Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TENA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TENA_HUMAN
GO:0043169 cation binding 52.9412 4 no
GO:0046872 metal ion binding 52.9412 5 no
GO:0019900 kinase binding 29.4118 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0002020 protease binding 23.5294 4 no
GO:0003723 RNA binding 23.5294 4 no
GO:0045545 syndecan binding 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TENA_HUMAN
GO:0048522 positive regulation of cellular process 94.1176 4 yes
GO:0009893 positive regulation of metabolic process 76.4706 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 76.4706 5 yes
GO:0031323 regulation of cellular metabolic process 76.4706 4 yes
GO:0048523 negative regulation of cellular process 76.4706 4 yes
GO:0060255 regulation of macromolecule metabolic process 76.4706 4 yes
GO:0009889 regulation of biosynthetic process 70.5882 4 yes
GO:0010468 regulation of gene expression 70.5882 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 70.5882 5 yes
GO:0031325 positive regulation of cellular metabolic process 70.5882 5 yes
GO:0031326 regulation of cellular biosynthetic process 70.5882 5 yes
GO:0051128 regulation of cellular component organization 64.7059 4 yes
GO:0009891 positive regulation of biosynthetic process 52.9412 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 52.9412 6 yes
GO:0030030 cell projection organization 52.9412 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 52.9412 6 yes
GO:0042127 regulation of cell population proliferation 52.9412 4 yes
GO:0010646 regulation of cell communication 52.9412 4 no
GO:0080090 regulation of primary metabolic process 52.9412 4 no
GO:0009892 negative regulation of metabolic process 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0010605 negative regulation of macromolecule metabolic process 47.0588 5 no
GO:0010628 positive regulation of gene expression 41.1765 7 yes
GO:0080134 regulation of response to stress 41.1765 4 yes
GO:1901701 cellular response to oxygen-containing compound 41.1765 4 yes
GO:0006996 organelle organization 41.1765 4 no
GO:0009894 regulation of catabolic process 41.1765 4 no
GO:0010648 negative regulation of cell communication 41.1765 5 no
GO:0023057 negative regulation of signaling 41.1765 4 no
GO:0031324 negative regulation of cellular metabolic process 41.1765 5 no
GO:0042981 regulation of apoptotic process 41.1765 5 no
GO:0043067 regulation of programmed cell death 41.1765 4 no
GO:0048585 negative regulation of response to stimulus 41.1765 4 no
GO:0051246 regulation of protein metabolic process 41.1765 5 no
GO:0051247 positive regulation of protein metabolic process 41.1765 6 no
GO:0006355 regulation of DNA-templated transcription 41.1765 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.1765 5 no
GO:0022607 cellular component assembly 41.1765 4 no
GO:0051049 regulation of transport 41.1765 4 no
GO:0051252 regulation of RNA metabolic process 41.1765 5 no
GO:2001141 regulation of RNA biosynthetic process 41.1765 6 no
GO:0051240 positive regulation of multicellular organismal process 41.1765 4 no
GO:0071310 cellular response to organic substance 35.2941 4 yes
GO:0120036 plasma membrane bounded cell projection organization 35.2941 5 yes
GO:0009968 negative regulation of signal transduction 35.2941 5 no
GO:0030162 regulation of proteolysis 35.2941 6 no
GO:0033043 regulation of organelle organization 35.2941 5 no
GO:0043065 positive regulation of apoptotic process 35.2941 6 no
GO:0043068 positive regulation of programmed cell death 35.2941 5 no
GO:0051248 negative regulation of protein metabolic process 35.2941 6 no
GO:0060341 regulation of cellular localization 35.2941 4 no
GO:0050890 cognition 35.2941 4 no
GO:0051241 negative regulation of multicellular organismal process 35.2941 4 no
GO:1902531 regulation of intracellular signal transduction 35.2941 5 no
GO:0051130 positive regulation of cellular component organization 35.2941 5 no
GO:0023056 positive regulation of signaling 35.2941 4 no
GO:2000026 regulation of multicellular organismal development 35.2941 4 no
GO:0045595 regulation of cell differentiation 35.2941 4 no
GO:0008284 positive regulation of cell population proliferation 29.4118 5 yes
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0036211 protein modification process 29.4118 4 no
GO:0043412 macromolecule modification 29.4118 4 no
GO:0051726 regulation of cell cycle 29.4118 4 no
GO:0009890 negative regulation of biosynthetic process 29.4118 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.4118 6 no
GO:0031327 negative regulation of cellular biosynthetic process 29.4118 6 no
GO:0043066 negative regulation of apoptotic process 29.4118 6 no
GO:0043069 negative regulation of programmed cell death 29.4118 5 no
GO:0043523 regulation of neuron apoptotic process 29.4118 6 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 no
GO:1902532 negative regulation of intracellular signal transduction 29.4118 6 no
GO:0051050 positive regulation of transport 29.4118 4 no
GO:0006357 regulation of transcription by RNA polymerase II 29.4118 8 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0050767 regulation of neurogenesis 29.4118 6 no
GO:0051960 regulation of nervous system development 29.4118 5 no
GO:0060284 regulation of cell development 29.4118 5 no
GO:0014070 response to organic cyclic compound 23.5294 4 yes
GO:0031175 neuron projection development 23.5294 6 yes
GO:0032101 regulation of response to external stimulus 23.5294 4 yes
GO:0033993 response to lipid 23.5294 4 yes
GO:0071396 cellular response to lipid 23.5294 5 yes
GO:0071407 cellular response to organic cyclic compound 23.5294 5 yes
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0010563 negative regulation of phosphorus metabolic process 23.5294 6 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0031400 negative regulation of protein modification process 23.5294 7 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0042326 negative regulation of phosphorylation 23.5294 8 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0043254 regulation of protein-containing complex assembly 23.5294 5 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0045936 negative regulation of phosphate metabolic process 23.5294 7 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0051338 regulation of transferase activity 23.5294 4 no
GO:1902903 regulation of supramolecular fiber organization 23.5294 5 no
GO:0001817 regulation of cytokine production 23.5294 4 no
GO:0007613 memory 23.5294 4 no
GO:0010629 negative regulation of gene expression 23.5294 7 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0043269 regulation of monoatomic ion transport 23.5294 5 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0065003 protein-containing complex assembly 23.5294 5 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:1903829 positive regulation of protein localization 23.5294 5 no
GO:0009059 macromolecule biosynthetic process 23.5294 4 no
GO:0006954 inflammatory response 23.5294 4 no
GO:0045893 positive regulation of DNA-templated transcription 23.5294 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 23.5294 9 no
GO:0051254 positive regulation of RNA metabolic process 23.5294 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.5294 7 no
GO:0010638 positive regulation of organelle organization 23.5294 6 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0051093 negative regulation of developmental process 23.5294 4 no
GO:0010720 positive regulation of cell development 23.5294 6 no
GO:0045597 positive regulation of cell differentiation 23.5294 5 no
GO:0050769 positive regulation of neurogenesis 23.5294 6 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051962 positive regulation of nervous system development 23.5294 5 no
GO:2000177 regulation of neural precursor cell proliferation 23.5294 5 no
GO:0001558 regulation of cell growth 17.6471 4 yes
GO:0002009 morphogenesis of an epithelium 17.6471 4 yes
GO:0007162 negative regulation of cell adhesion 17.6471 5 yes
GO:0030155 regulation of cell adhesion 17.6471 4 yes
GO:0030334 regulation of cell migration 17.6471 5 yes
GO:0031347 regulation of defense response 17.6471 5 yes
GO:0032526 response to retinoic acid 17.6471 4 yes
GO:0032870 cellular response to hormone stimulus 17.6471 4 yes
GO:0034330 cell junction organization 17.6471 4 yes
GO:0050727 regulation of inflammatory response 17.6471 5 yes
GO:0050808 synapse organization 17.6471 5 yes
GO:0061564 axon development 17.6471 7 yes
GO:0071300 cellular response to retinoic acid 17.6471 5 yes
GO:1901654 response to ketone 17.6471 4 yes
GO:1901655 cellular response to ketone 17.6471 5 yes
GO:2000145 regulation of cell motility 17.6471 4 yes
GO:0001649 osteoblast differentiation 11.7647 4 yes
GO:0003401 axis elongation 11.7647 4 yes
GO:0007528 neuromuscular junction development 11.7647 6 yes
GO:0014012 peripheral nervous system axon regeneration 11.7647 6 yes
GO:0031102 neuron projection regeneration 11.7647 4 yes
GO:0031103 axon regeneration 11.7647 5 yes
GO:0031670 cellular response to nutrient 11.7647 4 yes
GO:0033273 response to vitamin 11.7647 4 yes
GO:0033280 response to vitamin D 11.7647 4 yes
GO:0034694 response to prostaglandin 11.7647 4 yes
GO:0042475 odontogenesis of dentin-containing tooth 11.7647 5 yes
GO:0042476 odontogenesis 11.7647 4 yes
GO:0045471 response to ethanol 11.7647 5 yes
GO:0048678 response to axon injury 11.7647 4 yes
GO:0060447 bud outgrowth involved in lung branching 11.7647 6 yes
GO:0060602 branch elongation of an epithelium 11.7647 5 yes
GO:0060638 mesenchymal-epithelial cell signaling 11.7647 4 yes
GO:0060739 mesenchymal-epithelial cell signaling involved in prostate gland development 11.7647 5 yes
GO:0071295 cellular response to vitamin 11.7647 5 yes
GO:0071305 cellular response to vitamin D 11.7647 5 yes
GO:0071379 cellular response to prostaglandin stimulus 11.7647 5 yes
GO:0071774 response to fibroblast growth factor 11.7647 4 yes
GO:0071798 response to prostaglandin D 11.7647 5 yes
GO:0071799 cellular response to prostaglandin D stimulus 11.7647 6 yes
GO:0097305 response to alcohol 11.7647 4 yes
GO:0097306 cellular response to alcohol 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CO5A1_HUMAN [view interactions] Low throughput no no
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
FINC_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
SMOC1_HUMAN [view interactions] Low throughput no no
PGK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
NID2_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
ITA7_HUMAN [view interactions] Low throughput no yes
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
SMOC2_HUMAN [view interactions] Low throughput no no
SPRC_HUMAN [view interactions] Low throughput no yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
CD40L_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
TLR4_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MBD1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TEN1_HUMAN [view interactions] High throughput no no
CILP1_HUMAN [view interactions] High throughput no no
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes