Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002076 TRG_ER_diArg_1 TRG 862 865 -
ELMI002076 TRG_ER_diArg_1 TRG 862 865 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK5_HUMAN
GO:0004970 glutamate-gated receptor activity 46.1538 4 yes
GO:0005216 monoatomic ion channel activity 46.1538 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 46.1538 6 yes
GO:0008066 glutamate receptor activity 46.1538 4 yes
GO:0015267 channel activity 46.1538 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 46.1538 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 46.1538 5 yes
GO:0022834 ligand-gated channel activity 46.1538 6 yes
GO:0022835 transmitter-gated channel activity 46.1538 4 yes
GO:0022836 gated channel activity 46.1538 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 46.1538 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 46.1538 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 46.1538 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 46.1538 6 yes
GO:0005261 monoatomic cation channel activity 38.4615 5 yes
GO:0005267 potassium channel activity 38.4615 6 yes
GO:0005272 sodium channel activity 38.4615 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 38.4615 4 yes
GO:0015079 potassium ion transmembrane transporter activity 38.4615 6 yes
GO:0015081 sodium ion transmembrane transporter activity 38.4615 6 yes
GO:0015277 kainate selective glutamate receptor activity 38.4615 5 yes
GO:0015280 ligand-gated sodium channel activity 38.4615 7 yes
GO:0022890 inorganic cation transmembrane transporter activity 38.4615 4 yes
GO:0046873 metal ion transmembrane transporter activity 38.4615 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 38.4615 6 yes
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 30.7692 6 yes
GO:0030165 PDZ domain binding 30.7692 4 no
GO:0019900 kinase binding 30.7692 4 no
GO:0031625 ubiquitin protein ligase binding 23.0769 5 no
GO:0044389 ubiquitin-like protein ligase binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK5_HUMAN
GO:0010646 regulation of cell communication 76.9231 4 yes
GO:0007268 chemical synaptic transmission 69.2308 7 yes
GO:0098916 anterograde trans-synaptic signaling 69.2308 6 yes
GO:0099536 synaptic signaling 69.2308 4 yes
GO:0099537 trans-synaptic signaling 69.2308 5 yes
GO:0050804 modulation of chemical synaptic transmission 61.5385 5 yes
GO:0099177 regulation of trans-synaptic signaling 61.5385 4 yes
GO:0008104 protein localization 61.5385 4 no
GO:0035249 synaptic transmission, glutamatergic 53.8462 8 yes
GO:0051128 regulation of cellular component organization 53.8462 4 yes
GO:0048523 negative regulation of cellular process 53.8462 4 no
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0033043 regulation of organelle organization 38.4615 5 yes
GO:0051049 regulation of transport 38.4615 4 yes
GO:0060627 regulation of vesicle-mediated transport 38.4615 4 yes
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0060078 regulation of postsynaptic membrane potential 30.7692 4 yes
GO:0007215 glutamate receptor signaling pathway 30.7692 4 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0072657 protein localization to membrane 30.7692 4 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0033365 protein localization to organelle 30.7692 5 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0036211 protein modification process 30.7692 4 no
GO:0043412 macromolecule modification 30.7692 4 no
GO:0060079 excitatory postsynaptic potential 23.0769 5 yes
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 23.0769 6 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0010468 regulation of gene expression 23.0769 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043113 receptor clustering 23.0769 5 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0022607 cellular component assembly 23.0769 4 no
GO:0030100 regulation of endocytosis 23.0769 5 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0045859 regulation of protein kinase activity 23.0769 6 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0051051 negative regulation of transport 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0031338 regulation of vesicle fusion 15.3846 5 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 15.3846 6 yes
GO:1901632 regulation of synaptic vesicle membrane organization 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK3_HUMAN [view entry] [view interactions] Low throughput yes no
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK5_HUMAN [view entry] [view interactions] Low throughput yes no
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
GOLM1_HUMAN [view interactions] High throughput no yes
GPAA1_HUMAN [view interactions] High throughput no yes
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PORCN_HUMAN [view entry] [view interactions] High throughput yes yes
ADCY6_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MPIP2_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
SKP2_HUMAN [view interactions] High throughput no yes