CPEB4_HUMAN
Evidence for PS localization
Functions
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited . Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed). Stimulates proliferation of melanocytes (PubMed). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004633 | TRG_NESrev_CRM1_2 | TRG | 381 | 393 | - |
| ELMI004633 | TRG_NESrev_CRM1_2 | TRG | 381 | 393 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPEB4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 72.2222 | 4 | yes |
| GO:0003729 | mRNA binding | 47.2222 | 5 | yes |
| GO:0003730 | mRNA 3-UTR binding | 30.5556 | 6 | yes |
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0043168 | anion binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0005524 | ATP binding | 22.2222 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0043169 | cation binding | 19.4444 | 4 | yes |
| GO:0046872 | metal ion binding | 19.4444 | 5 | yes |
| GO:0043022 | ribosome binding | 16.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPEB4_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 72.2222 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 69.4444 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 66.6667 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 66.6667 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 66.6667 | 4 | yes |
| GO:0010468 | regulation of gene expression | 63.8889 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 61.1111 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 55.5556 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 50.0000 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 47.2222 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 44.4444 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 44.4444 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 44.4444 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 44.4444 | 5 | yes |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 41.6667 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 41.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 41.6667 | 6 | no |
| GO:0006417 | regulation of translation | 41.6667 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 38.8889 | 7 | yes |
| GO:0009894 | regulation of catabolic process | 38.8889 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.1111 | 4 | no |
| GO:0008104 | protein localization | 36.1111 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.1111 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 36.1111 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 36.1111 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0043488 | regulation of mRNA stability | 33.3333 | 4 | no |
| GO:0061013 | regulation of mRNA catabolic process | 33.3333 | 5 | no |
| GO:1903311 | regulation of mRNA metabolic process | 33.3333 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.5556 | 5 | no |
| GO:0071705 | nitrogen compound transport | 30.5556 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 30.5556 | 4 | no |
| GO:0017148 | negative regulation of translation | 27.7778 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 27.7778 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 27.7778 | 6 | no |
| GO:0045727 | positive regulation of translation | 27.7778 | 7 | no |
| GO:0016070 | RNA metabolic process | 27.7778 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.2222 | 4 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 22.2222 | 5 | no |
| GO:0006396 | RNA processing | 22.2222 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 16.6667 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 16.6667 | 5 | yes |
| GO:2000765 | regulation of cytoplasmic translation | 16.6667 | 7 | yes |
| GO:2000766 | negative regulation of cytoplasmic translation | 11.1111 | 8 | yes |
| GO:0036293 | response to decreased oxygen levels | 8.3333 | 4 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 8.3333 | 5 | yes |
| GO:0043200 | response to amino acid | 8.3333 | 4 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 8.3333 | 6 | yes |
| GO:0071453 | cellular response to oxygen levels | 8.3333 | 4 | yes |
| GO:0042149 | cellular response to glucose starvation | 5.5556 | 5 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 5.5556 | 7 | yes |
| GO:0071229 | cellular response to acid chemical | 5.5556 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 5.5556 | 5 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 5.5556 | 4 | yes |
| GO:0009267 | cellular response to starvation | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TOB1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | Low throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| PAIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| CCD77_HUMAN | [view interactions] | High throughput | no | yes |
| CNO6L_HUMAN | [view interactions] | High throughput | no | no |
| F193A_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI56_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYYC_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| PURG_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| HOMEZ_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| NDST1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALG13_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT7_HUMAN | [view interactions] | High throughput | no | no |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| CNO10_HUMAN | [view interactions] | High throughput | no | yes |
| CNO11_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT4_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| GPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| MCRI2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3A_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| NUP42_HUMAN | [view interactions] | High throughput | no | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| PUM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R3HD1_HUMAN | [view interactions] | High throughput | no | no |
| R3HD2_HUMAN | [view interactions] | High throughput | no | yes |
| RBMS1_HUMAN | [view interactions] | High throughput | no | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMG5_HUMAN | [view interactions] | High throughput | no | no |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| TUT4_HUMAN | [view interactions] | High throughput | no | yes |
| DAZL_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |