LAMA5_HUMAN
Evidence for PS localization
Functions
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 286 | Arg | Leu | Nephroticsyndrome26(NPHS26) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LAMA5_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LAMA5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.3684 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
| GO:0030030 | cell projection organization | 42.1053 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 36.8421 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 36.8421 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 36.8421 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.8421 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.8421 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.8421 | 4 | no |
| GO:0006996 | organelle organization | 31.5789 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.5789 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.5789 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.5789 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.5789 | 5 | no |
| GO:0008104 | protein localization | 26.3158 | 4 | yes |
| GO:0006508 | proteolysis | 26.3158 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.3158 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.3158 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.3158 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 26.3158 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.3158 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0001667 | ameboidal-type cell migration | 21.0526 | 4 | yes |
| GO:0002009 | morphogenesis of an epithelium | 21.0526 | 4 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 21.0526 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 21.0526 | 4 | yes |
| GO:0030334 | regulation of cell migration | 21.0526 | 5 | yes |
| GO:2000145 | regulation of cell motility | 21.0526 | 4 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 21.0526 | 9 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.0526 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.0526 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
| GO:0031175 | neuron projection development | 21.0526 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.0526 | 5 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 21.0526 | 8 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.0526 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 21.0526 | 6 | no |
| GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 21.0526 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | no |
| GO:0008284 | positive regulation of cell population proliferation | 21.0526 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 21.0526 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:0034330 | cell junction organization | 21.0526 | 4 | no |
| GO:0050767 | regulation of neurogenesis | 21.0526 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0051960 | regulation of nervous system development | 21.0526 | 5 | no |
| GO:0060284 | regulation of cell development | 21.0526 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
| GO:0030031 | cell projection assembly | 15.7895 | 5 | yes |
| GO:0048754 | branching morphogenesis of an epithelial tube | 15.7895 | 4 | yes |
| GO:0070925 | organelle assembly | 15.7895 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 15.7895 | 6 | yes |
| GO:0001658 | branching involved in ureteric bud morphogenesis | 10.5263 | 5 | yes |
| GO:0007517 | muscle organ development | 10.5263 | 4 | yes |
| GO:0045995 | regulation of embryonic development | 10.5263 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 10.5263 | 5 | yes |
| GO:0060445 | branching involved in salivary gland morphogenesis | 10.5263 | 4 | yes |
| GO:0072657 | protein localization to membrane | 10.5263 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 10.5263 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 10.5263 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MUC7_HUMAN | [view interactions] | Low throughput | no | no |
| BCAM_HUMAN | [view interactions] | Low throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LAMC1_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMB1_HUMAN | [view interactions] | Low throughput | no | yes |
| KNG1_HUMAN | [view interactions] | Low throughput | no | no |
| CO7A1_HUMAN | [view interactions] | Low throughput | no | no |
| FBLN2_HUMAN | [view interactions] | Low throughput | no | yes |
| MEP1A_HUMAN | [view interactions] | Low throughput | no | no |
| ITA6_HUMAN | [view interactions] | Low throughput | no | yes |
| STK4_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| MCAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2A_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| ODAPH_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| INSL5_HUMAN | [view interactions] | High throughput | no | no |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| CRP_HUMAN | [view interactions] | High throughput | no | no |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BTBDA_HUMAN | [view interactions] | High throughput | no | no |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOC_HUMAN | [view interactions] | High throughput | no | no |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| SG1C1_HUMAN | [view interactions] | High throughput | no | no |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| MFAP5_HUMAN | [view interactions] | High throughput | no | no |
| FGF4_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN5_HUMAN | [view interactions] | High throughput | no | no |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| LRRT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CL3L1_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| MANEA_HUMAN | [view interactions] | High throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| C1QT7_HUMAN | [view interactions] | High throughput | no | no |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| IGFL3_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAH6_HUMAN | [view interactions] | High throughput | no | no |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| EDN3_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN444_HUMAN | [view interactions] | High throughput | no | no |
| GML_HUMAN | [view interactions] | High throughput | no | no |
| LAIR2_HUMAN | [view interactions] | High throughput | no | no |
| ESPB1_HUMAN | [view interactions] | High throughput | no | no |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| PGCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| PI15_HUMAN | [view interactions] | High throughput | no | no |
| NCTR3_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| C1QB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP10_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| CO5A1_HUMAN | [view interactions] | High throughput | no | no |
| DNS2A_HUMAN | [view interactions] | High throughput | no | yes |
| GGNB2_HUMAN | [view interactions] | High throughput | no | yes |
| ITB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |