Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FBSP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration . Plays a role in the regulation of neurotransmission at mature neurons . May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway . Specifically recognizes TP73, promoting its ubiquitination and degradation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FBSP1_HUMAN
GO:0043169 cation binding 39.2857 4 no
GO:0046872 metal ion binding 39.2857 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no
GO:0003723 RNA binding 21.4286 4 no
GO:0005509 calcium ion binding 21.4286 6 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no
GO:0016462 pyrophosphatase activity 21.4286 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 no
GO:0016887 ATP hydrolysis activity 21.4286 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in FBSP1_HUMAN
GO:0031323 regulation of cellular metabolic process 71.4286 4 no
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 no
GO:0080090 regulation of primary metabolic process 71.4286 4 no
GO:0010646 regulation of cell communication 67.8571 4 yes
GO:0009893 positive regulation of metabolic process 64.2857 4 no
GO:0010604 positive regulation of macromolecule metabolic process 64.2857 5 no
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 46.4286 5 no
GO:0010556 regulation of macromolecule biosynthetic process 46.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 46.4286 5 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0022607 cellular component assembly 39.2857 4 yes
GO:0051247 positive regulation of protein metabolic process 39.2857 6 no
GO:0009968 negative regulation of signal transduction 39.2857 5 no
GO:0010648 negative regulation of cell communication 39.2857 5 no
GO:0023057 negative regulation of signaling 39.2857 4 no
GO:0033043 regulation of organelle organization 39.2857 5 no
GO:0060341 regulation of cellular localization 39.2857 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 39.2857 5 no
GO:0009892 negative regulation of metabolic process 39.2857 4 no
GO:0010605 negative regulation of macromolecule metabolic process 39.2857 5 no
GO:0010647 positive regulation of cell communication 35.7143 5 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0023056 positive regulation of signaling 35.7143 4 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0032880 regulation of protein localization 35.7143 5 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0036211 protein modification process 32.1429 4 yes
GO:0043412 macromolecule modification 32.1429 4 yes
GO:0051049 regulation of transport 32.1429 4 yes
GO:0009967 positive regulation of signal transduction 32.1429 5 no
GO:0031344 regulation of cell projection organization 32.1429 5 no
GO:0048584 positive regulation of response to stimulus 32.1429 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 32.1429 6 no
GO:0009891 positive regulation of biosynthetic process 32.1429 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 32.1429 5 no
GO:0051130 positive regulation of cellular component organization 32.1429 5 no
GO:0051248 negative regulation of protein metabolic process 32.1429 6 no
GO:0010468 regulation of gene expression 32.1429 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0008104 protein localization 28.5714 4 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0050807 regulation of synapse organization 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0030030 cell projection organization 25.0000 4 yes
GO:0043687 post-translational protein modification 25.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 yes
GO:0070647 protein modification by small protein conjugation or removal 25.0000 6 yes
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 yes
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0006508 proteolysis 21.4286 4 yes
GO:0016567 protein ubiquitination 21.4286 8 yes
GO:0032446 protein modification by small protein conjugation 21.4286 7 yes
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0006996 organelle organization 21.4286 4 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0010638 positive regulation of organelle organization 21.4286 6 no
GO:0033044 regulation of chromosome organization 21.4286 6 no
GO:1903829 positive regulation of protein localization 21.4286 5 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0001933 negative regulation of protein phosphorylation 21.4286 8 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.4286 6 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0000209 protein polyubiquitination 17.8571 9 yes
GO:0006511 ubiquitin-dependent protein catabolic process 17.8571 7 yes
GO:0009057 macromolecule catabolic process 17.8571 4 yes
GO:0010498 proteasomal protein catabolic process 17.8571 5 yes
GO:0019941 modification-dependent protein catabolic process 17.8571 6 yes
GO:0030163 protein catabolic process 17.8571 4 yes
GO:0034330 cell junction organization 17.8571 4 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 17.8571 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 17.8571 5 yes
GO:0048812 neuron projection morphogenesis 17.8571 5 yes
GO:0051603 proteolysis involved in protein catabolic process 17.8571 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 17.8571 4 yes
GO:1901565 organonitrogen compound catabolic process 17.8571 4 yes
GO:0007409 axonogenesis 14.2857 6 yes
GO:0034329 cell junction assembly 14.2857 5 yes
GO:0050808 synapse organization 14.2857 5 yes
GO:0070936 protein K48-linked ubiquitination 14.2857 10 yes
GO:0006974 DNA damage response 10.7143 4 yes
GO:0021952 central nervous system projection neuron axonogenesis 10.7143 8 yes
GO:0021955 central nervous system neuron axonogenesis 10.7143 7 yes
GO:0001764 neuron migration 7.1429 4 yes
GO:0007416 synapse assembly 7.1429 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SKP1_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
P73_HUMAN [view interactions] Low throughput no no
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
PAWR_HUMAN [view interactions] Low throughput no yes
HEY1_HUMAN [view interactions] Low throughput no yes
HEY2_HUMAN [view interactions] Low throughput no no
HEYL_HUMAN [view interactions] Low throughput no no
NMNA2_HUMAN [view interactions] Low throughput no no
UBP49_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
GGNB2_HUMAN [view interactions] Low throughput no yes
INLR1_HUMAN [view interactions] Low throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
LG3BP_HUMAN [view interactions] High throughput no no
CLC11_HUMAN [view interactions] High throughput no no
STAT2_HUMAN [view interactions] High throughput no yes
GDF10_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1B_HUMAN [view interactions] High throughput no yes
RFC4_HUMAN [view interactions] High throughput no yes
GALC_HUMAN [view interactions] High throughput no yes
NEUL4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
NOS2_HUMAN [view interactions] High throughput no yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CAD19_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
SPRY3_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
MMP13_HUMAN [view interactions] High throughput no no
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
FAXC_HUMAN [view interactions] High throughput no no
PCD10_HUMAN [view entry] [view interactions] High throughput yes yes
ABCA2_HUMAN [view interactions] High throughput no yes
NCKP5_HUMAN [view interactions] High throughput no no
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
PIGN_HUMAN [view interactions] High throughput no yes
ARSB_HUMAN [view interactions] High throughput no yes
FAT4_HUMAN [view interactions] High throughput no yes
TLR10_HUMAN [view interactions] High throughput no no
GRN_HUMAN [view interactions] High throughput no no
SHRM3_HUMAN [view interactions] High throughput no yes
PUM2_HUMAN [view entry] [view interactions] High throughput yes yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
KIF1A_HUMAN [view entry] [view interactions] High throughput yes no
ALPK2_HUMAN [view interactions] High throughput no no
Z780A_HUMAN [view interactions] High throughput no no
RBPS2_HUMAN [view interactions] High throughput no no
PGLT1_HUMAN [view interactions] High throughput no no
INHBE_HUMAN [view interactions] High throughput no no
NGRN_HUMAN [view interactions] High throughput no yes
INSL6_HUMAN [view interactions] High throughput no no
IBP4_HUMAN [view interactions] High throughput no no
IL25_HUMAN [view interactions] High throughput no no
TDGF1_HUMAN [view interactions] High throughput no no
CASQ2_HUMAN [view interactions] High throughput no no
CETN1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
MARH5_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
MYO10_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes