CLCA_HUMAN
Evidence for PS localization
Functions
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed, PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
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CLCA_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [CLCA_HUMAN]
Isoform [P09496-5] alignment
Isoform [P09496-2] alignment
Isoform [P09496-3] alignment
Isoform [P09496-4] alignment
Isoform [C9J8P9] alignment
Isoform [F8WF69] alignment
Isoform [S4R3F6] alignment
LOADING 95%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CLCA_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 25.5172 | 4 | no |
GO:0003723 | RNA binding | 25.5172 | 4 | no |
GO:0000166 | nucleotide binding | 22.7586 | 4 | no |
GO:0017076 | purine nucleotide binding | 22.7586 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 22.7586 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.0690 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 21.3793 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.3793 | 5 | no |
GO:0005524 | ATP binding | 20.6897 | 5 | no |
GO:0045296 | cadherin binding | 20.6897 | 4 | no |
GO:0051020 | GTPase binding | 8.2759 | 4 | yes |
GO:0032050 | clathrin heavy chain binding | 2.0690 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CLCA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 53.1034 | 4 | no |
GO:0051128 | regulation of cellular component organization | 48.9655 | 4 | no |
GO:0006996 | organelle organization | 46.8966 | 4 | no |
GO:0008104 | protein localization | 46.2069 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 46.2069 | 4 | no |
GO:0022607 | cellular component assembly | 44.8276 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 43.4483 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.7586 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.9310 | 4 | no |
GO:0071702 | organic substance transport | 37.2414 | 4 | yes |
GO:0071705 | nitrogen compound transport | 36.5517 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 34.4828 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.7931 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.7931 | 5 | no |
GO:0015031 | protein transport | 33.1034 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 33.1034 | 4 | no |
GO:0010468 | regulation of gene expression | 31.7241 | 6 | no |
GO:0098657 | import into cell | 31.0345 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.0345 | 5 | no |
GO:0010646 | regulation of cell communication | 31.0345 | 4 | no |
GO:0043933 | protein-containing complex organization | 30.3448 | 4 | yes |
GO:0051049 | regulation of transport | 29.6552 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.2759 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.5862 | 5 | no |
GO:0009966 | regulation of signal transduction | 26.8966 | 4 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AFTIN_HUMAN | [view interactions] | High throughput | no | yes |
AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
AHNK2_HUMAN | [view interactions] | High throughput | no | yes |
AL1A2_HUMAN | [view interactions] | High throughput | no | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1S2_HUMAN | [view interactions] | High throughput | no | no |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |