EXOC1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 28.8462 | 4 | yes |
| GO:0043169 | cation binding | 21.1538 | 4 | no |
| GO:0046872 | metal ion binding | 21.1538 | 5 | no |
| GO:0000166 | nucleotide binding | 21.1538 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.1538 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.1538 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.1538 | 4 | no |
| GO:0015631 | tubulin binding | 21.1538 | 4 | no |
| GO:0035091 | phosphatidylinositol binding | 9.6154 | 4 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 7.6923 | 5 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 7.6923 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 7.6923 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 63.4615 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0015031 | protein transport | 48.0769 | 4 | yes |
| GO:0006996 | organelle organization | 46.1538 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.3846 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.5385 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.6154 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 32.6923 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.6923 | 4 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.7692 | 5 | no |
| GO:0022607 | cellular component assembly | 26.9231 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.9231 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0046903 | secretion | 23.0769 | 4 | yes |
| GO:0061024 | membrane organization | 23.0769 | 4 | yes |
| GO:0051049 | regulation of transport | 23.0769 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.0769 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 21.1538 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 21.1538 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.1538 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.1538 | 5 | no |
| GO:0007010 | cytoskeleton organization | 21.1538 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 21.1538 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.1538 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.1538 | 5 | no |
| GO:0006893 | Golgi to plasma membrane transport | 19.2308 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 19.2308 | 4 | yes |
| GO:0048278 | vesicle docking | 19.2308 | 4 | yes |
| GO:0000281 | mitotic cytokinesis | 17.3077 | 4 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 17.3077 | 4 | yes |
| GO:0090148 | membrane fission | 17.3077 | 5 | yes |
| GO:0099022 | vesicle tethering | 17.3077 | 4 | yes |
| GO:0010506 | regulation of autophagy | 13.4615 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 13.4615 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 7.6923 | 7 | yes |
| GO:0140546 | defense response to symbiont | 7.6923 | 4 | yes |
| GO:0051607 | defense response to virus | 5.7692 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAKOR_HUMAN | [view interactions] | Low throughput | no | yes |
| RUBIC_HUMAN | [view interactions] | Low throughput | no | no |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | Low throughput | no | no |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RESF1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| CE295_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 3BP5_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| ATF4_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED1_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| COG5_HUMAN | [view interactions] | High throughput | no | yes |
| UN13B_HUMAN | [view interactions] | High throughput | no | no |
| SNX18_HUMAN | [view interactions] | High throughput | no | no |
| SFR1_HUMAN | [view interactions] | High throughput | no | no |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| KAL1L_HUMAN | [view interactions] | High throughput | no | yes |
| THAP5_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| TEKT2_HUMAN | [view interactions] | High throughput | no | no |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| IFT81_HUMAN | [view interactions] | High throughput | no | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SYBU_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| CC170_HUMAN | [view interactions] | High throughput | no | no |
| AF10_HUMAN | [view interactions] | High throughput | no | no |
| EPC1_HUMAN | [view interactions] | High throughput | no | no |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROM1_HUMAN | [view interactions] | High throughput | no | no |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| KANL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| THAP7_HUMAN | [view interactions] | High throughput | no | no |
| KI2S2_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEFF1_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| BL1S4_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| VPS50_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| POTEE_HUMAN | [view interactions] | High throughput | no | no |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| TSKS_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| CC122_HUMAN | [view interactions] | High throughput | no | yes |
| EDNRB_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| EX3L1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB6_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |