Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DAB2P_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on Ser-966, leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DAB2P_HUMAN
GO:0019900 kinase binding 36.3636 4 yes
GO:0019901 protein kinase binding 36.3636 5 yes
GO:0017076 purine nucleotide binding 36.3636 4 no
GO:0032555 purine ribonucleotide binding 36.3636 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.0909 4 no
GO:0030695 GTPase regulator activity 29.5455 4 yes
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019001 guanyl nucleotide binding 25.0000 5 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0046872 metal ion binding 25.0000 4 no
GO:0005096 GTPase activator activity 22.7273 4 yes
GO:0045296 cadherin binding 18.1818 4 yes
GO:0017124 SH3 domain binding 13.6364 4 yes
GO:0019887 protein kinase regulator activity 13.6364 4 yes
GO:0019902 phosphatase binding 9.0909 4 yes
GO:0019903 protein phosphatase binding 9.0909 5 yes
GO:0035091 phosphatidylinositol binding 9.0909 4 yes
GO:1901981 phosphatidylinositol phosphate binding 9.0909 5 yes
GO:0019209 kinase activator activity 6.8182 4 yes
GO:0030295 protein kinase activator activity 6.8182 5 yes
GO:0042803 protein homodimerization activity 6.8182 4 yes
GO:0070851 growth factor receptor binding 6.8182 4 yes
GO:0005123 death receptor binding 4.5455 6 yes
GO:0005126 cytokine receptor binding 4.5455 4 yes
GO:0005172 vascular endothelial growth factor receptor binding 4.5455 5 yes
GO:0031434 mitogen-activated protein kinase kinase binding 4.5455 6 yes
GO:0031435 mitogen-activated protein kinase kinase kinase binding 4.5455 6 yes
GO:0032266 phosphatidylinositol-3-phosphate binding 4.5455 6 yes
GO:0032813 tumor necrosis factor receptor superfamily binding 4.5455 5 yes
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4.5455 4 yes
GO:0043184 vascular endothelial growth factor receptor 2 binding 4.5455 6 yes
GO:0043539 protein serine/threonine kinase activator activity 4.5455 6 yes
GO:0051721 protein phosphatase 2A binding 4.5455 6 yes
GO:0070273 phosphatidylinositol-4-phosphate binding 4.5455 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DAB2P_HUMAN
GO:0060255 regulation of macromolecule metabolic process 61.3636 4 yes
GO:0010646 regulation of cell communication 61.3636 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 59.0909 4 yes
GO:0080090 regulation of primary metabolic process 59.0909 4 yes
GO:0031323 regulation of cellular metabolic process 59.0909 4 yes
GO:0048522 positive regulation of cellular process 59.0909 4 yes
GO:0048523 negative regulation of cellular process 56.8182 4 yes
GO:0051128 regulation of cellular component organization 54.5455 4 yes
GO:0009966 regulation of signal transduction 54.5455 4 yes
GO:0051246 regulation of protein metabolic process 47.7273 5 yes
GO:1902531 regulation of intracellular signal transduction 45.4545 5 yes
GO:0009893 positive regulation of metabolic process 40.9091 4 yes
GO:0010468 regulation of gene expression 40.9091 5 yes
GO:0006996 organelle organization 40.9091 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.9091 5 yes
GO:0031399 regulation of protein modification process 40.9091 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 38.6364 5 yes
GO:0009892 negative regulation of metabolic process 38.6364 4 yes
GO:0008104 protein localization 38.6364 4 no
GO:0022603 regulation of anatomical structure morphogenesis 38.6364 4 yes
GO:0030030 cell projection organization 38.6364 4 yes
GO:0031325 positive regulation of cellular metabolic process 38.6364 5 yes
GO:0045595 regulation of cell differentiation 38.6364 4 yes
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 yes
GO:0009889 regulation of biosynthetic process 36.3636 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 yes
GO:0019220 regulation of phosphate metabolic process 36.3636 6 yes
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.0909 6 yes
GO:0051049 regulation of transport 34.0909 4 no
GO:0071702 organic substance transport 34.0909 4 no
GO:0071705 nitrogen compound transport 34.0909 4 no
GO:0120036 plasma membrane bounded cell projection organization 34.0909 5 no
GO:0031344 regulation of cell projection organization 34.0909 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 31.8182 5 yes
GO:0051247 positive regulation of protein metabolic process 31.8182 6 yes
GO:2000145 regulation of cell motility 31.8182 4 yes
GO:0007264 small GTPase mediated signal transduction 31.8182 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8182 5 yes
GO:0010941 regulation of cell death 31.8182 4 yes
GO:0031175 neuron projection development 31.8182 6 no
GO:0030334 regulation of cell migration 31.8182 5 yes
GO:0042127 regulation of cell population proliferation 31.8182 4 yes
GO:0042981 regulation of apoptotic process 31.8182 6 yes
GO:0043067 regulation of programmed cell death 31.8182 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 29.5455 6 yes
GO:0051252 regulation of RNA metabolic process 29.5455 5 yes
GO:0071310 cellular response to organic substance 29.5455 4 yes
GO:1901701 cellular response to oxygen-containing compound 29.5455 4 yes
GO:0001932 regulation of protein phosphorylation 29.5455 7 yes
GO:0006355 regulation of DNA-templated transcription 29.5455 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 29.5455 7 yes
GO:2001141 regulation of RNA biosynthetic process 29.5455 6 yes
GO:0015031 protein transport 29.5455 4 no
GO:0007010 cytoskeleton organization 29.5455 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.5455 5 yes
GO:0031324 negative regulation of cellular metabolic process 29.5455 5 yes
GO:0031401 positive regulation of protein modification process 29.5455 7 yes
GO:0042325 regulation of phosphorylation 29.5455 7 yes
GO:0043085 positive regulation of catalytic activity 29.5455 4 yes
GO:0051094 positive regulation of developmental process 27.2727 4 yes
GO:0051248 negative regulation of protein metabolic process 27.2727 6 yes
GO:0051336 regulation of hydrolase activity 27.2727 4 yes
GO:0051338 regulation of transferase activity 27.2727 4 yes
GO:0007265 Ras protein signal transduction 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 yes
GO:2000147 positive regulation of cell motility 25.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 yes
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0010975 regulation of neuron projection development 25.0000 7 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0030335 positive regulation of cell migration 25.0000 6 yes
GO:0040017 positive regulation of locomotion 25.0000 4 yes
GO:0042327 positive regulation of phosphorylation 25.0000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 yes
GO:0051093 negative regulation of developmental process 22.7273 4 yes
GO:0051130 positive regulation of cellular component organization 22.7273 5 yes
GO:0051241 negative regulation of multicellular organismal process 22.7273 4 yes
GO:2000026 regulation of multicellular organismal development 22.7273 4 yes
GO:0009968 negative regulation of signal transduction 22.7273 5 yes
GO:0006886 intracellular protein transport 22.7273 4 no
GO:0010243 response to organonitrogen compound 22.7273 4 no
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0060284 regulation of cell development 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0051493 regulation of cytoskeleton organization 22.7273 6 no
GO:0022607 cellular component assembly 22.7273 4 no
GO:0031400 negative regulation of protein modification process 22.7273 7 yes
GO:0043087 regulation of GTPase activity 22.7273 5 yes
GO:0043549 regulation of kinase activity 22.7273 5 yes
GO:0044087 regulation of cellular component biogenesis 22.7273 4 yes
GO:0045596 negative regulation of cell differentiation 22.7273 5 yes
GO:0045859 regulation of protein kinase activity 22.7273 6 yes
GO:0048584 positive regulation of response to stimulus 22.7273 4 yes
GO:0051254 positive regulation of RNA metabolic process 20.4545 6 yes
GO:0051347 positive regulation of transferase activity 20.4545 5 yes
GO:0051726 regulation of cell cycle 20.4545 4 yes
GO:0080134 regulation of response to stress 20.4545 4 yes
GO:1902533 positive regulation of intracellular signal transduction 20.4545 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 20.4545 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 20.4545 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 20.4545 8 yes
GO:0009891 positive regulation of biosynthetic process 20.4545 5 yes
GO:0009894 regulation of catabolic process 20.4545 4 yes
GO:0009967 positive regulation of signal transduction 20.4545 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.4545 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 20.4545 6 yes
GO:0043066 negative regulation of apoptotic process 20.4545 7 no
GO:0043069 negative regulation of programmed cell death 20.4545 6 no
GO:0045597 positive regulation of cell differentiation 20.4545 5 no
GO:0060548 negative regulation of cell death 20.4545 5 no
GO:0071417 cellular response to organonitrogen compound 20.4545 4 no
GO:1901699 cellular response to nitrogen compound 20.4545 4 no
GO:0010647 positive regulation of cell communication 20.4545 5 yes
GO:0023056 positive regulation of signaling 20.4545 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 20.4545 6 yes
GO:0036211 protein modification process 20.4545 4 yes
GO:0042176 regulation of protein catabolic process 20.4545 5 yes
GO:0043412 macromolecule modification 20.4545 4 yes
GO:0045893 positive regulation of DNA-templated transcription 20.4545 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.4545 6 yes
GO:0045936 negative regulation of phosphate metabolic process 20.4545 7 yes
GO:0080135 regulation of cellular response to stress 18.1818 4 yes
GO:0030162 regulation of proteolysis 18.1818 6 yes
GO:0031346 positive regulation of cell projection organization 18.1818 6 yes
GO:0033674 positive regulation of kinase activity 18.1818 6 yes
GO:0043086 negative regulation of catalytic activity 18.1818 4 yes
GO:0043408 regulation of MAPK cascade 18.1818 6 yes
GO:0046578 regulation of Ras protein signal transduction 18.1818 7 yes
GO:0050776 regulation of immune response 15.9091 4 yes
GO:0051348 negative regulation of transferase activity 15.9091 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 15.9091 6 yes
GO:0070848 response to growth factor 15.9091 4 yes
GO:0071363 cellular response to growth factor stimulus 15.9091 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 15.9091 7 yes
GO:1902532 negative regulation of intracellular signal transduction 15.9091 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 15.9091 7 yes
GO:0006468 protein phosphorylation 15.9091 5 yes
GO:0006796 phosphate-containing compound metabolic process 15.9091 4 yes
GO:2000146 negative regulation of cell motility 15.9091 5 yes
GO:0008285 negative regulation of cell population proliferation 15.9091 5 yes
GO:0009890 negative regulation of biosynthetic process 15.9091 5 yes
GO:0010942 positive regulation of cell death 15.9091 5 yes
GO:0016310 phosphorylation 15.9091 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 15.9091 6 yes
GO:0033993 response to lipid 15.9091 4 yes
GO:0040013 negative regulation of locomotion 15.9091 4 yes
GO:0044089 positive regulation of cellular component biogenesis 15.9091 5 yes
GO:0045860 positive regulation of protein kinase activity 15.9091 7 yes
GO:0050678 regulation of epithelial cell proliferation 13.6364 5 yes
GO:0050773 regulation of dendrite development 13.6364 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 13.6364 7 yes
GO:0071396 cellular response to lipid 13.6364 5 yes
GO:0001933 negative regulation of protein phosphorylation 13.6364 8 yes
GO:0006469 negative regulation of protein kinase activity 13.6364 7 yes
GO:2001233 regulation of apoptotic signaling pathway 13.6364 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 13.6364 6 yes
GO:0030336 negative regulation of cell migration 13.6364 6 yes
GO:0033673 negative regulation of kinase activity 13.6364 6 yes
GO:0042326 negative regulation of phosphorylation 13.6364 8 yes
GO:0043065 positive regulation of apoptotic process 13.6364 7 yes
GO:0043068 positive regulation of programmed cell death 13.6364 6 yes
GO:0045862 positive regulation of proteolysis 13.6364 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 13.6364 8 yes
GO:0050807 regulation of synapse organization 11.3636 5 yes
GO:0051253 negative regulation of RNA metabolic process 11.3636 6 yes
GO:0051346 negative regulation of hydrolase activity 11.3636 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 11.3636 6 yes
GO:0071345 cellular response to cytokine stimulus 11.3636 5 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 11.3636 8 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 11.3636 7 yes
GO:1901565 organonitrogen compound catabolic process 11.3636 4 yes
GO:1901800 positive regulation of proteasomal protein catabolic process 11.3636 7 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.3636 7 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 11.3636 8 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 11.3636 8 yes
GO:0009057 macromolecule catabolic process 11.3636 4 yes
GO:0009895 negative regulation of catabolic process 11.3636 5 yes
GO:0009896 positive regulation of catabolic process 11.3636 5 yes
GO:0010564 regulation of cell cycle process 11.3636 5 yes
GO:0010594 regulation of endothelial cell migration 11.3636 5 yes
GO:0010632 regulation of epithelial cell migration 11.3636 4 yes
GO:0019216 regulation of lipid metabolic process 11.3636 5 yes
GO:0030111 regulation of Wnt signaling pathway 11.3636 5 yes
GO:0030163 protein catabolic process 11.3636 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 11.3636 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 11.3636 6 yes
GO:0034097 response to cytokine 11.3636 4 yes
GO:0043254 regulation of protein-containing complex assembly 11.3636 5 yes
GO:0043405 regulation of MAP kinase activity 11.3636 8 yes
GO:0043410 positive regulation of MAPK cascade 11.3636 7 yes
GO:0045732 positive regulation of protein catabolic process 11.3636 6 yes
GO:0045892 negative regulation of DNA-templated transcription 11.3636 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 11.3636 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 9.0909 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 9.0909 6 yes
GO:0071356 cellular response to tumor necrosis factor 9.0909 6 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 9.0909 8 yes
GO:1901342 regulation of vasculature development 9.0909 5 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 9.0909 8 yes
GO:0006915 apoptotic process 9.0909 4 yes
GO:0006954 inflammatory response 9.0909 4 yes
GO:2001222 regulation of neuron migration 9.0909 6 yes
GO:2001224 positive regulation of neuron migration 9.0909 7 yes
GO:0010976 positive regulation of neuron projection development 9.0909 7 yes
GO:0034612 response to tumor necrosis factor 9.0909 5 yes
GO:0042177 negative regulation of protein catabolic process 9.0909 6 yes
GO:0043550 regulation of lipid kinase activity 9.0909 6 yes
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 9.0909 7 yes
GO:0045765 regulation of angiogenesis 9.0909 5 yes
GO:0045786 negative regulation of cell cycle 9.0909 5 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 6.8182 7 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 6.8182 5 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 6.8182 8 yes
GO:0071364 cellular response to epidermal growth factor stimulus 6.8182 4 yes
GO:0090128 regulation of synapse maturation 6.8182 4 yes
GO:0090287 regulation of cellular response to growth factor stimulus 6.8182 4 yes
GO:0097191 extrinsic apoptotic signaling pathway 6.8182 4 yes
GO:0097193 intrinsic apoptotic signaling pathway 6.8182 4 yes
GO:1901184 regulation of ERBB signaling pathway 6.8182 5 yes
GO:1901343 negative regulation of vasculature development 6.8182 5 yes
GO:2000181 negative regulation of blood vessel morphogenesis 6.8182 5 yes
GO:0010717 regulation of epithelial to mesenchymal transition 6.8182 5 yes
GO:0016525 negative regulation of angiogenesis 6.8182 6 yes
GO:0032872 regulation of stress-activated MAPK cascade 6.8182 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 6.8182 7 yes
GO:0034121 regulation of toll-like receptor signaling pathway 6.8182 6 yes
GO:0034122 negative regulation of toll-like receptor signaling pathway 6.8182 6 yes
GO:0034143 regulation of toll-like receptor 4 signaling pathway 6.8182 7 yes
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 6.8182 7 yes
GO:0034260 negative regulation of GTPase activity 6.8182 4 yes
GO:0034976 response to endoplasmic reticulum stress 6.8182 4 yes
GO:0035924 cellular response to vascular endothelial growth factor stimulus 6.8182 6 yes
GO:0038026 reelin-mediated signaling pathway 6.8182 4 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 6.8182 6 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 6.8182 6 yes
GO:0043406 positive regulation of MAP kinase activity 6.8182 8 yes
GO:0043407 negative regulation of MAP kinase activity 6.8182 8 yes
GO:0043409 negative regulation of MAPK cascade 6.8182 7 yes
GO:0045833 negative regulation of lipid metabolic process 6.8182 5 yes
GO:0046328 regulation of JNK cascade 6.8182 7 yes
GO:0046330 positive regulation of JNK cascade 6.8182 8 yes
GO:0046580 negative regulation of Ras protein signal transduction 6.8182 8 yes
GO:0048145 regulation of fibroblast proliferation 6.8182 5 yes
GO:0048812 neuron projection morphogenesis 4.5455 7 yes
GO:0048858 cell projection morphogenesis 4.5455 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 4.5455 6 yes
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 4.5455 5 yes
GO:0070316 regulation of G0 to G1 transition 4.5455 6 yes
GO:0070317 negative regulation of G0 to G1 transition 4.5455 7 yes
GO:0070555 response to interleukin-1 4.5455 5 yes
GO:0071219 cellular response to molecule of bacterial origin 4.5455 4 yes
GO:0071222 cellular response to lipopolysaccharide 4.5455 5 yes
GO:0071347 cellular response to interleukin-1 4.5455 6 yes
GO:0072577 endothelial cell apoptotic process 4.5455 6 yes
GO:0090129 positive regulation of synapse maturation 4.5455 5 yes
GO:0090219 negative regulation of lipid kinase activity 4.5455 6 yes
GO:0090288 negative regulation of cellular response to growth factor stimulus 4.5455 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 4.5455 6 yes
GO:1900006 positive regulation of dendrite development 4.5455 5 yes
GO:1900101 regulation of endoplasmic reticulum unfolded protein response 4.5455 5 yes
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 4.5455 6 yes
GO:1900744 regulation of p38MAPK cascade 4.5455 7 yes
GO:1900746 regulation of vascular endothelial growth factor signaling pathway 4.5455 5 yes
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 4.5455 6 yes
GO:1901185 negative regulation of ERBB signaling pathway 4.5455 6 yes
GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 4.5455 5 yes
GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 4.5455 6 yes
GO:0002237 response to molecule of bacterial origin 4.5455 4 yes
GO:1903894 regulation of IRE1-mediated unfolded protein response 4.5455 6 yes
GO:1903896 positive regulation of IRE1-mediated unfolded protein response 4.5455 7 yes
GO:1904019 epithelial cell apoptotic process 4.5455 5 yes
GO:1905897 regulation of response to endoplasmic reticulum stress 4.5455 5 yes
GO:0006986 response to unfolded protein 4.5455 4 yes
GO:1905898 positive regulation of response to endoplasmic reticulum stress 4.5455 5 yes
GO:0007252 I-kappaB phosphorylation 4.5455 6 yes
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 4.5455 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 4.5455 6 yes
GO:0010596 negative regulation of endothelial cell migration 4.5455 6 yes
GO:0010633 negative regulation of epithelial cell migration 4.5455 5 yes
GO:0010719 negative regulation of epithelial to mesenchymal transition 4.5455 5 yes
GO:0010948 negative regulation of cell cycle process 4.5455 6 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 4.5455 6 yes
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 4.5455 7 yes
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 4.5455 5 yes
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 4.5455 6 yes
GO:0032088 negative regulation of NF-kappaB transcription factor activity 4.5455 5 yes
GO:0032496 response to lipopolysaccharide 4.5455 4 yes
GO:0032990 cell part morphogenesis 4.5455 4 yes
GO:0034620 cellular response to unfolded protein 4.5455 5 yes
GO:0035967 cellular response to topologically incorrect protein 4.5455 4 yes
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway 4.5455 7 yes
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 4.5455 7 yes
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4.5455 7 yes
GO:0043433 negative regulation of DNA-binding transcription factor activity 4.5455 4 yes
GO:0043506 regulation of JUN kinase activity 4.5455 9 yes
GO:0043507 positive regulation of JUN kinase activity 4.5455 9 yes
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity 4.5455 7 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 4.5455 6 yes
GO:0048147 negative regulation of fibroblast proliferation 4.5455 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DAB2_HUMAN [view interactions] Low throughput no yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF2_HUMAN [view interactions] Low throughput no yes
RIPK1_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
TRADD_HUMAN [view interactions] Low throughput no yes
P85A_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
CUL1_HUMAN [view interactions] Low throughput no yes
CUL4A_HUMAN [view interactions] Low throughput no no
SKP1_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
M3K5_HUMAN [view interactions] Low throughput no yes
DAB2P_HUMAN [view entry] [view interactions] Low throughput yes no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] High throughput no no
P63_HUMAN [view interactions] High throughput no no
P73_HUMAN [view interactions] High throughput no no
RFPL3_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
CD83_HUMAN [view interactions] High throughput no yes
CING_HUMAN [view interactions] High throughput no no
PACC1_HUMAN [view interactions] High throughput no no
SNX17_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CBAR1_HUMAN [view interactions] High throughput no no
TTC23_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CLC4A_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
EFNB1_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
COPT1_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
DDX3Y_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOH_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
RHG42_HUMAN [view interactions] High throughput no yes
PRIC1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
STRP2_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
CE152_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
MIS12_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
IWS1_HUMAN [view interactions] High throughput no yes
RNH2B_HUMAN [view interactions] High throughput no yes
RAB4B_HUMAN [view entry] [view interactions] High throughput yes no
EXOS9_HUMAN [view interactions] High throughput no yes
UGGG1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
CBY1_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
PTPA_HUMAN [view interactions] Computational no yes
TNR1B_HUMAN [view interactions] Computational no no
RRAS_HUMAN [view interactions] Computational no yes