CNTN2_HUMAN
Evidence for PS localization
Functions
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNTN2_HUMAN |
|---|---|---|---|---|
| GO:0098631 | cell adhesion mediator activity | 40.0000 | 4 | yes |
| GO:0098632 | cell-cell adhesion mediator activity | 40.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNTN2_HUMAN |
|---|---|---|---|---|
| GO:0030030 | cell projection organization | 80.0000 | 4 | yes |
| GO:0031175 | neuron projection development | 80.0000 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 80.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | no |
| GO:0007411 | axon guidance | 60.0000 | 8 | yes |
| GO:0097485 | neuron projection guidance | 60.0000 | 7 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | yes |
| GO:0045161 | neuronal ion channel clustering | 40.0000 | 5 | yes |
| GO:0061024 | membrane organization | 40.0000 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 40.0000 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 40.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 40.0000 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 40.0000 | 4 | no |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 30.0000 | 5 | yes |
| GO:0045163 | clustering of voltage-gated potassium channels | 30.0000 | 6 | yes |
| GO:0071205 | protein localization to juxtaparanode region of axon | 30.0000 | 6 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 30.0000 | 4 | yes |
| GO:0099612 | protein localization to axon | 30.0000 | 5 | yes |
| GO:0007420 | brain development | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0007417 | central nervous system development | 30.0000 | 4 | no |
| GO:0034330 | cell junction organization | 30.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 30.0000 | 5 | no |
| GO:0048638 | regulation of developmental growth | 30.0000 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 30.0000 | 5 | no |
| GO:0050807 | regulation of synapse organization | 30.0000 | 5 | no |
| GO:0050808 | synapse organization | 30.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 30.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
| GO:0002023 | reduction of food intake in response to dietary excess | 20.0000 | 5 | yes |
| GO:0042755 | eating behavior | 20.0000 | 4 | yes |
| GO:0045444 | fat cell differentiation | 20.0000 | 4 | yes |
| GO:0070593 | dendrite self-avoidance | 20.0000 | 4 | yes |
| GO:0071206 | establishment of protein localization to juxtaparanode region of axon | 20.0000 | 4 | yes |
| GO:0097090 | presynaptic membrane organization | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| CHK1_HUMAN | [view interactions] | Low throughput | no | no |
| CHK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| UBE4B_HUMAN | [view interactions] | Low throughput | no | yes |
| NRCAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCAN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDK4_HUMAN | [view interactions] | Low throughput | no | no |
| CNTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| RTCA_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| MLXPL_HUMAN | [view interactions] | High throughput | no | no |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEM3A_HUMAN | [view interactions] | High throughput | no | no |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| NFYB_HUMAN | [view interactions] | High throughput | no | yes |