HOOK3_HUMAN
Evidence for PS localization
Functions
(Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HOOK3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.2308 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.2308 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.2308 | 4 | no |
| GO:0005524 | ATP binding | 24.6154 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.6154 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.6154 | 5 | no |
| GO:0045296 | cadherin binding | 21.5385 | 4 | no |
| GO:0008017 | microtubule binding | 13.8462 | 5 | yes |
| GO:0015631 | tubulin binding | 13.8462 | 4 | yes |
| GO:0034452 | dynactin binding | 4.6154 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HOOK3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 49.2308 | 4 | no |
| GO:0006996 | organelle organization | 41.5385 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 33.8462 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.7692 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.7692 | 4 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.2308 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.6923 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.6923 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 26.1538 | 4 | yes |
| GO:0071702 | organic substance transport | 26.1538 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 26.1538 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.1538 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.1538 | 4 | no |
| GO:0015031 | protein transport | 24.6154 | 4 | yes |
| GO:0051049 | regulation of transport | 24.6154 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.6154 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 23.0769 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.5385 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.5385 | 5 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 13.8462 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 13.8462 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 13.8462 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 12.3077 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 10.7692 | 6 | yes |
| GO:0060284 | regulation of cell development | 10.7692 | 5 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 9.2308 | 4 | yes |
| GO:0016482 | cytosolic transport | 7.6923 | 4 | yes |
| GO:0033365 | protein localization to organelle | 7.6923 | 5 | yes |
| GO:0007034 | vacuolar transport | 6.1538 | 4 | yes |
| GO:0007041 | lysosomal transport | 6.1538 | 5 | yes |
| GO:0007097 | nuclear migration | 6.1538 | 4 | yes |
| GO:0008333 | endosome to lysosome transport | 6.1538 | 5 | yes |
| GO:0016050 | vesicle organization | 6.1538 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 6.1538 | 4 | yes |
| GO:0007033 | vacuole organization | 4.6154 | 5 | yes |
| GO:0034453 | microtubule anchoring | 4.6154 | 4 | yes |
| GO:0034454 | microtubule anchoring at centrosome | 4.6154 | 6 | yes |
| GO:0044380 | protein localization to cytoskeleton | 4.6154 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 4.6154 | 4 | yes |
| GO:0071539 | protein localization to centrosome | 4.6154 | 9 | yes |
| GO:0072393 | microtubule anchoring at microtubule organizing center | 4.6154 | 5 | yes |
| GO:0072698 | protein localization to microtubule cytoskeleton | 4.6154 | 7 | yes |
| GO:1905508 | protein localization to microtubule organizing center | 4.6154 | 8 | yes |
| GO:0007032 | endosome organization | 3.0769 | 6 | yes |
| GO:0007040 | lysosome organization | 3.0769 | 7 | yes |
| GO:0010721 | negative regulation of cell development | 3.0769 | 6 | yes |
| GO:0022027 | interkinetic nuclear migration | 3.0769 | 5 | yes |
| GO:0045022 | early endosome to late endosome transport | 3.0769 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 3.0769 | 5 | yes |
| GO:0050768 | negative regulation of neurogenesis | 3.0769 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 3.0769 | 5 | yes |
| GO:0080171 | lytic vacuole organization | 3.0769 | 6 | yes |
| GO:0098927 | vesicle-mediated transport between endosomal compartments | 3.0769 | 5 | yes |
| GO:1905719 | protein localization to perinuclear region of cytoplasm | 3.0769 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HOOK3_HUMAN |
|---|---|---|---|---|
| DOID:0080000 | muscular disease | 3.0769 | 3 | no |
| DOID:423 | myopathy | 3.0769 | 5 | no |
| DOID:66 | muscle tissue disease | 3.0769 | 4 | no |
| DOID:0050700 | cardiomyopathy | 3.0769 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.0769 | 5 | no |
| DOID:114 | heart disease | 3.0769 | 3 | no |
| DOID:2843 | long QT syndrome | 3.0769 | 6 | no |
| DOID:331 | central nervous system disease | 3.0769 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MSRE_HUMAN | [view interactions] | Low throughput | no | no |
| BICD2_HUMAN | [view interactions] | Low throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | Low throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TZAP_HUMAN | [view interactions] | High throughput | no | no |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| KLH10_HUMAN | [view interactions] | High throughput | no | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ZC4H2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| CNDH2_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| AP4E1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUBIC_HUMAN | [view interactions] | High throughput | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| LCTL_HUMAN | [view interactions] | High throughput | no | no |
| CBPC6_HUMAN | [view interactions] | High throughput | no | yes |
| SKAP1_HUMAN | [view interactions] | High throughput | no | no |
| ANR22_HUMAN | [view interactions] | High throughput | no | no |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFPT1_HUMAN | [view interactions] | High throughput | no | no |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPL1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| CERU_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRI1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| TBC23_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| TBKB1_HUMAN | [view interactions] | High throughput | no | no |
| WDR62_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| WAC2C_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS5_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| WASC5_HUMAN | [view interactions] | High throughput | no | yes |
| BSDC1_HUMAN | [view interactions] | High throughput | no | no |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| PHF8_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTV1_HUMAN | [view interactions] | High throughput | no | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| NBN_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL3_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D3_HUMAN | [view interactions] | High throughput | no | no |
| HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |