RHG32_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG32_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 44.9275 | 4 | no |
| GO:0019901 | protein kinase binding | 42.0290 | 5 | no |
| GO:0043168 | anion binding | 39.1304 | 4 | no |
| GO:0000166 | nucleotide binding | 37.6812 | 4 | no |
| GO:0017076 | purine nucleotide binding | 37.6812 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 37.6812 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.6812 | 4 | no |
| GO:0005524 | ATP binding | 23.1884 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.1884 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.1884 | 5 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 5 | no |
| GO:0030695 | GTPase regulator activity | 7.2464 | 4 | yes |
| GO:0005096 | GTPase activator activity | 4.3478 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 2.8986 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 2.8986 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG32_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 78.2609 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 68.1159 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 63.7681 | 4 | no |
| GO:0010646 | regulation of cell communication | 62.3188 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.4203 | 4 | no |
| GO:0009966 | regulation of signal transduction | 55.0725 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 53.6232 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 53.6232 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 53.6232 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 53.6232 | 4 | no |
| GO:0010468 | regulation of gene expression | 50.7246 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.7246 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 49.2754 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 47.8261 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 46.3768 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 44.9275 | 5 | no |
| GO:0022607 | cellular component assembly | 44.9275 | 4 | no |
| GO:0008104 | protein localization | 43.4783 | 4 | no |
| GO:0006996 | organelle organization | 42.0290 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.5797 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.5797 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 40.5797 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 37.6812 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 37.6812 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 37.6812 | 5 | no |
| GO:0051049 | regulation of transport | 37.6812 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 36.2319 | 5 | no |
| GO:0031399 | regulation of protein modification process | 36.2319 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.7826 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.7826 | 6 | no |
| GO:2000145 | regulation of cell motility | 34.7826 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 34.7826 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 34.7826 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 34.7826 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0030030 | cell projection organization | 31.8841 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.8841 | 6 | no |
| GO:0071310 | cellular response to organic substance | 31.8841 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 31.8841 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 30.4348 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.4348 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.4348 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.4348 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.4348 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.4348 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 28.9855 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.9855 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.9855 | 5 | no |
| GO:0034330 | cell junction organization | 28.9855 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 28.9855 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 28.9855 | 7 | no |
| GO:0007010 | cytoskeleton organization | 27.5362 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.0870 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 26.0870 | 7 | no |
| GO:0023057 | negative regulation of signaling | 26.0870 | 4 | no |
| GO:0043412 | macromolecule modification | 26.0870 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.0870 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.0870 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.0870 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.0870 | 4 | no |
| GO:0036211 | protein modification process | 24.6377 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.6377 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.6377 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.6377 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.6377 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.6377 | 6 | no |
| GO:0002684 | positive regulation of immune system process | 24.6377 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 24.6377 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 24.6377 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 24.6377 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.1884 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 23.1884 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 23.1884 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.1884 | 7 | no |
| GO:0040017 | positive regulation of locomotion | 23.1884 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 23.1884 | 6 | no |
| GO:0045785 | positive regulation of cell adhesion | 23.1884 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.1884 | 4 | no |
| GO:0071702 | organic substance transport | 23.1884 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.1884 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.1884 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.1884 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.1884 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.1884 | 5 | no |
| GO:0050807 | regulation of synapse organization | 23.1884 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.1884 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.7391 | 6 | no |
| GO:0016310 | phosphorylation | 21.7391 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.7391 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.7391 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.7391 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.7391 | 7 | no |
| GO:0051050 | positive regulation of transport | 21.7391 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 21.7391 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 21.7391 | 8 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.2899 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.2899 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 20.2899 | 4 | no |
| GO:0034329 | cell junction assembly | 20.2899 | 5 | no |
| GO:0045216 | cell-cell junction organization | 20.2899 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.2899 | 5 | no |
| GO:1901699 | cellular response to nitrogen compound | 20.2899 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 15.9420 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEG10_HUMAN | [view interactions] | High throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| PRDX4_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC11_HUMAN | [view interactions] | High throughput | no | no |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| KLH14_HUMAN | [view interactions] | High throughput | no | yes |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |