SHC1_HUMAN
Evidence for PS localization
Functions
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span . Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003687 | LIG_SH2_GRB2like | LIG | 317 | 320 | - |
| ELMI000811 | LIG_SH2_GRB2like | LIG | 349 | 352 | - |
| ELMI000812 | LIG_SH2_GRB2like | LIG | 427 | 430 | - |
| ELMI003687 | LIG_SH2_GRB2like | LIG | 317 | 320 | - |
| ELMI000811 | LIG_SH2_GRB2like | LIG | 349 | 352 | - |
| ELMI000812 | LIG_SH2_GRB2like | LIG | 427 | 430 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SHC1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 46.7153 | 4 | no |
| GO:0000166 | nucleotide binding | 45.2555 | 4 | no |
| GO:0017076 | purine nucleotide binding | 43.7956 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 43.7956 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.7956 | 4 | no |
| GO:0005524 | ATP binding | 36.4964 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 36.4964 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 36.4964 | 5 | no |
| GO:0019900 | kinase binding | 29.1971 | 4 | yes |
| GO:0019901 | protein kinase binding | 27.7372 | 5 | yes |
| GO:0003723 | RNA binding | 27.7372 | 4 | no |
| GO:0043169 | cation binding | 24.0876 | 4 | no |
| GO:0046872 | metal ion binding | 24.0876 | 5 | no |
| GO:0045309 | protein phosphorylated amino acid binding | 10.9489 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 10.9489 | 6 | yes |
| GO:0001784 | phosphotyrosine residue binding | 8.7591 | 5 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 8.0292 | 4 | yes |
| GO:0046875 | ephrin receptor binding | 7.2993 | 4 | yes |
| GO:0070851 | growth factor receptor binding | 7.2993 | 4 | yes |
| GO:0005126 | cytokine receptor binding | 5.8394 | 4 | yes |
| GO:0005158 | insulin receptor binding | 4.3796 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 4.3796 | 4 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 3.6496 | 5 | yes |
| GO:0005159 | insulin-like growth factor receptor binding | 3.6496 | 4 | yes |
| GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity | 2.9197 | 5 | yes |
| GO:0005165 | neurotrophin receptor binding | 2.9197 | 5 | yes |
| GO:0005167 | neurotrophin TRK receptor binding | 2.9197 | 6 | yes |
| GO:0005168 | neurotrophin TRKA receptor binding | 2.9197 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SHC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.9635 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.3942 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.3942 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 55.4745 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.7445 | 4 | yes |
| GO:0010646 | regulation of cell communication | 49.6350 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.6350 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 48.1752 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 48.1752 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.4453 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 45.9854 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.5255 | 4 | yes |
| GO:0006996 | organelle organization | 43.0657 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.0657 | 5 | yes |
| GO:0010468 | regulation of gene expression | 40.8759 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 38.6861 | 5 | yes |
| GO:0008104 | protein localization | 38.6861 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.6861 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.9562 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 37.2263 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.2263 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1168 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 31.3869 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 31.3869 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 31.3869 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.6569 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.6569 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 30.6569 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.6569 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 30.6569 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.9270 | 6 | no |
| GO:0060341 | regulation of cellular localization | 29.9270 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.1971 | 4 | no |
| GO:0051049 | regulation of transport | 29.1971 | 4 | no |
| GO:0071702 | organic substance transport | 29.1971 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.4672 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.4672 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 28.4672 | 6 | no |
| GO:0071705 | nitrogen compound transport | 28.4672 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.4672 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7372 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7372 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 27.7372 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.2774 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.2774 | 5 | no |
| GO:0015031 | protein transport | 26.2774 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.5474 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.5474 | 5 | yes |
| GO:0080134 | regulation of response to stress | 25.5474 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.5474 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 25.5474 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.8175 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.8175 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.8175 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.0876 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.3577 | 7 | yes |
| GO:0007010 | cytoskeleton organization | 23.3577 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 23.3577 | 6 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 22.6277 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 22.6277 | 5 | no |
| GO:0030030 | cell projection organization | 22.6277 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.6277 | 5 | no |
| GO:2000145 | regulation of cell motility | 22.6277 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.6277 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 21.8978 | 6 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.8978 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 21.8978 | 4 | no |
| GO:0036211 | protein modification process | 21.8978 | 4 | no |
| GO:0043412 | macromolecule modification | 21.8978 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.8978 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.8978 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.1679 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 21.1679 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 21.1679 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.1679 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 21.1679 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.4380 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 20.4380 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.4380 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.4380 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.4380 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.4380 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 19.7080 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 18.9781 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 16.7883 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 16.7883 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 16.7883 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 15.3285 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 14.5985 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 13.1387 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 13.1387 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 12.4088 | 4 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 12.4088 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 11.6788 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 11.6788 | 7 | yes |
| GO:0038127 | ERBB signaling pathway | 9.4891 | 6 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 9.4891 | 5 | yes |
| GO:0007173 | epidermal growth factor receptor signaling pathway | 8.0292 | 7 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 8.0292 | 8 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 8.0292 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 8.0292 | 7 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 7.2993 | 8 | yes |
| GO:0007507 | heart development | 6.5693 | 4 | yes |
| GO:0045765 | regulation of angiogenesis | 6.5693 | 5 | yes |
| GO:1901342 | regulation of vasculature development | 6.5693 | 5 | yes |
| GO:0008286 | insulin receptor signaling pathway | 5.1095 | 6 | yes |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 5.1095 | 6 | yes |
| GO:0042742 | defense response to bacterium | 4.3796 | 4 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 4.3796 | 5 | yes |
| GO:0090322 | regulation of superoxide metabolic process | 2.1898 | 6 | yes |
| GO:0016525 | negative regulation of angiogenesis | 1.4599 | 6 | yes |
| GO:0071863 | regulation of cell proliferation in bone marrow | 1.4599 | 5 | yes |
| GO:0071864 | positive regulation of cell proliferation in bone marrow | 1.4599 | 6 | yes |
| GO:1901343 | negative regulation of vasculature development | 1.4599 | 5 | yes |
| GO:2000181 | negative regulation of blood vessel morphogenesis | 1.4599 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBS3B_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK_HUMAN | [view interactions] | Low throughput | no | yes |
| MET_HUMAN | [view interactions] | Low throughput | no | yes |
| STA5A_HUMAN | [view interactions] | Low throughput | no | no |
| VGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| DOK1_HUMAN | [view interactions] | Low throughput | no | yes |
| PLS1_HUMAN | [view interactions] | Low throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL4RA_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG2_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSF3R_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| IL2RG_HUMAN | [view interactions] | Low throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPOR_HUMAN | [view interactions] | Low throughput | no | no |
| VAV3_HUMAN | [view interactions] | Low throughput | no | yes |
| IL2RB_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGF1_HUMAN | [view interactions] | Low throughput | no | yes |
| STA5B_HUMAN | [view interactions] | Low throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RON_HUMAN | [view interactions] | Low throughput | no | yes |
| IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| SOCS1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSF1R_HUMAN | [view interactions] | Low throughput | no | yes |
| DDR2_HUMAN | [view interactions] | Low throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INSR_HUMAN | [view interactions] | Low throughput | no | yes |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHCBP_HUMAN | [view interactions] | Low throughput | no | no |
| HGF_HUMAN | [view interactions] | Low throughput | no | yes |
| SOCS4_HUMAN | [view interactions] | Low throughput | no | yes |
| SOCS5_HUMAN | [view interactions] | Low throughput | no | yes |
| ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITAV_HUMAN | [view interactions] | Low throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| ITB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR2_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UFO_HUMAN | [view interactions] | Low throughput | no | no |
| PTN12_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN2_HUMAN | [view interactions] | Low throughput | no | yes |
| EGF_HUMAN | [view interactions] | Low throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB7_HUMAN | [view interactions] | Low throughput | no | no |
| FCG3A_HUMAN | [view interactions] | Low throughput | no | no |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG5_HUMAN | [view interactions] | Low throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P3C2B_HUMAN | [view interactions] | Low throughput | no | no |
| SH2B2_HUMAN | [view interactions] | Low throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SOMA_HUMAN | [view interactions] | Low throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| CEAM1_HUMAN | [view interactions] | Low throughput | no | no |
| ITB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| LCP2_HUMAN | [view interactions] | Low throughput | no | yes |
| IL3RB_HUMAN | [view interactions] | Low throughput | no | no |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
| CD22_HUMAN | [view interactions] | Low throughput | no | no |
| CADH5_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIE2_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RET_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GHR_HUMAN | [view interactions] | Low throughput | no | yes |
| FCG2B_HUMAN | [view interactions] | Low throughput | no | no |
| CD3E_HUMAN | [view interactions] | Low throughput | no | no |
| GRAP2_HUMAN | [view interactions] | Low throughput | no | no |
| GRAP_HUMAN | [view interactions] | Low throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LTK_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | Low throughput | no | no |
| FCGR1_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD3Z_HUMAN | [view interactions] | Low throughput | no | no |
| SHIP2_HUMAN | [view interactions] | Low throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTA1_HUMAN | [view interactions] | High throughput | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIP2_HUMAN | [view interactions] | High throughput | no | no |
| USP9Y_HUMAN | [view interactions] | High throughput | no | no |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| TRY3_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| K1C9_HUMAN | [view interactions] | High throughput | no | no |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| K2C3_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| TBAL3_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C1B_HUMAN | [view interactions] | High throughput | no | yes |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAM_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEC_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F118B_HUMAN | [view interactions] | High throughput | no | yes |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| NEU1_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| COR2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| GARE1_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7A_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| CD3G_HUMAN | [view interactions] | High throughput | no | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| CD3D_HUMAN | [view interactions] | High throughput | no | no |
| BRCC3_HUMAN | [view interactions] | High throughput | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDD2L_HUMAN | [view interactions] | High throughput | no | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK3_HUMAN | [view interactions] | High throughput | no | no |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUNX2_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI15_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| METK1_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| RMD1_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ITB7_HUMAN | [view interactions] | High throughput | no | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| SERB_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |