RHG32_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG32_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 44.7761 | 4 | no |
| GO:0019901 | protein kinase binding | 43.2836 | 5 | no |
| GO:0017076 | purine nucleotide binding | 40.2985 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 40.2985 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.2985 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.3731 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.3731 | 5 | no |
| GO:0005524 | ATP binding | 25.3731 | 5 | no |
| GO:0046872 | metal ion binding | 22.3881 | 4 | no |
| GO:0005096 | GTPase activator activity | 4.4776 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 4.4776 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 2.9851 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 2.9851 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG32_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 77.6119 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 70.1493 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 68.6567 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 64.1791 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 64.1791 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 64.1791 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 61.1940 | 4 | no |
| GO:0010646 | regulation of cell communication | 59.7015 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 56.7164 | 4 | no |
| GO:0009966 | regulation of signal transduction | 53.7313 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.7313 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 50.7463 | 5 | no |
| GO:0010468 | regulation of gene expression | 50.7463 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 49.2537 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 47.7612 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 43.2836 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 43.2836 | 4 | no |
| GO:0006996 | organelle organization | 41.7910 | 4 | no |
| GO:0022607 | cellular component assembly | 41.7910 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.7910 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 41.7910 | 4 | no |
| GO:0031399 | regulation of protein modification process | 41.7910 | 6 | no |
| GO:0008104 | protein localization | 40.2985 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 40.2985 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 40.2985 | 5 | no |
| GO:0051049 | regulation of transport | 38.8060 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.8060 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 38.8060 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.8060 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 37.3134 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 35.8209 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 35.8209 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.8209 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.8209 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.8209 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 35.8209 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 35.8209 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.8209 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.3284 | 6 | no |
| GO:0010941 | regulation of cell death | 34.3284 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.3284 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.8358 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.8358 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.8358 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 32.8358 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 32.8358 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 32.8358 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.8358 | 5 | no |
| GO:0030030 | cell projection organization | 32.8358 | 4 | no |
| GO:0043412 | macromolecule modification | 31.3433 | 4 | no |
| GO:2000145 | regulation of cell motility | 31.3433 | 4 | no |
| GO:0034330 | cell junction organization | 29.8507 | 4 | no |
| GO:0036211 | protein modification process | 29.8507 | 4 | no |
| GO:0030334 | regulation of cell migration | 29.8507 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 29.8507 | 4 | no |
| GO:0051338 | regulation of transferase activity | 29.8507 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 29.8507 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.3582 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.3582 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.3582 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 28.3582 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.3582 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.3582 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 28.3582 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 28.3582 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 28.3582 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 28.3582 | 7 | no |
| GO:0032880 | regulation of protein localization | 28.3582 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.3582 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.8657 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.8657 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 26.8657 | 4 | no |
| GO:0071702 | organic substance transport | 26.8657 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.8657 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.8657 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.8657 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.8657 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.8657 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.3731 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 25.3731 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.3731 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.3731 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.3731 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.3731 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.3731 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.3731 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.3731 | 8 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 23.8806 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.8806 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.8806 | 6 | no |
| GO:0051050 | positive regulation of transport | 23.8806 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.8806 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.8806 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.8806 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.8806 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 23.8806 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8806 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.8806 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 23.8806 | 6 | no |
| GO:0007264 | small GTPase mediated signal transduction | 22.3881 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 22.3881 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 22.3881 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.3881 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 22.3881 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 22.3881 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.3881 | 4 | no |
| GO:0060548 | negative regulation of cell death | 22.3881 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.3881 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.3881 | 6 | no |
| GO:0031175 | neuron projection development | 22.3881 | 6 | no |
| GO:0006468 | protein phosphorylation | 20.8955 | 5 | no |
| GO:0016310 | phosphorylation | 20.8955 | 5 | no |
| GO:0034329 | cell junction assembly | 20.8955 | 5 | no |
| GO:0002684 | positive regulation of immune system process | 20.8955 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.8955 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 20.8955 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 20.8955 | 5 | no |
| GO:0045785 | positive regulation of cell adhesion | 20.8955 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.8955 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 20.8955 | 5 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 14.9254 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RHG32_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 2.9851 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.9851 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEG10_HUMAN | [view interactions] | High throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| PRDX4_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC11_HUMAN | [view interactions] | High throughput | no | no |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| KLH14_HUMAN | [view interactions] | High throughput | no | yes |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGF_HUMAN | [view interactions] | Computational | no | no |