PRIC1_HUMAN
Evidence for PS localization
Functions
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PRIC1_HUMAN |
|---|---|---|---|---|
| GO:0030695 | GTPase regulator activity | 36.6667 | 4 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0043169 | cation binding | 26.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 26.6667 | 5 | yes |
| GO:0031267 | small GTPase binding | 26.6667 | 5 | no |
| GO:0051020 | GTPase binding | 26.6667 | 4 | no |
| GO:0005096 | GTPase activator activity | 26.6667 | 4 | no |
| GO:0019901 | protein kinase binding | 26.6667 | 5 | no |
| GO:0008270 | zinc ion binding | 20.0000 | 7 | yes |
| GO:0046914 | transition metal ion binding | 20.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PRIC1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 56.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.6667 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.3333 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 43.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 43.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.3333 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0030030 | cell projection organization | 40.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 36.6667 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 36.6667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.6667 | 4 | yes |
| GO:0010468 | regulation of gene expression | 36.6667 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.6667 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 36.6667 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 33.3333 | 6 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | yes |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.0000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.0000 | 7 | yes |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 26.6667 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 26.6667 | 8 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.6667 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 26.6667 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.6667 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.6667 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.6667 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 26.6667 | 7 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 23.3333 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 23.3333 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 23.3333 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 23.3333 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.3333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.3333 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.3333 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.3333 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.3333 | 4 | yes |
| GO:0034330 | cell junction organization | 23.3333 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 20.0000 | 8 | yes |
| GO:0048812 | neuron projection morphogenesis | 20.0000 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.0000 | 4 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 20.0000 | 7 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 20.0000 | 7 | yes |
| GO:0006915 | apoptotic process | 20.0000 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.0000 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 20.0000 | 6 | yes |
| GO:0046903 | secretion | 16.6667 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 16.6667 | 4 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 16.6667 | 6 | yes |
| GO:0071702 | organic substance transport | 16.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 16.6667 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 16.6667 | 6 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 16.6667 | 5 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 16.6667 | 5 | yes |
| GO:0009059 | macromolecule biosynthetic process | 16.6667 | 4 | yes |
| GO:0030031 | cell projection assembly | 16.6667 | 5 | yes |
| GO:0031175 | neuron projection development | 16.6667 | 6 | yes |
| GO:0033365 | protein localization to organelle | 16.6667 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 16.6667 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 13.3333 | 5 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 13.3333 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 13.3333 | 7 | yes |
| GO:0051093 | negative regulation of developmental process | 13.3333 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 13.3333 | 4 | yes |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | 13.3333 | 7 | yes |
| GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 13.3333 | 8 | yes |
| GO:1990138 | neuron projection extension | 13.3333 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 13.3333 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 13.3333 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 13.3333 | 5 | yes |
| GO:0015031 | protein transport | 13.3333 | 4 | yes |
| GO:0022411 | cellular component disassembly | 13.3333 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 13.3333 | 4 | yes |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 13.3333 | 6 | yes |
| GO:0044782 | cilium organization | 10.0000 | 5 | yes |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 10.0000 | 6 | yes |
| GO:0070925 | organelle assembly | 10.0000 | 5 | yes |
| GO:0150115 | cell-substrate junction organization | 10.0000 | 5 | yes |
| GO:1901873 | regulation of post-translational protein modification | 10.0000 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 10.0000 | 8 | yes |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 10.0000 | 6 | yes |
| GO:0006886 | intracellular protein transport | 10.0000 | 4 | yes |
| GO:0016055 | Wnt signaling pathway | 10.0000 | 4 | yes |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 10.0000 | 7 | yes |
| GO:0034504 | protein localization to nucleus | 10.0000 | 6 | yes |
| GO:0035567 | non-canonical Wnt signaling pathway | 10.0000 | 5 | yes |
| GO:0045229 | external encapsulating structure organization | 6.6667 | 4 | yes |
| GO:0051169 | nuclear transport | 6.6667 | 4 | yes |
| GO:0051170 | import into nucleus | 6.6667 | 6 | yes |
| GO:0051225 | spindle assembly | 6.6667 | 4 | yes |
| GO:0055001 | muscle cell development | 6.6667 | 4 | yes |
| GO:0060271 | cilium assembly | 6.6667 | 6 | yes |
| GO:0060429 | epithelium development | 6.6667 | 4 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 6.6667 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 6.6667 | 4 | yes |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 6.6667 | 7 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 6.6667 | 6 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 6.6667 | 8 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 6.6667 | 4 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 6.6667 | 9 | yes |
| GO:0001894 | tissue homeostasis | 6.6667 | 4 | yes |
| GO:0006606 | protein import into nucleus | 6.6667 | 5 | yes |
| GO:0006913 | nucleocytoplasmic transport | 6.6667 | 5 | yes |
| GO:0007052 | mitotic spindle organization | 6.6667 | 4 | yes |
| GO:0007173 | epidermal growth factor receptor signaling pathway | 6.6667 | 7 | yes |
| GO:0007409 | axonogenesis | 6.6667 | 6 | yes |
| GO:0010467 | gene expression | 6.6667 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 6.6667 | 5 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 6.6667 | 6 | yes |
| GO:0030198 | extracellular matrix organization | 6.6667 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 6.6667 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 6.6667 | 9 | yes |
| GO:0038127 | ERBB signaling pathway | 6.6667 | 6 | yes |
| GO:0043062 | extracellular structure organization | 6.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| REST_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL3_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| RASFA_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| KIF9_HUMAN | [view interactions] | High throughput | no | yes |
| UT14C_HUMAN | [view interactions] | High throughput | no | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAL_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL7_HUMAN | [view interactions] | High throughput | no | yes |
| KMT5B_HUMAN | [view interactions] | High throughput | no | no |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| GLI2_HUMAN | [view interactions] | High throughput | no | yes |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| LHX5_HUMAN | [view interactions] | High throughput | no | no |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |