CNTN1_HUMAN
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CNTN1_HUMAN |
---|---|---|---|---|
GO:0098631 | cell adhesion mediator activity | 17.5000 | 4 | yes |
GO:0098632 | cell-cell adhesion mediator activity | 17.5000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CNTN1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 65.0000 | 4 | yes |
GO:0030030 | cell projection organization | 55.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 52.5000 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 50.0000 | 5 | yes |
GO:0022607 | cellular component assembly | 47.5000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.5000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 47.5000 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 47.5000 | 6 | yes |
GO:0010646 | regulation of cell communication | 47.5000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 45.0000 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
GO:0031175 | neuron projection development | 42.5000 | 6 | yes |
GO:0031323 | regulation of cellular metabolic process | 42.5000 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 42.5000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | yes |
GO:0050890 | cognition | 37.5000 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
GO:0034330 | cell junction organization | 37.5000 | 4 | no |
GO:0050808 | synapse organization | 37.5000 | 5 | no |
GO:0010468 | regulation of gene expression | 35.0000 | 5 | yes |
GO:0010975 | regulation of neuron projection development | 35.0000 | 7 | yes |
GO:0031399 | regulation of protein modification process | 35.0000 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 32.5000 | 6 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 32.5000 | 5 | yes |
GO:0042325 | regulation of phosphorylation | 32.5000 | 7 | yes |
GO:0043269 | regulation of ion transport | 32.5000 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.5000 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 32.5000 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 32.5000 | 6 | yes |
GO:0006996 | organelle organization | 32.5000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 32.5000 | 5 | no |
GO:0023056 | positive regulation of signaling | 32.5000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 27.5000 | 6 | yes |
GO:0031346 | positive regulation of cell projection organization | 27.5000 | 6 | yes |
GO:0042327 | positive regulation of phosphorylation | 27.5000 | 8 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 27.5000 | 7 | yes |
GO:0051050 | positive regulation of transport | 27.5000 | 4 | yes |
GO:0007612 | learning | 27.5000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.5000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.5000 | 5 | no |
GO:0045595 | regulation of cell differentiation | 27.5000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 27.5000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 27.5000 | 4 | no |
GO:0008104 | protein localization | 27.5000 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | yes |
GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | yes |
GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0050807 | regulation of synapse organization | 25.0000 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | no |
GO:0032880 | regulation of protein localization | 22.5000 | 5 | no |
GO:0043933 | protein-containing complex organization | 22.5000 | 4 | no |
GO:0060341 | regulation of cellular localization | 22.5000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 22.5000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.5000 | 4 | no |
GO:0009894 | regulation of catabolic process | 22.5000 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.5000 | 4 | no |
GO:0030162 | regulation of proteolysis | 22.5000 | 6 | no |
GO:0031329 | regulation of cellular catabolic process | 22.5000 | 5 | no |
GO:0042981 | regulation of apoptotic process | 22.5000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 22.5000 | 5 | no |
GO:1904062 | regulation of cation transmembrane transport | 22.5000 | 6 | no |
GO:0007411 | axon guidance | 20.0000 | 8 | yes |
GO:0010628 | positive regulation of gene expression | 20.0000 | 6 | yes |
GO:0010959 | regulation of metal ion transport | 20.0000 | 6 | yes |
GO:0043270 | positive regulation of ion transport | 20.0000 | 5 | yes |
GO:0097485 | neuron projection guidance | 20.0000 | 7 | yes |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 17.5000 | 8 | yes |
GO:0007420 | brain development | 15.0000 | 4 | yes |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15.0000 | 9 | yes |
GO:0007219 | Notch signaling pathway | 12.5000 | 4 | yes |
GO:0010976 | positive regulation of neuron projection development | 12.5000 | 7 | yes |
GO:0002028 | regulation of sodium ion transport | 5.0000 | 7 | yes |
GO:0010765 | positive regulation of sodium ion transport | 5.0000 | 6 | yes |
GO:0032288 | myelin assembly | 5.0000 | 4 | yes |
GO:0032289 | central nervous system myelin formation | 5.0000 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CNTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
NOTC2_HUMAN | [view interactions] | Low throughput | no | yes |
CNTP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCN3A_HUMAN | [view interactions] | Low throughput | no | yes |
PTPRB_HUMAN | [view interactions] | Low throughput | no | yes |
CNTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PROP1_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K1C18_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPR37_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HXB5_HUMAN | [view interactions] | High throughput | no | no |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
CEA21_HUMAN | [view interactions] | High throughput | no | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
SIGL1_HUMAN | [view interactions] | High throughput | no | no |
PCDGD_HUMAN | [view interactions] | High throughput | no | no |
CXB7_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MED21_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K1C17_HUMAN | [view interactions] | High throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
MAGA3_HUMAN | [view interactions] | High throughput | no | no |
MYH4_HUMAN | [view interactions] | High throughput | no | no |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RYK_HUMAN | [view interactions] | High throughput | no | no |
STMN3_HUMAN | [view interactions] | High throughput | no | yes |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TENA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
QCR6_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
L1CAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NICA_HUMAN | [view interactions] | Computational | no | yes |
NRCAM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PSN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
APH1B_HUMAN | [view interactions] | Computational | no | no |
NFASC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
APH1A_HUMAN | [view interactions] | Computational | no | yes |
PEN2_HUMAN | [view interactions] | Computational | no | yes |