Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTN23_HUMAN

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed, PubMed). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed). Plays a role in ciliogenesis (PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PTN23_HUMAN
GO:0043168 anion binding 36.5854 4 no
GO:0000166 nucleotide binding 32.9268 4 no
GO:0017076 purine nucleotide binding 32.9268 5 no
GO:0032555 purine ribonucleotide binding 32.9268 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.9268 4 no
GO:0005524 ATP binding 26.8293 5 no
GO:0030554 adenyl nucleotide binding 26.8293 6 no
GO:0032559 adenyl ribonucleotide binding 26.8293 5 no
GO:0019900 kinase binding 14.6341 4 yes
GO:0019901 protein kinase binding 13.4146 5 yes
GO:0016791 phosphatase activity 4.8780 5 yes
GO:0042578 phosphoric ester hydrolase activity 4.8780 4 yes
GO:0004725 protein tyrosine phosphatase activity 3.6585 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTN23_HUMAN
GO:0048522 positive regulation of cellular process 52.4390 4 yes
GO:0051128 regulation of cellular component organization 48.7805 4 yes
GO:0031323 regulation of cellular metabolic process 48.7805 4 no
GO:0060255 regulation of macromolecule metabolic process 45.1220 4 no
GO:0008104 protein localization 42.6829 4 yes
GO:0006996 organelle organization 41.4634 4 yes
GO:0048523 negative regulation of cellular process 41.4634 4 yes
GO:0010646 regulation of cell communication 39.0244 4 yes
GO:0080090 regulation of primary metabolic process 39.0244 4 no
GO:0022607 cellular component assembly 37.8049 4 yes
GO:0009889 regulation of biosynthetic process 37.8049 4 no
GO:0010556 regulation of macromolecule biosynthetic process 36.5854 5 no
GO:0031326 regulation of cellular biosynthetic process 36.5854 5 no
GO:0071702 organic substance transport 35.3659 4 yes
GO:0071705 nitrogen compound transport 35.3659 4 yes
GO:0009893 positive regulation of metabolic process 34.1463 4 no
GO:0051246 regulation of protein metabolic process 34.1463 5 no
GO:0010468 regulation of gene expression 31.7073 6 no
GO:0010604 positive regulation of macromolecule metabolic process 31.7073 5 no
GO:0009966 regulation of signal transduction 31.7073 4 no
GO:0015031 protein transport 30.4878 4 yes
GO:0043933 protein-containing complex organization 30.4878 4 no
GO:0006796 phosphate-containing compound metabolic process 29.2683 4 yes
GO:0023056 positive regulation of signaling 29.2683 4 yes
GO:0010647 positive regulation of cell communication 28.0488 5 yes
GO:0051049 regulation of transport 28.0488 4 yes
GO:0051130 positive regulation of cellular component organization 28.0488 5 yes
GO:0031325 positive regulation of cellular metabolic process 28.0488 5 no
GO:0009892 negative regulation of metabolic process 28.0488 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.0488 5 no
GO:0009891 positive regulation of biosynthetic process 25.6098 5 no
GO:0031399 regulation of protein modification process 25.6098 6 no
GO:0044087 regulation of cellular component biogenesis 25.6098 4 no
GO:0048584 positive regulation of response to stimulus 25.6098 4 no
GO:0031324 negative regulation of cellular metabolic process 24.3902 5 no
GO:0036211 protein modification process 23.1707 4 no
GO:0043412 macromolecule modification 23.1707 4 no
GO:0009894 regulation of catabolic process 23.1707 4 no
GO:0031328 positive regulation of cellular biosynthetic process 23.1707 6 no
GO:0033043 regulation of organelle organization 23.1707 5 no
GO:0051247 positive regulation of protein metabolic process 23.1707 6 no
GO:0060341 regulation of cellular localization 21.9512 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 21.9512 6 no
GO:0009890 negative regulation of biosynthetic process 21.9512 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.9512 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.9512 6 no
GO:0065003 protein-containing complex assembly 21.9512 5 no
GO:1902531 regulation of intracellular signal transduction 21.9512 5 no
GO:0032880 regulation of protein localization 20.7317 5 yes
GO:0060627 regulation of vesicle-mediated transport 20.7317 4 yes
GO:0042981 regulation of apoptotic process 20.7317 5 no
GO:0043067 regulation of programmed cell death 20.7317 4 no
GO:0051248 negative regulation of protein metabolic process 20.7317 6 no
GO:0098657 import into cell 20.7317 4 no
GO:0009967 positive regulation of signal transduction 20.7317 5 no
GO:0006886 intracellular protein transport 19.5122 4 yes
GO:0051050 positive regulation of transport 19.5122 4 yes
GO:0006508 proteolysis 18.2927 4 yes
GO:0009057 macromolecule catabolic process 17.0732 4 yes
GO:0030030 cell projection organization 17.0732 4 yes
GO:0051603 proteolysis involved in protein catabolic process 15.8537 5 yes
GO:0007034 vacuolar transport 14.6341 4 yes
GO:0019941 modification-dependent protein catabolic process 14.6341 6 yes
GO:0030155 regulation of cell adhesion 14.6341 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 14.6341 5 yes
GO:0033365 protein localization to organelle 13.4146 5 yes
GO:0051046 regulation of secretion 13.4146 5 yes
GO:0070925 organelle assembly 13.4146 5 yes
GO:0120036 plasma membrane bounded cell projection organization 13.4146 5 yes
GO:0006511 ubiquitin-dependent protein catabolic process 12.1951 7 yes
GO:0030334 regulation of cell migration 12.1951 5 yes
GO:1903530 regulation of secretion by cell 12.1951 4 yes
GO:1903829 positive regulation of protein localization 12.1951 5 yes
GO:2000145 regulation of cell motility 12.1951 4 yes
GO:0051047 positive regulation of secretion 10.9756 5 yes
GO:1903532 positive regulation of secretion by cell 10.9756 5 yes
GO:0022407 regulation of cell-cell adhesion 9.7561 5 yes
GO:0032509 endosome transport via multivesicular body sorting pathway 9.7561 4 yes
GO:0032386 regulation of intracellular transport 8.5366 5 yes
GO:0045785 positive regulation of cell adhesion 8.5366 5 yes
GO:0051223 regulation of protein transport 8.5366 5 yes
GO:0070201 regulation of establishment of protein localization 8.5366 6 yes
GO:0022409 positive regulation of cell-cell adhesion 7.3171 6 yes
GO:0032456 endocytic recycling 7.3171 4 yes
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 7.3171 8 yes
GO:0051241 negative regulation of multicellular organismal process 7.3171 4 yes
GO:0072594 establishment of protein localization to organelle 7.3171 4 yes
GO:0010632 regulation of epithelial cell migration 6.0976 4 yes
GO:0030336 negative regulation of cell migration 6.0976 6 yes
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 6.0976 4 yes
GO:0040013 negative regulation of locomotion 6.0976 4 yes
GO:0051222 positive regulation of protein transport 6.0976 5 yes
GO:1904951 positive regulation of establishment of protein localization 6.0976 6 yes
GO:2000146 negative regulation of cell motility 6.0976 5 yes
GO:2000641 regulation of early endosome to late endosome transport 6.0976 5 yes
GO:0030031 cell projection assembly 4.8780 5 yes
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 4.8780 5 yes
GO:0044782 cilium organization 4.8780 5 yes
GO:0045022 early endosome to late endosome transport 4.8780 5 yes
GO:0050708 regulation of protein secretion 4.8780 5 yes
GO:0072665 protein localization to vacuole 4.8780 6 yes
GO:0072666 establishment of protein localization to vacuole 4.8780 5 yes
GO:0098927 vesicle-mediated transport between endosomal compartments 4.8780 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 4.8780 6 yes
GO:0016311 dephosphorylation 3.6585 5 yes
GO:0032388 positive regulation of intracellular transport 3.6585 5 yes
GO:0050714 positive regulation of protein secretion 3.6585 6 yes
GO:0060271 cilium assembly 3.6585 6 yes
GO:0010633 negative regulation of epithelial cell migration 2.4390 5 yes
GO:0061356 regulation of Wnt protein secretion 2.4390 4 yes
GO:0061357 positive regulation of Wnt protein secretion 2.4390 5 yes
GO:1903385 regulation of homophilic cell adhesion 2.4390 6 yes
GO:1903387 positive regulation of homophilic cell adhesion 2.4390 7 yes
GO:1903391 regulation of adherens junction organization 2.4390 5 yes
GO:1903393 positive regulation of adherens junction organization 2.4390 6 yes
GO:2000643 positive regulation of early endosome to late endosome transport 2.4390 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALG2_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
UBAP1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
STAM2_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
STAM1_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
ZFYV9_HUMAN [view interactions] Low throughput no yes
PTN23_HUMAN [view entry] [view interactions] Low throughput yes yes
CHM4C_HUMAN [view interactions] Low throughput no yes
GRAP2_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
TS101_HUMAN [view entry] [view interactions] Low throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] Low throughput yes yes
PDCD6_HUMAN [view interactions] Low throughput no no
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
CHM4A_HUMAN [view interactions] Low throughput no no
ZFY16_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
BICD1_HUMAN [view interactions] Low throughput no yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
LGR4_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
SPAST_HUMAN [view interactions] High throughput no yes
ABCG2_HUMAN [view interactions] High throughput no no
IST1_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
BAZ2B_HUMAN [view interactions] High throughput no yes
KDIS_HUMAN [view entry] [view interactions] High throughput yes yes
CTC1_HUMAN [view interactions] High throughput no no
VMA5A_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
UBP11_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
DUS16_HUMAN [view interactions] High throughput no yes
FA24B_HUMAN [view interactions] High throughput no no
ISCA1_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
HPBP1_HUMAN [view interactions] High throughput no yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
SNX12_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ARMD3_HUMAN [view interactions] High throughput no yes
P63_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
LAGE3_HUMAN [view interactions] High throughput no yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
DIAP1_HUMAN [view interactions] High throughput no yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
P4R3B_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
ARHGG_HUMAN [view interactions] High throughput no yes
ATX2L_HUMAN [view interactions] High throughput no no
NRCAM_HUMAN [view entry] [view interactions] High throughput yes no
ATX2_HUMAN [view interactions] High throughput no yes
PBDC1_HUMAN [view interactions] High throughput no no
CHID1_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
SMAP2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
ALMS1_HUMAN [view interactions] High throughput no no
TNIP1_HUMAN [view interactions] High throughput no yes
RABE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNRG_HUMAN [view interactions] High throughput no yes
TNR6B_HUMAN [view interactions] High throughput no yes
WNK1_HUMAN [view entry] [view interactions] High throughput yes no
SH319_HUMAN [view interactions] High throughput no no
P3C2A_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
DHYS_HUMAN [view interactions] High throughput no no
C1TC_HUMAN [view entry] [view interactions] High throughput yes yes
KS6C1_HUMAN [view entry] [view interactions] High throughput yes no
AGFG1_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
TM1L2_HUMAN [view entry] [view interactions] High throughput yes yes
TOM1_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
DTX3L_HUMAN [view interactions] High throughput no yes
ENTR1_HUMAN [view interactions] High throughput no no
RABX5_HUMAN [view interactions] High throughput no no
RELCH_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
TICRR_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
S53A1_HUMAN [view interactions] High throughput no yes
CHM1B_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
CHM1A_HUMAN [view entry] [view interactions] High throughput yes no
STABP_HUMAN [view interactions] High throughput no yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
CHMP3_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
CL004_HUMAN [view interactions] High throughput no yes
CHM2A_HUMAN [view interactions] High throughput no yes
BST2_HUMAN [view interactions] High throughput no yes
PDC6I_HUMAN [view entry] [view interactions] High throughput yes yes
CHM2B_HUMAN [view entry] [view interactions] High throughput yes yes
RAI3_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
MITD1_HUMAN [view interactions] High throughput no no
CAVN3_HUMAN [view interactions] High throughput no no
CAN7_HUMAN [view interactions] High throughput no no
UMAD1_HUMAN [view interactions] High throughput no yes
CHMP5_HUMAN [view interactions] High throughput no yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
PACN3_HUMAN [view interactions] High throughput no yes
CYBR1_HUMAN [view entry] [view interactions] High throughput yes no
FGL1_HUMAN [view interactions] High throughput no no
EPN4_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
P3H1_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
ARL1_HUMAN [view interactions] High throughput no yes
NTPCR_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
DDX24_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no