SRBS1_HUMAN
Evidence for PS localization
Functions
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SRBS1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 33.8710 | 4 | no |
| GO:0019901 | protein kinase binding | 30.6452 | 5 | no |
| GO:0043169 | cation binding | 27.4194 | 4 | no |
| GO:0046872 | metal ion binding | 27.4194 | 5 | no |
| GO:0003779 | actin binding | 25.8065 | 4 | yes |
| GO:0045296 | cadherin binding | 25.8065 | 4 | no |
| GO:0000166 | nucleotide binding | 24.1935 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1935 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1935 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1935 | 4 | no |
| GO:0043168 | anion binding | 24.1935 | 4 | no |
| GO:0005524 | ATP binding | 22.5806 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5806 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.5806 | 5 | no |
| GO:0030159 | signaling receptor complex adaptor activity | 4.8387 | 4 | yes |
| GO:0005158 | insulin receptor binding | 3.2258 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SRBS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9032 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.6774 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.0645 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.0645 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.0645 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 54.8387 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 54.8387 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.6129 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.7742 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.1613 | 5 | yes |
| GO:0022607 | cellular component assembly | 45.1613 | 4 | yes |
| GO:0030030 | cell projection organization | 43.5484 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.5484 | 5 | no |
| GO:0006996 | organelle organization | 41.9355 | 4 | yes |
| GO:0008104 | protein localization | 41.9355 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.3226 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 38.7097 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.7097 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.7097 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 38.7097 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 38.7097 | 5 | no |
| GO:0010468 | regulation of gene expression | 37.0968 | 6 | no |
| GO:0031399 | regulation of protein modification process | 37.0968 | 6 | no |
| GO:0051049 | regulation of transport | 33.8710 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 33.8710 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.8710 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.2581 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 32.2581 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.2581 | 6 | no |
| GO:0071310 | cellular response to organic substance | 30.6452 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.6452 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.6452 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.6452 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 30.6452 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.6452 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.6452 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 30.6452 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.0323 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.4194 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 27.4194 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 27.4194 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.4194 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 27.4194 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 27.4194 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.4194 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.4194 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.4194 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.4194 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 27.4194 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.4194 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.4194 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.4194 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.4194 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.4194 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 25.8065 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.8065 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.8065 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.1935 | 5 | yes |
| GO:0034330 | cell junction organization | 24.1935 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 24.1935 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 24.1935 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 24.1935 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1935 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.1935 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.1935 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 24.1935 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.1935 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.1935 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 24.1935 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 22.5806 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 22.5806 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 22.5806 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 22.5806 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 22.5806 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 22.5806 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.5806 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.9677 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 20.9677 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.9677 | 6 | no |
| GO:0031175 | neuron projection development | 20.9677 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.9677 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.9677 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 20.9677 | 6 | no |
| GO:0051338 | regulation of transferase activity | 20.9677 | 4 | no |
| GO:0060284 | regulation of cell development | 20.9677 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.9677 | 4 | no |
| GO:0034329 | cell junction assembly | 19.3548 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 19.3548 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 19.3548 | 4 | yes |
| GO:0007015 | actin filament organization | 17.7419 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 12.9032 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 8.0645 | 5 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 8.0645 | 7 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 8.0645 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.0645 | 6 | yes |
| GO:0032868 | response to insulin | 6.4516 | 5 | yes |
| GO:0032869 | cellular response to insulin stimulus | 6.4516 | 6 | yes |
| GO:0032870 | cellular response to hormone stimulus | 6.4516 | 4 | yes |
| GO:0043434 | response to peptide hormone | 6.4516 | 4 | yes |
| GO:0051017 | actin filament bundle assembly | 6.4516 | 5 | yes |
| GO:0061572 | actin filament bundle organization | 6.4516 | 6 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 6.4516 | 5 | yes |
| GO:0150115 | cell-substrate junction organization | 6.4516 | 5 | yes |
| GO:1903078 | positive regulation of protein localization to plasma membrane | 6.4516 | 7 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 6.4516 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 6.4516 | 6 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 4.8387 | 5 | yes |
| GO:0007044 | cell-substrate junction assembly | 4.8387 | 6 | yes |
| GO:0007160 | cell-matrix adhesion | 4.8387 | 4 | yes |
| GO:0008286 | insulin receptor signaling pathway | 4.8387 | 6 | yes |
| GO:0010906 | regulation of glucose metabolic process | 4.8387 | 5 | yes |
| GO:0010907 | positive regulation of glucose metabolic process | 4.8387 | 6 | yes |
| GO:0045913 | positive regulation of carbohydrate metabolic process | 4.8387 | 5 | yes |
| GO:0048041 | focal adhesion assembly | 4.8387 | 7 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 4.8387 | 4 | yes |
| GO:0062013 | positive regulation of small molecule metabolic process | 4.8387 | 5 | yes |
| GO:0005979 | regulation of glycogen biosynthetic process | 3.2258 | 7 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 3.2258 | 5 | yes |
| GO:0010828 | positive regulation of glucose transmembrane transport | 3.2258 | 6 | yes |
| GO:0010962 | regulation of glucan biosynthetic process | 3.2258 | 7 | yes |
| GO:0019216 | regulation of lipid metabolic process | 3.2258 | 5 | yes |
| GO:0030038 | contractile actin filament bundle assembly | 3.2258 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 3.2258 | 4 | yes |
| GO:0032881 | regulation of polysaccharide metabolic process | 3.2258 | 5 | yes |
| GO:0032885 | regulation of polysaccharide biosynthetic process | 3.2258 | 6 | yes |
| GO:0043149 | stress fiber assembly | 3.2258 | 5 | yes |
| GO:0043255 | regulation of carbohydrate biosynthetic process | 3.2258 | 5 | yes |
| GO:0043467 | regulation of generation of precursor metabolites and energy | 3.2258 | 5 | yes |
| GO:0045725 | positive regulation of glycogen biosynthetic process | 3.2258 | 7 | yes |
| GO:0045834 | positive regulation of lipid metabolic process | 3.2258 | 5 | yes |
| GO:0046324 | regulation of glucose import | 3.2258 | 6 | yes |
| GO:0046326 | positive regulation of glucose import | 3.2258 | 7 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 3.2258 | 5 | yes |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | 3.2258 | 6 | yes |
| GO:0046889 | positive regulation of lipid biosynthetic process | 3.2258 | 6 | yes |
| GO:0046890 | regulation of lipid biosynthetic process | 3.2258 | 5 | yes |
| GO:0070873 | regulation of glycogen metabolic process | 3.2258 | 6 | yes |
| GO:0070875 | positive regulation of glycogen metabolic process | 3.2258 | 6 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 3.2258 | 4 | yes |
| GO:1900078 | positive regulation of cellular response to insulin stimulus | 3.2258 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHIP2_HUMAN | [view interactions] | Low throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX7_HUMAN | [view interactions] | Low throughput | no | no |
| INSR_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| INSM1_HUMAN | [view interactions] | Low throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRS2_HUMAN | [view interactions] | Low throughput | no | no |
| TEN1_HUMAN | [view interactions] | Low throughput | no | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| SH2B2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EFNB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA15_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3_HUMAN | [view interactions] | High throughput | no | yes |
| PILRA_HUMAN | [view interactions] | High throughput | no | yes |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S26A7_HUMAN | [view interactions] | High throughput | no | no |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREX2_HUMAN | [view interactions] | High throughput | no | no |
| PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |