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PUM2_HUMAN

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5-UGUANAUA-3, that is related to the Nanos Response Element (NRE) (, PubMed). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed, PubMed). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3-UTR and facilitating miRNA regulation (PubMed). Plays a role in cytoplasmic sensing of viral infection (PubMed). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed). May regulate DCUN1D3 mRNA levels (PubMed). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PUM2_HUMAN
GO:0003723 RNA binding 72.2222 4 yes
GO:0003729 mRNA binding 55.5556 5 yes
GO:0003730 mRNA 3-UTR binding 50.0000 6 yes
GO:0061980 regulatory RNA binding 33.3333 5 yes
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0035198 miRNA binding 27.7778 6 yes
GO:0003725 double-stranded RNA binding 22.2222 5 no
GO:0003727 single-stranded RNA binding 22.2222 5 no
GO:0106222 lncRNA binding 16.6667 5 yes
GO:0062104 pumilio-response element binding 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PUM2_HUMAN
GO:0009889 regulation of biosynthetic process 83.3333 4 yes
GO:0010468 regulation of gene expression 83.3333 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 83.3333 5 yes
GO:0031323 regulation of cellular metabolic process 83.3333 4 yes
GO:0031326 regulation of cellular biosynthetic process 83.3333 5 yes
GO:0060255 regulation of macromolecule metabolic process 83.3333 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0009892 negative regulation of metabolic process 66.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 66.6667 5 no
GO:0010608 post-transcriptional regulation of gene expression 61.1111 7 yes
GO:0022607 cellular component assembly 61.1111 4 yes
GO:0048522 positive regulation of cellular process 61.1111 4 yes
GO:0009890 negative regulation of biosynthetic process 61.1111 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 61.1111 6 no
GO:0010629 negative regulation of gene expression 61.1111 7 no
GO:0031324 negative regulation of cellular metabolic process 61.1111 5 no
GO:0031327 negative regulation of cellular biosynthetic process 61.1111 6 no
GO:0048523 negative regulation of cellular process 61.1111 4 no
GO:0009894 regulation of catabolic process 55.5556 4 yes
GO:0016070 RNA metabolic process 55.5556 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 55.5556 5 yes
GO:0051252 regulation of RNA metabolic process 55.5556 5 yes
GO:0090304 nucleic acid metabolic process 55.5556 4 yes
GO:0006396 RNA processing 50.0000 6 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0009896 positive regulation of catabolic process 38.8889 5 yes
GO:0043488 regulation of mRNA stability 38.8889 4 yes
GO:0051094 positive regulation of developmental process 38.8889 4 yes
GO:0061013 regulation of mRNA catabolic process 38.8889 5 yes
GO:1903311 regulation of mRNA metabolic process 38.8889 6 yes
GO:0006996 organelle organization 33.3333 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0051128 regulation of cellular component organization 33.3333 4 yes
GO:0009057 macromolecule catabolic process 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0006417 regulation of translation 33.3333 6 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051253 negative regulation of RNA metabolic process 33.3333 6 no
GO:0009966 regulation of signal transduction 27.7778 4 yes
GO:0010647 positive regulation of cell communication 27.7778 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 27.7778 4 yes
GO:0023056 positive regulation of signaling 27.7778 4 yes
GO:0051130 positive regulation of cellular component organization 27.7778 5 yes
GO:0051254 positive regulation of RNA metabolic process 27.7778 6 yes
GO:0070925 organelle assembly 27.7778 5 yes
GO:0080134 regulation of response to stress 27.7778 4 yes
GO:0051049 regulation of transport 27.7778 4 no
GO:0065003 protein-containing complex assembly 27.7778 5 no
GO:0007005 mitochondrion organization 22.2222 5 yes
GO:0031344 regulation of cell projection organization 22.2222 5 yes
GO:0035196 miRNA processing 22.2222 8 yes
GO:0048584 positive regulation of response to stimulus 22.2222 4 yes
GO:0060147 regulation of post-transcriptional gene silencing 22.2222 7 yes
GO:0060964 regulation of miRNA-mediated gene silencing 22.2222 9 yes
GO:0060966 regulation of gene silencing by regulatory ncRNA 22.2222 7 yes
GO:0061014 positive regulation of mRNA catabolic process 22.2222 6 yes
GO:0070918 regulatory ncRNA processing 22.2222 7 yes
GO:0080135 regulation of cellular response to stress 22.2222 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 yes
GO:0140694 non-membrane-bounded organelle assembly 22.2222 6 yes
GO:1900368 regulation of post-transcriptional gene silencing by regulatory ncRNA 22.2222 8 yes
GO:1903313 positive regulation of mRNA metabolic process 22.2222 7 yes
GO:0030163 protein catabolic process 22.2222 4 no
GO:0036211 protein modification process 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0048524 positive regulation of viral process 22.2222 4 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0016441 post-transcriptional gene silencing 22.2222 8 no
GO:0017148 negative regulation of translation 22.2222 7 no
GO:0031047 regulatory ncRNA-mediated gene silencing 22.2222 8 no
GO:0045727 positive regulation of translation 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0008104 protein localization 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0006397 mRNA processing 22.2222 7 no
GO:0008380 RNA splicing 22.2222 7 no
GO:0016071 mRNA metabolic process 22.2222 6 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:1902369 negative regulation of RNA catabolic process 22.2222 6 no
GO:1902373 negative regulation of mRNA catabolic process 22.2222 6 no
GO:1903312 negative regulation of mRNA metabolic process 22.2222 7 no
GO:2000765 regulation of cytoplasmic translation 22.2222 7 no
GO:0001558 regulation of cell growth 16.6667 4 yes
GO:0002831 regulation of response to biotic stimulus 16.6667 4 yes
GO:0009967 positive regulation of signal transduction 16.6667 5 yes
GO:0010564 regulation of cell cycle process 16.6667 5 yes
GO:0030307 positive regulation of cell growth 16.6667 5 yes
GO:0031346 positive regulation of cell projection organization 16.6667 6 yes
GO:0031347 regulation of defense response 16.6667 5 yes
GO:0032101 regulation of response to external stimulus 16.6667 4 yes
GO:0034063 stress granule assembly 16.6667 7 yes
GO:0045088 regulation of innate immune response 16.6667 5 yes
GO:0045927 positive regulation of growth 16.6667 4 yes
GO:0048638 regulation of developmental growth 16.6667 4 yes
GO:0048639 positive regulation of developmental growth 16.6667 5 yes
GO:0050776 regulation of immune response 16.6667 4 yes
GO:0050779 RNA destabilization 16.6667 4 yes
GO:0051726 regulation of cell cycle 16.6667 4 yes
GO:0060148 positive regulation of post-transcriptional gene silencing 16.6667 4 yes
GO:0060341 regulation of cellular localization 16.6667 4 yes
GO:0061157 mRNA destabilization 16.6667 5 yes
GO:1900370 positive regulation of post-transcriptional gene silencing by RNA 16.6667 5 yes
GO:2000637 positive regulation of miRNA-mediated gene silencing 16.6667 6 yes
GO:0001501 skeletal system development 11.1111 4 yes
GO:0002684 positive regulation of immune system process 11.1111 4 yes
GO:0002833 positive regulation of response to biotic stimulus 11.1111 5 yes
GO:0010975 regulation of neuron projection development 11.1111 7 yes
GO:0010976 positive regulation of neuron projection development 11.1111 7 yes
GO:0022900 electron transport chain 11.1111 4 yes
GO:0022904 respiratory electron transport chain 11.1111 5 yes
GO:0031349 positive regulation of defense response 11.1111 5 yes
GO:0032103 positive regulation of response to external stimulus 11.1111 5 yes
GO:0039531 regulation of cytoplasmic pattern recognition receptor signaling pathway 11.1111 6 yes
GO:0039535 regulation of RIG-I signaling pathway 11.1111 7 yes
GO:0045089 positive regulation of innate immune response 11.1111 6 yes
GO:0048679 regulation of axon regeneration 11.1111 5 yes
GO:0048680 positive regulation of axon regeneration 11.1111 6 yes
GO:0048686 regulation of sprouting of injured axon 11.1111 5 yes
GO:0048687 positive regulation of sprouting of injured axon 11.1111 6 yes
GO:0050778 positive regulation of immune response 11.1111 5 yes
GO:0051276 chromosome organization 11.1111 5 yes
GO:0051983 regulation of chromosome segregation 11.1111 6 yes
GO:0060612 adipose tissue development 11.1111 5 yes
GO:0061158 3-UTR-mediated mRNA destabilization 11.1111 6 yes
GO:0061387 regulation of extent of cell growth 11.1111 5 yes
GO:0061448 connective tissue development 11.1111 4 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 11.1111 5 yes
GO:0062208 positive regulation of pattern recognition receptor signaling pathway 11.1111 6 yes
GO:0070570 regulation of neuron projection regeneration 11.1111 4 yes
GO:0070572 positive regulation of neuron projection regeneration 11.1111 5 yes
GO:1900246 positive regulation of RIG-I signaling pathway 11.1111 7 yes
GO:1903034 regulation of response to wounding 11.1111 5 yes
GO:1903036 positive regulation of response to wounding 11.1111 5 yes
GO:1904580 regulation of intracellular mRNA localization 11.1111 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DAZ1_HUMAN [view interactions] Low throughput no no
DAZL_HUMAN [view interactions] Low throughput no no
BOLL_HUMAN [view interactions] Low throughput no no
PUM2_HUMAN [view entry] [view interactions] Low throughput yes yes
NANO1_HUMAN [view interactions] Low throughput no yes
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
RBBP6_HUMAN [view interactions] Low throughput no yes
NANO3_HUMAN [view interactions] Low throughput no no
SIAH1_HUMAN [view interactions] Low throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
NUP35_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
HAPR1_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
EYA4_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
NANP8_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
SAMD1_HUMAN [view interactions] High throughput no no
RBM45_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
MED4_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
PRC2B_HUMAN [view interactions] High throughput no no
DMRTB_HUMAN [view interactions] High throughput no no
QKI_HUMAN [view interactions] High throughput no no
SRSF8_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
RBM38_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
ILF2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
CLASR_HUMAN [view interactions] High throughput no yes
ELAV2_HUMAN [view interactions] High throughput no yes
CELF5_HUMAN [view interactions] High throughput no yes
STRBP_HUMAN [view interactions] High throughput no yes
CDX1_HUMAN [view interactions] High throughput no no
LITAF_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM39_HUMAN [view interactions] High throughput no yes
RTP3_HUMAN [view interactions] High throughput no no
PTBP3_HUMAN [view interactions] High throughput no no
DAZ2_HUMAN [view interactions] High throughput no no
HNRPC_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
F120A_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
YBOX2_HUMAN [view interactions] High throughput no no
NUP42_HUMAN [view interactions] High throughput no no
PABP5_HUMAN [view interactions] High throughput no yes
PAI2B_HUMAN [view interactions] High throughput no no
HNRC1_HUMAN [view interactions] High throughput no no
BACE2_HUMAN [view interactions] High throughput no yes
FBSP1_HUMAN [view entry] [view interactions] High throughput yes no
PURG_HUMAN [view interactions] High throughput no yes
O13C3_HUMAN [view interactions] High throughput no no
MSI1H_HUMAN [view interactions] High throughput no no
LAR4B_HUMAN [view interactions] High throughput no yes
PAIP1_HUMAN [view interactions] High throughput no yes
ERF3B_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
RBMS2_HUMAN [view interactions] High throughput no yes
RBM47_HUMAN [view interactions] High throughput no yes
CBX6_HUMAN [view interactions] High throughput no yes
LOXL4_HUMAN [view interactions] High throughput no no
NUFP2_HUMAN [view interactions] High throughput no no
PSA5_HUMAN [view interactions] High throughput no yes
PSMG3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TIF1A_HUMAN [view interactions] High throughput no yes
R113A_HUMAN [view interactions] High throughput no yes
TBX5_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
GCSP_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
ALG13_HUMAN [view interactions] High throughput no yes
CELF1_HUMAN [view interactions] High throughput no yes
CNOT2_HUMAN [view interactions] High throughput no yes
CNOT9_HUMAN [view interactions] High throughput no yes
CPEB4_HUMAN [view entry] [view interactions] High throughput yes no
4ET_HUMAN [view interactions] High throughput no yes
F120C_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FUBP3_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PAIP2_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
PUM1_HUMAN [view interactions] High throughput no yes
R3HD2_HUMAN [view interactions] High throughput no yes
RBMS1_HUMAN [view interactions] High throughput no no
SMAP2_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
YTHD2_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
Z3H7A_HUMAN [view interactions] High throughput no no
TTP_HUMAN [view interactions] High throughput no yes
IF2B2_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
TNR6B_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
RN214_HUMAN [view interactions] High throughput no yes
XRN1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes