Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIRA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Displays low GTPase activity and exists predominantly in the GTP-bound form. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIRA2_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0000166 nucleotide binding 29.6296 4 yes
GO:0017076 purine nucleotide binding 29.6296 5 yes
GO:0032555 purine ribonucleotide binding 29.6296 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.6296 4 yes
GO:0043168 anion binding 29.6296 4 yes
GO:0016462 pyrophosphatase activity 25.9259 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.9259 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.9259 6 yes
GO:0019901 protein kinase binding 25.9259 5 no
GO:0031625 ubiquitin protein ligase binding 25.9259 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.9259 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0030554 adenyl nucleotide binding 22.2222 6 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0003723 RNA binding 22.2222 4 no
GO:0005525 GTP binding 11.1111 5 yes
GO:0019001 guanyl nucleotide binding 11.1111 6 yes
GO:0032561 guanyl ribonucleotide binding 11.1111 5 yes
GO:0003924 GTPase activity 7.4074 7 yes
GO:0019003 GDP binding 7.4074 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DIRA2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 62.9630 4 no
GO:0048522 positive regulation of cellular process 62.9630 4 no
GO:0048523 negative regulation of cellular process 59.2593 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0010646 regulation of cell communication 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0009893 positive regulation of metabolic process 48.1481 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0031399 regulation of protein modification process 40.7407 6 no
GO:0051049 regulation of transport 40.7407 4 no
GO:0006996 organelle organization 37.0370 4 no
GO:0009889 regulation of biosynthetic process 37.0370 4 no
GO:0009892 negative regulation of metabolic process 37.0370 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.0370 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.0370 5 no
GO:0019220 regulation of phosphate metabolic process 37.0370 6 no
GO:0022607 cellular component assembly 37.0370 4 no
GO:0031326 regulation of cellular biosynthetic process 37.0370 5 no
GO:0042325 regulation of phosphorylation 37.0370 7 no
GO:0044087 regulation of cellular component biogenesis 37.0370 4 no
GO:0051174 regulation of phosphorus metabolic process 37.0370 5 no
GO:0071702 organic substance transport 37.0370 4 no
GO:1902531 regulation of intracellular signal transduction 37.0370 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0008104 protein localization 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0031401 positive regulation of protein modification process 29.6296 7 no
GO:0042981 regulation of apoptotic process 29.6296 5 no
GO:0043067 regulation of programmed cell death 29.6296 4 no
GO:0043549 regulation of kinase activity 29.6296 5 no
GO:0051338 regulation of transferase activity 29.6296 4 no
GO:0031324 negative regulation of cellular metabolic process 29.6296 5 no
GO:0009894 regulation of catabolic process 25.9259 4 no
GO:0009891 positive regulation of biosynthetic process 25.9259 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.9259 6 no
GO:0010562 positive regulation of phosphorus metabolic process 25.9259 6 no
GO:0010648 negative regulation of cell communication 25.9259 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.9259 5 no
GO:0023057 negative regulation of signaling 25.9259 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.9259 6 no
GO:0042327 positive regulation of phosphorylation 25.9259 8 no
GO:0043066 negative regulation of apoptotic process 25.9259 6 no
GO:0043069 negative regulation of programmed cell death 25.9259 5 no
GO:0043085 positive regulation of catalytic activity 25.9259 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.9259 7 no
GO:0051248 negative regulation of protein metabolic process 25.9259 6 no
GO:0051336 regulation of hydrolase activity 25.9259 4 no
GO:0032880 regulation of protein localization 25.9259 5 no
GO:0060341 regulation of cellular localization 25.9259 4 no
GO:0051726 regulation of cell cycle 25.9259 4 no
GO:0097435 supramolecular fiber organization 25.9259 4 no
GO:0071310 cellular response to organic substance 25.9259 4 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0015031 protein transport 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0050890 cognition 22.2222 4 no
GO:0043269 regulation of monoatomic ion transport 22.2222 5 no
GO:0043270 positive regulation of monoatomic ion transport 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13B_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
FTO_HUMAN [view interactions] High throughput no yes
ZN581_HUMAN [view interactions] High throughput no no
SIRPD_HUMAN [view interactions] High throughput no no
PK3CB_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SIM26_HUMAN [view interactions] High throughput no no
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
RIPP1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SPOP_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
FAP20_HUMAN [view interactions] High throughput no no
DIRA1_HUMAN [view entry] [view interactions] High throughput yes no
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C9_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
K22E_HUMAN [view interactions] High throughput no no
K1C10_HUMAN [view interactions] High throughput no no
K1C16_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
K2C6A_HUMAN [view entry] [view interactions] High throughput yes no
HORN_HUMAN [view interactions] High throughput no no
THOC4_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
FBW1A_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes