Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TENR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TENR_HUMAN
GO:0019900 kinase binding 28.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TENR_HUMAN
GO:0048522 positive regulation of cellular process 76.0000 4 yes
GO:0010646 regulation of cell communication 68.0000 4 yes
GO:0051128 regulation of cellular component organization 64.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.0000 4 no
GO:0031323 regulation of cellular metabolic process 52.0000 4 no
GO:0030030 cell projection organization 48.0000 4 yes
GO:0009966 regulation of signal transduction 48.0000 4 no
GO:0022607 cellular component assembly 48.0000 4 no
GO:0080090 regulation of primary metabolic process 48.0000 4 no
GO:0009893 positive regulation of metabolic process 44.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.0000 5 no
GO:0051246 regulation of protein metabolic process 44.0000 5 no
GO:0031344 regulation of cell projection organization 40.0000 5 yes
GO:0120036 plasma membrane bounded cell projection organization 40.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 36.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 36.0000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.0000 6 yes
GO:0001932 regulation of protein phosphorylation 36.0000 7 no
GO:0006996 organelle organization 36.0000 4 no
GO:0042325 regulation of phosphorylation 36.0000 7 no
GO:0051247 positive regulation of protein metabolic process 36.0000 6 no
GO:0010647 positive regulation of cell communication 32.0000 5 yes
GO:0023056 positive regulation of signaling 32.0000 4 yes
GO:0050890 cognition 32.0000 4 yes
GO:0009889 regulation of biosynthetic process 32.0000 4 no
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0010468 regulation of gene expression 32.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 32.0000 5 no
GO:0042127 regulation of cell population proliferation 32.0000 4 no
GO:0051049 regulation of transport 32.0000 4 no
GO:0031175 neuron projection development 28.0000 6 yes
GO:0045595 regulation of cell differentiation 28.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 28.0000 8 no
GO:0008104 protein localization 28.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.0000 6 no
GO:0031401 positive regulation of protein modification process 28.0000 7 no
GO:0042327 positive regulation of phosphorylation 28.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.0000 7 no
GO:0031324 negative regulation of cellular metabolic process 28.0000 5 no
GO:0044087 regulation of cellular component biogenesis 28.0000 4 no
GO:0051248 negative regulation of protein metabolic process 28.0000 6 no
GO:0010648 negative regulation of cell communication 24.0000 5 yes
GO:0023057 negative regulation of signaling 24.0000 4 yes
GO:0048585 negative regulation of response to stimulus 24.0000 4 yes
GO:0050767 regulation of neurogenesis 24.0000 6 yes
GO:0051240 positive regulation of multicellular organismal process 24.0000 4 yes
GO:0051960 regulation of nervous system development 24.0000 5 yes
GO:0060284 regulation of cell development 24.0000 5 yes
GO:2000026 regulation of multicellular organismal development 24.0000 4 yes
GO:0009967 positive regulation of signal transduction 24.0000 5 no
GO:0048584 positive regulation of response to stimulus 24.0000 4 no
GO:1902531 regulation of intracellular signal transduction 24.0000 5 no
GO:0043933 protein-containing complex organization 24.0000 4 no
GO:0051130 positive regulation of cellular component organization 24.0000 5 no
GO:0051094 positive regulation of developmental process 24.0000 4 no
GO:0043085 positive regulation of catalytic activity 24.0000 4 no
GO:0043269 regulation of monoatomic ion transport 24.0000 5 no
GO:0007612 learning 20.0000 4 yes
GO:0010975 regulation of neuron projection development 20.0000 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.0000 4 yes
GO:0051129 negative regulation of cellular component organization 20.0000 5 yes
GO:0007411 axon guidance 16.0000 8 yes
GO:0030155 regulation of cell adhesion 16.0000 4 yes
GO:0031644 regulation of nervous system process 16.0000 5 yes
GO:0034330 cell junction organization 16.0000 4 yes
GO:0044057 regulation of system process 16.0000 4 yes
GO:0050806 positive regulation of synaptic transmission 16.0000 5 yes
GO:0050808 synapse organization 16.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 16.0000 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 16.0000 6 yes
GO:0080134 regulation of response to stress 16.0000 4 yes
GO:0097485 neuron projection guidance 16.0000 7 yes
GO:0007268 chemical synaptic transmission 12.0000 7 yes
GO:0022407 regulation of cell-cell adhesion 12.0000 5 yes
GO:0032101 regulation of response to external stimulus 12.0000 4 yes
GO:0032102 negative regulation of response to external stimulus 12.0000 5 yes
GO:0045926 negative regulation of growth 12.0000 4 yes
GO:0050905 neuromuscular process 12.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 12.0000 6 yes
GO:0099536 synaptic signaling 12.0000 4 yes
GO:0099537 trans-synaptic signaling 12.0000 5 yes
GO:0001558 regulation of cell growth 8.0000 4 yes
GO:0007162 negative regulation of cell adhesion 8.0000 5 yes
GO:0008306 associative learning 8.0000 5 yes
GO:0022408 negative regulation of cell-cell adhesion 8.0000 6 yes
GO:0030308 negative regulation of cell growth 8.0000 5 yes
GO:0030334 regulation of cell migration 8.0000 5 yes
GO:0031345 negative regulation of cell projection organization 8.0000 6 yes
GO:0035641 locomotory exploration behavior 8.0000 4 yes
GO:0045596 negative regulation of cell differentiation 8.0000 5 yes
GO:0048638 regulation of developmental growth 8.0000 4 yes
GO:0048640 negative regulation of developmental growth 8.0000 5 yes
GO:0050805 negative regulation of synaptic transmission 8.0000 5 yes
GO:0050885 neuromuscular process controlling balance 8.0000 5 yes
GO:0051093 negative regulation of developmental process 8.0000 4 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 8.0000 6 yes
GO:0051969 regulation of transmission of nerve impulse 8.0000 5 yes
GO:0080135 regulation of cellular response to stress 8.0000 4 yes
GO:1990138 neuron projection extension 8.0000 4 yes
GO:2000145 regulation of cell motility 8.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PGCA_HUMAN [view interactions] Low throughput no no
PGCB_HUMAN [view entry] [view interactions] Low throughput yes yes
IL34_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TLR4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
MAGB4_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RPC3_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
PPL13_HUMAN [view interactions] High throughput no no
CC146_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
CSN8_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes