NGAP_HUMAN
Inhibitory regulator of the Ras-cyclic AMP pathway. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NGAP_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 48.3333 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 48.3333 | 4 | no |
GO:0019900 | kinase binding | 33.3333 | 4 | no |
GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | no |
GO:0019901 | protein kinase binding | 31.6667 | 5 | no |
GO:0003924 | GTPase activity | 28.3333 | 7 | no |
GO:0005525 | GTP binding | 28.3333 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 28.3333 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 28.3333 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 23.3333 | 5 | no |
GO:0005524 | ATP binding | 21.6667 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.6667 | 5 | no |
GO:0030695 | GTPase regulator activity | 15.0000 | 4 | yes |
GO:0005096 | GTPase activator activity | 13.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NGAP_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.3333 | 4 | no |
GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 56.6667 | 4 | no |
GO:0010646 | regulation of cell communication | 55.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 55.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 53.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 53.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 51.6667 | 4 | no |
GO:0051128 | regulation of cellular component organization | 51.6667 | 4 | no |
GO:0006996 | organelle organization | 48.3333 | 4 | no |
GO:0008104 | protein localization | 41.6667 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.3333 | 5 | no |
GO:0071702 | organic substance transport | 38.3333 | 4 | no |
GO:0022607 | cellular component assembly | 36.6667 | 4 | no |
GO:0045595 | regulation of cell differentiation | 35.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 35.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 35.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.6667 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 31.6667 | 4 | no |
GO:0030030 | cell projection organization | 31.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.6667 | 5 | no |
GO:0031399 | regulation of protein modification process | 31.6667 | 6 | no |
GO:0071310 | cellular response to organic substance | 31.6667 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
GO:0010941 | regulation of cell death | 28.3333 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 28.3333 | 6 | no |
GO:0031344 | regulation of cell projection organization | 28.3333 | 5 | no |
GO:0042981 | regulation of apoptotic process | 28.3333 | 6 | no |
GO:0043067 | regulation of programmed cell death | 28.3333 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 28.3333 | 4 | no |
GO:0051094 | positive regulation of developmental process | 28.3333 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 28.3333 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.3333 | 6 | no |
GO:0015031 | protein transport | 28.3333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 26.6667 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
GO:0007264 | small GTPase mediated signal transduction | 25.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 23.3333 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 23.3333 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 23.3333 | 7 | no |
GO:0030334 | regulation of cell migration | 23.3333 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.3333 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 23.3333 | 5 | no |
GO:2000145 | regulation of cell motility | 23.3333 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 23.3333 | 6 | no |
GO:0010648 | negative regulation of cell communication | 21.6667 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.6667 | 4 | no |
GO:0036211 | protein modification process | 21.6667 | 4 | no |
GO:0043412 | macromolecule modification | 21.6667 | 4 | no |
GO:0051726 | regulation of cell cycle | 21.6667 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.6667 | 6 | no |
GO:0006886 | intracellular protein transport | 21.6667 | 4 | no |
GO:0007265 | Ras protein signal transduction | 21.6667 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 21.6667 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 21.6667 | 5 | no |
GO:0032880 | regulation of protein localization | 21.6667 | 5 | no |
GO:0060341 | regulation of cellular localization | 21.6667 | 4 | no |
GO:0043087 | regulation of GTPase activity | 15.0000 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NGAP_HUMAN |
---|---|---|---|---|
DOID:0111962 | combined immunodeficiency | 3.3333 | 4 | no |
DOID:612 | primary immunodeficiency disease | 3.3333 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
HS12B_HUMAN | [view interactions] | High throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP78_HUMAN | [view interactions] | High throughput | no | yes |
MGP_HUMAN | [view interactions] | High throughput | no | no |
ANR28_HUMAN | [view interactions] | High throughput | no | no |
KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1A_HUMAN | [view interactions] | High throughput | no | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIA2_HUMAN | [view interactions] | High throughput | no | yes |
TRAF1_HUMAN | [view interactions] | High throughput | no | no |
USBP1_HUMAN | [view interactions] | High throughput | no | no |
IKBB_HUMAN | [view interactions] | High throughput | no | no |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
F110B_HUMAN | [view interactions] | High throughput | no | yes |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
TESK2_HUMAN | [view interactions] | High throughput | no | yes |
CING_HUMAN | [view interactions] | High throughput | no | no |
LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INP5E_HUMAN | [view interactions] | High throughput | no | yes |
KI13B_HUMAN | [view interactions] | High throughput | no | yes |
RTKN_HUMAN | [view interactions] | High throughput | no | yes |
LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
SIN1_HUMAN | [view interactions] | High throughput | no | yes |
SRS12_HUMAN | [view interactions] | High throughput | no | no |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
AN34A_HUMAN | [view interactions] | High throughput | no | no |
DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K21_HUMAN | [view interactions] | High throughput | no | yes |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NADK_HUMAN | [view interactions] | High throughput | no | yes |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IF4E2_HUMAN | [view interactions] | High throughput | no | no |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FA53C_HUMAN | [view interactions] | High throughput | no | yes |
KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
UBP21_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K5_HUMAN | [view interactions] | Computational | no | yes |
TRAF2_HUMAN | [view interactions] | Computational | no | yes |