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SRBS1_HUMAN

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SRBS1_HUMAN
GO:0019900 kinase binding 36.5385 4 no
GO:0019901 protein kinase binding 34.6154 5 no
GO:0003779 actin binding 26.9231 4 yes
GO:0046872 metal ion binding 26.9231 4 no
GO:0017076 purine nucleotide binding 23.0769 4 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0045296 cadherin binding 23.0769 4 no
GO:0030695 GTPase regulator activity 21.1538 4 no
GO:0005524 ATP binding 21.1538 5 no
GO:0030554 adenyl nucleotide binding 21.1538 5 no
GO:0032559 adenyl ribonucleotide binding 21.1538 5 no
GO:0030159 signaling receptor complex adaptor activity 9.6154 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SRBS1_HUMAN
GO:0010646 regulation of cell communication 65.3846 4 yes
GO:0009966 regulation of signal transduction 59.6154 4 yes
GO:0048522 positive regulation of cellular process 59.6154 4 yes
GO:0048523 negative regulation of cellular process 57.6923 4 no
GO:0060255 regulation of macromolecule metabolic process 55.7692 4 yes
GO:0080090 regulation of primary metabolic process 53.8462 4 yes
GO:0031323 regulation of cellular metabolic process 51.9231 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0006996 organelle organization 46.1538 4 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.2308 5 yes
GO:0022607 cellular component assembly 44.2308 4 yes
GO:0030030 cell projection organization 44.2308 4 no
GO:1902531 regulation of intracellular signal transduction 44.2308 5 no
GO:0051246 regulation of protein metabolic process 42.3077 5 no
GO:0031325 positive regulation of cellular metabolic process 40.3846 5 yes
GO:0071310 cellular response to organic substance 40.3846 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 38.4615 5 no
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 no
GO:0008104 protein localization 38.4615 4 no
GO:0009889 regulation of biosynthetic process 36.5385 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.5385 5 yes
GO:0031326 regulation of cellular biosynthetic process 36.5385 5 yes
GO:0010468 regulation of gene expression 36.5385 5 no
GO:0031344 regulation of cell projection organization 36.5385 5 no
GO:0007010 cytoskeleton organization 34.6154 5 yes
GO:0031399 regulation of protein modification process 34.6154 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.6154 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.6154 5 no
GO:0048584 positive regulation of response to stimulus 32.6923 4 yes
GO:1901699 cellular response to nitrogen compound 32.6923 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 32.6923 4 no
GO:0019220 regulation of phosphate metabolic process 32.6923 6 no
GO:0045595 regulation of cell differentiation 32.6923 4 no
GO:0051174 regulation of phosphorus metabolic process 32.6923 5 no
GO:0051252 regulation of RNA metabolic process 32.6923 5 no
GO:0009967 positive regulation of signal transduction 30.7692 5 yes
GO:0010243 response to organonitrogen compound 30.7692 4 yes
GO:0010647 positive regulation of cell communication 30.7692 5 yes
GO:0023056 positive regulation of signaling 30.7692 4 yes
GO:0051049 regulation of transport 30.7692 4 yes
GO:0071417 cellular response to organonitrogen compound 30.7692 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 yes
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0006355 regulation of DNA-templated transcription 30.7692 6 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:1903506 regulation of nucleic acid-templated transcription 30.7692 7 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0051247 positive regulation of protein metabolic process 28.8462 6 no
GO:0001932 regulation of protein phosphorylation 28.8462 7 no
GO:0010648 negative regulation of cell communication 28.8462 5 no
GO:0023057 negative regulation of signaling 28.8462 4 no
GO:0048585 negative regulation of response to stimulus 28.8462 4 no
GO:0051338 regulation of transferase activity 28.8462 4 no
GO:0044087 regulation of cellular component biogenesis 28.8462 4 no
GO:0009968 negative regulation of signal transduction 26.9231 5 no
GO:0010941 regulation of cell death 26.9231 4 no
GO:0042981 regulation of apoptotic process 26.9231 6 no
GO:0043067 regulation of programmed cell death 26.9231 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 26.9231 6 no
GO:0043549 regulation of kinase activity 26.9231 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0032880 regulation of protein localization 23.0769 5 yes
GO:0060341 regulation of cellular localization 23.0769 4 yes
GO:0097435 supramolecular fiber organization 23.0769 4 yes
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0030155 regulation of cell adhesion 23.0769 4 no
GO:0014070 response to organic cyclic compound 21.1538 4 no
GO:0071407 cellular response to organic cyclic compound 21.1538 5 no
GO:0007015 actin filament organization 21.1538 5 yes
GO:0034329 cell junction assembly 21.1538 5 yes
GO:0051248 negative regulation of protein metabolic process 21.1538 6 no
GO:0010562 positive regulation of phosphorus metabolic process 21.1538 6 no
GO:0042327 positive regulation of phosphorylation 21.1538 8 no
GO:0043066 negative regulation of apoptotic process 21.1538 7 no
GO:0043069 negative regulation of programmed cell death 21.1538 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.1538 6 no
GO:0045937 positive regulation of phosphate metabolic process 21.1538 7 no
GO:0060548 negative regulation of cell death 21.1538 5 no
GO:2000145 regulation of cell motility 21.1538 4 no
GO:0034762 regulation of transmembrane transport 19.2308 4 yes
GO:1901652 response to peptide 15.3846 4 yes
GO:1901653 cellular response to peptide 15.3846 5 yes
GO:0034764 positive regulation of transmembrane transport 11.5385 5 yes
GO:1903829 positive regulation of protein localization 11.5385 5 yes
GO:0019216 regulation of lipid metabolic process 9.6154 5 yes
GO:0032870 cellular response to hormone stimulus 9.6154 4 yes
GO:0043434 response to peptide hormone 9.6154 4 yes
GO:0045834 positive regulation of lipid metabolic process 9.6154 5 yes
GO:0071375 cellular response to peptide hormone stimulus 9.6154 5 yes
GO:1905475 regulation of protein localization to membrane 9.6154 6 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 9.6154 6 yes
GO:0007044 cell-substrate junction assembly 7.6923 6 yes
GO:0032868 response to insulin 7.6923 5 yes
GO:0032869 cellular response to insulin stimulus 7.6923 6 yes
GO:0051017 actin filament bundle assembly 7.6923 5 yes
GO:0061572 actin filament bundle organization 7.6923 6 yes
GO:0150115 cell-substrate junction organization 7.6923 5 yes
GO:1903076 regulation of protein localization to plasma membrane 7.6923 7 yes
GO:1904375 regulation of protein localization to cell periphery 7.6923 6 yes
GO:1905477 positive regulation of protein localization to membrane 7.6923 6 yes
GO:0006109 regulation of carbohydrate metabolic process 5.7692 5 yes
GO:0007160 cell-matrix adhesion 5.7692 4 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 5.7692 5 yes
GO:0010676 positive regulation of cellular carbohydrate metabolic process 5.7692 6 yes
GO:0010906 regulation of glucose metabolic process 5.7692 5 yes
GO:0010907 positive regulation of glucose metabolic process 5.7692 6 yes
GO:0045913 positive regulation of carbohydrate metabolic process 5.7692 5 yes
GO:0046626 regulation of insulin receptor signaling pathway 5.7692 5 yes
GO:0046628 positive regulation of insulin receptor signaling pathway 5.7692 6 yes
GO:0048041 focal adhesion assembly 5.7692 7 yes
GO:0062012 regulation of small molecule metabolic process 5.7692 4 yes
GO:0062013 positive regulation of small molecule metabolic process 5.7692 5 yes
GO:1900076 regulation of cellular response to insulin stimulus 5.7692 4 yes
GO:1900078 positive regulation of cellular response to insulin stimulus 5.7692 5 yes
GO:1903078 positive regulation of protein localization to plasma membrane 5.7692 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 5.7692 6 yes
GO:0005979 regulation of glycogen biosynthetic process 3.8462 7 yes
GO:0008286 insulin receptor signaling pathway 3.8462 6 yes
GO:0010827 regulation of glucose transmembrane transport 3.8462 5 yes
GO:0010828 positive regulation of glucose transmembrane transport 3.8462 6 yes
GO:0010962 regulation of glucan biosynthetic process 3.8462 6 yes
GO:0030038 contractile actin filament bundle assembly 3.8462 6 yes
GO:0031032 actomyosin structure organization 3.8462 4 yes
GO:0032881 regulation of polysaccharide metabolic process 3.8462 5 yes
GO:0032885 regulation of polysaccharide biosynthetic process 3.8462 6 yes
GO:0043149 stress fiber assembly 3.8462 5 yes
GO:0043255 regulation of carbohydrate biosynthetic process 3.8462 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 3.8462 5 yes
GO:0045725 positive regulation of glycogen biosynthetic process 3.8462 7 yes
GO:0046324 regulation of glucose import 3.8462 6 yes
GO:0046326 positive regulation of glucose import 3.8462 7 yes
GO:0070873 regulation of glycogen metabolic process 3.8462 6 yes
GO:0070875 positive regulation of glycogen metabolic process 3.8462 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHIP2_HUMAN [view interactions] Low throughput no yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
VINC_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBLB_HUMAN [view interactions] Low throughput no yes
ATX7_HUMAN [view interactions] Low throughput no no
INSR_HUMAN [view interactions] Low throughput no yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
INSM1_HUMAN [view interactions] Low throughput no no
FLOT1_HUMAN [view entry] [view interactions] Low throughput yes yes
FRS2_HUMAN [view interactions] Low throughput no no
TEN1_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAD_HUMAN [view interactions] Low throughput no yes
CASP8_HUMAN [view interactions] Low throughput no yes
NTRK1_HUMAN [view interactions] Low throughput no yes
SH2B2_HUMAN [view interactions] Low throughput no no
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB1_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
PAXI_HUMAN [view interactions] Low throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
SEM6A_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
ADA15_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
CDK6_HUMAN [view interactions] High throughput no yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
P3_HUMAN [view interactions] High throughput no yes
PILRA_HUMAN [view interactions] High throughput no yes
M4K3_HUMAN [view interactions] High throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FGFR4_HUMAN [view interactions] High throughput no no
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
RT4I1_HUMAN [view interactions] High throughput no yes
CDK4_HUMAN [view interactions] High throughput no no
TGS1_HUMAN [view interactions] High throughput no yes
TOIP1_HUMAN [view interactions] High throughput no yes
SIDT2_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
CD2AP_HUMAN [view interactions] High throughput no no
CHIO_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
S26A7_HUMAN [view interactions] High throughput no no
RHG42_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
PREX2_HUMAN [view interactions] High throughput no no
PRIC1_HUMAN [view interactions] High throughput no yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
VAV_HUMAN [view interactions] High throughput no no
VINEX_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
GRRE1_HUMAN [view interactions] High throughput no no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
SYNE3_HUMAN [view interactions] High throughput no no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
VASP_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SPART_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
IRS1_HUMAN [view entry] [view interactions] Computational yes yes
KI3L1_HUMAN [view interactions] Computational no no
TRI45_HUMAN [view interactions] Computational no no
ITB5_HUMAN [view interactions] Computational no yes
HLAC_HUMAN [view interactions] Computational no no
FLOT2_HUMAN [view entry] [view interactions] Computational yes yes
FCSD2_HUMAN [view interactions] Computational no no
TLN1_HUMAN [view entry] [view interactions] Computational yes no
RPGF1_HUMAN [view interactions] Computational no yes
ITA1_HUMAN [view interactions] Computational no yes
CRK_HUMAN [view entry] [view interactions] Computational yes no
RHOQ_HUMAN [view interactions] Computational no no