0033993 response to lipid 50.0000 4 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0042981 regulation of apoptotic process 50.0000 6 no
GO:0043067 regulation of programmed cell death 50.0000 5 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0045595 regulation of cell differentiation 50.0000 4 no
GO:0045596 negative regulation of cell differentiation 50.0000 5 no
GO:0045893 positive regulation of DNA-templated transcription 50.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 50.0000 8 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0050678 regulation of epithelial cell proliferation 50.0000 5 no
GO:0050679 positive regulation of epithelial cell proliferation 50.0000 6 no
GO:0050767 regulation of neurogenesis 50.0000 6 no
GO:0050768 negative regulation of neurogenesis 50.0000 6 no
GO:0050770 regulation of axonogenesis 50.0000 5 no
GO:0050807 regulation of synapse organization 50.0000 5 no
GO:0051050 positive regulation of transport 50.0000 4 no
GO:0051093 negative regulation of developmental process 50.0000 4 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0051254 positive regulation of RNA metabolic process 50.0000 6 no
GO:0051960 regulation of nervous system development 50.0000 5 no
GO:0051961 negative regulation of nervous system development 50.0000 5 no
GO:0051963 regulation of synapse assembly 50.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0060284 regulation of cell development 50.0000 5 no
GO:0060548 negative regulation of cell death 50.0000 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 50.0000 6 no
GO:0062009 secondary palate development 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0099054 presynapse assembly 50.0000 5 no
GO:0099172 presynapse organization 50.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 no
GO:1901214 regulation of neuron death 50.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 no
GO:1901888 regulation of cell junction assembly 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 50.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 50.0000 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 50.0000 8 no
GO:2000026 regulation of multicellular organismal development 50.0000 4 no
GO:2000027 regulation of animal organ morphogenesis 50.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0023061 signal release 50.0000 4 yes
GO:0046903 secretion 50.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 50.0000 7 no
GO:0008284 positive regulation of cell population proliferation 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010628 positive regulation of gene expression 50.0000 6 no
GO:0010721 negative regulation of cell development 50.0000 6 no
GO:0010975 regulation of neuron projection development 50.0000 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 50.0000 5 no
GO:0030177 positive regulation of Wnt signaling pathway 50.0000 6 no
GO:0030182 neuron differentiation 50.0000 4 no
GO:0031175 neuron projection development 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0033135 regulation of peptidyl-serine phosphorylation 33.3333 8 no
GO:0033138 positive regulation of peptidyl-serine phosphorylation 33.3333 9 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0034329 cell junction assembly 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0035567 non-canonical Wnt signaling pathway 33.3333 6 no
GO:0040013 negative regulation of locomotion 33.3333 4 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0042659 regulation of cell fate specification 33.3333 5 no
GO:0042733 embryonic digit morphogenesis 33.3333 4 no
GO:0043065 positive regulation of apoptotic process 33.3333 7 no
GO:0043066 negative regulation of apoptotic process 33.3333 7 no
GO:0043068 positive regulation of programmed cell death 33.3333 6 no
GO:0043069 negative regulation of programmed cell death 33.3333 6 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 33.3333 6 no
GO:0043393 regulation of protein binding 33.3333 4 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0043410 positive regulation of MAPK cascade 33.3333 7 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045598 regulation of fat cell differentiation 33.3333 5 no
GO:0045599 negative regulation of fat cell differentiation 33.3333 6 no
GO:0045785 positive regulation of cell adhesion 33.3333 5 no
GO:0045807 positive regulation of endocytosis 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045926 negative regulation of growth 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0046328 regulation of JNK cascade 33.3333 7 no
GO:0046330 positive regulation of JNK cascade 33.3333 8 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0048638 regulation of developmental growth 33.3333 4 no
GO:0048640 negative regulation of developmental growth 33.3333 5 no
GO:0048841 regulation of axon extension involved in axon guidance 33.3333 6 no
GO:0048843 negative regulation of axon extension involved in axon guidance 33.3333 6 no
GO:0048878 chemical homeostasis 33.3333 4 no
GO:0050771 negative regulation of axonogenesis 33.3333 6 no
GO:0050808 synapse organization 33.3333 5 no
GO:0050865 regulation of cell activation 33.3333 4 no
GO:0050867 positive regulation of cell activation 33.3333 5 no
GO:0050920 regulation of chemotaxis 33.3333 4 no
GO:0050922 negative regulation of chemotaxis 33.3333 5 no
GO:0051091 positive regulation of DNA-binding transcription factor activity 33.3333 4 no
GO:0051099 positive regulation of binding 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 33.3333 7 no
GO:0060562 epithelial tube morphogenesis 33.3333 4 no
GO:0061311 cell surface receptor signaling pathway involved in heart development 33.3333 4 no
GO:0061387 regulation of extent of cell growth 33.3333 5 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 33.3333 5 no
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 33.3333 6 no
GO:0070848 response to growth factor 33.3333 4 no
GO:0071300 cellular response to retinoic acid 33.3333 5 no
GO:0071363 cellular response to growth factor stimulus 33.3333 5 no
GO:0071396 cellular response to lipid 33.3333 5 no
GO:0071560 cellular response to transforming growth factor beta stimulus 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0080135 regulation of cellular response to stress 33.3333 4 no
GO:0090175 regulation of establishment of planar polarity 33.3333 6 no
GO:0090381 regulation of heart induction 33.3333 4 no
GO:0097485 neuron projection guidance 33.3333 7 no
GO:0099068 postsynapse assembly 33.3333 5 no
GO:0099173 postsynapse organization 33.3333 4 no
GO:0099175 regulation of postsynapse organization 33.3333 6 no
GO:1901216 positive regulation of neuron death 33.3333 6 no
GO:1902473 regulation of protein localization to synapse 33.3333 6 no
GO:1902474 positive regulation of protein localization to synapse 33.3333 6 no
GO:1904861 excitatory synapse assembly 33.3333 7 no
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 33.3333 6 no
GO:2000047 regulation of cell-cell adhesion mediated by cadherin 33.3333 6 no
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 33.3333 7 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:2000177 regulation of neural precursor cell proliferation 33.3333 5 no
GO:2000826 regulation of heart morphogenesis 33.3333 6 no
GO:0009953 dorsal/ventral pattern formation 33.3333 4 no
GO:0021846 cell proliferation in forebrain 33.3333 4 no
GO:0021953 central nervous system neuron differentiation 33.3333 5 no
GO:0036465 synaptic vesicle recycling 33.3333 4 no
GO:0048103 somatic stem cell division 33.3333 4 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0099174 regulation of presynapse organization 33.3333 6 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:1905606 regulation of presynapse assembly 33.3333 7 no
GO:0048732 gland development 33.3333 4 no
GO:0090263 positive regulation of canonical Wnt signaling pathway 33.3333 7 no
GO:0009306 protein secretion 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0035592 establishment of protein localization to extracellular region 33.3333 4 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0061355 Wnt protein secretion 33.3333 5 yes
GO:0071692 protein localization to extracellular region 33.3333 5 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0000578 embryonic axis specification 33.3333 4 no
GO:0001558 regulation of cell growth 33.3333 4 no
GO:0001707 mesoderm formation 33.3333 4 no
GO:0001817 regulation of cytokine production 33.3333 4 no
GO:0001819 positive regulation of cytokine production 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0001947 heart looping 33.3333 5 no
GO:0002009 morphogenesis of an epithelium 33.3333 4 no
GO:0002064 epithelial cell development 33.3333 4 no
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0002694 regulation of leukocyte activation 33.3333 4 no
GO:0002696 positive regulation of leukocyte activation 33.3333 5 no
GO:0003143 embryonic heart tube morphogenesis 33.3333 4 no
GO:0003156 regulation of animal organ formation 33.3333 6 no
GO:0003306 Wnt signaling pathway involved in heart development 33.3333 5 no
GO:0007411 axon guidance 33.3333 8 no
GO:0007416 synapse assembly 33.3333 6 no
GO:0009948 anterior/posterior axis specification 33.3333 4 no
GO:0010453 regulation of cell fate commitment 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010594 regulation of endothelial cell migration 33.3333 5 no
GO:0010595 positive regulation of endothelial cell migration 33.3333 6 no
GO:0010632 regulation of epithelial cell migration 33.3333 4 no
GO:0010634 positive regulation of epithelial cell migration 33.3333 5 no
GO:0010942 positive regulation of cell death 33.3333 5 no
GO:0010977 negative regulation of neuron projection development 33.3333 7 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0022407 regulation of cell-cell adhesion 33.3333 5 no
GO:0022409 positive regulation of cell-cell adhesion 33.3333 6 no
GO:0030100 regulation of endocytosis 33.3333 5 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0030308 negative regulation of cell growth 33.3333 5 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0030516 regulation of axon extension 33.3333 5 no
GO:0030517 negative regulation of axon extension 33.3333 6 no
GO:0031345 negative regulation of cell projection organization 33.3333 6 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0032092 positive regulation of protein binding 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0032102 negative regulation of response to external stimulus 33.3333 5 no
GO:0032526 response to retinoic acid 33.3333 4 no
GO:0032872 regulation of stress-activated MAPK cascade 33.3333 6 no
GO:0032874 positive regulation of stress-activated MAPK cascade 33.3333 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
WNT1_HUMAN [view interactions] Low throughput no no
WNT3_HUMAN [view interactions] Low throughput no no
WNT3A_HUMAN [view entry] [view interactions] Low throughput yes no
WNT4_HUMAN [view interactions] Low throughput no no
WNT5A_HUMAN [view entry] [view interactions] Low throughput yes no
WNT5B_HUMAN [view interactions] Low throughput no no
WNT6_HUMAN [view interactions] Low throughput no yes
WNT7A_HUMAN [view entry] [view interactions] Low throughput yes no
WNT7B_HUMAN [view interactions] Low throughput no no
CBARP_HUMAN [view interactions] High throughput no no
APOC2_HUMAN [view interactions] High throughput no no
APOC4_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
GRIK5_HUMAN [view entry] [view interactions] High throughput yes no
WNT9B_HUMAN [view interactions] Computational no no
WN10A_HUMAN [view interactions] Computational no no
WNT16_HUMAN [view interactions] Computational no no
WNT2_HUMAN [view interactions] Computational no no
WNT11_HUMAN [view interactions] Computational no no
WNT2B_HUMAN [view interactions] Computational no no
WNT8B_HUMAN [view interactions] Computational no no
WNT9A_HUMAN [view interactions] Computational no no
WN10B_HUMAN [view interactions] Computational no yes