Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ZC4H2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in interneurons differentiation (PubMed). Involved in neuronal development and in neuromuscular junction formation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
63 Val Leu Wieacker-Wolfsyndrome(WRWF) -
198 Arg Gln Wieacker-Wolfsyndrome(WRWF) -
201 Pro Ser Wieacker-Wolfsyndrome(WRWF) -
213 Arg Trp Wieacker-Wolfsyndrome(WRWF) -
18 Arg Lys Wieacker-Wolfsyndrome(WRWF) -
66 Leu His Wieacker-Wolfsyndrome(WRWF) -
70 His Gln Wieacker-Wolfsyndrome(WRWF) -
200 Ala Thr Wieacker-Wolfsyndrome(WRWF) -
200 Ala Val Wieacker-Wolfsyndrome(WRWF) -
201 Pro His Wieacker-Wolfsyndrome(WRWF) -
203 Cys Ser Wieacker-Wolffsyndrome,female-restricted(WRWFFR) -
206 Cys Phe Wieacker-Wolffsyndrome,female-restricted(WRWFFR) -
217 Lys Arg Wieacker-Wolfsyndrome(WRWF) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ZC4H2_HUMAN
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0008017 microtubule binding 28.5714 5 no
GO:0015631 tubulin binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ZC4H2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 yes
GO:0006996 organelle organization 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0071702 organic substance transport 57.1429 4 no
GO:0071705 nitrogen compound transport 57.1429 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0010468 regulation of gene expression 42.8571 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0048522 positive regulation of cellular process 42.8571 4 yes
GO:0051252 regulation of RNA metabolic process 42.8571 5 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0003358 noradrenergic neuron development 28.5714 5 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 7 yes
GO:0006513 protein monoubiquitination 28.5714 9 yes
GO:0007399 nervous system development 28.5714 4 yes
GO:0016567 protein ubiquitination 28.5714 8 yes
GO:0032446 protein modification by small protein conjugation 28.5714 7 yes
GO:0036211 protein modification process 28.5714 4 yes
GO:0043412 macromolecule modification 28.5714 4 yes
GO:0043687 post-translational protein modification 28.5714 5 yes
GO:0045595 regulation of cell differentiation 28.5714 4 yes
GO:0048666 neuron development 28.5714 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 28.5714 4 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0051101 regulation of DNA binding 28.5714 4 yes
GO:0070647 protein modification by small protein conjugation or removal 28.5714 6 yes
GO:2000677 regulation of transcription regulatory region DNA binding 28.5714 5 yes
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 yes
GO:0008104 protein localization 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0016050 vesicle organization 28.5714 5 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0015931 nucleobase-containing compound transport 28.5714 5 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0061024 membrane organization 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0051046 regulation of secretion 28.5714 5 no
GO:0051048 negative regulation of secretion 28.5714 5 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:1903530 regulation of secretion by cell 28.5714 4 no
GO:1903531 negative regulation of secretion by cell 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RNF12_HUMAN [view interactions] Low throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
GT2D1_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
ZN524_HUMAN [view interactions] High throughput no no
ZN223_HUMAN [view interactions] High throughput no yes
ZN490_HUMAN [view interactions] High throughput no no
GCC1_HUMAN [view interactions] High throughput no yes
ZNF76_HUMAN [view interactions] High throughput no no
ZN408_HUMAN [view interactions] High throughput no no
ZN669_HUMAN [view interactions] High throughput no no
GEM_HUMAN [view interactions] High throughput no yes
ATP4B_HUMAN [view interactions] High throughput no no
RN151_HUMAN [view interactions] High throughput no no
F161B_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
HXB5_HUMAN [view interactions] High throughput no no
KXDL1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DGCR6_HUMAN [view interactions] High throughput no no
ZN250_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
ZN688_HUMAN [view interactions] High throughput no yes
CMIP_HUMAN [view interactions] High throughput no yes
PKHN1_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
AGGF1_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
RN220_HUMAN [view entry] [view interactions] High throughput yes yes
HM20A_HUMAN [view interactions] High throughput no yes
PMF1_HUMAN [view interactions] High throughput no no
COL12_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
ELOB_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
KRT38_HUMAN [view interactions] High throughput no no
K2C75_HUMAN [view interactions] High throughput no no
SYCE1_HUMAN [view interactions] High throughput no no
KRT37_HUMAN [view interactions] High throughput no no
ANGP4_HUMAN [view interactions] High throughput no no
TM214_HUMAN [view interactions] High throughput no no
SYPM_HUMAN [view interactions] High throughput no yes
DIDO1_HUMAN [view interactions] High throughput no yes
ADT4_HUMAN [view entry] [view interactions] High throughput yes no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
SRBP2_HUMAN [view interactions] High throughput no yes