Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRCAM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRCAM_HUMAN
GO:0019900 kinase binding 28.0000 4 no
GO:0019901 protein kinase binding 24.0000 5 no
GO:0098631 cell adhesion mediator activity 16.0000 4 yes
GO:0098632 cell-cell adhesion mediator activity 16.0000 5 yes
GO:0030506 ankyrin binding 12.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRCAM_HUMAN
GO:0048522 positive regulation of cellular process 64.0000 4 yes
GO:0008104 protein localization 52.0000 4 yes
GO:0051128 regulation of cellular component organization 52.0000 4 yes
GO:0048523 negative regulation of cellular process 52.0000 4 no
GO:0030030 cell projection organization 48.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.0000 4 no
GO:0051049 regulation of transport 48.0000 4 no
GO:0043269 regulation of ion transport 44.0000 5 no
GO:0031344 regulation of cell projection organization 40.0000 5 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0072657 protein localization to membrane 40.0000 4 no
GO:0010975 regulation of neuron projection development 36.0000 7 yes
GO:0031175 neuron projection development 36.0000 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.0000 6 yes
GO:0120036 plasma membrane bounded cell projection organization 36.0000 5 yes
GO:0031323 regulation of cellular metabolic process 36.0000 4 no
GO:0031399 regulation of protein modification process 36.0000 6 no
GO:0034762 regulation of transmembrane transport 36.0000 4 no
GO:0034765 regulation of ion transmembrane transport 36.0000 5 no
GO:0022607 cellular component assembly 32.0000 4 yes
GO:0032990 cell part morphogenesis 32.0000 4 yes
GO:0048812 neuron projection morphogenesis 32.0000 7 yes
GO:0048858 cell projection morphogenesis 32.0000 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 32.0000 6 yes
GO:0009966 regulation of signal transduction 32.0000 4 no
GO:0001932 regulation of protein phosphorylation 32.0000 7 no
GO:0019220 regulation of phosphate metabolic process 32.0000 6 no
GO:0042325 regulation of phosphorylation 32.0000 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 32.0000 5 no
GO:0051247 positive regulation of protein metabolic process 32.0000 6 no
GO:1990778 protein localization to cell periphery 32.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 32.0000 4 no
GO:0034330 cell junction organization 28.0000 4 yes
GO:0045595 regulation of cell differentiation 28.0000 4 yes
GO:0051094 positive regulation of developmental process 28.0000 4 yes
GO:0061024 membrane organization 28.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 28.0000 5 no
GO:0031401 positive regulation of protein modification process 28.0000 7 no
GO:0010468 regulation of gene expression 28.0000 5 no
GO:0016192 vesicle-mediated transport 28.0000 4 no
GO:0072659 protein localization to plasma membrane 28.0000 5 no
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0050890 cognition 28.0000 4 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0007411 axon guidance 24.0000 8 yes
GO:0097485 neuron projection guidance 24.0000 7 yes
GO:0044087 regulation of cellular component biogenesis 24.0000 4 no
GO:0051129 negative regulation of cellular component organization 24.0000 5 no
GO:0051338 regulation of transferase activity 24.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 24.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 24.0000 6 no
GO:0042327 positive regulation of phosphorylation 24.0000 8 no
GO:0043085 positive regulation of catalytic activity 24.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 24.0000 7 no
GO:0010959 regulation of metal ion transport 24.0000 6 no
GO:0044057 regulation of system process 24.0000 4 no
GO:0051050 positive regulation of transport 24.0000 4 no
GO:1904062 regulation of cation transmembrane transport 24.0000 6 no
GO:0030155 regulation of cell adhesion 24.0000 4 no
GO:0051960 regulation of nervous system development 24.0000 5 no
GO:2000026 regulation of multicellular organismal development 24.0000 4 no
GO:0022604 regulation of cell morphogenesis 24.0000 5 no
GO:0009967 positive regulation of signal transduction 24.0000 5 no
GO:0023056 positive regulation of signaling 24.0000 4 no
GO:0048584 positive regulation of response to stimulus 24.0000 4 no
GO:0007010 cytoskeleton organization 24.0000 5 no
GO:0001508 action potential 20.0000 4 yes
GO:0007409 axonogenesis 20.0000 8 yes
GO:0034329 cell junction assembly 20.0000 5 yes
GO:0045597 positive regulation of cell differentiation 20.0000 5 yes
GO:0050807 regulation of synapse organization 20.0000 5 yes
GO:0050808 synapse organization 20.0000 5 yes
GO:0099175 regulation of postsynapse organization 20.0000 6 yes
GO:0001764 neuron migration 16.0000 4 yes
GO:0048638 regulation of developmental growth 16.0000 4 yes
GO:0007416 synapse assembly 12.0000 6 yes
GO:0007417 central nervous system development 12.0000 4 yes
GO:0007420 brain development 12.0000 4 yes
GO:0045161 neuronal ion channel clustering 12.0000 5 yes
GO:0001558 regulation of cell growth 8.0000 4 yes
GO:0007413 axonal fasciculation 8.0000 4 yes
GO:0030516 regulation of axon extension 8.0000 5 yes
GO:0045162 clustering of voltage-gated sodium channels 8.0000 6 yes
GO:0045664 regulation of neuron differentiation 8.0000 5 yes
GO:0061387 regulation of extent of cell growth 8.0000 5 yes
GO:0106030 neuron projection fasciculation 8.0000 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in NRCAM_HUMAN
DOID:0050701 electroclinical syndrome 12.0000 6 no
DOID:0112202 developmental and epileptic encephalopathy 12.0000 7 no
DOID:1826 epilepsy 12.0000 5 no
DOID:331 central nervous system disease 12.0000 3 no
DOID:936 brain disease 12.0000 4 no
DOID:0050703 infancy electroclinical syndrome 8.0000 7 no
DOID:0060169 benign familial infantile epilepsy 8.0000 8 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRB_HUMAN [view interactions] Low throughput no yes
CNTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI3_HUMAN [view interactions] High throughput no no
FRMD5_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes
RS17_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] Computational yes yes
SEM6D_HUMAN [view interactions] Computational no no
ANK3_HUMAN [view entry] [view interactions] Computational yes yes
SCN8A_HUMAN [view entry] [view interactions] Computational yes no
DLG3_HUMAN [view entry] [view interactions] Computational yes yes
KCNQ2_HUMAN [view entry] [view interactions] Computational yes yes
PTPRZ_HUMAN [view entry] [view interactions] Computational yes yes
SCN2A_HUMAN [view entry] [view interactions] Computational yes yes
NRP2_HUMAN [view entry] [view interactions] Computational yes yes
CNTN1_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
ANK1_HUMAN [view entry] [view interactions] Computational yes no
PLXA1_HUMAN [view entry] [view interactions] Computational yes yes
SPTN4_HUMAN [view entry] [view interactions] Computational yes no
GLDN_HUMAN [view interactions] Computational no no