Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CNTN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CNTN2_HUMAN
GO:0098631 cell adhesion mediator activity 30.7692 4 yes
GO:0098632 cell-cell adhesion mediator activity 30.7692 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CNTN2_HUMAN
GO:0030030 cell projection organization 76.9231 4 yes
GO:0031175 neuron projection development 69.2308 6 yes
GO:0048522 positive regulation of cellular process 69.2308 4 yes
GO:0051128 regulation of cellular component organization 69.2308 4 yes
GO:0120036 plasma membrane bounded cell projection organization 69.2308 5 yes
GO:0007411 axon guidance 53.8462 8 yes
GO:0008104 protein localization 53.8462 4 yes
GO:0031344 regulation of cell projection organization 53.8462 5 yes
GO:0097485 neuron projection guidance 53.8462 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 53.8462 6 yes
GO:0010975 regulation of neuron projection development 46.1538 7 yes
GO:0009893 positive regulation of metabolic process 38.4615 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 yes
GO:0010646 regulation of cell communication 38.4615 4 yes
GO:0016192 vesicle-mediated transport 38.4615 4 yes
GO:0045595 regulation of cell differentiation 38.4615 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 38.4615 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 38.4615 5 yes
GO:0051246 regulation of protein metabolic process 38.4615 5 yes
GO:0051247 positive regulation of protein metabolic process 38.4615 6 yes
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 yes
GO:0080090 regulation of primary metabolic process 38.4615 4 yes
GO:0022607 cellular component assembly 38.4615 4 no
GO:0007612 learning 30.7692 4 yes
GO:0009966 regulation of signal transduction 30.7692 4 yes
GO:0010468 regulation of gene expression 30.7692 5 yes
GO:0010628 positive regulation of gene expression 30.7692 6 yes
GO:0010647 positive regulation of cell communication 30.7692 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 yes
GO:0023056 positive regulation of signaling 30.7692 4 yes
GO:0045161 neuronal ion channel clustering 30.7692 5 yes
GO:0045664 regulation of neuron differentiation 30.7692 5 yes
GO:0048523 negative regulation of cellular process 30.7692 4 yes
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 yes
GO:0050890 cognition 30.7692 4 yes
GO:0061024 membrane organization 30.7692 4 yes
GO:0071205 protein localization to juxtaparanode region of axon 30.7692 6 yes
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 yes
GO:0099612 protein localization to axon 30.7692 5 yes
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0032990 cell part morphogenesis 30.7692 4 no
GO:0034330 cell junction organization 30.7692 4 no
GO:0048812 neuron projection morphogenesis 30.7692 7 no
GO:0048858 cell projection morphogenesis 30.7692 5 no
GO:0050808 synapse organization 30.7692 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.7692 6 no
GO:0001764 neuron migration 23.0769 4 yes
GO:0006897 endocytosis 23.0769 5 yes
GO:0006996 organelle organization 23.0769 4 yes
GO:0007010 cytoskeleton organization 23.0769 5 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 23.0769 5 yes
GO:0007413 axonal fasciculation 23.0769 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 23.0769 5 yes
GO:0008344 adult locomotory behavior 23.0769 4 yes
GO:0009967 positive regulation of signal transduction 23.0769 5 yes
GO:0022010 central nervous system myelination 23.0769 5 yes
GO:0030162 regulation of proteolysis 23.0769 6 yes
GO:0032291 axon ensheathment in central nervous system 23.0769 4 yes
GO:0042552 myelination 23.0769 4 yes
GO:0045163 clustering of voltage-gated potassium channels 23.0769 6 yes
GO:0045596 negative regulation of cell differentiation 23.0769 5 yes
GO:0045665 negative regulation of neuron differentiation 23.0769 6 yes
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 23.0769 6 yes
GO:0045862 positive regulation of proteolysis 23.0769 7 yes
GO:0048168 regulation of neuronal synaptic plasticity 23.0769 4 yes
GO:0048584 positive regulation of response to stimulus 23.0769 4 yes
GO:0050770 regulation of axonogenesis 23.0769 5 yes
GO:0051093 negative regulation of developmental process 23.0769 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 23.0769 4 yes
GO:0106030 neuron projection fasciculation 23.0769 7 yes
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0007420 brain development 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0031323 regulation of cellular metabolic process 23.0769 4 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 23.0769 9 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0099175 regulation of postsynapse organization 23.0769 6 no
GO:0007409 axonogenesis 23.0769 8 no
GO:0034329 cell junction assembly 23.0769 5 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0048638 regulation of developmental growth 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0001558 regulation of cell growth 23.0769 4 no
GO:0002023 reduction of food intake in response to dietary excess 15.3846 5 yes
GO:0006898 receptor-mediated endocytosis 15.3846 6 yes
GO:0007628 adult walking behavior 15.3846 5 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 15.3846 6 yes
GO:0010954 positive regulation of protein processing 15.3846 8 yes
GO:0021826 substrate-independent telencephalic tangential migration 15.3846 6 yes
GO:0021830 interneuron migration from the subpallium to the cortex 15.3846 8 yes
GO:0021843 substrate-independent telencephalic tangential interneuron migration 15.3846 7 yes
GO:0021853 cerebral cortex GABAergic interneuron migration 15.3846 6 yes
GO:0021885 forebrain cell migration 15.3846 4 yes
GO:0022029 telencephalon cell migration 15.3846 5 yes
GO:0022604 regulation of cell morphogenesis 15.3846 5 yes
GO:0031133 regulation of axon diameter 15.3846 6 yes
GO:0031623 receptor internalization 15.3846 7 yes
GO:0032535 regulation of cellular component size 15.3846 4 yes
GO:0032536 regulation of cell projection size 15.3846 5 yes
GO:0042755 eating behavior 15.3846 4 yes
GO:0045444 fat cell differentiation 15.3846 4 yes
GO:0045685 regulation of glial cell differentiation 15.3846 5 yes
GO:0048710 regulation of astrocyte differentiation 15.3846 6 yes
GO:0060167 regulation of adenosine receptor signaling pathway 15.3846 6 yes
GO:0060168 positive regulation of adenosine receptor signaling pathway 15.3846 7 yes
GO:0070593 dendrite self-avoidance 15.3846 4 yes
GO:0070613 regulation of protein processing 15.3846 7 yes
GO:0071206 establishment of protein localization to juxtaparanode region of axon 15.3846 4 yes
GO:0090659 walking behavior 15.3846 4 yes
GO:0097090 presynaptic membrane organization 15.3846 5 yes
GO:1903317 regulation of protein maturation 15.3846 6 yes
GO:1903319 positive regulation of protein maturation 15.3846 7 yes
GO:1904936 interneuron migration 15.3846 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in CNTN2_HUMAN
DOID:331 central nervous system disease 15.3846 3 no
DOID:936 brain disease 15.3846 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K7_HUMAN [view interactions] Low throughput no yes
TGFR2_HUMAN [view interactions] Low throughput no no
CNTP2_HUMAN [view entry] [view interactions] Low throughput yes yes
NEMO_HUMAN [view interactions] Low throughput no yes
CHK1_HUMAN [view interactions] Low throughput no no
CHK2_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
UBE4B_HUMAN [view interactions] Low throughput no yes
NRCAM_HUMAN [view entry] [view interactions] Low throughput yes no
L1CAM_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
CDK4_HUMAN [view interactions] Low throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
RTCA_HUMAN [view interactions] High throughput no yes
CSPG4_HUMAN [view interactions] High throughput no yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
CNTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SEM3A_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
NFYB_HUMAN [view interactions] High throughput no yes
CNTP1_HUMAN [view entry] [view interactions] Computational yes yes
CREB1_HUMAN [view interactions] Computational no yes
USH1C_HUMAN [view interactions] Computational no yes
LGI1_HUMAN [view entry] [view interactions] Computational yes no
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes