Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIRA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Displays low GTPase activity and exists predominantly in the GTP-bound form. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIRA2_HUMAN
GO:0019900 kinase binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 4 no
GO:0019888 protein phosphatase regulator activity 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0003924 GTPase activity 12.5000 7 yes
GO:0005525 GTP binding 12.5000 5 yes
GO:0016462 pyrophosphatase activity 12.5000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 12.5000 4 yes
GO:0017076 purine nucleotide binding 12.5000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 12.5000 6 yes
GO:0019001 guanyl nucleotide binding 12.5000 5 yes
GO:0019003 GDP binding 12.5000 4 yes
GO:0032555 purine ribonucleotide binding 12.5000 4 yes
GO:0032561 guanyl ribonucleotide binding 12.5000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DIRA2_HUMAN
GO:0048522 positive regulation of cellular process 68.7500 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0010646 regulation of cell communication 56.2500 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 43.7500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 no
GO:0031324 negative regulation of cellular metabolic process 43.7500 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 43.7500 5 no
GO:0009966 regulation of signal transduction 43.7500 4 no
GO:0043269 regulation of ion transport 43.7500 5 no
GO:0043270 positive regulation of ion transport 43.7500 5 no
GO:0051049 regulation of transport 43.7500 4 no
GO:0051050 positive regulation of transport 43.7500 4 no
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:0051336 regulation of hydrolase activity 43.7500 4 no
GO:0051726 regulation of cell cycle 37.5000 4 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051924 regulation of calcium ion transport 31.2500 7 no
GO:0051928 positive regulation of calcium ion transport 31.2500 6 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:1903169 regulation of calcium ion transmembrane transport 31.2500 7 no
GO:1904062 regulation of cation transmembrane transport 31.2500 6 no
GO:1904064 positive regulation of cation transmembrane transport 31.2500 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 31.2500 7 no
GO:0010038 response to metal ion 31.2500 4 no
GO:0010563 negative regulation of phosphorus metabolic process 31.2500 6 no
GO:0010564 regulation of cell cycle process 31.2500 5 no
GO:0031400 negative regulation of protein modification process 31.2500 7 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0045936 negative regulation of phosphate metabolic process 31.2500 7 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0051248 negative regulation of protein metabolic process 31.2500 6 no
GO:0051345 positive regulation of hydrolase activity 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:0010468 regulation of gene expression 31.2500 5 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0010921 regulation of phosphatase activity 31.2500 5 no
GO:0010959 regulation of metal ion transport 31.2500 6 no
GO:0034762 regulation of transmembrane transport 31.2500 4 no
GO:0034764 positive regulation of transmembrane transport 31.2500 5 no
GO:0034765 regulation of ion transmembrane transport 31.2500 5 no
GO:0034767 positive regulation of ion transmembrane transport 31.2500 6 no
GO:0035303 regulation of dephosphorylation 31.2500 7 no
GO:0035304 regulation of protein dephosphorylation 31.2500 7 no
GO:0043549 regulation of kinase activity 31.2500 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 31.2500 6 no
GO:0044087 regulation of cellular component biogenesis 31.2500 4 no
GO:0050848 regulation of calcium-mediated signaling 31.2500 6 no
GO:0050890 cognition 31.2500 4 no
GO:0051338 regulation of transferase activity 31.2500 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 25.0000 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 25.0000 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 25.0000 6 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:2001259 positive regulation of cation channel activity 25.0000 6 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0019722 calcium-mediated signaling 25.0000 5 no
GO:0019932 second-messenger-mediated signaling 25.0000 4 no
GO:0021762 substantia nigra development 25.0000 4 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0033993 response to lipid 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0051592 response to calcium ion 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0032411 positive regulation of transporter activity 25.0000 4 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 25.0000 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 25.0000 6 no
GO:0051282 regulation of sequestering of calcium ion 25.0000 4 no

Disease

Term Name % Distance from top the of the tree Annotated in DIRA2_HUMAN
DOID:0050700 cardiomyopathy 12.5000 4 no
DOID:0060036 intrinsic cardiomyopathy 12.5000 5 no
DOID:114 heart disease 12.5000 3 no
DOID:2843 long QT syndrome 12.5000 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
FTO_HUMAN [view interactions] High throughput no yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
UN13B_HUMAN [view interactions] High throughput no no
ZN581_HUMAN [view interactions] High throughput no no
SIRPD_HUMAN [view interactions] High throughput no no
PK3CB_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
RIPP1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SPOP_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
FAP20_HUMAN [view interactions] High throughput no no
DIRA1_HUMAN [view entry] [view interactions] High throughput yes no
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no