NGAP_HUMAN
Evidence for PS localization
Functions
Inhibitory regulator of the Ras-cyclic AMP pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NGAP_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 47.8873 | 4 | no |
| GO:0000166 | nucleotide binding | 45.0704 | 4 | no |
| GO:0017076 | purine nucleotide binding | 45.0704 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 45.0704 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.6620 | 4 | no |
| GO:0019900 | kinase binding | 29.5775 | 4 | no |
| GO:0019901 | protein kinase binding | 29.5775 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 28.1690 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.1690 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.1690 | 6 | no |
| GO:0003924 | GTPase activity | 23.9437 | 7 | no |
| GO:0005525 | GTP binding | 23.9437 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.9437 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.9437 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5352 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.5352 | 5 | no |
| GO:0005524 | ATP binding | 21.1268 | 5 | no |
| GO:0030695 | GTPase regulator activity | 12.6761 | 4 | yes |
| GO:0005096 | GTPase activator activity | 11.2676 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NGAP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.0141 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.5634 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.7465 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.9296 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.5211 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.5211 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.7042 | 4 | no |
| GO:0009966 | regulation of signal transduction | 49.2958 | 4 | no |
| GO:0008104 | protein localization | 47.8873 | 4 | no |
| GO:0006996 | organelle organization | 45.0704 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.6620 | 4 | yes |
| GO:0010468 | regulation of gene expression | 43.6620 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.6620 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.6620 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.2535 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.8451 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.8451 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.8451 | 5 | no |
| GO:0022607 | cellular component assembly | 38.0282 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.6197 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.6197 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2113 | 4 | no |
| GO:0051049 | regulation of transport | 35.2113 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.8028 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.8028 | 5 | no |
| GO:0060341 | regulation of cellular localization | 33.8028 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.3944 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 32.3944 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 32.3944 | 4 | no |
| GO:0032880 | regulation of protein localization | 32.3944 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.9859 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 29.5775 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.5775 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.5775 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.1690 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.1690 | 6 | no |
| GO:0030030 | cell projection organization | 28.1690 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.1690 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 28.1690 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 28.1690 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.1690 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.1690 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.1690 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.7606 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.7606 | 4 | no |
| GO:0071702 | organic substance transport | 26.7606 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.7606 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.7606 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.7606 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 26.7606 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.3521 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.3521 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.3521 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.3521 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.3521 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.3521 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.3521 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.3521 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.3521 | 6 | no |
| GO:0030334 | regulation of cell migration | 23.9437 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.9437 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.9437 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.9437 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.9437 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.9437 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.9437 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.5352 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 22.5352 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.5352 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.5352 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.5352 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5352 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.5352 | 6 | no |
| GO:0015031 | protein transport | 22.5352 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.5352 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 21.1268 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 21.1268 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.1268 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.1268 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.1268 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 21.1268 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 7.0423 | 4 | yes |
| GO:0010467 | gene expression | 5.6338 | 5 | yes |
| GO:1903317 | regulation of protein maturation | 5.6338 | 6 | yes |
| GO:0009743 | response to carbohydrate | 4.2254 | 4 | yes |
| GO:0009746 | response to hexose | 2.8169 | 6 | yes |
| GO:0009749 | response to glucose | 2.8169 | 7 | yes |
| GO:0034284 | response to monosaccharide | 2.8169 | 5 | yes |
| GO:0060612 | adipose tissue development | 2.8169 | 5 | yes |
| GO:0061448 | connective tissue development | 2.8169 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTP5_HUMAN | [view interactions] | High throughput | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| HS12B_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP78_HUMAN | [view interactions] | High throughput | no | yes |
| MGP_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| MIA2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| IKBB_HUMAN | [view interactions] | High throughput | no | no |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |