Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DIRA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Displays low GTPase activity and exists predominantly in the GTP-bound form. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DIRA1_HUMAN
GO:0000166 nucleotide binding 36.3636 4 yes
GO:0017076 purine nucleotide binding 36.3636 5 yes
GO:0032555 purine ribonucleotide binding 36.3636 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 yes
GO:0043168 anion binding 36.3636 4 yes
GO:0003924 GTPase activity 27.2727 7 yes
GO:0005525 GTP binding 27.2727 5 yes
GO:0016462 pyrophosphatase activity 27.2727 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.2727 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.2727 6 yes
GO:0019001 guanyl nucleotide binding 27.2727 6 yes
GO:0032561 guanyl ribonucleotide binding 27.2727 5 yes
GO:0043169 cation binding 27.2727 4 no
GO:0046872 metal ion binding 27.2727 5 no
GO:0019003 GDP binding 18.1818 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DIRA1_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0010646 regulation of cell communication 45.4545 4 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0048523 negative regulation of cellular process 36.3636 4 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:1902531 regulation of intracellular signal transduction 36.3636 5 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0006873 intracellular monoatomic ion homeostasis 27.2727 4 no
GO:0030003 intracellular monoatomic cation homeostasis 27.2727 5 no
GO:0055080 monoatomic cation homeostasis 27.2727 4 no
GO:0098657 import into cell 27.2727 4 no
GO:0002684 positive regulation of immune system process 27.2727 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0032101 regulation of response to external stimulus 27.2727 4 no
GO:0032103 positive regulation of response to external stimulus 27.2727 5 no
GO:0036211 protein modification process 27.2727 4 no
GO:0043412 macromolecule modification 27.2727 4 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0097435 supramolecular fiber organization 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:0006996 organelle organization 27.2727 4 no
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0010605 negative regulation of macromolecule metabolic process 27.2727 5 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0050807 regulation of synapse organization 27.2727 5 no
GO:0051246 regulation of protein metabolic process 27.2727 5 no
GO:0051247 positive regulation of protein metabolic process 27.2727 6 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0007528 neuromuscular junction development 27.2727 6 no
GO:0034330 cell junction organization 27.2727 4 no
GO:0050808 synapse organization 27.2727 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MANS1_HUMAN [view interactions] High throughput no yes
I20RA_HUMAN [view interactions] High throughput no no
ARL4C_HUMAN [view interactions] High throughput no yes
AK1D1_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PK3CB_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
CD006_HUMAN [view interactions] High throughput no no
SNX20_HUMAN [view interactions] High throughput no no
TCAL9_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SPT13_HUMAN [view interactions] High throughput no yes
RABE2_HUMAN [view interactions] High throughput no yes
UN13B_HUMAN [view interactions] High throughput no no
TBCE_HUMAN [view interactions] High throughput no no
GBA3_HUMAN [view interactions] High throughput no no
UN13A_HUMAN [view entry] [view interactions] High throughput yes no
SL9A5_HUMAN [view entry] [view interactions] High throughput yes no
NCOA7_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA2_HUMAN [view entry] [view interactions] High throughput yes no
ZN274_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
HAPR1_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes