Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRCAM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRCAM_HUMAN
GO:0019900 kinase binding 41.1765 4 no
GO:0043169 cation binding 35.2941 4 no
GO:0046872 metal ion binding 29.4118 5 no
GO:0019901 protein kinase binding 29.4118 5 no
GO:0000166 nucleotide binding 23.5294 4 no
GO:0017076 purine nucleotide binding 23.5294 5 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0032555 purine ribonucleotide binding 23.5294 4 no
GO:0032559 adenyl ribonucleotide binding 23.5294 5 no
GO:0043168 anion binding 23.5294 4 no
GO:0098631 cell adhesion mediator activity 17.6471 4 yes
GO:0098632 cell-cell adhesion mediator activity 17.6471 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRCAM_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0010646 regulation of cell communication 58.8235 4 no
GO:0051128 regulation of cellular component organization 52.9412 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0008104 protein localization 47.0588 4 yes
GO:0006996 organelle organization 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0022607 cellular component assembly 41.1765 4 yes
GO:0030030 cell projection organization 41.1765 4 yes
GO:0120036 plasma membrane bounded cell projection organization 41.1765 5 yes
GO:0051049 regulation of transport 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0010647 positive regulation of cell communication 41.1765 5 no
GO:0023056 positive regulation of signaling 41.1765 4 no
GO:0031175 neuron projection development 35.2941 6 yes
GO:0031344 regulation of cell projection organization 35.2941 5 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0080090 regulation of primary metabolic process 35.2941 4 no
GO:0048584 positive regulation of response to stimulus 35.2941 4 no
GO:0010975 regulation of neuron projection development 29.4118 7 yes
GO:0034330 cell junction organization 29.4118 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 no
GO:0030155 regulation of cell adhesion 29.4118 4 no
GO:0044057 regulation of system process 29.4118 4 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0051130 positive regulation of cellular component organization 29.4118 5 no
GO:2000026 regulation of multicellular organismal development 29.4118 4 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0051246 regulation of protein metabolic process 29.4118 5 no
GO:0051338 regulation of transferase activity 29.4118 4 no
GO:0034329 cell junction assembly 23.5294 5 yes
GO:0045595 regulation of cell differentiation 23.5294 4 yes
GO:0048812 neuron projection morphogenesis 23.5294 5 yes
GO:0050807 regulation of synapse organization 23.5294 5 yes
GO:0051094 positive regulation of developmental process 23.5294 4 yes
GO:0061024 membrane organization 23.5294 4 yes
GO:0099175 regulation of postsynapse organization 23.5294 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.5294 4 yes
GO:0007010 cytoskeleton organization 23.5294 5 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0032880 regulation of protein localization 23.5294 5 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0051960 regulation of nervous system development 23.5294 5 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0072657 protein localization to membrane 23.5294 4 no
GO:0031644 regulation of nervous system process 23.5294 5 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0050890 cognition 23.5294 4 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0098815 modulation of excitatory postsynaptic potential 23.5294 4 no
GO:0099173 postsynapse organization 23.5294 4 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 23.5294 5 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0045859 regulation of protein kinase activity 23.5294 6 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0030334 regulation of cell migration 23.5294 5 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0051248 negative regulation of protein metabolic process 23.5294 6 no
GO:2000145 regulation of cell motility 23.5294 4 no
GO:0045597 positive regulation of cell differentiation 17.6471 5 yes
GO:0048638 regulation of developmental growth 17.6471 4 yes
GO:0050808 synapse organization 17.6471 5 yes
GO:0097485 neuron projection guidance 17.6471 7 yes
GO:0001558 regulation of cell growth 17.6471 4 yes
GO:0007411 axon guidance 17.6471 8 yes
GO:0007416 synapse assembly 17.6471 6 yes
GO:0007417 central nervous system development 11.7647 4 yes
GO:0007420 brain development 11.7647 4 yes
GO:0030516 regulation of axon extension 11.7647 5 yes
GO:0045161 neuronal ion channel clustering 11.7647 5 yes
GO:0061387 regulation of extent of cell growth 11.7647 5 yes
GO:0007409 axonogenesis 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRB_HUMAN [view interactions] Low throughput no yes
CNTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI3_HUMAN [view interactions] High throughput no no
FRMD5_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
LCOR_HUMAN [view interactions] High throughput no yes
VP26C_HUMAN [view interactions] High throughput no yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
RSPH1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes
RS17_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
KIME_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD2_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes