UN13A_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release . Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UN13A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 5 | yes |
| GO:0017075 | syntaxin-1 binding | 22.2222 | 5 | yes |
| GO:0019905 | syntaxin binding | 22.2222 | 4 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0005509 | calcium ion binding | 11.1111 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UN13A_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 72.2222 | 4 | yes |
| GO:0022607 | cellular component assembly | 66.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 61.1111 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 61.1111 | 4 | yes |
| GO:0006996 | organelle organization | 55.5556 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 50.0000 | 4 | no |
| GO:0046903 | secretion | 44.4444 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 44.4444 | 5 | no |
| GO:0023056 | positive regulation of signaling | 44.4444 | 4 | no |
| GO:0016079 | synaptic vesicle exocytosis | 38.8889 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 38.8889 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 38.8889 | 4 | yes |
| GO:0023061 | signal release | 38.8889 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 38.8889 | 4 | yes |
| GO:0045055 | regulated exocytosis | 38.8889 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 38.8889 | 5 | yes |
| GO:0099643 | signal release from synapse | 38.8889 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 38.8889 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 38.8889 | 5 | no |
| GO:0051046 | regulation of secretion | 38.8889 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 38.8889 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0046928 | regulation of neurotransmitter secretion | 33.3333 | 5 | no |
| GO:0051588 | regulation of neurotransmitter transport | 33.3333 | 5 | no |
| GO:1903305 | regulation of regulated secretory pathway | 33.3333 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 27.7778 | 7 | yes |
| GO:0016050 | vesicle organization | 27.7778 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 27.7778 | 5 | yes |
| GO:0034330 | cell junction organization | 27.7778 | 4 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 27.7778 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 27.7778 | 6 | yes |
| GO:0099536 | synaptic signaling | 27.7778 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 27.7778 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 27.7778 | 4 | no |
| GO:0015031 | protein transport | 27.7778 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 22.2222 | 4 | no |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 22.2222 | 6 | no |
| GO:0006886 | intracellular protein transport | 22.2222 | 4 | no |
| GO:0031644 | regulation of nervous system process | 22.2222 | 5 | no |
| GO:0044057 | regulation of system process | 22.2222 | 4 | no |
| GO:0001558 | regulation of cell growth | 22.2222 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 22.2222 | 4 | yes |
| GO:0007269 | neurotransmitter secretion | 22.2222 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 22.2222 | 5 | yes |
| GO:0045927 | positive regulation of growth | 22.2222 | 4 | yes |
| GO:0048278 | vesicle docking | 22.2222 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 22.2222 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 22.2222 | 5 | yes |
| GO:0050808 | synapse organization | 22.2222 | 5 | yes |
| GO:1903859 | regulation of dendrite extension | 22.2222 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 22.2222 | 6 | yes |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0061024 | membrane organization | 22.2222 | 4 | no |
| GO:0072657 | protein localization to membrane | 22.2222 | 4 | no |
| GO:0072659 | protein localization to plasma membrane | 22.2222 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 22.2222 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0032252 | secretory granule localization | 16.6667 | 4 | yes |
| GO:0032253 | dense core granule localization | 16.6667 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 16.6667 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 16.6667 | 6 | yes |
| GO:0099011 | neuronal dense core vesicle exocytosis | 16.6667 | 6 | yes |
| GO:0099525 | presynaptic dense core vesicle exocytosis | 16.6667 | 6 | yes |
| GO:1990504 | dense core granule exocytosis | 16.6667 | 5 | yes |
| GO:0007528 | neuromuscular junction development | 11.1111 | 6 | yes |
| GO:0016081 | synaptic vesicle docking | 11.1111 | 4 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 11.1111 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UN13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIMS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBSP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBX10_HUMAN | [view interactions] | High throughput | no | yes |