Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002076 TRG_ER_diArg_1 TRG 862 865 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK5_HUMAN
GO:0004970 ionotropic glutamate receptor activity 41.6667 5 yes
GO:0005216 ion channel activity 41.6667 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 41.6667 6 yes
GO:0008066 glutamate receptor activity 41.6667 4 yes
GO:0015267 channel activity 41.6667 4 yes
GO:0015276 ligand-gated ion channel activity 41.6667 5 yes
GO:0022824 transmitter-gated ion channel activity 41.6667 5 yes
GO:0022834 ligand-gated channel activity 41.6667 6 yes
GO:0022835 transmitter-gated channel activity 41.6667 4 yes
GO:0022836 gated channel activity 41.6667 5 yes
GO:0030165 PDZ domain binding 41.6667 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 41.6667 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 41.6667 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 41.6667 6 yes
GO:0005261 cation channel activity 33.3333 5 yes
GO:0005267 potassium channel activity 33.3333 6 yes
GO:0005272 sodium channel activity 33.3333 6 yes
GO:0008324 cation transmembrane transporter activity 33.3333 4 yes
GO:0015079 potassium ion transmembrane transporter activity 33.3333 6 yes
GO:0015081 sodium ion transmembrane transporter activity 33.3333 6 yes
GO:0015277 kainate selective glutamate receptor activity 33.3333 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 yes
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 yes
GO:0099094 ligand-gated cation channel activity 33.3333 6 yes
GO:0019902 phosphatase binding 33.3333 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0017124 SH3 domain binding 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK5_HUMAN
GO:0008104 protein localization 75.0000 4 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0007268 chemical synaptic transmission 58.3333 6 yes
GO:0051128 regulation of cellular component organization 58.3333 4 yes
GO:0098916 anterograde trans-synaptic signaling 58.3333 5 yes
GO:0099537 trans-synaptic signaling 58.3333 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0043113 receptor clustering 50.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0072657 protein localization to membrane 50.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0033043 regulation of organelle organization 41.6667 5 yes
GO:0035249 synaptic transmission, glutamatergic 41.6667 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0043523 regulation of neuron apoptotic process 33.3333 6 yes
GO:0060078 regulation of postsynaptic membrane potential 33.3333 4 yes
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 yes
GO:1901214 regulation of neuron death 33.3333 5 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1905475 regulation of protein localization to membrane 25.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0010942 positive regulation of cell death 25.0000 5 yes
GO:0043065 positive regulation of apoptotic process 25.0000 7 yes
GO:0043068 positive regulation of programmed cell death 25.0000 6 yes
GO:0043525 positive regulation of neuron apoptotic process 25.0000 7 yes
GO:0048878 chemical homeostasis 25.0000 4 yes
GO:0060079 excitatory postsynaptic potential 25.0000 5 yes
GO:0071310 cellular response to organic substance 25.0000 4 yes
GO:1901216 positive regulation of neuron death 25.0000 6 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0001678 cellular glucose homeostasis 16.6667 4 yes
GO:0006621 protein retention in ER lumen 16.6667 6 yes
GO:0009743 response to carbohydrate 16.6667 4 yes
GO:0009746 response to hexose 16.6667 6 yes
GO:0009749 response to glucose 16.6667 7 yes
GO:0031338 regulation of vesicle fusion 16.6667 5 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 16.6667 6 yes
GO:0033500 carbohydrate homeostasis 16.6667 5 yes
GO:0034284 response to monosaccharide 16.6667 5 yes
GO:0035437 maintenance of protein localization in endoplasmic reticulum 16.6667 5 yes
GO:0042593 glucose homeostasis 16.6667 6 yes
GO:0071322 cellular response to carbohydrate stimulus 16.6667 5 yes
GO:0071326 cellular response to monosaccharide stimulus 16.6667 6 yes
GO:0071331 cellular response to hexose stimulus 16.6667 7 yes
GO:0071333 cellular response to glucose stimulus 16.6667 5 yes
GO:0072595 maintenance of protein localization in organelle 16.6667 4 yes
GO:1901632 regulation of synaptic vesicle membrane organization 16.6667 5 yes
GO:1901701 cellular response to oxygen-containing compound 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIK5_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GPAA1_HUMAN [view interactions] High throughput no yes
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PORCN_HUMAN [view entry] [view interactions] High throughput yes yes
ADCY6_HUMAN [view interactions] High throughput no yes
MPIP2_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
SKP2_HUMAN [view interactions] High throughput no yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
GOLM1_HUMAN [view interactions] High throughput no yes
GPR6_HUMAN [view interactions] Computational no no
DLG1_HUMAN [view entry] [view interactions] Computational yes yes
SYK_HUMAN [view interactions] Computational no yes