ADT4_HUMAN
Evidence for PS localization
Functions
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell . Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane . Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis . In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity . Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis . Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) . Proton transporter activity requires free fatty acids as cofactor, but does not transport it . Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death . It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADT4_HUMAN |
|---|---|---|---|---|
| GO:0008509 | anion transmembrane transporter activity | 36.8421 | 4 | yes |
| GO:0046872 | metal ion binding | 31.5789 | 4 | no |
| GO:0022853 | active ion transmembrane transporter activity | 26.3158 | 4 | yes |
| GO:0000295 | adenine nucleotide transmembrane transporter activity | 21.0526 | 6 | yes |
| GO:0005346 | purine ribonucleotide transmembrane transporter activity | 21.0526 | 4 | yes |
| GO:0005347 | ATP transmembrane transporter activity | 21.0526 | 5 | yes |
| GO:0005471 | ATP:ADP antiporter activity | 21.0526 | 5 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 21.0526 | 5 | yes |
| GO:0015215 | nucleotide transmembrane transporter activity | 21.0526 | 4 | yes |
| GO:0015216 | purine nucleotide transmembrane transporter activity | 21.0526 | 5 | yes |
| GO:0015217 | ADP transmembrane transporter activity | 21.0526 | 5 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 21.0526 | 4 | yes |
| GO:0015297 | antiporter activity | 21.0526 | 5 | yes |
| GO:0140323 | solute:anion antiporter activity | 21.0526 | 6 | yes |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADT4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.1579 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 63.1579 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | no |
| GO:0033043 | regulation of organelle organization | 47.3684 | 5 | no |
| GO:0006996 | organelle organization | 47.3684 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.3684 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.1053 | 4 | no |
| GO:0071702 | organic substance transport | 42.1053 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 42.1053 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.1053 | 4 | no |
| GO:0051049 | regulation of transport | 36.8421 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 36.8421 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.8421 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.8421 | 4 | no |
| GO:0006811 | ion transport | 36.8421 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.8421 | 5 | no |
| GO:0006820 | anion transport | 31.5789 | 5 | yes |
| GO:0006915 | apoptotic process | 31.5789 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 26.3158 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 26.3158 | 5 | no |
| GO:0043269 | regulation of ion transport | 26.3158 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.3158 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3158 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 26.3158 | 6 | no |
| GO:0008104 | protein localization | 26.3158 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0010941 | regulation of cell death | 26.3158 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 26.3158 | 5 | no |
| GO:0061024 | membrane organization | 26.3158 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 26.3158 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 26.3158 | 6 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.0526 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0010821 | regulation of mitochondrion organization | 21.0526 | 6 | no |
| GO:0010468 | regulation of gene expression | 21.0526 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.0526 | 5 | no |
| GO:0031331 | positive regulation of cellular catabolic process | 21.0526 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.0526 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.0526 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 6 | no |
| GO:0006862 | nucleotide transport | 21.0526 | 6 | yes |
| GO:0007005 | mitochondrion organization | 21.0526 | 5 | yes |
| GO:0007006 | mitochondrial membrane organization | 21.0526 | 5 | yes |
| GO:0015711 | organic anion transport | 21.0526 | 5 | yes |
| GO:0015748 | organophosphate ester transport | 21.0526 | 5 | yes |
| GO:0015865 | purine nucleotide transport | 21.0526 | 7 | yes |
| GO:0015866 | ADP transport | 21.0526 | 6 | yes |
| GO:0015867 | ATP transport | 21.0526 | 6 | yes |
| GO:0015868 | purine ribonucleotide transport | 21.0526 | 6 | yes |
| GO:0015931 | nucleobase-containing compound transport | 21.0526 | 5 | yes |
| GO:0046902 | regulation of mitochondrial membrane permeability | 21.0526 | 4 | yes |
| GO:0051503 | adenine nucleotide transport | 21.0526 | 8 | yes |
| GO:0098656 | anion transmembrane transport | 21.0526 | 4 | yes |
| GO:0140021 | mitochondrial ADP transmembrane transport | 21.0526 | 4 | yes |
| GO:1901264 | carbohydrate derivative transport | 21.0526 | 5 | yes |
| GO:1990544 | mitochondrial ATP transmembrane transport | 21.0526 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 21.0526 | 4 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 21.0526 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMHA1_HUMAN | [view interactions] | High throughput | no | no |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| LRCC1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| CCBE1_HUMAN | [view interactions] | High throughput | no | no |
| HLX_HUMAN | [view interactions] | High throughput | no | yes |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| SC16B_HUMAN | [view interactions] | High throughput | no | no |
| FBXL3_HUMAN | [view interactions] | High throughput | no | no |
| ZC4H2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| FRPD2_HUMAN | [view interactions] | High throughput | no | no |
| CD003_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| ZC3HA_HUMAN | [view interactions] | High throughput | no | yes |
| GGT1_HUMAN | [view interactions] | High throughput | no | no |
| TASL_HUMAN | [view interactions] | High throughput | no | no |
| TXND2_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PPID_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TSPO_HUMAN | [view interactions] | Computational | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PPIF_HUMAN | [view interactions] | Computational | no | no |
| ADT2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |