PGCB_HUMAN
Evidence for PS localization
Functions
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PGCB_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 46.6667 | 4 | no |
| GO:0005509 | calcium ion binding | 26.6667 | 5 | no |
| GO:0005540 | hyaluronic acid binding | 13.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PGCB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 46.6667 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 46.6667 | 6 | no |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
| GO:0032880 | regulation of protein localization | 46.6667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 46.6667 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 40.0000 | 4 | no |
| GO:0030030 | cell projection organization | 40.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 40.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 40.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 40.0000 | 4 | no |
| GO:0050807 | regulation of synapse organization | 40.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 5 | no |
| GO:0034330 | cell junction organization | 26.6667 | 4 | yes |
| GO:0050808 | synapse organization | 26.6667 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 26.6667 | 7 | no |
| GO:0030155 | regulation of cell adhesion | 26.6667 | 4 | no |
| GO:0031175 | neuron projection development | 26.6667 | 6 | no |
| GO:0050890 | cognition | 26.6667 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 26.6667 | 4 | no |
| GO:0051960 | regulation of nervous system development | 26.6667 | 5 | no |
| GO:0080134 | regulation of response to stress | 26.6667 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 26.6667 | 4 | no |
| GO:0051963 | regulation of synapse assembly | 26.6667 | 6 | no |
| GO:1901888 | regulation of cell junction assembly | 26.6667 | 5 | no |
| GO:1905475 | regulation of protein localization to membrane | 26.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 26.6667 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.6667 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 26.6667 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0033674 | positive regulation of kinase activity | 26.6667 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0043549 | regulation of kinase activity | 26.6667 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 26.6667 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 26.6667 | 8 | no |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 26.6667 | 9 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051223 | regulation of protein transport | 26.6667 | 5 | no |
| GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 26.6667 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 26.6667 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.6667 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 26.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0036211 | protein modification process | 26.6667 | 4 | no |
| GO:0043412 | macromolecule modification | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.6667 | 5 | no |
| GO:0060548 | negative regulation of cell death | 26.6667 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.6667 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.6667 | 6 | no |
| GO:0007417 | central nervous system development | 20.0000 | 4 | yes |
| GO:0001501 | skeletal system development | 13.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FBLN2_HUMAN | [view interactions] | Low throughput | no | yes |
| MMP1_HUMAN | [view interactions] | Low throughput | no | no |
| MMP2_HUMAN | [view interactions] | Low throughput | no | no |
| MMP3_HUMAN | [view interactions] | Low throughput | no | no |
| MMP7_HUMAN | [view interactions] | Low throughput | no | no |
| MMP8_HUMAN | [view interactions] | Low throughput | no | no |
| MMP10_HUMAN | [view interactions] | Low throughput | no | no |
| MMP13_HUMAN | [view interactions] | Low throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| CSPG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ULK3_HUMAN | [view interactions] | High throughput | no | yes |
| REPI1_HUMAN | [view interactions] | High throughput | no | yes |
| CCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDBF2_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| BGLR_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| CILP2_HUMAN | [view interactions] | High throughput | no | no |
| THSD4_HUMAN | [view interactions] | High throughput | no | no |
| METRL_HUMAN | [view interactions] | High throughput | no | no |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CTRL_HUMAN | [view interactions] | High throughput | no | no |
| SEM3B_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATS7_HUMAN | [view interactions] | High throughput | no | no |
| JAG2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTF_HUMAN | [view interactions] | Computational | no | yes |
| CHSTE_HUMAN | [view interactions] | Computational | no | no |
| GPC3_HUMAN | [view interactions] | Computational | no | no |
| MMP19_HUMAN | [view interactions] | Computational | no | no |
| GPC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDC4_HUMAN | [view interactions] | Computational | no | yes |
| GPC5_HUMAN | [view interactions] | Computational | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CHST7_HUMAN | [view interactions] | Computational | no | yes |
| ATS4_HUMAN | [view interactions] | Computational | no | yes |
| GPC2_HUMAN | [view interactions] | Computational | no | no |
| PTPRZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FINC_HUMAN | [view interactions] | Computational | no | yes |
| DSEL_HUMAN | [view interactions] | Computational | no | no |
| SDC2_HUMAN | [view interactions] | Computational | no | yes |
| SDC3_HUMAN | [view interactions] | Computational | no | yes |
| B3GT6_HUMAN | [view interactions] | Computational | no | no |
| B3GA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CGAT2_HUMAN | [view interactions] | Computational | no | yes |
| CHSTD_HUMAN | [view interactions] | Computational | no | no |
| SDC1_HUMAN | [view interactions] | Computational | no | no |
| B3GA1_HUMAN | [view interactions] | Computational | no | yes |
| CHSS2_HUMAN | [view interactions] | Computational | no | yes |
| UST_HUMAN | [view interactions] | Computational | no | yes |
| CHSTB_HUMAN | [view interactions] | Computational | no | yes |
| B4GT7_HUMAN | [view interactions] | Computational | no | yes |
| CHSS3_HUMAN | [view interactions] | Computational | no | no |
| DSE_HUMAN | [view interactions] | Computational | no | yes |
| B3GA2_HUMAN | [view interactions] | Computational | no | no |
| CHPF2_HUMAN | [view interactions] | Computational | no | yes |
| CHSS1_HUMAN | [view interactions] | Computational | no | no |
| CGAT1_HUMAN | [view interactions] | Computational | no | no |
| PGBM_HUMAN | [view interactions] | Computational | no | no |
| ATS5_HUMAN | [view interactions] | Computational | no | yes |
| CHST9_HUMAN | [view interactions] | Computational | no | yes |
| CHST3_HUMAN | [view interactions] | Computational | no | yes |
| XYLT2_HUMAN | [view interactions] | Computational | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHSTC_HUMAN | [view interactions] | Computational | no | yes |
| GPC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| XYLT1_HUMAN | [view interactions] | Computational | no | yes |