CPEB4_HUMAN
Evidence for PS localization
Functions
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited . Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed). Stimulates proliferation of melanocytes (PubMed). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPEB4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 67.7419 | 4 | yes |
| GO:0003729 | mRNA binding | 41.9355 | 5 | yes |
| GO:0003730 | mRNA 3-UTR binding | 29.0323 | 6 | yes |
| GO:0017076 | purine nucleotide binding | 29.0323 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.0323 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.0323 | 4 | no |
| GO:0005524 | ATP binding | 25.8065 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.8065 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.8065 | 5 | no |
| GO:0043022 | ribosome binding | 16.1290 | 4 | yes |
| GO:0046872 | metal ion binding | 16.1290 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPEB4_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 74.1935 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 74.1935 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 74.1935 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 70.9677 | 4 | yes |
| GO:0010468 | regulation of gene expression | 64.5161 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 61.2903 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 58.0645 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 58.0645 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 58.0645 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 58.0645 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 54.8387 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 51.6129 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 51.6129 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 51.6129 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.6129 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 51.6129 | 5 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 48.3871 | 6 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 48.3871 | 5 | yes |
| GO:0006417 | regulation of translation | 45.1613 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 45.1613 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 45.1613 | 5 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 45.1613 | 6 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.1613 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 45.1613 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 41.9355 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 41.9355 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.9355 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 41.9355 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 38.7097 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 38.7097 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 38.7097 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 35.4839 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 35.4839 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 35.4839 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 35.4839 | 6 | no |
| GO:0008104 | protein localization | 35.4839 | 4 | no |
| GO:0006996 | organelle organization | 35.4839 | 4 | no |
| GO:0017148 | negative regulation of translation | 32.2581 | 7 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 32.2581 | 6 | yes |
| GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 32.2581 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 32.2581 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.2581 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.2581 | 6 | no |
| GO:0043488 | regulation of mRNA stability | 32.2581 | 4 | no |
| GO:0061013 | regulation of mRNA catabolic process | 32.2581 | 6 | no |
| GO:1903311 | regulation of mRNA metabolic process | 32.2581 | 6 | no |
| GO:0071702 | organic substance transport | 32.2581 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.2581 | 4 | no |
| GO:0022607 | cellular component assembly | 32.2581 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.0323 | 4 | no |
| GO:0034250 | positive regulation of cellular amide metabolic process | 29.0323 | 6 | no |
| GO:0045727 | positive regulation of translation | 29.0323 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 29.0323 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 29.0323 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 25.8065 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 25.8065 | 4 | yes |
| GO:0016070 | RNA metabolic process | 25.8065 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 22.5806 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 22.5806 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
| GO:0006396 | RNA processing | 22.5806 | 6 | no |
| GO:0006886 | intracellular protein transport | 22.5806 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.5806 | 4 | no |
| GO:0015031 | protein transport | 22.5806 | 4 | no |
| GO:0033365 | protein localization to organelle | 22.5806 | 5 | no |
| GO:0010941 | regulation of cell death | 19.3548 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 19.3548 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 19.3548 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 19.3548 | 4 | yes |
| GO:2000765 | regulation of cytoplasmic translation | 19.3548 | 7 | yes |
| GO:0043066 | negative regulation of apoptotic process | 16.1290 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 16.1290 | 6 | yes |
| GO:0060548 | negative regulation of cell death | 16.1290 | 5 | yes |
| GO:2000766 | negative regulation of cytoplasmic translation | 12.9032 | 8 | yes |
| GO:0031667 | response to nutrient levels | 9.6774 | 4 | yes |
| GO:0031669 | cellular response to nutrient levels | 9.6774 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 9.6774 | 4 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 9.6774 | 5 | yes |
| GO:0043200 | response to amino acid | 9.6774 | 4 | yes |
| GO:0071453 | cellular response to oxygen levels | 9.6774 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 6.4516 | 4 | yes |
| GO:0009267 | cellular response to starvation | 6.4516 | 4 | yes |
| GO:0042149 | cellular response to glucose starvation | 6.4516 | 5 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 6.4516 | 6 | yes |
| GO:0071229 | cellular response to acid chemical | 6.4516 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 6.4516 | 5 | yes |
| GO:1901214 | regulation of neuron death | 6.4516 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TOB1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | Low throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMG5_HUMAN | [view interactions] | High throughput | no | no |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| TUT4_HUMAN | [view interactions] | High throughput | no | yes |
| DAZL_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| PAIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| CCD77_HUMAN | [view interactions] | High throughput | no | yes |
| CNO6L_HUMAN | [view interactions] | High throughput | no | no |
| F193A_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI56_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYYC_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| PURG_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| HOMEZ_HUMAN | [view interactions] | High throughput | no | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| NDST1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALG13_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT7_HUMAN | [view interactions] | High throughput | no | no |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| CNO10_HUMAN | [view interactions] | High throughput | no | yes |
| CNO11_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT4_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| GPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| MCRI2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3A_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| NUP42_HUMAN | [view interactions] | High throughput | no | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| PUM2_HUMAN | [view interactions] | High throughput | no | yes |
| R3HD1_HUMAN | [view interactions] | High throughput | no | no |
| R3HD2_HUMAN | [view interactions] | High throughput | no | yes |
| RBMS1_HUMAN | [view interactions] | High throughput | no | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | Computational | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCNB2_HUMAN | [view interactions] | Computational | no | yes |
| CDK1_HUMAN | [view interactions] | Computational | no | no |