CTNB1_HUMAN
Evidence for PS localization
Functions
Key downstream component of the canonical Wnt signaling pathway (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex . Acts as a negative regulator of centrosome cohesion (PubMed). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle . Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001302 | DEG_SCF_TRCP1_1 | DEG | 32 | 37 | - |
| ELMI001964 | DOC_WW_Pin1_4 | DOC | 243 | 248 | - |
| ELMI001576 | LIG_PDZ_Class_1 | LIG | 776 | 781 | - |
| ELMI002616 | MOD_GSK3_1 | MOD | 30 | 37 | - |
| ELMI001502 | MOD_PKA_1 | MOD | 549 | 555 | - |
| ELMI001503 | MOD_PKA_1 | MOD | 672 | 678 | - |
| ELMI001302 | DEG_SCF_TRCP1_1 | DEG | 32 | 37 | - |
| ELMI001964 | DOC_WW_Pin1_4 | DOC | 243 | 248 | - |
| ELMI001576 | LIG_PDZ_Class_1 | LIG | 776 | 781 | - |
| ELMI002616 | MOD_GSK3_1 | MOD | 30 | 37 | - |
| ELMI001502 | MOD_PKA_1 | MOD | 549 | 555 | - |
| ELMI001503 | MOD_PKA_1 | MOD | 672 | 678 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CTNB1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.1164 | 4 | no |
| GO:0000166 | nucleotide binding | 27.0784 | 4 | no |
| GO:0043168 | anion binding | 26.6033 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.3658 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.9905 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.5154 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.6152 | 6 | no |
| GO:0043169 | cation binding | 21.3777 | 4 | no |
| GO:0046872 | metal ion binding | 21.1401 | 5 | no |
| GO:0019900 | kinase binding | 19.9525 | 4 | yes |
| GO:0019901 | protein kinase binding | 17.8147 | 5 | yes |
| GO:0045296 | cadherin binding | 17.5772 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 11.1639 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 10.9264 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 6.4133 | 4 | yes |
| GO:0019902 | phosphatase binding | 5.7007 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 5.2257 | 5 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 4.9881 | 5 | yes |
| GO:0016922 | nuclear receptor binding | 2.6128 | 6 | yes |
| GO:0097718 | disordered domain specific binding | 2.3753 | 4 | yes |
| GO:0001221 | transcription coregulator binding | 2.1378 | 4 | yes |
| GO:0030331 | nuclear estrogen receptor binding | 1.1876 | 7 | yes |
| GO:0001222 | transcription corepressor binding | 0.9501 | 5 | yes |
| GO:1990226 | histone methyltransferase binding | 0.7126 | 4 | yes |
| GO:0070411 | I-SMAD binding | 0.4751 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CTNB1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.0570 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.4062 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.2185 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.0309 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.3682 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.7553 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.1425 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 39.6675 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 38.9549 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.9549 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.2423 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.5297 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.0546 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.8171 | 5 | yes |
| GO:0022607 | cellular component assembly | 36.1045 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.0166 | 5 | yes |
| GO:0006996 | organelle organization | 32.7791 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5914 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.4537 | 4 | yes |
| GO:0008104 | protein localization | 28.2660 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.0285 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.0285 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.5534 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.0784 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 26.6033 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |