K2C6A_HUMAN
Evidence for PS localization
Functions
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in K2C6A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 37.9310 | 4 | no |
| GO:0046872 | metal ion binding | 37.9310 | 5 | no |
| GO:0019900 | kinase binding | 31.0345 | 4 | no |
| GO:0019901 | protein kinase binding | 31.0345 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.1379 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.6897 | 5 | no |
| GO:0015631 | tubulin binding | 20.6897 | 4 | no |
| GO:0000166 | nucleotide binding | 20.6897 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.6897 | 5 | no |
| GO:0003723 | RNA binding | 20.6897 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in K2C6A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.9655 | 4 | yes |
| GO:0006996 | organelle organization | 65.5172 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 65.5172 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 62.0690 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 62.0690 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 55.1724 | 4 | no |
| GO:0022607 | cellular component assembly | 55.1724 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 51.7241 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 51.7241 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 51.7241 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 51.7241 | 4 | no |
| GO:0008104 | protein localization | 48.2759 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 48.2759 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 48.2759 | 4 | no |
| GO:0010468 | regulation of gene expression | 48.2759 | 6 | no |
| GO:0010646 | regulation of cell communication | 48.2759 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.8276 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 44.8276 | 5 | no |
| GO:0009966 | regulation of signal transduction | 44.8276 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 44.8276 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 41.3793 | 5 | no |
| GO:0071702 | organic substance transport | 37.9310 | 4 | no |
| GO:0071705 | nitrogen compound transport | 37.9310 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 37.9310 | 4 | no |
| GO:0007010 | cytoskeleton organization | 34.4828 | 5 | yes |
| GO:0036211 | protein modification process | 34.4828 | 4 | no |
| GO:0043412 | macromolecule modification | 34.4828 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 34.4828 | 5 | no |
| GO:0043933 | protein-containing complex organization | 34.4828 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.4828 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.4828 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 34.4828 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 34.4828 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 34.4828 | 6 | no |
| GO:0033043 | regulation of organelle organization | 34.4828 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 31.0345 | 6 | no |
| GO:0015031 | protein transport | 31.0345 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 31.0345 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 31.0345 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 31.0345 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.0345 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.5862 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 27.5862 | 6 | no |
| GO:0070925 | organelle assembly | 27.5862 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 27.5862 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.5862 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.5862 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.5862 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.5862 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.5862 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.5862 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5862 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5862 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.5862 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 27.5862 | 6 | no |
| GO:0060341 | regulation of cellular localization | 27.5862 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.1379 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.1379 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 24.1379 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.1379 | 7 | no |
| GO:0009968 | negative regulation of signal transduction | 24.1379 | 5 | no |
| GO:0030162 | regulation of proteolysis | 24.1379 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.1379 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.1379 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 24.1379 | 7 | no |
| GO:0043687 | post-translational protein modification | 20.6897 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.6897 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.6897 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.6897 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.6897 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.6897 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.6897 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.6897 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.6897 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.6897 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.6897 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.6897 | 5 | no |
| GO:0002009 | morphogenesis of an epithelium | 10.3448 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 10.3448 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 10.3448 | 4 | yes |
| GO:0140546 | defense response to symbiont | 10.3448 | 4 | yes |
| GO:0042060 | wound healing | 6.8966 | 4 | yes |
| GO:0042742 | defense response to bacterium | 6.8966 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TCHP_HUMAN | [view interactions] | Low throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IGHG1_HUMAN | [view interactions] | High throughput | no | no |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| K1C25_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| K1C28_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K1C26_HUMAN | [view interactions] | High throughput | no | no |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPD5_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| MINY4_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP14B_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA1_HUMAN | [view interactions] | High throughput | no | no |
| EFNA3_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| RN138_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPG_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| CO4A_HUMAN | [view interactions] | High throughput | no | no |
| CO4B_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |