Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HOOK3_HUMAN

(Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HOOK3_HUMAN
GO:0000166 nucleotide binding 30.6667 4 no
GO:0043168 anion binding 30.6667 4 no
GO:0017076 purine nucleotide binding 28.0000 5 no
GO:0032555 purine ribonucleotide binding 28.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.0000 4 no
GO:0005524 ATP binding 24.0000 5 no
GO:0030554 adenyl nucleotide binding 24.0000 6 no
GO:0032559 adenyl ribonucleotide binding 24.0000 5 no
GO:0043169 cation binding 21.3333 4 no
GO:0046872 metal ion binding 21.3333 5 no
GO:0008017 microtubule binding 14.6667 5 yes
GO:0015631 tubulin binding 14.6667 4 yes
GO:0034452 dynactin binding 4.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HOOK3_HUMAN
GO:0048522 positive regulation of cellular process 45.3333 4 no
GO:0051128 regulation of cellular component organization 45.3333 4 no
GO:0006996 organelle organization 42.6667 4 yes
GO:0048523 negative regulation of cellular process 41.3333 4 yes
GO:0008104 protein localization 37.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 34.6667 4 no
GO:0007010 cytoskeleton organization 30.6667 5 yes
GO:0010646 regulation of cell communication 30.6667 4 no
GO:0031323 regulation of cellular metabolic process 29.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 29.3333 4 no
GO:0022607 cellular component assembly 29.3333 4 no
GO:0051049 regulation of transport 29.3333 4 no
GO:0033043 regulation of organelle organization 28.0000 5 no
GO:0080090 regulation of primary metabolic process 26.6667 4 no
GO:0009966 regulation of signal transduction 26.6667 4 no
GO:0071702 organic substance transport 24.0000 4 yes
GO:0071705 nitrogen compound transport 24.0000 4 yes
GO:0051130 positive regulation of cellular component organization 24.0000 5 no
GO:0015031 protein transport 22.6667 4 yes
GO:0043933 protein-containing complex organization 22.6667 4 no
GO:0009892 negative regulation of metabolic process 21.3333 4 no
GO:0097435 supramolecular fiber organization 20.0000 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 16.0000 4 yes
GO:0045595 regulation of cell differentiation 13.3333 4 yes
GO:2000026 regulation of multicellular organismal development 13.3333 4 yes
GO:0016050 vesicle organization 12.0000 5 yes
GO:0051960 regulation of nervous system development 12.0000 5 yes
GO:0007034 vacuolar transport 10.6667 4 yes
GO:0007041 lysosomal transport 10.6667 5 yes
GO:0050767 regulation of neurogenesis 10.6667 6 yes
GO:0051241 negative regulation of multicellular organismal process 10.6667 4 yes
GO:0060284 regulation of cell development 10.6667 5 yes
GO:0007033 vacuole organization 8.0000 5 yes
GO:0031122 cytoplasmic microtubule organization 6.6667 4 yes
GO:0033365 protein localization to organelle 6.6667 5 yes
GO:0051093 negative regulation of developmental process 6.6667 4 yes
GO:0007032 endosome organization 5.3333 6 yes
GO:0007097 nuclear migration 5.3333 4 yes
GO:0007040 lysosome organization 4.0000 7 yes
GO:0034453 microtubule anchoring 4.0000 4 yes
GO:0034454 microtubule anchoring at centrosome 4.0000 6 yes
GO:0044380 protein localization to cytoskeleton 4.0000 6 yes
GO:0071539 protein localization to centrosome 4.0000 9 yes
GO:0072393 microtubule anchoring at microtubule organizing center 4.0000 5 yes
GO:0072698 protein localization to microtubule cytoskeleton 4.0000 7 yes
GO:0080171 lytic vacuole organization 4.0000 6 yes
GO:1905508 protein localization to microtubule organizing center 4.0000 8 yes
GO:0010721 negative regulation of cell development 2.6667 6 yes
GO:0022027 interkinetic nuclear migration 2.6667 5 yes
GO:0045022 early endosome to late endosome transport 2.6667 5 yes
GO:0045596 negative regulation of cell differentiation 2.6667 5 yes
GO:0050768 negative regulation of neurogenesis 2.6667 6 yes
GO:0051961 negative regulation of nervous system development 2.6667 5 yes
GO:0098927 vesicle-mediated transport between endosomal compartments 2.6667 4 yes
GO:1905719 protein localization to perinuclear region of cytoplasm 2.6667 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MSRE_HUMAN [view interactions] Low throughput no no
AP4E1_HUMAN [view interactions] Low throughput no no
BICD2_HUMAN [view interactions] Low throughput no yes
KIF1C_HUMAN [view interactions] Low throughput no yes
DC1L1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
ZN326_HUMAN [view interactions] High throughput no yes
RAD50_HUMAN [view interactions] High throughput no yes
MCCA_HUMAN [view entry] [view interactions] High throughput yes yes
GFPT1_HUMAN [view interactions] High throughput no no
PCCB_HUMAN [view interactions] High throughput no yes
AASS_HUMAN [view interactions] High throughput no yes
PAPD1_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
BPL1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
MCM5_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
ABCB7_HUMAN [view interactions] High throughput no yes
PYC_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
CERU_HUMAN [view interactions] High throughput no no
PCCA_HUMAN [view entry] [view interactions] High throughput yes yes
PATL1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
KRI1_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
RBM14_HUMAN [view interactions] High throughput no yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
KLC4_HUMAN [view interactions] High throughput no yes
TBC23_HUMAN [view interactions] High throughput no yes
KIF1B_HUMAN [view entry] [view interactions] High throughput yes yes
WDR11_HUMAN [view interactions] High throughput no yes
F91A1_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA5_HUMAN [view interactions] High throughput no yes
TBKB1_HUMAN [view interactions] High throughput no no
WDR62_HUMAN [view interactions] High throughput no no
PCM1_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
TPD54_HUMAN [view interactions] High throughput no yes
CBPD_HUMAN [view interactions] High throughput no yes
K319L_HUMAN [view interactions] High throughput no yes
PP6R2_HUMAN [view interactions] High throughput no no
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
ATG2A_HUMAN [view interactions] High throughput no yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
WAC2A_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
GRDN_HUMAN [view interactions] High throughput no no
WAC2C_HUMAN [view interactions] High throughput no yes
NP1L4_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
ANR52_HUMAN [view interactions] High throughput no yes
HAUS5_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
GPTC1_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
WASC5_HUMAN [view interactions] High throughput no yes
BSDC1_HUMAN [view interactions] High throughput no no
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
F120A_HUMAN [view interactions] High throughput no yes
LUZP1_HUMAN [view interactions] High throughput no yes
COBL_HUMAN [view interactions] High throughput no yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
BACH2_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L3_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R3_HUMAN [view interactions] High throughput no yes
AFTIN_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
BCCIP_HUMAN [view interactions] High throughput no no
WDR83_HUMAN [view interactions] High throughput no yes
PHF8_HUMAN [view interactions] High throughput no yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
LTV1_HUMAN [view interactions] High throughput no yes
ALMS1_HUMAN [view interactions] High throughput no no
NBN_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
OSBL3_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
IFT27_HUMAN [view interactions] High throughput no yes
CING_HUMAN [view interactions] High throughput no no
SYNRG_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
HBS1L_HUMAN [view interactions] High throughput no yes
CEP97_HUMAN [view interactions] High throughput no yes
Z3H7A_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
MPRI_HUMAN [view interactions] High throughput no yes
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
SPAG5_HUMAN [view interactions] High throughput no yes
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
CSDE1_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK1_HUMAN [view interactions] High throughput no no
AKTIP_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
NEDD1_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
TZAP_HUMAN [view interactions] High throughput no no
IFT57_HUMAN [view interactions] High throughput no yes
FNTB_HUMAN [view interactions] High throughput no no
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
SYCE3_HUMAN [view interactions] High throughput no no
TN13B_HUMAN [view interactions] High throughput no no
KLH10_HUMAN [view interactions] High throughput no no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1A_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
KLH20_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
K1C13_HUMAN [view interactions] High throughput no no
K1C27_HUMAN [view interactions] High throughput no no
PNMA5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ADIP_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2A_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
MEOX2_HUMAN [view interactions] High throughput no no
CTIF_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
VPS41_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC8_HUMAN [view interactions] High throughput no yes
ZC4H2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
CDC16_HUMAN [view interactions] High throughput no yes
CNDH2_HUMAN [view interactions] High throughput no no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
KRT37_HUMAN [view interactions] High throughput no no
SYCE1_HUMAN [view interactions] High throughput no no
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
RUBIC_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TMM74_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
FAM9C_HUMAN [view interactions] High throughput no no
NUBP1_HUMAN [view interactions] High throughput no yes
TNR5_HUMAN [view interactions] High throughput no no
MAGA8_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
GPR17_HUMAN [view interactions] High throughput no no
KRT34_HUMAN [view interactions] High throughput no no
LCTL_HUMAN [view interactions] High throughput no no
CBPC6_HUMAN [view interactions] High throughput no yes
SKAP1_HUMAN [view interactions] High throughput no no
ANR22_HUMAN [view interactions] High throughput no no
FEM1A_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
TRI52_HUMAN [view interactions] High throughput no yes
ARHGA_HUMAN [view interactions] High throughput no yes
PPARD_HUMAN [view interactions] High throughput no yes
CAB45_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
MRE11_HUMAN [view interactions] High throughput no yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
GCSH_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
CREL2_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
VPS11_HUMAN [view entry] [view interactions] High throughput yes no
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BRPF1_HUMAN [view interactions] High throughput no yes
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
HYOU1_HUMAN [view interactions] High throughput no yes
ACOT9_HUMAN [view interactions] High throughput no yes
K1C19_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
ACACB_HUMAN [view interactions] High throughput no no
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes