CNTN1_HUMAN
Evidence for PS localization
Functions
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNTN1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.5814 | 4 | no |
| GO:0046872 | metal ion binding | 25.5814 | 5 | no |
| GO:0098631 | cell adhesion mediator activity | 9.3023 | 4 | yes |
| GO:0098632 | cell-cell adhesion mediator activity | 9.3023 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNTN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.4419 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 65.1163 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.8140 | 4 | no |
| GO:0030030 | cell projection organization | 53.4884 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.4884 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.1628 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.1628 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.5116 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 46.5116 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.1860 | 4 | no |
| GO:0031175 | neuron projection development | 41.8605 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 41.8605 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.8605 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.5349 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 39.5349 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.2093 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.2093 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.2093 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2093 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.2093 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.2093 | 5 | yes |
| GO:0051049 | regulation of transport | 37.2093 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 37.2093 | 5 | yes |
| GO:0006996 | organelle organization | 37.2093 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.2093 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.2093 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 37.2093 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.2093 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.8837 | 5 | no |
| GO:0034330 | cell junction organization | 30.2326 | 4 | no |
| GO:0050808 | synapse organization | 30.2326 | 5 | no |
| GO:0050890 | cognition | 30.2326 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.2326 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.2326 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 27.9070 | 7 | yes |
| GO:0009967 | positive regulation of signal transduction | 27.9070 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.9070 | 6 | no |
| GO:0031346 | positive regulation of cell projection organization | 25.5814 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 25.5814 | 4 | no |
| GO:0008104 | protein localization | 25.5814 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.5814 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.5814 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.5814 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5814 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.5814 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.5814 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5814 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 25.5814 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.5814 | 5 | no |
| GO:0050807 | regulation of synapse organization | 25.5814 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.2558 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.2558 | 6 | yes |
| GO:0007612 | learning | 23.2558 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.2558 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.2558 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.2558 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 23.2558 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.2558 | 5 | no |
| GO:0060284 | regulation of cell development | 23.2558 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 23.2558 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.2558 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.2558 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.2558 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.2558 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.2558 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.2558 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.2558 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.2558 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.9302 | 6 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 20.9302 | 5 | yes |
| GO:0051050 | positive regulation of transport | 20.9302 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 20.9302 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.9302 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.9302 | 4 | no |
| GO:0050767 | regulation of neurogenesis | 20.9302 | 6 | no |
| GO:0051960 | regulation of nervous system development | 20.9302 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 20.9302 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.9302 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 20.9302 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 20.9302 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 18.6047 | 7 | yes |
| GO:0010959 | regulation of metal ion transport | 18.6047 | 6 | yes |
| GO:0007411 | axon guidance | 16.2791 | 8 | yes |
| GO:0097485 | neuron projection guidance | 16.2791 | 7 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 13.9535 | 5 | yes |
| GO:0007219 | Notch signaling pathway | 11.6279 | 4 | yes |
| GO:0010976 | positive regulation of neuron projection development | 11.6279 | 7 | yes |
| GO:0007420 | brain development | 6.9767 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 6.9767 | 4 | yes |
| GO:0002028 | regulation of sodium ion transport | 4.6512 | 7 | yes |
| GO:0010467 | gene expression | 4.6512 | 5 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 4.6512 | 6 | yes |
| GO:0032288 | myelin assembly | 4.6512 | 4 | yes |
| GO:0032289 | central nervous system myelin formation | 4.6512 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
| NOTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOTC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN3A_HUMAN | [view interactions] | Low throughput | no | yes |
| MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP25_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRB_HUMAN | [view interactions] | Low throughput | no | yes |
| CNTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROP1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |