DNJB2_HUMAN
Evidence for PS localization
Functions
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed, PubMed). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed, PubMed). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed, PubMed, PubMed, PubMed, PubMed). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003835 | MOD_CK2_1 | MOD | 247 | 253 | - |
| ELMI003835 | MOD_CK2_1 | MOD | 247 | 253 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DNJB2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 44.4444 | 4 | no |
| GO:0017076 | purine nucleotide binding | 44.4444 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 44.4444 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.4444 | 4 | no |
| GO:0043168 | anion binding | 44.4444 | 4 | no |
| GO:0005524 | ATP binding | 40.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 40.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 37.7778 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 37.7778 | 4 | yes |
| GO:0003723 | RNA binding | 26.6667 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 22.2222 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.2222 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.2222 | 6 | no |
| GO:0030544 | Hsp70 protein binding | 6.6667 | 4 | yes |
| GO:0043130 | ubiquitin binding | 4.4444 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DNJB2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 57.7778 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.1111 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 48.8889 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 48.8889 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.4444 | 5 | no |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.4444 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.2222 | 6 | no |
| GO:0006996 | organelle organization | 42.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.2222 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.7778 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 35.5556 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 35.5556 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.5556 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.5556 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
| GO:0036211 | protein modification process | 31.1111 | 4 | no |
| GO:0043412 | macromolecule modification | 31.1111 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.1111 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.1111 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 28.8889 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 28.8889 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.8889 | 5 | no |
| GO:0008104 | protein localization | 28.8889 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 28.8889 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 28.8889 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0030162 | regulation of proteolysis | 26.6667 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 24.4444 | 6 | yes |
| GO:1901873 | regulation of post-translational protein modification | 24.4444 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 24.4444 | 8 | yes |
| GO:0009968 | negative regulation of signal transduction | 24.4444 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.4444 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.4444 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.4444 | 4 | no |
| GO:0051726 | regulation of cell cycle | 24.4444 | 4 | no |
| GO:0006508 | proteolysis | 24.4444 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 24.4444 | 9 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 22.2222 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 22.2222 | 4 | no |
| GO:0043687 | post-translational protein modification | 22.2222 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 22.2222 | 6 | no |
| GO:0080134 | regulation of response to stress | 22.2222 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0019941 | modification-dependent protein catabolic process | 22.2222 | 6 | yes |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 22.2222 | 5 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 22.2222 | 5 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 20.0000 | 7 | yes |
| GO:0006986 | response to unfolded protein | 20.0000 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 20.0000 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.0000 | 5 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 17.7778 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 17.7778 | 7 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 15.5556 | 4 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 15.5556 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 15.5556 | 7 | yes |
| GO:0090083 | regulation of inclusion body assembly | 13.3333 | 5 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 13.3333 | 8 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 13.3333 | 9 | yes |
| GO:0001558 | regulation of cell growth | 13.3333 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 13.3333 | 5 | yes |
| GO:0030163 | protein catabolic process | 13.3333 | 4 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 13.3333 | 10 | yes |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 13.3333 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 13.3333 | 6 | yes |
| GO:0090084 | negative regulation of inclusion body assembly | 11.1111 | 6 | yes |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | 11.1111 | 7 | yes |
| GO:1901874 | negative regulation of post-translational protein modification | 11.1111 | 8 | yes |
| GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 11.1111 | 8 | yes |
| GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 11.1111 | 9 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 11.1111 | 5 | yes |
| GO:0010498 | proteasomal protein catabolic process | 11.1111 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 11.1111 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 11.1111 | 7 | yes |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 8.8889 | 6 | yes |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 8.8889 | 7 | yes |
| GO:0030308 | negative regulation of cell growth | 6.6667 | 5 | yes |
| GO:0032091 | negative regulation of protein binding | 6.6667 | 5 | yes |
| GO:0043393 | regulation of protein binding | 6.6667 | 4 | yes |
| GO:0045926 | negative regulation of growth | 6.6667 | 4 | yes |
| GO:0051100 | negative regulation of binding | 6.6667 | 4 | yes |
| GO:1903332 | regulation of protein folding | 4.4444 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| PSA6_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPSD_HUMAN | [view interactions] | Low throughput | no | no |
| SODC_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| SPB5_HUMAN | [view interactions] | Low throughput | no | no |
| TADBP_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26C_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| DNJB8_HUMAN | [view interactions] | High throughput | no | no |
| NSE4A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| TROP_HUMAN | [view interactions] | High throughput | no | no |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP7B_HUMAN | [view interactions] | High throughput | no | no |
| BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPGB_HUMAN | [view interactions] | High throughput | no | yes |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
| GET3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| ZTRF1_HUMAN | [view interactions] | High throughput | no | no |
| TM276_HUMAN | [view interactions] | High throughput | no | no |
| RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| RN115_HUMAN | [view interactions] | High throughput | no | yes |
| RNF12_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| BLTP2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| DHDH_HUMAN | [view interactions] | High throughput | no | no |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARH7_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BBS7_HUMAN | [view interactions] | High throughput | no | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| BBS2_HUMAN | [view interactions] | High throughput | no | no |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |