Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TENA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TENA_HUMAN
GO:0046872 metal ion binding 50.0000 4 no
GO:0002020 protease binding 31.2500 4 no
GO:0019900 kinase binding 31.2500 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0045545 syndecan binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TENA_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0009893 positive regulation of metabolic process 81.2500 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 81.2500 5 yes
GO:0060255 regulation of macromolecule metabolic process 81.2500 4 yes
GO:0010468 regulation of gene expression 75.0000 5 yes
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 62.5000 5 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0010646 regulation of cell communication 56.2500 4 no
GO:0051049 regulation of transport 56.2500 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0010628 positive regulation of gene expression 50.0000 6 yes
GO:0051050 positive regulation of transport 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0023056 positive regulation of signaling 43.7500 4 no
GO:0043085 positive regulation of catalytic activity 43.7500 4 no
GO:0060341 regulation of cellular localization 43.7500 4 no
GO:0051129 negative regulation of cellular component organization 43.7500 5 no
GO:0051248 negative regulation of protein metabolic process 43.7500 6 no
GO:0030030 cell projection organization 43.7500 4 yes
GO:0042127 regulation of cell population proliferation 43.7500 4 yes
GO:0080134 regulation of response to stress 43.7500 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 43.7500 6 no
GO:0019220 regulation of phosphate metabolic process 43.7500 6 no
GO:0022607 cellular component assembly 43.7500 4 no
GO:0031399 regulation of protein modification process 43.7500 6 no
GO:0042325 regulation of phosphorylation 43.7500 7 no
GO:0042327 positive regulation of phosphorylation 43.7500 8 no
GO:0045937 positive regulation of phosphate metabolic process 43.7500 7 no
GO:0051174 regulation of phosphorus metabolic process 43.7500 5 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0010648 negative regulation of cell communication 37.5000 5 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0010942 positive regulation of cell death 37.5000 5 no
GO:0023057 negative regulation of signaling 37.5000 4 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:1901701 cellular response to oxygen-containing compound 37.5000 4 no
GO:0030162 regulation of proteolysis 37.5000 6 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0051347 positive regulation of transferase activity 37.5000 5 no
GO:0006355 regulation of DNA-templated transcription 37.5000 6 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 37.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0006996 organelle organization 37.5000 4 no
GO:0009968 negative regulation of signal transduction 31.2500 5 no
GO:0042981 regulation of apoptotic process 31.2500 6 no
GO:0043065 positive regulation of apoptotic process 31.2500 7 no
GO:0043066 negative regulation of apoptotic process 31.2500 7 no
GO:0043067 regulation of programmed cell death 31.2500 5 no
GO:0043068 positive regulation of programmed cell death 31.2500 6 no
GO:0043069 negative regulation of programmed cell death 31.2500 6 no
GO:0048585 negative regulation of response to stimulus 31.2500 4 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0050890 cognition 31.2500 4 no
GO:0051093 negative regulation of developmental process 31.2500 4 no
GO:0060548 negative regulation of cell death 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:1902532 negative regulation of intracellular signal transduction 31.2500 6 no
GO:1903829 positive regulation of protein localization 31.2500 5 no
GO:0033043 regulation of organelle organization 31.2500 5 no
GO:0045859 regulation of protein kinase activity 31.2500 6 no
GO:0045860 positive regulation of protein kinase activity 31.2500 7 no
GO:0009891 positive regulation of biosynthetic process 31.2500 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0009894 regulation of catabolic process 31.2500 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0007613 memory 25.0000 4 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031334 positive regulation of protein-containing complex assembly 25.0000 6 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0032147 activation of protein kinase activity 25.0000 8 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 25.0000 8 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0032386 regulation of intracellular transport 25.0000 5 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 yes
GO:0030155 regulation of cell adhesion 25.0000 4 yes
GO:0031175 neuron projection development 25.0000 6 yes
GO:0031347 regulation of defense response 25.0000 5 yes
GO:0032101 regulation of response to external stimulus 25.0000 4 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0050727 regulation of inflammatory response 25.0000 5 yes
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0000904 cell morphogenesis involved in differentiation 25.0000 4 no
GO:0007229 integrin-mediated signaling pathway 25.0000 4 no
GO:0001558 regulation of cell growth 18.7500 4 yes
GO:0002009 morphogenesis of an epithelium 18.7500 4 yes
GO:0050808 synapse organization 18.7500 5 yes
GO:0061564 axon development 18.7500 7 yes
GO:0001649 osteoblast differentiation 12.5000 4 yes
GO:0007528 neuromuscular junction development 12.5000 6 yes
GO:0014012 peripheral nervous system axon regeneration 12.5000 6 yes
GO:0031102 neuron projection regeneration 12.5000 4 yes
GO:0031103 axon regeneration 12.5000 5 yes
GO:0048678 response to axon injury 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CO5A1_HUMAN [view interactions] Low throughput no no
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
FINC_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
SMOC1_HUMAN [view interactions] Low throughput no no
PGK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
NID2_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
ITA7_HUMAN [view interactions] Low throughput no yes
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
SMOC2_HUMAN [view interactions] Low throughput no no
SPRC_HUMAN [view interactions] Low throughput no yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
CD40L_HUMAN [view interactions] Low throughput no no
TLR4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MBD1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TEN1_HUMAN [view interactions] High throughput no no
CILP1_HUMAN [view interactions] High throughput no no
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2_HUMAN [view interactions] Computational no yes
SDC1_HUMAN [view interactions] Computational no no
ITB3_HUMAN [view entry] [view interactions] Computational yes no
SDC4_HUMAN [view interactions] Computational no yes
ITA9_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
ITB6_HUMAN [view interactions] Computational no no
SAT1_HUMAN [view interactions] Computational no yes
ITAV_HUMAN [view interactions] Computational no yes
PAXI_HUMAN [view interactions] Computational no yes
PGCA_HUMAN [view interactions] Computational no no