Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

UN13A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release . Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in UN13A_HUMAN
GO:0046872 metal ion binding 38.4615 4 yes
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 26.9231 5 no
GO:0005509 calcium ion binding 23.0769 5 yes
GO:0017075 syntaxin-1 binding 23.0769 5 yes
GO:0019905 syntaxin binding 23.0769 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in UN13A_HUMAN
GO:0010646 regulation of cell communication 76.9231 4 yes
GO:0048522 positive regulation of cellular process 69.2308 4 yes
GO:0050804 modulation of chemical synaptic transmission 61.5385 5 yes
GO:0099177 regulation of trans-synaptic signaling 61.5385 4 yes
GO:0051128 regulation of cellular component organization 57.6923 4 yes
GO:0051049 regulation of transport 57.6923 4 no
GO:0022607 cellular component assembly 53.8462 4 yes
GO:0016192 vesicle-mediated transport 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0006887 exocytosis 46.1538 4 yes
GO:0006996 organelle organization 46.1538 4 yes
GO:0046903 secretion 46.1538 4 yes
GO:0051046 regulation of secretion 46.1538 5 no
GO:1903530 regulation of secretion by cell 46.1538 4 no
GO:0016079 synaptic vesicle exocytosis 42.3077 4 yes
GO:0023061 signal release 42.3077 4 yes
GO:0045055 regulated exocytosis 42.3077 5 yes
GO:0099003 vesicle-mediated transport in synapse 42.3077 5 yes
GO:0099643 signal release from synapse 42.3077 5 yes
GO:0010647 positive regulation of cell communication 42.3077 5 no
GO:0023056 positive regulation of signaling 42.3077 4 no
GO:0060255 regulation of macromolecule metabolic process 42.3077 4 no
GO:0017156 calcium-ion regulated exocytosis 38.4615 6 yes
GO:0043933 protein-containing complex organization 38.4615 4 yes
GO:0065003 protein-containing complex assembly 38.4615 5 yes
GO:0050806 positive regulation of synaptic transmission 38.4615 5 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0060627 regulation of vesicle-mediated transport 38.4615 4 no
GO:0007268 chemical synaptic transmission 34.6154 6 yes
GO:0098916 anterograde trans-synaptic signaling 34.6154 5 yes
GO:0099537 trans-synaptic signaling 34.6154 4 yes
GO:0031323 regulation of cellular metabolic process 34.6154 4 no
GO:0043269 regulation of ion transport 34.6154 5 no
GO:0051171 regulation of nitrogen compound metabolic process 34.6154 4 no
GO:0080090 regulation of primary metabolic process 34.6154 4 no
GO:0017157 regulation of exocytosis 34.6154 5 no
GO:0071702 organic substance transport 34.6154 4 no
GO:0071705 nitrogen compound transport 34.6154 4 no
GO:0006836 neurotransmitter transport 30.7692 4 yes
GO:0016050 vesicle organization 30.7692 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 yes
GO:0048278 vesicle docking 30.7692 4 yes
GO:0061024 membrane organization 30.7692 4 no
GO:0044057 regulation of system process 30.7692 4 no
GO:0048523 negative regulation of cellular process 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0015031 protein transport 30.7692 4 no
GO:0046928 regulation of neurotransmitter secretion 30.7692 4 no
GO:0051588 regulation of neurotransmitter transport 30.7692 5 no
GO:0007269 neurotransmitter secretion 26.9231 4 yes
GO:0034330 cell junction organization 26.9231 4 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 26.9231 5 yes
GO:0051094 positive regulation of developmental process 26.9231 4 yes
GO:0001932 regulation of protein phosphorylation 26.9231 7 no
GO:0009893 positive regulation of metabolic process 26.9231 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.9231 5 no
GO:0019220 regulation of phosphate metabolic process 26.9231 6 no
GO:0031399 regulation of protein modification process 26.9231 6 no
GO:0042325 regulation of phosphorylation 26.9231 7 no
GO:0051174 regulation of phosphorus metabolic process 26.9231 5 no
GO:0048584 positive regulation of response to stimulus 26.9231 4 no
GO:0072657 protein localization to membrane 26.9231 4 no
GO:0001558 regulation of cell growth 23.0769 4 yes
GO:0022604 regulation of cell morphogenesis 23.0769 5 yes
GO:0050808 synapse organization 23.0769 5 yes
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043270 positive regulation of ion transport 23.0769 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0051051 negative regulation of transport 23.0769 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:1903305 regulation of regulated secretory pathway 23.0769 6 no
GO:0010468 regulation of gene expression 23.0769 5 no
GO:0016081 synaptic vesicle docking 19.2308 4 yes
GO:0030307 positive regulation of cell growth 19.2308 5 yes
GO:0045927 positive regulation of growth 19.2308 4 yes
GO:0048638 regulation of developmental growth 19.2308 4 yes
GO:0048639 positive regulation of developmental growth 19.2308 5 yes
GO:1903859 regulation of dendrite extension 19.2308 5 yes
GO:1903861 positive regulation of dendrite extension 19.2308 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 15.3846 6 yes
GO:0099011 neuronal dense core vesicle exocytosis 11.5385 8 yes
GO:0099525 presynaptic dense core vesicle exocytosis 11.5385 6 yes
GO:1990504 dense core granule exocytosis 11.5385 7 yes
GO:0007528 neuromuscular junction development 7.6923 6 yes
GO:0035249 synaptic transmission, glutamatergic 7.6923 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in UN13A_HUMAN
DOID:0050700 cardiomyopathy 7.6923 4 no
DOID:0060036 intrinsic cardiomyopathy 7.6923 5 no
DOID:114 heart disease 7.6923 3 no
DOID:2843 long QT syndrome 7.6923 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
RIMS2_HUMAN [view entry] [view interactions] Low throughput yes no
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
FBSP1_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
YAP1_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DNPEP_HUMAN [view interactions] High throughput no yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
DIRA1_HUMAN [view entry] [view interactions] High throughput yes no
UBX10_HUMAN [view interactions] High throughput no yes
UN13C_HUMAN [view interactions] Computational no no
CALM1_HUMAN [view entry] [view interactions] Computational yes yes
CALM2_HUMAN [view entry] [view interactions] Computational yes yes
CALM3_HUMAN [view entry] [view interactions] Computational yes yes
STX1B_HUMAN [view entry] [view interactions] Computational yes yes
SYT1_HUMAN [view entry] [view interactions] Computational yes no
RB6I2_HUMAN [view entry] [view interactions] Computational yes yes
SNP25_HUMAN [view entry] [view interactions] Computational yes yes
RAB3A_HUMAN [view entry] [view interactions] Computational yes yes
RIMS1_HUMAN [view entry] [view interactions] Computational yes yes
UN13B_HUMAN [view interactions] Computational no no