SYNE1_HUMAN
Evidence for PS localization
Functions
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 8095 | Arg | His | Emery-Dreifussmusculardystrophy4,autosomaldominant(EDMD4) | - |
| 8461 | Glu | Lys | Emery-Dreifussmusculardystrophy4,autosomaldominant(EDMD4) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYNE1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 27.2727 | 4 | no |
| GO:0043169 | cation binding | 27.2727 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 5 | no |
| GO:0000166 | nucleotide binding | 21.2121 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.2121 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.2121 | 4 | no |
| GO:0003723 | RNA binding | 18.1818 | 4 | yes |
| GO:0003779 | actin binding | 15.1515 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 6.0606 | 4 | yes |
| GO:0140444 | cytoskeleton-nuclear membrane anchor activity | 6.0606 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYNE1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.7273 | 4 | yes |
| GO:0006996 | organelle organization | 54.5455 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.5455 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.5152 | 4 | yes |
| GO:0008104 | protein localization | 51.5152 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.4848 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.4848 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.4545 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 42.4242 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.4242 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 39.3939 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 39.3939 | 6 | yes |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 30.3030 | 7 | yes |
| GO:0051049 | regulation of transport | 30.3030 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 30.3030 | 5 | no |
| GO:0030030 | cell projection organization | 30.3030 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 30.3030 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.2424 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 24.2424 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 24.2424 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.2424 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.2424 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.2424 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.2424 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.2424 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 24.2424 | 6 | no |
| GO:0043933 | protein-containing complex organization | 24.2424 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.2424 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.2424 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 21.2121 | 5 | yes |
| GO:0051050 | positive regulation of transport | 21.2121 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.2121 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
| GO:0072657 | protein localization to membrane | 21.2121 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.2121 | 5 | no |
| GO:0034330 | cell junction organization | 21.2121 | 4 | no |
| GO:0061024 | membrane organization | 21.2121 | 4 | no |
| GO:0050807 | regulation of synapse organization | 21.2121 | 5 | no |
| GO:0030100 | regulation of endocytosis | 18.1818 | 5 | yes |
| GO:0044057 | regulation of system process | 18.1818 | 4 | yes |
| GO:0002090 | regulation of receptor internalization | 15.1515 | 7 | yes |
| GO:0043066 | negative regulation of apoptotic process | 15.1515 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 15.1515 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 15.1515 | 6 | yes |
| GO:0031644 | regulation of nervous system process | 12.1212 | 5 | yes |
| GO:0045807 | positive regulation of endocytosis | 12.1212 | 5 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 12.1212 | 4 | yes |
| GO:0006997 | nucleus organization | 9.0909 | 5 | yes |
| GO:0007030 | Golgi organization | 9.0909 | 5 | yes |
| GO:0010464 | regulation of mesenchymal cell proliferation | 9.0909 | 5 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 9.0909 | 6 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 9.0909 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 9.0909 | 4 | yes |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | 6.0606 | 6 | yes |
| GO:0009416 | response to light stimulus | 6.0606 | 4 | yes |
| GO:0035051 | cardiocyte differentiation | 6.0606 | 4 | yes |
| GO:0042692 | muscle cell differentiation | 6.0606 | 4 | yes |
| GO:0043578 | nuclear matrix organization | 6.0606 | 6 | yes |
| GO:0048232 | male gamete generation | 6.0606 | 4 | yes |
| GO:0051146 | striated muscle cell differentiation | 6.0606 | 5 | yes |
| GO:0051457 | maintenance of protein location in nucleus | 6.0606 | 5 | yes |
| GO:0055007 | cardiac muscle cell differentiation | 6.0606 | 5 | yes |
| GO:0061884 | regulation of mini excitatory postsynaptic potential | 6.0606 | 5 | yes |
| GO:0061886 | negative regulation of mini excitatory postsynaptic potential | 6.0606 | 5 | yes |
| GO:0072595 | maintenance of protein localization in organelle | 6.0606 | 4 | yes |
| GO:0090292 | nuclear matrix anchoring at nuclear membrane | 6.0606 | 6 | yes |
| GO:0090394 | negative regulation of excitatory postsynaptic potential | 6.0606 | 4 | yes |
| GO:1903353 | regulation of nucleus organization | 6.0606 | 6 | yes |
| GO:2001053 | regulation of mesenchymal cell apoptotic process | 6.0606 | 6 | yes |
| GO:2001054 | negative regulation of mesenchymal cell apoptotic process | 6.0606 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AT1B4_HUMAN | [view interactions] | Low throughput | no | no |
| SUN3_HUMAN | [view interactions] | Low throughput | no | no |
| SPAG4_HUMAN | [view interactions] | Low throughput | no | no |
| SUN2_HUMAN | [view interactions] | Low throughput | no | yes |
| SUN1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | Low throughput | no | no |
| SYNE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MUSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CROCC_HUMAN | [view interactions] | Low throughput | no | no |
| EMD_HUMAN | [view interactions] | Low throughput | no | yes |
| FHOD1_HUMAN | [view interactions] | Low throughput | no | no |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| AXDN1_HUMAN | [view interactions] | High throughput | no | no |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPE1_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BKRB2_HUMAN | [view interactions] | High throughput | no | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MYOM1_HUMAN | [view interactions] | High throughput | no | no |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BP5_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEY1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| TNF18_HUMAN | [view interactions] | High throughput | no | no |
| MMP19_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUL_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
| OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |