ZC4H2_HUMAN
Evidence for PS localization
Functions
Plays a role in interneurons differentiation (PubMed). Involved in neuronal development and in neuromuscular junction formation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 63 | Val | Leu | Wieacker-Wolfsyndrome(WRWF) | - |
| 198 | Arg | Gln | Wieacker-Wolfsyndrome(WRWF) | - |
| 201 | Pro | Ser | Wieacker-Wolfsyndrome(WRWF) | - |
| 213 | Arg | Trp | Wieacker-Wolfsyndrome(WRWF) | - |
| 18 | Arg | Lys | Wieacker-Wolfsyndrome(WRWF) | - |
| 66 | Leu | His | Wieacker-Wolfsyndrome(WRWF) | - |
| 70 | His | Gln | Wieacker-Wolfsyndrome(WRWF) | - |
| 200 | Ala | Thr | Wieacker-Wolfsyndrome(WRWF) | - |
| 200 | Ala | Val | Wieacker-Wolfsyndrome(WRWF) | - |
| 201 | Pro | His | Wieacker-Wolfsyndrome(WRWF) | - |
| 203 | Cys | Ser | Wieacker-Wolffsyndrome,female-restricted(WRWFFR) | - |
| 206 | Cys | Phe | Wieacker-Wolffsyndrome,female-restricted(WRWFFR) | - |
| 217 | Lys | Arg | Wieacker-Wolfsyndrome(WRWF) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZC4H2_HUMAN |
|---|---|---|---|---|
| GO:0008017 | microtubule binding | 33.3333 | 5 | no |
| GO:0015631 | tubulin binding | 33.3333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZC4H2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 66.6667 | 4 | no |
| GO:0071702 | organic substance transport | 66.6667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 66.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0007399 | nervous system development | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | yes |
| GO:0015931 | nucleobase-containing compound transport | 33.3333 | 5 | no |
| GO:0061024 | membrane organization | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | no |
| GO:0051048 | negative regulation of secretion | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051051 | negative regulation of transport | 33.3333 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | no |
| GO:1903531 | negative regulation of secretion by cell | 33.3333 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0016050 | vesicle organization | 33.3333 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | no |
| GO:0016482 | cytosolic transport | 33.3333 | 4 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| ZN524_HUMAN | [view interactions] | High throughput | no | no |
| ZN223_HUMAN | [view interactions] | High throughput | no | yes |
| ZN490_HUMAN | [view interactions] | High throughput | no | no |
| GCC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF76_HUMAN | [view interactions] | High throughput | no | no |
| ZN408_HUMAN | [view interactions] | High throughput | no | no |
| ZN669_HUMAN | [view interactions] | High throughput | no | no |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| ATP4B_HUMAN | [view interactions] | High throughput | no | no |
| RN151_HUMAN | [view interactions] | High throughput | no | no |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGCR6_HUMAN | [view interactions] | High throughput | no | no |
| ZN250_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| ZN688_HUMAN | [view interactions] | High throughput | no | yes |
| CMIP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHN1_HUMAN | [view interactions] | High throughput | no | yes |
| AGGF1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN220_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| ANGP4_HUMAN | [view interactions] | High throughput | no | no |
| TM214_HUMAN | [view interactions] | High throughput | no | no |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| ADT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |