Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TENR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TENR_HUMAN
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 26.9231 5 no
GO:0046872 metal ion binding 26.9231 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TENR_HUMAN
GO:0048522 positive regulation of cellular process 73.0769 4 yes
GO:0010646 regulation of cell communication 65.3846 4 yes
GO:0048523 negative regulation of cellular process 61.5385 4 yes
GO:0051128 regulation of cellular component organization 57.6923 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.6923 4 no
GO:0009966 regulation of signal transduction 53.8462 4 no
GO:0031323 regulation of cellular metabolic process 53.8462 4 no
GO:0051171 regulation of nitrogen compound metabolic process 53.8462 4 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0030030 cell projection organization 50.0000 4 yes
GO:0001932 regulation of protein phosphorylation 46.1538 7 no
GO:0010604 positive regulation of macromolecule metabolic process 46.1538 5 no
GO:0019220 regulation of phosphate metabolic process 46.1538 6 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0031399 regulation of protein modification process 46.1538 6 no
GO:0042325 regulation of phosphorylation 46.1538 7 no
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 no
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.3077 5 no
GO:0031344 regulation of cell projection organization 42.3077 5 yes
GO:0050890 cognition 38.4615 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 yes
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 yes
GO:0008104 protein localization 38.4615 4 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 38.4615 5 no
GO:0051247 positive regulation of protein metabolic process 38.4615 6 no
GO:0010647 positive regulation of cell communication 38.4615 5 yes
GO:0023056 positive regulation of signaling 38.4615 4 yes
GO:0050804 modulation of chemical synaptic transmission 34.6154 5 yes
GO:0099177 regulation of trans-synaptic signaling 34.6154 4 yes
GO:0043269 regulation of ion transport 34.6154 5 no
GO:0001934 positive regulation of protein phosphorylation 34.6154 8 no
GO:0010468 regulation of gene expression 34.6154 5 no
GO:0010562 positive regulation of phosphorus metabolic process 34.6154 6 no
GO:0031324 negative regulation of cellular metabolic process 34.6154 5 no
GO:0031401 positive regulation of protein modification process 34.6154 7 no
GO:0042327 positive regulation of phosphorylation 34.6154 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.6154 7 no
GO:0051248 negative regulation of protein metabolic process 34.6154 6 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0080134 regulation of response to stress 26.9231 4 yes
GO:0051050 positive regulation of transport 26.9231 4 no
GO:0009889 regulation of biosynthetic process 26.9231 4 no
GO:0010556 regulation of macromolecule biosynthetic process 26.9231 5 no
GO:0031326 regulation of cellular biosynthetic process 26.9231 5 no
GO:0010941 regulation of cell death 26.9231 4 no
GO:0043549 regulation of kinase activity 26.9231 5 no
GO:0045859 regulation of protein kinase activity 26.9231 6 no
GO:0051338 regulation of transferase activity 26.9231 4 no
GO:1902531 regulation of intracellular signal transduction 26.9231 5 no
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0010648 negative regulation of cell communication 26.9231 5 yes
GO:0023057 negative regulation of signaling 26.9231 4 yes
GO:0051129 negative regulation of cellular component organization 23.0769 5 yes
GO:0080135 regulation of cellular response to stress 23.0769 4 yes
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 no
GO:0032412 regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0034765 regulation of ion transmembrane transport 23.0769 5 no
GO:1904062 regulation of cation transmembrane transport 23.0769 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0042981 regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0060548 negative regulation of cell death 23.0769 5 no
GO:0006996 organelle organization 23.0769 4 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0007612 learning 23.0769 4 yes
GO:0010975 regulation of neuron projection development 23.0769 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 yes
GO:0031175 neuron projection development 23.0769 6 yes
GO:0045595 regulation of cell differentiation 23.0769 4 yes
GO:0050808 synapse organization 19.2308 5 yes
GO:0031644 regulation of nervous system process 19.2308 5 yes
GO:0034330 cell junction organization 19.2308 4 yes
GO:0044057 regulation of system process 19.2308 4 yes
GO:0048585 negative regulation of response to stimulus 19.2308 4 yes
GO:0050806 positive regulation of synaptic transmission 15.3846 5 yes
GO:0051093 negative regulation of developmental process 15.3846 4 yes
GO:0051240 positive regulation of multicellular organismal process 15.3846 4 yes
GO:2000026 regulation of multicellular organismal development 15.3846 4 yes
GO:2000145 regulation of cell motility 15.3846 4 yes
GO:0030155 regulation of cell adhesion 15.3846 4 yes
GO:0030334 regulation of cell migration 15.3846 5 yes
GO:0045596 negative regulation of cell differentiation 15.3846 5 yes
GO:0050805 negative regulation of synaptic transmission 11.5385 5 yes
GO:0051241 negative regulation of multicellular organismal process 11.5385 4 yes
GO:0051960 regulation of nervous system development 11.5385 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 11.5385 6 yes
GO:0060284 regulation of cell development 11.5385 5 yes
GO:0097485 neuron projection guidance 11.5385 7 yes
GO:0007411 axon guidance 11.5385 8 yes
GO:0008306 associative learning 11.5385 5 yes
GO:0022407 regulation of cell-cell adhesion 11.5385 5 yes
GO:0030198 extracellular matrix organization 11.5385 5 yes
GO:0031345 negative regulation of cell projection organization 11.5385 6 yes
GO:0043062 extracellular structure organization 11.5385 4 yes
GO:0045229 external encapsulating structure organization 11.5385 4 yes
GO:0045926 negative regulation of growth 11.5385 4 yes
GO:0050767 regulation of neurogenesis 11.5385 6 yes
GO:0050885 neuromuscular process controlling balance 7.6923 5 yes
GO:0050905 neuromuscular process 7.6923 4 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 7.6923 6 yes
GO:0051969 regulation of transmission of nerve impulse 7.6923 4 yes
GO:1903034 regulation of response to wounding 7.6923 5 yes
GO:0001558 regulation of cell growth 7.6923 4 yes
GO:0007162 negative regulation of cell adhesion 7.6923 5 yes
GO:0010977 negative regulation of neuron projection development 7.6923 7 yes
GO:0022408 negative regulation of cell-cell adhesion 7.6923 6 yes
GO:0030308 negative regulation of cell growth 7.6923 5 yes
GO:0035641 locomotory exploration behavior 7.6923 4 yes
GO:0048638 regulation of developmental growth 7.6923 4 yes
GO:0048640 negative regulation of developmental growth 7.6923 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PGCA_HUMAN [view interactions] Low throughput no no
PGCB_HUMAN [view entry] [view interactions] Low throughput yes yes
IL34_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TLR4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
MAGB4_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RPC3_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
PPL13_HUMAN [view interactions] High throughput no no
CC146_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CSN8_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
ITA8_HUMAN [view entry] [view interactions] Computational yes no
ITAV_HUMAN [view interactions] Computational no yes
ITB6_HUMAN [view interactions] Computational no no
ITA9_HUMAN [view interactions] Computational no no
SDC4_HUMAN [view interactions] Computational no yes
ITB3_HUMAN [view entry] [view interactions] Computational yes no
SDC1_HUMAN [view interactions] Computational no no