UBA1_HUMAN
Evidence for PS localization
Functions
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed, PubMed). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 539 | Met | Ile | SpinalmuscularatrophyX-linked2(SMAX2) | - |
| 547 | Ser | Gly | SpinalmuscularatrophyX-linked2(SMAX2) | - |
| 557 | Glu | Val | SpinalmuscularatrophyX-linked2(SMAX2) | - |
| 41 | Met | Leu | VEXASsyndrome(VEXAS) | - |
| 41 | Met | Thr | VEXASsyndrome(VEXAS) | - |
| 41 | Met | Val | VEXASsyndrome(VEXAS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBA1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.4706 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.5294 | 4 | yes |
| GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.5490 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.5490 | 4 | yes |
| GO:0003723 | RNA binding | 18.6275 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.6471 | 5 | yes |
| GO:0005524 | ATP binding | 16.6667 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
| GO:0004839 | ubiquitin activating enzyme activity | 1.9608 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.7843 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.9020 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 53.9216 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.9216 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.9216 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 49.0196 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 47.0588 | 5 | no |
| GO:0010646 | regulation of cell communication | 46.0784 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 46.0784 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.1176 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.1765 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.1765 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2353 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.2353 | 5 | no |
| GO:0043412 | macromolecule modification | 37.2549 | 4 | yes |
| GO:0006996 | organelle organization | 37.2549 | 4 | no |
| GO:0036211 | protein modification process | 36.2745 | 4 | yes |
| GO:0051049 | regulation of transport | 36.2745 | 4 | no |
| GO:0031399 | regulation of protein modification process | 36.2745 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.2941 | 6 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 31.3725 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.3725 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.3922 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.4314 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.4314 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.4510 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.4510 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 26.4706 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 26.4706 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.4706 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4706 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.4902 | 5 | no |
| GO:0051338 | regulation of transferase activity | 25.4902 | 4 | no |
| GO:0010941 | regulation of cell death | 25.4902 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4902 | 5 | no |
| GO:0071702 | organic substance transport | 24.5098 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 24.5098 | 7 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.5098 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.5098 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0071705 | nitrogen compound transport | 22.5490 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.5490 | 5 | no |
| GO:0080134 | regulation of response to stress | 22.5490 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.5490 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5490 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.5490 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.5490 | 4 | no |
| GO:0006508 | proteolysis | 21.5686 | 4 | yes |
| GO:0015031 | protein transport | 21.5686 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.5686 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.5686 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.5686 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.5686 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.5686 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 20.5882 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5882 | 4 | no |
| GO:0030162 | regulation of proteolysis | 20.5882 | 6 | no |
| GO:0071310 | cellular response to organic substance | 20.5882 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 18.6275 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 17.6471 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 16.6667 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 15.6863 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 15.6863 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 15.6863 | 5 | yes |
| GO:0016567 | protein ubiquitination | 14.7059 | 7 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 11.7647 | 7 | yes |
| GO:0006974 | cellular response to DNA damage stimulus | 9.8039 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UBA1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.9020 | 3 | yes |
| DOID:1289 | neurodegenerative disease | 3.9216 | 4 | yes |
| DOID:231 | motor neuron disease | 2.9412 | 5 | yes |
| DOID:0050700 | cardiomyopathy | 2.9412 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.9412 | 5 | no |
| DOID:114 | heart disease | 2.9412 | 3 | no |
| DOID:0111827 | X-linked spinal muscular atrophy 2 | 1.9608 | 7 | yes |
| DOID:12377 | spinal muscular atrophy | 1.9608 | 6 | yes |
| DOID:2843 | long QT syndrome | 1.9608 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NHLC1_HUMAN | [view interactions] | Low throughput | no | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBD_HUMAN | [view interactions] | Low throughput | no | no |
| UBTD2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRPM8_HUMAN | [view interactions] | Low throughput | no | no |
| TRIM4_HUMAN | [view interactions] | Low throughput | no | yes |
| GAN_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2J1_HUMAN | [view interactions] | Low throughput | no | yes |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2K_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2C_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2B_HUMAN | [view interactions] | Low throughput | no | no |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | Low throughput | no | no |
| UBE2S_HUMAN | [view interactions] | Low throughput | no | no |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2T_HUMAN | [view interactions] | Low throughput | no | no |
| UB2R1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2G1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2G2_HUMAN | [view interactions] | Low throughput | no | yes |
| CHK1_HUMAN | [view interactions] | Low throughput | no | no |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| UB2L6_HUMAN | [view interactions] | Low throughput | no | no |
| UBE2Z_HUMAN | [view interactions] | Low throughput | no | yes |
| ABCF1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM4_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E2_HUMAN | [view interactions] | Low throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| DCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| DEN6B_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| CAR14_HUMAN | [view interactions] | High throughput | no | no |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| ILRUN_HUMAN | [view interactions] | High throughput | no | yes |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| APEX2_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| MTMRD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| CTF8_HUMAN | [view interactions] | High throughput | no | no |
| IBTK_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| INAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| GRWD1_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMAL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| RHGBB_HUMAN | [view interactions] | High throughput | no | no |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| RHG33_HUMAN | [view interactions] | High throughput | no | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MAF_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| AMPB_HUMAN | [view interactions] | High throughput | no | yes |
| RAB24_HUMAN | [view interactions] | High throughput | no | no |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| BUB3_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD5_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| F10C1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| NVL_HUMAN | [view interactions] | High throughput | no | no |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| SAPC2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| DERPC_HUMAN | [view interactions] | High throughput | no | no |
| GCP6_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| GCP2_HUMAN | [view interactions] | High throughput | no | yes |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| TIRR_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCP5_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MZT2B_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| TBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG06_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOS2_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2W_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMGN_HUMAN | [view interactions] | High throughput | no | no |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| UB2Q2_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| UB2J2_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| TAF9_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAC_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR73_HUMAN | [view interactions] | High throughput | no | yes |
| TMCC2_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| SEM3F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSSC4_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYCP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| USH1C_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNG_HUMAN | [view interactions] | High throughput | no | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| DNPH1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1B_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSHR_HUMAN | [view interactions] | High throughput | no | no |
| MAGA2_HUMAN | [view interactions] | High throughput | no | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGC2_HUMAN | [view interactions] | High throughput | no | no |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK3_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THA_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| RET2_HUMAN | [view interactions] | High throughput | no | no |
| DPP3_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| GFPT1_HUMAN | [view interactions] | High throughput | no | no |
| TYW4_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT6_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| MFSD6_HUMAN | [view interactions] | High throughput | no | yes |
| GUAD_HUMAN | [view interactions] | High throughput | no | yes |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| SL9B2_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| RN135_HUMAN | [view interactions] | High throughput | no | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBF4B_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| RN182_HUMAN | [view interactions] | High throughput | no | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF34_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC7_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
| PELI1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| NADC_HUMAN | [view interactions] | High throughput | no | yes |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN122_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDDC2_HUMAN | [view interactions] | High throughput | no | yes |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CCD69_HUMAN | [view interactions] | High throughput | no | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM10_HUMAN | [view interactions] | Computational | no | yes |
| UB2Q1_HUMAN | [view interactions] | Computational | no | no |
| ATG7_HUMAN | [view interactions] | Computational | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SUMO1_HUMAN | [view interactions] | Computational | no | yes |
| UBA7_HUMAN | [view interactions] | Computational | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UROK_HUMAN | [view interactions] | Computational | no | no |
| NEDD8_HUMAN | [view interactions] | Computational | no | yes |
| UBE2O_HUMAN | [view interactions] | Computational | no | yes |
| UBA5_HUMAN | [view interactions] | Computational | no | yes |
| UBA3_HUMAN | [view interactions] | Computational | no | yes |
| UBE2F_HUMAN | [view interactions] | Computational | no | yes |
| TPA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLMN_HUMAN | [view interactions] | Computational | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | Computational | yes | no |