Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RN220_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B . Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed, PubMed). Plays a critical role in the regulation of nuclear lamina (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RN220_HUMAN
GO:0044389 ubiquitin-like protein ligase binding 41.1765 4 no
GO:0031625 ubiquitin protein ligase binding 35.2941 5 no
GO:0003723 RNA binding 23.5294 4 no
GO:0043169 cation binding 17.6471 4 yes
GO:0046872 metal ion binding 17.6471 5 yes
GO:0004842 ubiquitin-protein transferase activity 11.7647 4 yes
GO:0016755 aminoacyltransferase activity 11.7647 4 yes
GO:0061630 ubiquitin protein ligase activity 11.7647 5 yes
GO:0061659 ubiquitin-like protein ligase activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RN220_HUMAN
GO:0010646 regulation of cell communication 64.7059 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.7059 4 yes
GO:0009889 regulation of biosynthetic process 58.8235 4 yes
GO:0010468 regulation of gene expression 58.8235 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 58.8235 5 yes
GO:0031323 regulation of cellular metabolic process 58.8235 4 yes
GO:0031326 regulation of cellular biosynthetic process 58.8235 5 yes
GO:0048522 positive regulation of cellular process 58.8235 4 yes
GO:0080090 regulation of primary metabolic process 52.9412 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0009966 regulation of signal transduction 47.0588 4 yes
GO:0010647 positive regulation of cell communication 41.1765 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.1765 5 yes
GO:0023056 positive regulation of signaling 41.1765 4 yes
GO:0036211 protein modification process 41.1765 4 yes
GO:0043412 macromolecule modification 41.1765 4 yes
GO:0051252 regulation of RNA metabolic process 41.1765 5 yes
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.1765 5 no
GO:0006355 regulation of DNA-templated transcription 35.2941 7 yes
GO:0009967 positive regulation of signal transduction 35.2941 5 yes
GO:0016567 protein ubiquitination 35.2941 8 yes
GO:0032446 protein modification by small protein conjugation 35.2941 7 yes
GO:0043687 post-translational protein modification 35.2941 5 yes
GO:0048584 positive regulation of response to stimulus 35.2941 4 yes
GO:0070647 protein modification by small protein conjugation or removal 35.2941 6 yes
GO:2001141 regulation of RNA biosynthetic process 35.2941 6 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0010648 negative regulation of cell communication 35.2941 5 no
GO:0023057 negative regulation of signaling 35.2941 4 no
GO:0042981 regulation of apoptotic process 35.2941 5 no
GO:0043067 regulation of programmed cell death 35.2941 4 no
GO:0006996 organelle organization 29.4118 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.4118 6 no
GO:0006508 proteolysis 29.4118 4 no
GO:0009057 macromolecule catabolic process 29.4118 4 no
GO:0009890 negative regulation of biosynthetic process 29.4118 5 no
GO:0009891 positive regulation of biosynthetic process 29.4118 5 no
GO:0009968 negative regulation of signal transduction 29.4118 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 29.4118 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.4118 6 no
GO:0010628 positive regulation of gene expression 29.4118 7 no
GO:0019941 modification-dependent protein catabolic process 29.4118 6 no
GO:0031324 negative regulation of cellular metabolic process 29.4118 5 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0031327 negative regulation of cellular biosynthetic process 29.4118 6 no
GO:0031328 positive regulation of cellular biosynthetic process 29.4118 6 no
GO:0043632 modification-dependent macromolecule catabolic process 29.4118 5 no
GO:0048585 negative regulation of response to stimulus 29.4118 4 no
GO:0051246 regulation of protein metabolic process 29.4118 5 no
GO:0051247 positive regulation of protein metabolic process 29.4118 6 no
GO:0051603 proteolysis involved in protein catabolic process 29.4118 5 no
GO:1902532 negative regulation of intracellular signal transduction 29.4118 6 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0043933 protein-containing complex organization 23.5294 4 no
GO:0009059 macromolecule biosynthetic process 23.5294 4 no
GO:0007268 chemical synaptic transmission 23.5294 7 no
GO:0008104 protein localization 23.5294 4 no
GO:0010243 response to organonitrogen compound 23.5294 4 no
GO:0010629 negative regulation of gene expression 23.5294 7 no
GO:0022607 cellular component assembly 23.5294 4 no
GO:0031396 regulation of protein ubiquitination 23.5294 9 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0042127 regulation of cell population proliferation 23.5294 4 no
GO:0043066 negative regulation of apoptotic process 23.5294 6 no
GO:0043069 negative regulation of programmed cell death 23.5294 5 no
GO:0045595 regulation of cell differentiation 23.5294 4 no
GO:0045597 positive regulation of cell differentiation 23.5294 5 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051128 regulation of cellular component organization 23.5294 4 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:0051241 negative regulation of multicellular organismal process 23.5294 4 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0071417 cellular response to organonitrogen compound 23.5294 4 no
GO:0098916 anterograde trans-synaptic signaling 23.5294 6 no
GO:0099536 synaptic signaling 23.5294 4 no
GO:0099537 trans-synaptic signaling 23.5294 5 no
GO:1901699 cellular response to nitrogen compound 23.5294 4 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:1901873 regulation of post-translational protein modification 23.5294 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 23.5294 8 no
GO:2001233 regulation of apoptotic signaling pathway 23.5294 5 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0006513 protein monoubiquitination 17.6471 9 yes
GO:0030111 regulation of Wnt signaling pathway 17.6471 5 yes
GO:0048666 neuron development 17.6471 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 17.6471 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 17.6471 6 yes
GO:0003358 noradrenergic neuron development 11.7647 5 yes
GO:0051101 regulation of DNA binding 11.7647 4 yes
GO:0051865 protein autoubiquitination 11.7647 9 yes
GO:2000677 regulation of transcription regulatory region DNA binding 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBP7_HUMAN [view interactions] Low throughput no yes
UB2E1_HUMAN [view interactions] Low throughput no yes
UB2E3_HUMAN [view interactions] Low throughput no yes
SIN3B_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
LMNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TADBP_HUMAN [view interactions] Low throughput no yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
UB2E2_HUMAN [view interactions] High throughput no yes
UBE2W_HUMAN [view interactions] High throughput no yes
CLC3A_HUMAN [view interactions] High throughput no no
WDR5B_HUMAN [view interactions] High throughput no yes
PE2R4_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
PELI2_HUMAN [view interactions] High throughput no yes
ZC4H2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
PIP_HUMAN [view interactions] High throughput no no
SPSB4_HUMAN [view interactions] High throughput no no
RL37_HUMAN [view entry] [view interactions] High throughput yes no
ZN653_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
DDX54_HUMAN [view interactions] High throughput no yes
NOM1_HUMAN [view interactions] High throughput no yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UB2L3_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
H33_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes