Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIRA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Displays low GTPase activity and exists predominantly in the GTP-bound form. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIRA1_HUMAN
GO:0017076 purine nucleotide binding 44.4444 4 yes
GO:0032555 purine ribonucleotide binding 44.4444 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 yes
GO:0003924 GTPase activity 33.3333 7 yes
GO:0005525 GTP binding 33.3333 5 yes
GO:0016462 pyrophosphatase activity 33.3333 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 yes
GO:0019001 guanyl nucleotide binding 33.3333 5 yes
GO:0032561 guanyl ribonucleotide binding 33.3333 5 yes
GO:0046872 metal ion binding 33.3333 4 no
GO:0019003 GDP binding 22.2222 4 yes
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0001664 G protein-coupled receptor binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DIRA1_HUMAN
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0060341 regulation of cellular localization 44.4444 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0016192 vesicle-mediated transport 44.4444 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0007528 neuromuscular junction development 33.3333 6 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0050808 synapse organization 33.3333 5 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0050807 regulation of synapse organization 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0002684 positive regulation of immune system process 22.2222 4 no
GO:0002685 regulation of leukocyte migration 22.2222 4 no
GO:0002687 positive regulation of leukocyte migration 22.2222 5 no
GO:0002688 regulation of leukocyte chemotaxis 22.2222 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 22.2222 6 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0032103 positive regulation of response to external stimulus 22.2222 5 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0050865 regulation of cell activation 22.2222 4 no
GO:0050920 regulation of chemotaxis 22.2222 4 no
GO:0050921 positive regulation of chemotaxis 22.2222 5 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:2000377 regulation of reactive oxygen species metabolic process 22.2222 5 no
GO:0006887 exocytosis 22.2222 4 no
GO:0046903 secretion 22.2222 4 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0061097 regulation of protein tyrosine kinase activity 22.2222 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0099175 regulation of postsynapse organization 22.2222 6 no
GO:1903828 negative regulation of protein localization 22.2222 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0006873 cellular ion homeostasis 22.2222 4 no
GO:0006874 cellular calcium ion homeostasis 22.2222 7 no
GO:0006875 cellular metal ion homeostasis 22.2222 6 no
GO:0006897 endocytosis 22.2222 5 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0009966 regulation of signal transduction 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010468 regulation of gene expression 22.2222 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0030003 cellular cation homeostasis 22.2222 5 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0031329 regulation of cellular catabolic process 22.2222 5 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0032469 endoplasmic reticulum calcium ion homeostasis 22.2222 8 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0036211 protein modification process 22.2222 4 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0045732 positive regulation of protein catabolic process 22.2222 6 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0048878 chemical homeostasis 22.2222 4 no
GO:0050801 ion homeostasis 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0055065 metal ion homeostasis 22.2222 7 no
GO:0055074 calcium ion homeostasis 22.2222 8 no
GO:0055080 cation homeostasis 22.2222 6 no
GO:0072503 cellular divalent inorganic cation homeostasis 22.2222 6 no
GO:0072507 divalent inorganic cation homeostasis 22.2222 7 no
GO:0098771 inorganic ion homeostasis 22.2222 6 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 22.2222 8 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UN13A_HUMAN [view entry] [view interactions] High throughput yes no
SL9A5_HUMAN [view interactions] High throughput no no
NCOA7_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA2_HUMAN [view entry] [view interactions] High throughput yes no
ZN274_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MANS1_HUMAN [view interactions] High throughput no yes
I20RA_HUMAN [view interactions] High throughput no no
ARL4C_HUMAN [view interactions] High throughput no yes
AK1D1_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PK3CB_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
CD006_HUMAN [view interactions] High throughput no no
SNX20_HUMAN [view interactions] High throughput no no
TCAL9_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SPT13_HUMAN [view interactions] High throughput no yes
RABE2_HUMAN [view interactions] High throughput no yes
UN13B_HUMAN [view interactions] High throughput no no
TBCE_HUMAN [view interactions] High throughput no no
GBA3_HUMAN [view interactions] High throughput no no