Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ZO2_HUMAN

GO
G2C
SynGO

Plays a role in tight junctions and adherens junctions. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ZO2_HUMAN
GO:0045296 cadherin binding 34.2857 4 yes
GO:0019900 kinase binding 28.5714 4 yes
GO:0019901 protein kinase binding 27.1429 5 yes
GO:0003779 actin binding 25.7143 4 no
GO:0003723 RNA binding 22.8571 4 no
GO:0016301 kinase activity 11.4286 4 yes
GO:1990782 protein tyrosine kinase binding 10.0000 6 yes
GO:0004385 guanylate kinase activity 2.8571 6 yes
GO:0016776 phosphotransferase activity, phosphate group as acceptor 2.8571 4 yes
GO:0019205 nucleobase-containing compound kinase activity 2.8571 5 yes
GO:0050145 nucleoside monophosphate kinase activity 2.8571 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ZO2_HUMAN
GO:0048523 negative regulation of cellular process 62.8571 4 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 55.7143 4 no
GO:0060255 regulation of macromolecule metabolic process 55.7143 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.8571 4 no
GO:0080090 regulation of primary metabolic process 52.8571 4 no
GO:0008104 protein localization 47.1429 4 yes
GO:0051128 regulation of cellular component organization 47.1429 4 no
GO:0010646 regulation of cell communication 45.7143 4 no
GO:0009966 regulation of signal transduction 41.4286 4 no
GO:0006996 organelle organization 41.4286 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0010468 regulation of gene expression 37.1429 5 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0031324 negative regulation of cellular metabolic process 32.8571 5 no
GO:0007010 cytoskeleton organization 31.4286 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.4286 4 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0015031 protein transport 27.1429 4 no
GO:0031399 regulation of protein modification process 27.1429 6 no
GO:0009889 regulation of biosynthetic process 27.1429 4 no
GO:0031326 regulation of cellular biosynthetic process 27.1429 5 no
GO:0042981 regulation of apoptotic process 27.1429 6 no
GO:0043067 regulation of programmed cell death 27.1429 5 no
GO:0019220 regulation of phosphate metabolic process 25.7143 6 no
GO:0051174 regulation of phosphorus metabolic process 25.7143 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.7143 5 no
GO:1902531 regulation of intracellular signal transduction 25.7143 5 no
GO:0051049 regulation of transport 25.7143 4 no
GO:0051726 regulation of cell cycle 25.7143 4 no
GO:0034330 cell junction organization 24.2857 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 24.2857 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.2857 5 no
GO:1901701 cellular response to oxygen-containing compound 24.2857 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.2857 5 no
GO:2000145 regulation of cell motility 24.2857 4 no
GO:0032880 regulation of protein localization 24.2857 5 no
GO:0060341 regulation of cellular localization 24.2857 4 no
GO:0001932 regulation of protein phosphorylation 22.8571 7 no
GO:0006886 intracellular protein transport 22.8571 4 no
GO:0042325 regulation of phosphorylation 22.8571 7 no
GO:0045595 regulation of cell differentiation 22.8571 4 no
GO:0030334 regulation of cell migration 22.8571 5 no
GO:0033043 regulation of organelle organization 22.8571 5 no
GO:0051252 regulation of RNA metabolic process 22.8571 5 no
GO:0048584 positive regulation of response to stimulus 22.8571 4 no
GO:2000026 regulation of multicellular organismal development 22.8571 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0045216 cell-cell junction organization 17.1429 5 yes
GO:0001894 tissue homeostasis 12.8571 5 yes
GO:0060249 anatomical structure homeostasis 12.8571 4 yes
GO:1902414 protein localization to cell junction 10.0000 5 yes
GO:0002064 epithelial cell development 8.5714 4 yes
GO:0003018 vascular process in circulatory system 8.5714 4 yes
GO:0150105 protein localization to cell-cell junction 8.5714 6 yes
GO:0034109 homotypic cell-cell adhesion 7.1429 4 yes
GO:0035633 maintenance of blood-brain barrier 7.1429 6 yes
GO:0001885 endothelial cell development 5.7143 5 yes
GO:0061028 establishment of endothelial barrier 5.7143 6 yes
GO:0090557 establishment of endothelial intestinal barrier 5.7143 7 yes
GO:0043117 positive regulation of vascular permeability 4.2857 4 yes
GO:1905603 regulation of blood-brain barrier permeability 4.2857 4 yes
GO:1905605 positive regulation of blood-brain barrier permeability 4.2857 5 yes
GO:0050892 intestinal absorption 2.8571 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
ZO2_HUMAN [view entry] [view interactions] Low throughput yes no
LASP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZYX_HUMAN [view interactions] Low throughput no no
LPP_HUMAN [view interactions] Low throughput no yes
CLD1_HUMAN [view interactions] Low throughput no no
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
SSR3_HUMAN [view interactions] Low throughput no yes
WWTR1_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
ZO1_HUMAN [view entry] [view interactions] Low throughput yes no
EPB41_HUMAN [view entry] [view interactions] Low throughput yes no
CLD2_HUMAN [view interactions] Low throughput no no
OCLN_HUMAN [view interactions] Low throughput no no
CXD2_HUMAN [view interactions] Low throughput no no
E41L5_HUMAN [view interactions] Low throughput no no
CTNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CING_HUMAN [view interactions] Low throughput no no
SH319_HUMAN [view interactions] High throughput no no
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L3_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
TCHP_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
TRIP6_HUMAN [view interactions] High throughput no yes
UBP53_HUMAN [view interactions] High throughput no yes
UBP54_HUMAN [view interactions] High throughput no yes
AKAP2_HUMAN [view interactions] High throughput no no
ALMS1_HUMAN [view interactions] High throughput no no
APC_HUMAN [view entry] [view interactions] High throughput yes no
BIG3_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
RHG35_HUMAN [view interactions] High throughput no yes
BCAS3_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
CCD25_HUMAN [view interactions] High throughput no yes
CC85C_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
CUED2_HUMAN [view interactions] High throughput no no
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
DVL3_HUMAN [view interactions] High throughput no yes
EDF1_HUMAN [view interactions] High throughput no yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
IFT74_HUMAN [view interactions] High throughput no yes
CRACD_HUMAN [view interactions] High throughput no yes
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
M21D2_HUMAN [view interactions] High throughput no yes
MTMR6_HUMAN [view interactions] High throughput no no
NEBL_HUMAN [view entry] [view interactions] High throughput yes no
NEDD1_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
RPGF6_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
TTF2_HUMAN [view interactions] High throughput no yes
UBIP1_HUMAN [view interactions] High throughput no no
RAE1_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
EXOS5_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
MK08_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
AT1B3_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
RASA1_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
LITD1_HUMAN [view interactions] High throughput no no
HMGB1_HUMAN [view interactions] High throughput no yes
EGLN_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
CDK6_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LATS1_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
PGAM5_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
K1671_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
ODFP2_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
RAE1L_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
SRPK1_HUMAN [view interactions] High throughput no yes
SNAI2_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
LUZP4_HUMAN [view interactions] High throughput no no
SNAI3_HUMAN [view interactions] High throughput no no
MAGIX_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no
NUD12_HUMAN [view interactions] High throughput no yes
GILT_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
JPH4_HUMAN [view interactions] High throughput no no
CDK15_HUMAN [view interactions] High throughput no no
CAN13_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
ZUP1_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
PAIRB_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
VRK1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
PTN3_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
RHG12_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RBM39_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
CO8A1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
JPH3_HUMAN [view interactions] High throughput no no
GAG2E_HUMAN [view interactions] High throughput no no
SUMO1_HUMAN [view interactions] High throughput no yes
CT197_HUMAN [view interactions] High throughput no no
QCR10_HUMAN [view interactions] High throughput no no
IFI6_HUMAN [view interactions] High throughput no yes
H2AJ_HUMAN [view interactions] High throughput no yes
EZH1_HUMAN [view interactions] High throughput no yes
NOG2_HUMAN [view interactions] High throughput no yes
CX001_HUMAN [view interactions] High throughput no no
APC15_HUMAN [view interactions] High throughput no yes
GAGE5_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
TM14B_HUMAN [view interactions] High throughput no no
ANR50_HUMAN [view interactions] High throughput no no
PEN2_HUMAN [view interactions] High throughput no yes
BEX1_HUMAN [view interactions] High throughput no yes
SERF2_HUMAN [view interactions] High throughput no no
KR197_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes
CP141_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
I27L1_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
TPX2_HUMAN [view interactions] High throughput no yes
PLCA_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
PIGT_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
ANTR1_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI1_HUMAN [view interactions] High throughput no no
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
BIN3_HUMAN [view interactions] High throughput no yes
TF2H5_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
UBN1_HUMAN [view interactions] High throughput no yes
THOC5_HUMAN [view interactions] High throughput no no
ZMYM3_HUMAN [view interactions] High throughput no yes
KCMF1_HUMAN [view interactions] High throughput no yes
LRC47_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1B_HUMAN [view interactions] High throughput no no
MCM3_HUMAN [view interactions] High throughput no no
PUS7_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
BICD2_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
AMOT_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
AFAD_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
CBL_HUMAN [view interactions] High throughput no yes
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
CCNB1_HUMAN [view interactions] High throughput no no
CCNB2_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CFA97_HUMAN [view interactions] High throughput no yes
CPNE8_HUMAN [view interactions] High throughput no yes
DIP2A_HUMAN [view interactions] High throughput no no
DNMBP_HUMAN [view interactions] High throughput no no
EFHD1_HUMAN [view interactions] High throughput no no
F107B_HUMAN [view interactions] High throughput no no
FNBP1_HUMAN [view interactions] High throughput no yes
FBP1L_HUMAN [view interactions] High throughput no yes
IFT57_HUMAN [view interactions] High throughput no yes
JCAD_HUMAN [view interactions] High throughput no yes
KNTC1_HUMAN [view interactions] High throughput no no
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP1_HUMAN [view interactions] High throughput no yes
MTMR1_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
NECT2_HUMAN [view interactions] High throughput no no
PAK4_HUMAN [view interactions] High throughput no yes
PEAK1_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RASF8_HUMAN [view interactions] High throughput no yes
RPAP2_HUMAN [view interactions] High throughput no yes
ENTR1_HUMAN [view interactions] High throughput no no
RPGF2_HUMAN [view entry] [view interactions] Computational yes no
SAFB1_HUMAN [view interactions] Computational no yes
HNRPC_HUMAN [view interactions] Computational no yes
FOS_HUMAN [view interactions] Computational no yes
CASP3_HUMAN [view interactions] Computational no yes
ARVC_HUMAN [view entry] [view interactions] Computational yes yes
JAM1_HUMAN [view interactions] Computational no yes
ZBT17_HUMAN [view interactions] Computational no yes
MAX_HUMAN [view interactions] Computational no yes
JUN_HUMAN [view interactions] Computational no yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
F1892_HUMAN [view interactions] Computational no yes