LRSM1_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001342 | LIG_PTAP_UEV_1 | LIG | 648 | 653 | - |
| ELMI001343 | LIG_PTAP_UEV_1 | LIG | 660 | 665 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRSM1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 53.8462 | 4 | no |
| GO:0045296 | cadherin binding | 28.2051 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.2051 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.2051 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.2051 | 4 | no |
| GO:0005524 | ATP binding | 25.6410 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.6410 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.6410 | 5 | no |
| GO:0003729 | mRNA binding | 23.0769 | 5 | no |
| GO:0042803 | protein homodimerization activity | 20.5128 | 4 | no |
| GO:0046872 | metal ion binding | 12.8205 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 10.2564 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 7.6923 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRSM1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 74.3590 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 71.7949 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 69.2308 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 69.2308 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 66.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 61.5385 | 4 | yes |
| GO:0010468 | regulation of gene expression | 61.5385 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 56.4103 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 53.8462 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 53.8462 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 53.8462 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.8462 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 53.8462 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 48.7179 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 48.7179 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 46.1538 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 43.5897 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 43.5897 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 43.5897 | 5 | no |
| GO:0010646 | regulation of cell communication | 43.5897 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 41.0256 | 4 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | yes |
| GO:0080134 | regulation of response to stress | 38.4615 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 38.4615 | 5 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.8974 | 4 | yes |
| GO:0051049 | regulation of transport | 35.8974 | 4 | yes |
| GO:0071702 | organic substance transport | 35.8974 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 35.8974 | 4 | yes |
| GO:0006996 | organelle organization | 35.8974 | 4 | no |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 33.3333 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 33.3333 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.7692 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.7692 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.7692 | 6 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.7692 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 30.7692 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 30.7692 | 6 | no |
| GO:0016070 | RNA metabolic process | 30.7692 | 5 | no |
| GO:0015031 | protein transport | 28.2051 | 4 | yes |
| GO:0043412 | macromolecule modification | 28.2051 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 28.2051 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 28.2051 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.2051 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 28.2051 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.2051 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0080135 | regulation of cellular response to stress | 28.2051 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.2051 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.2051 | 4 | no |
| GO:0006396 | RNA processing | 28.2051 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 25.6410 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 25.6410 | 5 | yes |
| GO:0036211 | protein modification process | 25.6410 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.6410 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.6410 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.6410 | 5 | no |
| GO:0008380 | RNA splicing | 25.6410 | 7 | no |
| GO:0009057 | macromolecule catabolic process | 23.0769 | 4 | yes |
| GO:0033365 | protein localization to organelle | 23.0769 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.0769 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 23.0769 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 23.0769 | 6 | no |
| GO:0016071 | mRNA metabolic process | 23.0769 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 23.0769 | 6 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 23.0769 | 6 | no |
| GO:0030100 | regulation of endocytosis | 20.5128 | 5 | yes |
| GO:0006417 | regulation of translation | 20.5128 | 6 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 20.5128 | 5 | no |
| GO:1903311 | regulation of mRNA metabolic process | 20.5128 | 6 | no |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 20.5128 | 6 | no |
| GO:0009895 | negative regulation of catabolic process | 20.5128 | 5 | no |
| GO:0030030 | cell projection organization | 20.5128 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.5128 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5128 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.5128 | 5 | no |
| GO:0006397 | mRNA processing | 20.5128 | 7 | no |
| GO:0051726 | regulation of cell cycle | 20.5128 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.5128 | 7 | no |
| GO:0009896 | positive regulation of catabolic process | 17.9487 | 5 | yes |
| GO:0016567 | protein ubiquitination | 17.9487 | 7 | yes |
| GO:0032446 | protein modification by small protein conjugation | 17.9487 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 17.9487 | 5 | yes |
| GO:0006897 | endocytosis | 15.3846 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 15.3846 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 15.3846 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 15.3846 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 12.8205 | 4 | yes |
| GO:0031347 | regulation of defense response | 12.8205 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 12.8205 | 4 | yes |
| GO:0051051 | negative regulation of transport | 12.8205 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 12.8205 | 5 | yes |
| GO:0000209 | protein polyubiquitination | 10.2564 | 8 | yes |
| GO:0030163 | protein catabolic process | 10.2564 | 4 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 10.2564 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 10.2564 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 10.2564 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 10.2564 | 4 | yes |
| GO:0010506 | regulation of autophagy | 7.6923 | 6 | yes |
| GO:0010508 | positive regulation of autophagy | 7.6923 | 7 | yes |
| GO:0016239 | positive regulation of macroautophagy | 7.6923 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 7.6923 | 7 | yes |
| GO:0045806 | negative regulation of endocytosis | 7.6923 | 5 | yes |
| GO:1902117 | positive regulation of organelle assembly | 7.6923 | 6 | yes |
| GO:0044088 | regulation of vacuole organization | 5.1282 | 6 | yes |
| GO:0044090 | positive regulation of vacuole organization | 5.1282 | 7 | yes |
| GO:0051865 | protein autoubiquitination | 5.1282 | 8 | yes |
| GO:0070086 | ubiquitin-dependent endocytosis | 5.1282 | 5 | yes |
| GO:0098657 | import into cell | 5.1282 | 4 | yes |
| GO:1904415 | regulation of xenophagy | 5.1282 | 5 | yes |
| GO:1904417 | positive regulation of xenophagy | 5.1282 | 6 | yes |
| GO:2000785 | regulation of autophagosome assembly | 5.1282 | 6 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 5.1282 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LRSM1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.6923 | 3 | no |
| DOID:1289 | neurodegenerative disease | 5.1282 | 4 | no |
| DOID:231 | motor neuron disease | 5.1282 | 5 | no |
| DOID:936 | brain disease | 5.1282 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LRSM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| PHF23_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| CHTOP_HUMAN | [view interactions] | High throughput | no | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2W_HUMAN | [view interactions] | High throughput | no | yes |
| UEVLD_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| TRI17_HUMAN | [view interactions] | High throughput | no | yes |
| TRI74_HUMAN | [view interactions] | High throughput | no | no |
| VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM4_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| XAF1_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F178B_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MGT4B_HUMAN | [view interactions] | High throughput | no | no |
| MUTYH_HUMAN | [view interactions] | High throughput | no | yes |
| MLRV_HUMAN | [view interactions] | High throughput | no | no |
| RXRG_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP108_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT4_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC46_HUMAN | [view interactions] | High throughput | no | no |
| LIPG_HUMAN | [view interactions] | High throughput | no | no |
| UTP6_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYB4Y_HUMAN | [view interactions] | High throughput | no | no |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CNO6L_HUMAN | [view interactions] | High throughput | no | no |
| KCNH7_HUMAN | [view interactions] | High throughput | no | no |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| PAPOG_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CACO2_HUMAN | [view interactions] | Computational | no | yes |