Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FBSP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration . Plays a role in the regulation of neurotransmission at mature neurons . May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway . Specifically recognizes TP73, promoting its ubiquitination and degradation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FBSP1_HUMAN
GO:0046872 metal ion binding 37.5000 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005509 calcium ion binding 25.0000 5 no
GO:0019887 protein kinase regulator activity 20.8333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FBSP1_HUMAN
GO:0051128 regulation of cellular component organization 70.8333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 70.8333 4 no
GO:0060255 regulation of macromolecule metabolic process 70.8333 4 no
GO:0080090 regulation of primary metabolic process 70.8333 4 no
GO:0048522 positive regulation of cellular process 70.8333 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 58.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 58.3333 5 no
GO:0009966 regulation of signal transduction 54.1667 4 no
GO:0048523 negative regulation of cellular process 54.1667 4 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0032880 regulation of protein localization 41.6667 5 no
GO:0060341 regulation of cellular localization 41.6667 4 no
GO:0043085 positive regulation of catalytic activity 41.6667 4 no
GO:0019220 regulation of phosphate metabolic process 41.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 no
GO:0022607 cellular component assembly 37.5000 4 yes
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0022603 regulation of anatomical structure morphogenesis 29.1667 4 no
GO:0010563 negative regulation of phosphorus metabolic process 29.1667 6 no
GO:0045936 negative regulation of phosphate metabolic process 29.1667 7 no
GO:0050804 modulation of chemical synaptic transmission 29.1667 5 no
GO:0099177 regulation of trans-synaptic signaling 29.1667 4 no
GO:0043269 regulation of ion transport 29.1667 5 no
GO:0010975 regulation of neuron projection development 29.1667 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 29.1667 6 no
GO:0051130 positive regulation of cellular component organization 29.1667 5 no
GO:0009968 negative regulation of signal transduction 29.1667 5 no
GO:0010243 response to organonitrogen compound 29.1667 4 no
GO:0010648 negative regulation of cell communication 29.1667 5 no
GO:0023057 negative regulation of signaling 29.1667 4 no
GO:0042327 positive regulation of phosphorylation 29.1667 8 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 yes
GO:0010468 regulation of gene expression 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:1901699 cellular response to nitrogen compound 20.8333 4 no
GO:0016192 vesicle-mediated transport 20.8333 4 no
GO:0033674 positive regulation of kinase activity 20.8333 6 no
GO:0051924 regulation of calcium ion transport 20.8333 7 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0009967 positive regulation of signal transduction 20.8333 5 no
GO:0048584 positive regulation of response to stimulus 20.8333 4 no
GO:0006996 organelle organization 20.8333 4 no
GO:0032990 cell part morphogenesis 20.8333 4 yes
GO:0034330 cell junction organization 20.8333 4 yes
GO:0048812 neuron projection morphogenesis 20.8333 7 yes
GO:0048858 cell projection morphogenesis 20.8333 5 yes
GO:0070647 protein modification by small protein conjugation or removal 20.8333 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.8333 6 yes
GO:0010638 positive regulation of organelle organization 20.8333 6 no
GO:0032204 regulation of telomere maintenance 20.8333 6 no
GO:0032206 positive regulation of telomere maintenance 20.8333 7 no
GO:0032210 regulation of telomere maintenance via telomerase 20.8333 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 20.8333 8 no
GO:0033044 regulation of chromosome organization 20.8333 6 no
GO:0051052 regulation of DNA metabolic process 20.8333 5 no
GO:0051054 positive regulation of DNA metabolic process 20.8333 6 no
GO:0070201 regulation of establishment of protein localization 20.8333 6 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 20.8333 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 20.8333 8 no
GO:1904951 positive regulation of establishment of protein localization 20.8333 6 no
GO:2000278 regulation of DNA biosynthetic process 20.8333 6 no
GO:2000573 positive regulation of DNA biosynthetic process 20.8333 7 no
GO:2001252 positive regulation of chromosome organization 20.8333 7 no
GO:0006886 intracellular protein transport 20.8333 4 no
GO:0010941 regulation of cell death 20.8333 4 no
GO:0015031 protein transport 20.8333 4 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0042981 regulation of apoptotic process 20.8333 6 no
GO:0043067 regulation of programmed cell death 20.8333 5 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0071417 cellular response to organonitrogen compound 20.8333 4 no
GO:0071702 organic substance transport 20.8333 4 no
GO:0071705 nitrogen compound transport 20.8333 4 no
GO:0006508 proteolysis 16.6667 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 16.6667 7 yes
GO:0007409 axonogenesis 16.6667 8 yes
GO:0009057 macromolecule catabolic process 16.6667 4 yes
GO:0016567 protein ubiquitination 16.6667 7 yes
GO:0019941 modification-dependent protein catabolic process 16.6667 6 yes
GO:0032446 protein modification by small protein conjugation 16.6667 6 yes
GO:0034329 cell junction assembly 16.6667 5 yes
GO:0043632 modification-dependent macromolecule catabolic process 16.6667 5 yes
GO:0044265 cellular macromolecule catabolic process 16.6667 4 yes
GO:0050808 synapse organization 16.6667 5 yes
GO:0051603 proteolysis involved in protein catabolic process 16.6667 5 yes
GO:0010498 proteasomal protein catabolic process 12.5000 5 yes
GO:0021952 central nervous system projection neuron axonogenesis 12.5000 10 yes
GO:0021955 central nervous system neuron axonogenesis 12.5000 9 yes
GO:0030163 protein catabolic process 12.5000 4 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 12.5000 6 yes
GO:1901565 organonitrogen compound catabolic process 12.5000 4 yes
GO:0001764 neuron migration 8.3333 4 yes
GO:0006974 cellular response to DNA damage stimulus 8.3333 4 yes
GO:0007416 synapse assembly 8.3333 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in FBSP1_HUMAN
DOID:0050700 cardiomyopathy 8.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 8.3333 5 no
DOID:114 heart disease 8.3333 3 no
DOID:2843 long QT syndrome 8.3333 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SKP1_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
P73_HUMAN [view interactions] Low throughput no no
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
PAWR_HUMAN [view interactions] Low throughput no yes
HEY1_HUMAN [view interactions] Low throughput no yes
HEY2_HUMAN [view interactions] Low throughput no no
HEYL_HUMAN [view interactions] Low throughput no no
NMNA2_HUMAN [view interactions] Low throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
LG3BP_HUMAN [view interactions] High throughput no no
CLC11_HUMAN [view interactions] High throughput no no
STAT2_HUMAN [view interactions] High throughput no yes
GDF10_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1B_HUMAN [view interactions] High throughput no yes
RFC4_HUMAN [view interactions] High throughput no yes
GALC_HUMAN [view interactions] High throughput no yes
NEUL4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
NOS2_HUMAN [view interactions] High throughput no yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CAD19_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
SPRY3_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
MMP13_HUMAN [view interactions] High throughput no no
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
FAXC_HUMAN [view interactions] High throughput no no
PCD10_HUMAN [view interactions] High throughput no yes
ABCA2_HUMAN [view interactions] High throughput no yes
NCKP5_HUMAN [view interactions] High throughput no no
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
PIGN_HUMAN [view interactions] High throughput no yes
ARSB_HUMAN [view interactions] High throughput no yes
FAT4_HUMAN [view interactions] High throughput no yes
TLR10_HUMAN [view interactions] High throughput no no
GRN_HUMAN [view interactions] High throughput no no
SHRM3_HUMAN [view interactions] High throughput no yes
PUM2_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
KIF1A_HUMAN [view entry] [view interactions] High throughput yes no
ALPK2_HUMAN [view interactions] High throughput no no
Z780A_HUMAN [view interactions] High throughput no no
RBPS2_HUMAN [view interactions] High throughput no no
PGLT1_HUMAN [view interactions] High throughput no no
INHBE_HUMAN [view interactions] High throughput no no
NGRN_HUMAN [view interactions] High throughput no yes
INSL6_HUMAN [view interactions] High throughput no no
IBP4_HUMAN [view interactions] High throughput no no
IL25_HUMAN [view interactions] High throughput no no
TDGF1_HUMAN [view interactions] High throughput no no
CASQ2_HUMAN [view interactions] High throughput no no
CETN1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
WDR53_HUMAN [view interactions] Computational no yes