GRAP1_HUMAN
Evidence for PS localization
Functions
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRAP1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0003723 | RNA binding | 24.2424 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRAP1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 60.6061 | 4 | yes |
| GO:0071702 | organic substance transport | 54.5455 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 54.5455 | 4 | yes |
| GO:0015031 | protein transport | 54.5455 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.4848 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 48.4848 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 39.3939 | 4 | yes |
| GO:0006886 | intracellular protein transport | 36.3636 | 4 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 33.3333 | 4 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.3030 | 4 | no |
| GO:0016197 | endosomal transport | 30.3030 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0032456 | endocytic recycling | 27.2727 | 5 | yes |
| GO:0032880 | regulation of protein localization | 24.2424 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 24.2424 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.2424 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 24.2424 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 24.2424 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.2121 | 4 | yes |
| GO:0072657 | protein localization to membrane | 21.2121 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 21.2121 | 5 | yes |
| GO:0010468 | regulation of gene expression | 21.2121 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.2121 | 5 | no |
| GO:0009966 | regulation of signal transduction | 21.2121 | 4 | no |
| GO:0022607 | cellular component assembly | 21.2121 | 4 | no |
| GO:0061024 | membrane organization | 21.2121 | 4 | no |
| GO:0035418 | protein localization to synapse | 18.1818 | 6 | yes |
| GO:0051223 | regulation of protein transport | 18.1818 | 5 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 18.1818 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 18.1818 | 6 | yes |
| GO:0072659 | protein localization to plasma membrane | 18.1818 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 18.1818 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 18.1818 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 18.1818 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 15.1515 | 7 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 15.1515 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 15.1515 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 15.1515 | 4 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 15.1515 | 5 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 15.1515 | 7 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 15.1515 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 15.1515 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 15.1515 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 15.1515 | 6 | yes |
| GO:0033157 | regulation of intracellular protein transport | 9.0909 | 6 | yes |
| GO:0050807 | regulation of synapse organization | 9.0909 | 5 | yes |
| GO:1902683 | regulation of receptor localization to synapse | 9.0909 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 9.0909 | 5 | yes |
| GO:0099158 | regulation of recycling endosome localization within postsynapse | 6.0606 | 6 | yes |
| GO:1902473 | regulation of protein localization to synapse | 6.0606 | 6 | yes |
| GO:1903421 | regulation of synaptic vesicle recycling | 6.0606 | 5 | yes |
| GO:1905244 | regulation of modification of synaptic structure | 6.0606 | 6 | yes |
| GO:1905749 | regulation of endosome to plasma membrane protein transport | 6.0606 | 6 | yes |
| GO:2001135 | regulation of endocytic recycling | 6.0606 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GRAP1_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 9.0909 | 6 | no |
| DOID:440 | neuromuscular disease | 9.0909 | 5 | no |
| DOID:574 | peripheral nervous system disease | 9.0909 | 3 | no |
| DOID:870 | neuropathy | 9.0909 | 4 | no |
| DOID:1289 | neurodegenerative disease | 9.0909 | 4 | no |
| DOID:331 | central nervous system disease | 9.0909 | 3 | no |
| DOID:12377 | spinal muscular atrophy | 6.0606 | 6 | no |
| DOID:231 | motor neuron disease | 6.0606 | 5 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 6.0606 | 7 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CCNT1_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP3_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| PKNX2_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| CALB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDSL_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F1892_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTGE2_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF35_HUMAN | [view interactions] | High throughput | no | no |
| CCNH_HUMAN | [view interactions] | High throughput | no | yes |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| CC185_HUMAN | [view interactions] | High throughput | no | no |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| T10IP_HUMAN | [view interactions] | High throughput | no | no |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| CC103_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE57L_HUMAN | [view interactions] | High throughput | no | yes |
| ING4_HUMAN | [view interactions] | High throughput | no | no |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| TSH2_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| CFA53_HUMAN | [view interactions] | High throughput | no | no |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| AARD_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| STAP1_HUMAN | [view interactions] | High throughput | no | no |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| ZN835_HUMAN | [view interactions] | High throughput | no | no |
| ZN219_HUMAN | [view interactions] | High throughput | no | yes |
| TCP1L_HUMAN | [view interactions] | High throughput | no | no |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| BMAL1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB3_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| VPS50_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TBC30_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR11_HUMAN | [view interactions] | High throughput | no | yes |
| SNPC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZN250_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| CGNL1_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |