Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CNTN1_HUMAN

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CNTN1_HUMAN
GO:0098631 cell adhesion mediator activity 17.5000 4 yes
GO:0098632 cell-cell adhesion mediator activity 17.5000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CNTN1_HUMAN
GO:0048522 positive regulation of cellular process 70.0000 4 yes
GO:0051128 regulation of cellular component organization 65.0000 4 yes
GO:0030030 cell projection organization 55.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.5000 4 yes
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 yes
GO:0022607 cellular component assembly 47.5000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.5000 4 yes
GO:0080090 regulation of primary metabolic process 47.5000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.5000 6 yes
GO:0010646 regulation of cell communication 47.5000 4 no
GO:0051246 regulation of protein metabolic process 45.0000 5 yes
GO:0048523 negative regulation of cellular process 45.0000 4 no
GO:0031175 neuron projection development 42.5000 6 yes
GO:0031323 regulation of cellular metabolic process 42.5000 4 yes
GO:0051130 positive regulation of cellular component organization 42.5000 5 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 yes
GO:0050890 cognition 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0034330 cell junction organization 37.5000 4 no
GO:0050808 synapse organization 37.5000 5 no
GO:0010468 regulation of gene expression 35.0000 5 yes
GO:0010975 regulation of neuron projection development 35.0000 7 yes
GO:0031399 regulation of protein modification process 35.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 32.5000 6 yes
GO:0031325 positive regulation of cellular metabolic process 32.5000 5 yes
GO:0042325 regulation of phosphorylation 32.5000 7 yes
GO:0043269 regulation of ion transport 32.5000 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 32.5000 5 yes
GO:0051174 regulation of phosphorus metabolic process 32.5000 5 yes
GO:0051247 positive regulation of protein metabolic process 32.5000 6 yes
GO:0006996 organelle organization 32.5000 4 no
GO:0010647 positive regulation of cell communication 32.5000 5 no
GO:0023056 positive regulation of signaling 32.5000 4 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 27.5000 6 yes
GO:0031346 positive regulation of cell projection organization 27.5000 6 yes
GO:0042327 positive regulation of phosphorylation 27.5000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 27.5000 7 yes
GO:0051050 positive regulation of transport 27.5000 4 yes
GO:0007612 learning 27.5000 4 no
GO:0009892 negative regulation of metabolic process 27.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5000 5 no
GO:0045595 regulation of cell differentiation 27.5000 4 no
GO:0048584 positive regulation of response to stimulus 27.5000 4 no
GO:0051094 positive regulation of developmental process 27.5000 4 no
GO:0008104 protein localization 27.5000 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 yes
GO:0031401 positive regulation of protein modification process 25.0000 7 yes
GO:0010941 regulation of cell death 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0032880 regulation of protein localization 22.5000 5 no
GO:0043933 protein-containing complex organization 22.5000 4 no
GO:0060341 regulation of cellular localization 22.5000 4 no
GO:0009967 positive regulation of signal transduction 22.5000 5 no
GO:0051240 positive regulation of multicellular organismal process 22.5000 4 no
GO:0009894 regulation of catabolic process 22.5000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.5000 4 no
GO:0030162 regulation of proteolysis 22.5000 6 no
GO:0031329 regulation of cellular catabolic process 22.5000 5 no
GO:0042981 regulation of apoptotic process 22.5000 6 no
GO:0043067 regulation of programmed cell death 22.5000 5 no
GO:1904062 regulation of cation transmembrane transport 22.5000 6 no
GO:0007411 axon guidance 20.0000 8 yes
GO:0010628 positive regulation of gene expression 20.0000 6 yes
GO:0010959 regulation of metal ion transport 20.0000 6 yes
GO:0043270 positive regulation of ion transport 20.0000 5 yes
GO:0097485 neuron projection guidance 20.0000 7 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 17.5000 8 yes
GO:0007420 brain development 15.0000 4 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 15.0000 9 yes
GO:0007219 Notch signaling pathway 12.5000 4 yes
GO:0010976 positive regulation of neuron projection development 12.5000 7 yes
GO:0002028 regulation of sodium ion transport 5.0000 7 yes
GO:0010765 positive regulation of sodium ion transport 5.0000 6 yes
GO:0032288 myelin assembly 5.0000 4 yes
GO:0032289 central nervous system myelin formation 5.0000 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN1B_HUMAN [view interactions] Low throughput no no
NOTC1_HUMAN [view interactions] Low throughput no yes
NOTC2_HUMAN [view interactions] Low throughput no yes
CNTP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN3A_HUMAN [view interactions] Low throughput no yes
PTPRB_HUMAN [view interactions] Low throughput no yes
CNTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PROP1_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
K1C18_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
INSR_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
GPR37_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
HXB5_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
CEA21_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
CCNL2_HUMAN [view interactions] High throughput no yes
PCDGK_HUMAN [view interactions] High throughput no yes
SIGL1_HUMAN [view interactions] High throughput no no
PCDGD_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
MED21_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C17_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
MYH4_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FCGRN_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view interactions] High throughput no no
STMN3_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
TENA_HUMAN [view entry] [view interactions] High throughput yes no
TENR_HUMAN [view entry] [view interactions] High throughput yes no
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
L1CAM_HUMAN [view entry] [view interactions] Computational yes yes
PSN2_HUMAN [view entry] [view interactions] Computational yes no
NICA_HUMAN [view interactions] Computational no yes
NRCAM_HUMAN [view entry] [view interactions] Computational yes no
PSN1_HUMAN [view entry] [view interactions] Computational yes yes
APH1B_HUMAN [view interactions] Computational no no
NFASC_HUMAN [view entry] [view interactions] Computational yes yes
APH1A_HUMAN [view interactions] Computational no yes
PEN2_HUMAN [view interactions] Computational no yes