Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCAN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCAN_HUMAN
GO:0046872 metal ion binding 26.0870 4 yes
GO:0005509 calcium ion binding 8.6957 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NCAN_HUMAN
GO:0048522 positive regulation of cellular process 65.2174 4 no
GO:0010646 regulation of cell communication 60.8696 4 no
GO:0051128 regulation of cellular component organization 60.8696 4 no
GO:0030030 cell projection organization 60.8696 4 no
GO:0031175 neuron projection development 52.1739 6 no
GO:0120036 plasma membrane bounded cell projection organization 52.1739 5 no
GO:0009966 regulation of signal transduction 47.8261 4 no
GO:0031344 regulation of cell projection organization 47.8261 5 no
GO:0045595 regulation of cell differentiation 47.8261 4 no
GO:0048523 negative regulation of cellular process 47.8261 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.8261 6 no
GO:0010975 regulation of neuron projection development 43.4783 7 no
GO:0050890 cognition 43.4783 4 no
GO:0022603 regulation of anatomical structure morphogenesis 39.1304 4 no
GO:0034330 cell junction organization 39.1304 4 no
GO:0050808 synapse organization 39.1304 5 no
GO:0050804 modulation of chemical synaptic transmission 34.7826 5 no
GO:0051094 positive regulation of developmental process 34.7826 4 no
GO:0051960 regulation of nervous system development 34.7826 5 no
GO:0060255 regulation of macromolecule metabolic process 34.7826 4 no
GO:0060284 regulation of cell development 34.7826 5 no
GO:0099177 regulation of trans-synaptic signaling 34.7826 4 no
GO:2000026 regulation of multicellular organismal development 34.7826 4 no
GO:0044087 regulation of cellular component biogenesis 30.4348 4 no
GO:0009893 positive regulation of metabolic process 30.4348 4 no
GO:0010468 regulation of gene expression 30.4348 5 no
GO:0045597 positive regulation of cell differentiation 30.4348 5 no
GO:0050767 regulation of neurogenesis 30.4348 6 no
GO:0051240 positive regulation of multicellular organismal process 30.4348 4 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0050807 regulation of synapse organization 26.0870 5 no
GO:0060341 regulation of cellular localization 26.0870 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.0870 5 no
GO:0010720 positive regulation of cell development 26.0870 6 no
GO:0048638 regulation of developmental growth 26.0870 4 no
GO:0050770 regulation of axonogenesis 26.0870 5 no
GO:0051130 positive regulation of cellular component organization 26.0870 5 no
GO:0051171 regulation of nitrogen compound metabolic process 26.0870 4 no
GO:0051962 positive regulation of nervous system development 26.0870 5 no
GO:0080090 regulation of primary metabolic process 26.0870 4 no
GO:0051049 regulation of transport 26.0870 4 no
GO:0007411 axon guidance 26.0870 8 no
GO:0097485 neuron projection guidance 26.0870 7 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 21.7391 4 no
GO:0001558 regulation of cell growth 21.7391 4 no
GO:0006996 organelle organization 21.7391 4 no
GO:0010941 regulation of cell death 21.7391 4 no
GO:0031323 regulation of cellular metabolic process 21.7391 4 no
GO:0043085 positive regulation of catalytic activity 21.7391 4 no
GO:0050769 positive regulation of neurogenesis 21.7391 6 no
GO:0051093 negative regulation of developmental process 21.7391 4 no
GO:0051129 negative regulation of cellular component organization 21.7391 5 no
GO:0051246 regulation of protein metabolic process 21.7391 5 no
GO:0080134 regulation of response to stress 21.7391 4 no
GO:1901214 regulation of neuron death 21.7391 5 no
GO:0008104 protein localization 21.7391 4 no
GO:0007612 learning 21.7391 4 no
GO:0010648 negative regulation of cell communication 21.7391 5 no
GO:0023057 negative regulation of signaling 21.7391 4 no
GO:0007417 central nervous system development 8.6957 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NCAM1_HUMAN [view entry] [view interactions] Low throughput yes no
L1CAM_HUMAN [view entry] [view interactions] Low throughput yes yes
TENR_HUMAN [view entry] [view interactions] Low throughput yes no
HMGB1_HUMAN [view interactions] Low throughput no yes
CNTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CHSTC_HUMAN [view interactions] Computational no yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
XYLT2_HUMAN [view interactions] Computational no no
CHST3_HUMAN [view interactions] Computational no yes
XYLT1_HUMAN [view interactions] Computational no yes
GPC4_HUMAN [view entry] [view interactions] Computational yes yes
CHST9_HUMAN [view interactions] Computational no yes
CHSS1_HUMAN [view interactions] Computational no no
PGBM_HUMAN [view interactions] Computational no no
CGAT1_HUMAN [view interactions] Computational no no
CSPG5_HUMAN [view entry] [view interactions] Computational yes yes
B3GA2_HUMAN [view interactions] Computational no no
CHPF2_HUMAN [view interactions] Computational no yes
DSE_HUMAN [view interactions] Computational no yes
CHSTB_HUMAN [view interactions] Computational no yes
CHSS3_HUMAN [view interactions] Computational no no
B4GT7_HUMAN [view interactions] Computational no yes
UST_HUMAN [view interactions] Computational no yes
B3GA1_HUMAN [view interactions] Computational no yes
CHSS2_HUMAN [view interactions] Computational no yes
SDC1_HUMAN [view interactions] Computational no no
CHSTD_HUMAN [view interactions] Computational no no
CGAT2_HUMAN [view interactions] Computational no yes
B3GA3_HUMAN [view entry] [view interactions] Computational yes yes
B3GT6_HUMAN [view interactions] Computational no no
SDC3_HUMAN [view interactions] Computational no yes
NCHL1_HUMAN [view entry] [view interactions] Computational yes yes
PTPRZ_HUMAN [view entry] [view interactions] Computational yes yes
SDC2_HUMAN [view interactions] Computational no yes
DSEL_HUMAN [view interactions] Computational no no
SDC4_HUMAN [view interactions] Computational no yes
GPC2_HUMAN [view interactions] Computational no no
CHST7_HUMAN [view interactions] Computational no yes
GPC1_HUMAN [view entry] [view interactions] Computational yes no
GPC5_HUMAN [view interactions] Computational no yes
GPC6_HUMAN [view entry] [view interactions] Computational yes yes
GPC3_HUMAN [view interactions] Computational no no
CHSTF_HUMAN [view interactions] Computational no yes
CHSTE_HUMAN [view interactions] Computational no no