PORCN_HUMAN
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
60 | Gly | Arg | Focaldermalhypoplasia(FODH) | - |
365 | Arg | Gly | Focaldermalhypoplasia(FODH) | - |
136 | Ser | Phe | Focaldermalhypoplasia(FODH) | - |
168 | Gly | Arg | Focaldermalhypoplasia(FODH) | - |
258 | Val | Glu | Focaldermalhypoplasia(FODH) | - |
341 | His | Leu | Focaldermalhypoplasia(FODH) | - |
365 | Arg | Gln | Focaldermalhypoplasia(FODH) | - |
385 | Cys | Arg | Focaldermalhypoplasia(FODH) | - |
439 | Trp | Arg | Focaldermalhypoplasia(FODH) | - |
252 | His | Tyr | Focaldermalhypoplasia(FODH) | - |
297 | Ser | Leu | Focaldermalhypoplasia(FODH) | - |
331 | Leu | Arg | Focaldermalhypoplasia(FODH) | - |
361 | Glu | Val | Focaldermalhypoplasia(FODH) | - |
385 | Cys | Tyr | Focaldermalhypoplasia(FODH) | - |
374 | Ala | Pro | Focaldermalhypoplasia(FODH) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PORCN_HUMAN |
---|---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | 50.0000 | 4 | no |
GO:0005109 | frizzled binding | 50.0000 | 5 | no |
GO:0005125 | cytokine activity | 50.0000 | 5 | no |
GO:0048018 | receptor ligand activity | 50.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PORCN_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 83.3333 | 4 | no |
GO:0008104 | protein localization | 83.3333 | 4 | yes |
GO:0016055 | Wnt signaling pathway | 83.3333 | 4 | yes |
GO:0010646 | regulation of cell communication | 83.3333 | 4 | no |
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 66.6667 | 4 | no |
GO:0060341 | regulation of cellular localization | 66.6667 | 4 | no |
GO:1903829 | positive regulation of protein localization | 66.6667 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | no |
GO:0051128 | regulation of cellular component organization | 66.6667 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 66.6667 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | no |
GO:0009966 | regulation of signal transduction | 66.6667 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 66.6667 | 5 | no |
GO:0010647 | positive regulation of cell communication | 66.6667 | 5 | no |
GO:0023056 | positive regulation of signaling | 66.6667 | 4 | no |
GO:0032880 | regulation of protein localization | 66.6667 | 5 | no |
GO:0051050 | positive regulation of transport | 50.0000 | 4 | no |
GO:0060828 | regulation of canonical Wnt signaling pathway | 50.0000 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 50.0000 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 50.0000 | 6 | no |
GO:0033043 | regulation of organelle organization | 50.0000 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 50.0000 | 7 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 50.0000 | 8 | no |
GO:0008284 | positive regulation of cell population proliferation | 50.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 50.0000 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 50.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 50.0000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 50.0000 | 7 | no |
GO:0010721 | negative regulation of cell development | 50.0000 | 6 | no |
GO:0010975 | regulation of neuron projection development | 50.0000 | 7 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
GO:0030030 | cell projection organization | 50.0000 | 4 | no |
GO:0030182 | neuron differentiation | 50.0000 | 4 | no |
GO:0031175 | neuron projection development | 50.0000 | 6 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 50.0000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | no |
GO:0033993 | response to lipid | 50.0000 | 4 | no |
GO:0035567 | non-canonical Wnt signaling pathway | 50.0000 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 50.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 50.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | no |
GO:0045596 | negative regulation of cell differentiation | 50.0000 | 5 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 50.0000 | 8 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | no |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 50.0000 | 9 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0050678 | regulation of epithelial cell proliferation | 50.0000 | 5 | no |
GO:0050679 | positive regulation of epithelial cell proliferation | 50.0000 | 6 | no |
GO:0050767 | regulation of neurogenesis | 50.0000 | 6 | no |
GO:0050768 | negative regulation of neurogenesis | 50.0000 | 6 | no |
GO:0050770 | regulation of axonogenesis | 50.0000 | 5 | no |
GO:0050807 | regulation of synapse organization | 50.0000 | 5 | no |
GO:0051093 | negative regulation of developmental process | 50.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 50.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 50.0000 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 50.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 50.0000 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 50.0000 | 5 | no |
GO:0051254 | positive regulation of RNA metabolic process | 50.0000 | 6 | no |
GO:0051960 | regulation of nervous system development | 50.0000 | 5 | no |
GO:0051961 | negative regulation of nervous system development | 50.0000 | 5 | no |
GO:0051963 | regulation of synapse assembly | 50.0000 | 6 | no |
GO:0060070 | canonical Wnt signaling pathway | 50.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0060284 | regulation of cell development | 50.0000 | 5 | no |
GO:0062009 | secondary palate development | 50.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0099054 | presynapse assembly | 50.0000 | 5 | no |
GO:0099172 | presynapse organization | 50.0000 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 50.0000 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 50.0000 | 5 | no |
GO:1901888 | regulation of cell junction assembly | 50.0000 | 5 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 50.0000 | 7 | no |
GO:2000026 | regulation of multicellular organismal development | 50.0000 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 50.0000 | 6 | no |
GO:0023061 | signal release | 50.0000 | 4 | yes |
GO:0046903 | secretion | 50.0000 | 4 | yes |
GO:0030111 | regulation of Wnt signaling pathway | 50.0000 | 5 | no |
GO:0030177 | positive regulation of Wnt signaling pathway | 50.0000 | 6 | no |
GO:0048732 | gland development | 33.3333 | 4 | no |
GO:0051046 | regulation of secretion | 33.3333 | 5 | no |
GO:0090263 | positive regulation of canonical Wnt signaling pathway | 33.3333 | 7 | no |
GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | no |
GO:0000578 | embryonic axis specification | 33.3333 | 4 | no |
GO:0001558 | regulation of cell growth | 33.3333 | 4 | no |
GO:0001817 | regulation of cytokine production | 33.3333 | 4 | no |
GO:0001819 | positive regulation of cytokine production | 33.3333 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 33.3333 | 8 | no |
GO:0001947 | heart looping | 33.3333 | 5 | no |
GO:0002009 | morphogenesis of an epithelium | 33.3333 | 4 | no |
GO:0002064 | epithelial cell development | 33.3333 | 4 | no |
GO:0002684 | positive regulation of immune system process | 33.3333 | 4 | no |
GO:0002694 | regulation of leukocyte activation | 33.3333 | 4 | no |
GO:0002696 | positive regulation of leukocyte activation | 33.3333 | 5 | no |
GO:0003143 | embryonic heart tube morphogenesis | 33.3333 | 4 | no |
GO:0006915 | apoptotic process | 33.3333 | 4 | no |
GO:0007411 | axon guidance | 33.3333 | 8 | no |
GO:0007416 | synapse assembly | 33.3333 | 6 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
GO:0010594 | regulation of endothelial cell migration | 33.3333 | 5 | no |
GO:0010595 | positive regulation of endothelial cell migration | 33.3333 | 6 | no |
GO:0010632 | regulation of epithelial cell migration | 33.3333 | 4 | no |
GO:0010634 | positive regulation of epithelial cell migration | 33.3333 | 5 | no |
GO:0010977 | negative regulation of neuron projection development | 33.3333 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0022407 | regulation of cell-cell adhesion | 33.3333 | 5 | no |
GO:0022409 | positive regulation of cell-cell adhesion | 33.3333 | 6 | no |
GO:0030100 | regulation of endocytosis | 33.3333 | 5 | no |
GO:0030155 | regulation of cell adhesion | 33.3333 | 4 | no |
GO:0030308 | negative regulation of cell growth | 33.3333 | 5 | no |
GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
GO:0030335 | positive regulation of cell migration | 33.3333 | 6 | no |
GO:0030516 | regulation of axon extension | 33.3333 | 5 | no |
GO:0030517 | negative regulation of axon extension | 33.3333 | 6 | no |
GO:0031345 | negative regulation of cell projection organization | 33.3333 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 33.3333 | 6 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
GO:0032101 | regulation of response to external stimulus | 33.3333 | 4 | no |
GO:0032102 | negative regulation of response to external stimulus | 33.3333 | 5 | no |
GO:0032526 | response to retinoic acid | 33.3333 | 4 | no |
GO:0033135 | regulation of peptidyl-serine phosphorylation | 33.3333 | 8 | no |
GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 33.3333 | 9 | no |
GO:0034329 | cell junction assembly | 33.3333 | 5 | no |
GO:0034330 | cell junction organization | 33.3333 | 4 | no |
GO:0040013 | negative regulation of locomotion | 33.3333 | 4 | no |
GO:0040017 | positive regulation of locomotion | 33.3333 | 4 | no |
GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
GO:0042733 | embryonic digit morphogenesis | 33.3333 | 4 | no |
GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 33.3333 | 6 | no |
GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | no |
GO:0043069 | negative regulation of programmed cell death | 33.3333 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 33.3333 | 6 | no |
GO:0043410 | positive regulation of MAPK cascade | 33.3333 | 7 | no |
GO:0045598 | regulation of fat cell differentiation | 33.3333 | 5 | no |
GO:0045599 | negative regulation of fat cell differentiation | 33.3333 | 6 | no |
GO:0045785 | positive regulation of cell adhesion | 33.3333 | 5 | no |
GO:0045807 | positive regulation of endocytosis | 33.3333 | 5 | no |
GO:0045926 | negative regulation of growth | 33.3333 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
GO:0046328 | regulation of JNK cascade | 33.3333 | 7 | no |
GO:0046330 | positive regulation of JNK cascade | 33.3333 | 8 | no |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
GO:0048638 | regulation of developmental growth | 33.3333 | 4 | no |
GO:0048640 | negative regulation of developmental growth | 33.3333 | 5 | no |
GO:0048841 | regulation of axon extension involved in axon guidance | 33.3333 | 6 | no |
GO:0048843 | negative regulation of axon extension involved in axon guidance | 33.3333 | 6 | no |
GO:0050771 | negative regulation of axonogenesis | 33.3333 | 6 | no |
GO:0050808 | synapse organization | 33.3333 | 5 | no |
GO:0050865 | regulation of cell activation | 33.3333 | 4 | no |
GO:0050867 | positive regulation of cell activation | 33.3333 | 5 | no |
GO:0050920 | regulation of chemotaxis | 33.3333 | 4 | no |
GO:0050922 | negative regulation of chemotaxis | 33.3333 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 33.3333 | 6 | no |
GO:0060562 | epithelial tube morphogenesis | 33.3333 | 4 | no |
GO:0061387 | regulation of extent of cell growth | 33.3333 | 5 | no |
GO:0071300 | cellular response to retinoic acid | 33.3333 | 5 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0071363 | cellular response to growth factor stimulus | 33.3333 | 4 | no |
GO:0071396 | cellular response to lipid | 33.3333 | 5 | no |
GO:0071542 | dopaminergic neuron differentiation | 33.3333 | 5 | no |
GO:0071559 | response to transforming growth factor beta | 33.3333 | 4 | no |
GO:0071560 | cellular response to transforming growth factor beta stimulus | 33.3333 | 5 | no |
GO:0097485 | neuron projection guidance | 33.3333 | 7 | no |
GO:0099068 | postsynapse assembly | 33.3333 | 5 | no |
GO:0099173 | postsynapse organization | 33.3333 | 4 | no |
GO:0099175 | regulation of postsynapse organization | 33.3333 | 6 | no |
GO:1901701 | cellular response to oxygen-containing compound | 33.3333 | 4 | no |
GO:1902473 | regulation of protein localization to synapse | 33.3333 | 6 | no |
GO:1902474 | positive regulation of protein localization to synapse | 33.3333 | 6 | no |
GO:1904861 | excitatory synapse assembly | 33.3333 | 7 | no |
GO:1904948 | midbrain dopaminergic neuron differentiation | 33.3333 | 6 | no |
GO:2000027 | regulation of animal organ morphogenesis | 33.3333 | 5 | no |
GO:2000047 | regulation of cell-cell adhesion mediated by cadherin | 33.3333 | 6 | no |
GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin | 33.3333 | 7 | no |
GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
GO:2000147 | positive regulation of cell motility | 33.3333 | 5 | no |
GO:2000177 | regulation of neural precursor cell proliferation | 33.3333 | 5 | no |
GO:0009953 | dorsal/ventral pattern formation | 33.3333 | 4 | no |
GO:0021846 | cell proliferation in forebrain | 33.3333 | 4 | no |
GO:0021953 | central nervous system neuron differentiation | 33.3333 | 5 | no |
GO:0036465 | synaptic vesicle recycling | 33.3333 | 4 | no |
GO:0048103 | somatic stem cell division | 33.3333 | 4 | no |
GO:0051962 | positive regulation of nervous system development | 33.3333 | 5 | no |
GO:0099174 | regulation of presynapse organization | 33.3333 | 6 | no |
GO:1905606 | regulation of presynapse assembly | 33.3333 | 7 | no |
GO:0009306 | protein secretion | 33.3333 | 4 | yes |
GO:0015031 | protein transport | 33.3333 | 4 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 33.3333 | 4 | yes |
GO:0061355 | Wnt protein secretion | 33.3333 | 5 | yes |
GO:0071692 | protein localization to extracellular region | 33.3333 | 5 | yes |
GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
GO:0001707 | mesoderm formation | 33.3333 | 4 | no |
GO:0009948 | anterior/posterior axis specification | 33.3333 | 4 | no |
GO:0043122 | regulation of canonical NF-kappaB signal transduction | 33.3333 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WNT1_HUMAN | [view interactions] | Low throughput | no | no |
WNT3_HUMAN | [view interactions] | Low throughput | no | no |
WNT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WNT4_HUMAN | [view interactions] | Low throughput | no | no |
WNT5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WNT5B_HUMAN | [view interactions] | Low throughput | no | no |
WNT6_HUMAN | [view interactions] | Low throughput | no | yes |
WNT7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WNT7B_HUMAN | [view interactions] | Low throughput | no | no |
CBARP_HUMAN | [view interactions] | High throughput | no | no |
APOC2_HUMAN | [view interactions] | High throughput | no | no |
APOC4_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
GRIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |