EXOC1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.1852 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.1852 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1852 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 29.6296 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.6296 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.6296 | 6 | no |
| GO:0003924 | GTPase activity | 22.2222 | 7 | no |
| GO:0005525 | GTP binding | 22.2222 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.2222 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0035091 | phosphatidylinositol binding | 9.2593 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 7.4074 | 5 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 5.5556 | 4 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 5.5556 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 64.8148 | 4 | yes |
| GO:0006996 | organelle organization | 57.4074 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 53.7037 | 4 | yes |
| GO:0015031 | protein transport | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 44.4444 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 42.5926 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 40.7407 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.1852 | 4 | no |
| GO:0022607 | cellular component assembly | 35.1852 | 4 | no |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 33.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 31.4815 | 4 | yes |
| GO:0046903 | secretion | 29.6296 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 29.6296 | 5 | no |
| GO:0010646 | regulation of cell communication | 29.6296 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.7778 | 4 | yes |
| GO:0072657 | protein localization to membrane | 27.7778 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 27.7778 | 5 | no |
| GO:0006887 | exocytosis | 25.9259 | 4 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 25.9259 | 6 | yes |
| GO:0048193 | Golgi vesicle transport | 25.9259 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 25.9259 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 24.0741 | 4 | no |
| GO:0031175 | neuron projection development | 24.0741 | 6 | no |
| GO:0030031 | cell projection assembly | 24.0741 | 5 | no |
| GO:0120031 | plasma membrane bounded cell projection assembly | 24.0741 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.0741 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.2222 | 4 | no |
| GO:0006893 | Golgi to plasma membrane transport | 20.3704 | 5 | yes |
| GO:0006886 | intracellular protein transport | 20.3704 | 4 | no |
| GO:0072659 | protein localization to plasma membrane | 20.3704 | 5 | no |
| GO:0033365 | protein localization to organelle | 20.3704 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 20.3704 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.3704 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.3704 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 20.3704 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 20.3704 | 4 | no |
| GO:2000145 | regulation of cell motility | 20.3704 | 4 | no |
| GO:0051046 | regulation of secretion | 18.5185 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 18.5185 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 16.6667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 16.6667 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.8148 | 5 | yes |
| GO:0051223 | regulation of protein transport | 12.9630 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 12.9630 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 12.9630 | 5 | yes |
| GO:0010506 | regulation of autophagy | 11.1111 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 9.2593 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 9.2593 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 9.2593 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 9.2593 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 7.4074 | 7 | yes |
| GO:0050708 | regulation of protein secretion | 5.5556 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 5.5556 | 6 | yes |
| GO:0051607 | defense response to virus | 3.7037 | 4 | yes |
| GO:0140546 | defense response to symbiont | 3.7037 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.5556 | 3 | no |
| DOID:0060038 | specific developmental disorder | 3.7037 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 3.7037 | 5 | no |
| DOID:1059 | intellectual disability | 3.7037 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIBRA_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RUBIC_HUMAN | [view interactions] | Low throughput | no | no |
| BAKOR_HUMAN | [view interactions] | Low throughput | no | yes |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | Low throughput | no | no |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RESF1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| CE295_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 3BP5_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| ATF4_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| TMED1_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| COG5_HUMAN | [view interactions] | High throughput | no | yes |
| UN13B_HUMAN | [view interactions] | High throughput | no | no |
| SNX18_HUMAN | [view interactions] | High throughput | no | no |
| SFR1_HUMAN | [view interactions] | High throughput | no | no |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| KAL1L_HUMAN | [view interactions] | High throughput | no | yes |
| THAP5_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| TEKT2_HUMAN | [view interactions] | High throughput | no | no |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| IFT81_HUMAN | [view interactions] | High throughput | no | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SYBU_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| CC170_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| AF10_HUMAN | [view interactions] | High throughput | no | no |
| EPC1_HUMAN | [view interactions] | High throughput | no | no |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROM1_HUMAN | [view interactions] | High throughput | no | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3B_HUMAN | [view interactions] | High throughput | no | no |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| KANL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| THAP7_HUMAN | [view interactions] | High throughput | no | no |
| KI2S2_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEFF1_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| BL1S4_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| VPS50_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| POTEE_HUMAN | [view interactions] | High throughput | no | no |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| TSKS_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| CC122_HUMAN | [view interactions] | High throughput | no | yes |
| EDNRB_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| EX3L1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| C2CD5_HUMAN | [view interactions] | Computational | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDR2_HUMAN | [view interactions] | Computational | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHOQ_HUMAN | [view interactions] | Computational | no | no |