PTN23_HUMAN
Evidence for PS localization
Functions
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed, PubMed). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed). Plays a role in ciliogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTN23_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.0656 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 34.4262 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.4262 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 29.5082 | 5 | no |
| GO:0005524 | ATP binding | 27.8689 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.8689 | 5 | no |
| GO:0019900 | kinase binding | 14.7541 | 4 | yes |
| GO:0019901 | protein kinase binding | 13.1148 | 5 | yes |
| GO:0016791 | phosphatase activity | 8.1967 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 8.1967 | 4 | yes |
| GO:0004725 | protein tyrosine phosphatase activity | 6.5574 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTN23_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 49.1803 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.1803 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.5410 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.5410 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.9016 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.2623 | 4 | no |
| GO:0006996 | organelle organization | 44.2623 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 42.6230 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.9836 | 4 | yes |
| GO:0008104 | protein localization | 39.3443 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 37.7049 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.0656 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.0656 | 4 | yes |
| GO:0010468 | regulation of gene expression | 34.4262 | 5 | no |
| GO:0043933 | protein-containing complex organization | 32.7869 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.7869 | 4 | no |
| GO:0051049 | regulation of transport | 31.1475 | 4 | yes |
| GO:0071702 | organic substance transport | 31.1475 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 31.1475 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.5082 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.5082 | 5 | no |
| GO:0015031 | protein transport | 29.5082 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 27.8689 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.8689 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.8689 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 27.8689 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 27.8689 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.2295 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.5902 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.5902 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.5902 | 5 | no |
| GO:0036211 | protein modification process | 24.5902 | 4 | no |
| GO:0043412 | macromolecule modification | 24.5902 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.5902 | 4 | no |
| GO:0010941 | regulation of cell death | 24.5902 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5902 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.9508 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.9508 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 22.9508 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.9508 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.9508 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.9508 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9508 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.9508 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9508 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.3115 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.3115 | 5 | no |
| GO:0051726 | regulation of cell cycle | 21.3115 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.3115 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.3115 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.3115 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.3115 | 5 | no |
| GO:0006508 | proteolysis | 21.3115 | 4 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 19.6721 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 19.6721 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 19.6721 | 4 | yes |
| GO:0016197 | endosomal transport | 19.6721 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 18.0328 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 18.0328 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 16.3934 | 5 | yes |
| GO:0070925 | organelle assembly | 16.3934 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 16.3934 | 6 | yes |
| GO:0030030 | cell projection organization | 16.3934 | 4 | yes |
| GO:0051046 | regulation of secretion | 14.7541 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 14.7541 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 14.7541 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 14.7541 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 14.7541 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 14.7541 | 7 | yes |
| GO:0016482 | cytosolic transport | 14.7541 | 4 | yes |
| GO:0030334 | regulation of cell migration | 13.1148 | 5 | yes |
| GO:2000145 | regulation of cell motility | 13.1148 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 13.1148 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 11.4754 | 5 | yes |
| GO:0051223 | regulation of protein transport | 11.4754 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 11.4754 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 11.4754 | 5 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 11.4754 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 9.8361 | 5 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 9.8361 | 8 | yes |
| GO:0051222 | positive regulation of protein transport | 8.1967 | 5 | yes |
| GO:1903649 | regulation of cytoplasmic transport | 8.1967 | 6 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 8.1967 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 8.1967 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 6.5574 | 6 | yes |
| GO:0032456 | endocytic recycling | 6.5574 | 5 | yes |
| GO:0040013 | negative regulation of locomotion | 6.5574 | 4 | yes |
| GO:0045022 | early endosome to late endosome transport | 6.5574 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 6.5574 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 6.5574 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 6.5574 | 4 | yes |
| GO:0098927 | vesicle-mediated transport between endosomal compartments | 6.5574 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 6.5574 | 6 | yes |
| GO:2000146 | negative regulation of cell motility | 6.5574 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 6.5574 | 4 | yes |
| GO:0030031 | cell projection assembly | 6.5574 | 5 | yes |
| GO:0044782 | cilium organization | 4.9180 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 4.9180 | 6 | yes |
| GO:0060271 | cilium assembly | 4.9180 | 6 | yes |
| GO:0032388 | positive regulation of intracellular transport | 3.2787 | 5 | yes |
| GO:0061356 | regulation of Wnt protein secretion | 3.2787 | 4 | yes |
| GO:0061357 | positive regulation of Wnt protein secretion | 3.2787 | 5 | yes |
| GO:1903385 | regulation of homophilic cell adhesion | 3.2787 | 6 | yes |
| GO:1903387 | positive regulation of homophilic cell adhesion | 3.2787 | 7 | yes |
| GO:1903391 | regulation of adherens junction organization | 3.2787 | 5 | yes |
| GO:1903393 | positive regulation of adherens junction organization | 3.2787 | 6 | yes |
| GO:1903651 | positive regulation of cytoplasmic transport | 3.2787 | 6 | yes |
| GO:2000643 | positive regulation of early endosome to late endosome transport | 3.2787 | 6 | yes |
| GO:0010633 | negative regulation of epithelial cell migration | 3.2787 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRAP2_HUMAN | [view interactions] | Low throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDCD6_HUMAN | [view interactions] | Low throughput | no | no |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZFY16_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM4A_HUMAN | [view interactions] | Low throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZFYV9_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | Low throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP3_HUMAN | [view interactions] | High throughput | no | yes |
| CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
| CYBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| UMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN7_HUMAN | [view interactions] | High throughput | no | no |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| MITD1_HUMAN | [view interactions] | High throughput | no | no |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| CL004_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPR1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| TICRR_HUMAN | [view interactions] | High throughput | no | no |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG2_HUMAN | [view interactions] | High throughput | no | no |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| KDIS_HUMAN | [view interactions] | High throughput | no | yes |
| CTC1_HUMAN | [view interactions] | High throughput | no | no |
| VMA5A_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMD3_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN14_HUMAN | [view interactions] | Computational | no | yes |
| PTN4_HUMAN | [view interactions] | Computational | no | no |
| SMAD3_HUMAN | [view interactions] | Computational | no | yes |
| PTN6_HUMAN | [view interactions] | Computational | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PTN5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PTN12_HUMAN | [view interactions] | Computational | no | yes |
| PTN13_HUMAN | [view interactions] | Computational | no | yes |
| PTN9_HUMAN | [view interactions] | Computational | no | yes |
| IL37_HUMAN | [view interactions] | Computational | no | no |
| PTN7_HUMAN | [view interactions] | Computational | no | no |
| PTN2_HUMAN | [view interactions] | Computational | no | yes |
| PTN20_HUMAN | [view interactions] | Computational | no | yes |
| PTN18_HUMAN | [view interactions] | Computational | no | yes |