Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCAN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCAN_HUMAN
GO:0043169 cation binding 23.5294 4 yes
GO:0046872 metal ion binding 23.5294 5 yes
GO:0003779 actin binding 23.5294 4 no
GO:0017124 SH3 domain binding 23.5294 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NCAN_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0030030 cell projection organization 64.7059 4 no
GO:0051128 regulation of cellular component organization 64.7059 4 no
GO:0031175 neuron projection development 58.8235 6 no
GO:0120036 plasma membrane bounded cell projection organization 58.8235 5 no
GO:0010646 regulation of cell communication 58.8235 4 no
GO:0034330 cell junction organization 52.9412 4 no
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0045595 regulation of cell differentiation 47.0588 4 yes
GO:2000026 regulation of multicellular organismal development 47.0588 4 yes
GO:0010975 regulation of neuron projection development 47.0588 7 no
GO:0031344 regulation of cell projection organization 47.0588 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.0588 6 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0050808 synapse organization 47.0588 5 no
GO:0050767 regulation of neurogenesis 41.1765 6 yes
GO:0051960 regulation of nervous system development 41.1765 5 yes
GO:0060284 regulation of cell development 41.1765 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 41.1765 4 no
GO:0050890 cognition 41.1765 4 no
GO:0031323 regulation of cellular metabolic process 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0051240 positive regulation of multicellular organismal process 35.2941 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.2941 5 no
GO:0099177 regulation of trans-synaptic signaling 35.2941 4 no
GO:0001558 regulation of cell growth 35.2941 4 no
GO:0009889 regulation of biosynthetic process 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 no
GO:0010720 positive regulation of cell development 29.4118 6 yes
GO:0042127 regulation of cell population proliferation 29.4118 4 yes
GO:0045597 positive regulation of cell differentiation 29.4118 5 yes
GO:0050769 positive regulation of neurogenesis 29.4118 6 yes
GO:0051094 positive regulation of developmental process 29.4118 4 yes
GO:0051962 positive regulation of nervous system development 29.4118 5 yes
GO:0008104 protein localization 29.4118 4 no
GO:0051130 positive regulation of cellular component organization 29.4118 5 no
GO:0007411 axon guidance 29.4118 8 no
GO:0048638 regulation of developmental growth 29.4118 4 no
GO:0050770 regulation of axonogenesis 29.4118 5 no
GO:0097485 neuron projection guidance 29.4118 7 no
GO:0032101 regulation of response to external stimulus 23.5294 4 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:0006996 organelle organization 23.5294 4 no
GO:0007612 learning 23.5294 4 no
GO:0022607 cellular component assembly 23.5294 4 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0050807 regulation of synapse organization 23.5294 5 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0051493 regulation of cytoskeleton organization 23.5294 6 no
GO:1902903 regulation of supramolecular fiber organization 23.5294 5 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0030155 regulation of cell adhesion 23.5294 4 no
GO:0030334 regulation of cell migration 23.5294 5 no
GO:0030516 regulation of axon extension 23.5294 5 no
GO:0051093 negative regulation of developmental process 23.5294 4 no
GO:0061387 regulation of extent of cell growth 23.5294 5 no
GO:2000145 regulation of cell motility 23.5294 4 no
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0009893 positive regulation of metabolic process 23.5294 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.5294 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 no
GO:0030307 positive regulation of cell growth 23.5294 5 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0045927 positive regulation of growth 23.5294 4 no
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:0080090 regulation of primary metabolic process 23.5294 4 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0008284 positive regulation of cell population proliferation 17.6471 5 yes
GO:2000177 regulation of neural precursor cell proliferation 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NCAM1_HUMAN [view entry] [view interactions] Low throughput yes no
L1CAM_HUMAN [view entry] [view interactions] Low throughput yes yes
TENR_HUMAN [view entry] [view interactions] Low throughput yes no
HMGB1_HUMAN [view interactions] Low throughput no yes
CNTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
UBA6_HUMAN [view interactions] High throughput no no
DNLI1_HUMAN [view interactions] High throughput no yes
MAT1_HUMAN [view interactions] High throughput no yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CMTR1_HUMAN [view interactions] High throughput no yes