AP2S1_HUMAN

G2C

SynGO

SynaptomeDB

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif . May also play a role in extracellular calcium homeostasis. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 46%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

AP2S1_HUMAN

AP2B1_HUMAN

LOADING 67%

AP2S1_HUMAN

AP2M1_HUMAN

LOADING 67%

AP2S1_HUMAN has binary interactions with 50 proteins

Download full PS network for entry.

Interacting regions

Canonical [AP2S1_HUMAN]

Isoform [P53680-2] alignment

Isoform [P53680-2] sequence

Isoform [M0R0N4] alignment

Isoform [M0R0N4] sequence

Isoform [M0R1S0] alignment

Isoform [M0R1S0] sequence

Isoform [M0QZ21] alignment

Isoform [M0QZ21] sequence

Isoform [M0QYZ2] alignment

Isoform [M0QYZ2] sequence

Isoform [X6R390] alignment

Isoform [X6R390] sequence

LOADING 34%

Position	Amino acid	Mutation	Disease	Overlap with binding region
15	Arg	Cys	Hypocalciurichypercalcemia,familial3(HHC3)	-
15	Arg	His	Hypocalciurichypercalcemia,familial3(HHC3)	-
15	Arg	Leu	Hypocalciurichypercalcemia,familial3(HHC3)	-

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in AP2S1_HUMAN
GO:0043169	cation binding	25.0000	4	no
GO:0046872	metal ion binding	25.0000	5	no
GO:0000166	nucleotide binding	21.6667	4	no
GO:0017076	purine nucleotide binding	21.6667	5	no
GO:0032555	purine ribonucleotide binding	21.6667	4	no
GO:0043168	anion binding	21.6667	4	no
GO:0035615	clathrin adaptor activity	10.0000	4	yes

Showing 1 to 7 of 7 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in AP2S1_HUMAN
GO:0048522	positive regulation of cellular process	56.6667	4	no
GO:0008104	protein localization	43.3333	4	yes
GO:0051128	regulation of cellular component organization	43.3333	4	yes
GO:0071702	organic substance transport	43.3333	4	yes
GO:0098657	import into cell	43.3333	4	yes
GO:0048523	negative regulation of cellular process	41.6667	4	no
GO:0071705	nitrogen compound transport	41.6667	4	yes
GO:0060255	regulation of macromolecule metabolic process	38.3333	4	no
GO:0006996	organelle organization	38.3333	4	no
GO:0051049	regulation of transport	36.6667	4	yes
GO:0031323	regulation of cellular metabolic process	36.6667	4	no
GO:0022607	cellular component assembly	35.0000	4	yes
GO:0009893	positive regulation of metabolic process	35.0000	4	no
GO:0010646	regulation of cell communication	35.0000	4	no
GO:0080090	regulation of primary metabolic process	33.3333	4	no
GO:0015031	protein transport	33.3333	4	yes
GO:0009966	regulation of signal transduction	31.6667	4	no
GO:0010604	positive regulation of macromolecule metabolic process	31.6667	5	no
GO:0043933	protein-containing complex organization	28.3333	4	yes
GO:0009889	regulation of biosynthetic process	28.3333	4	no
GO:0031325	positive regulation of cellular metabolic process	28.3333	5	no
GO:0051246	regulation of protein metabolic process	26.6667	5	no
GO:0006886	intracellular protein transport	26.6667	4	yes
GO:0010556	regulation of macromolecule biosynthetic process	26.6667	5	no
GO:0031326	regulation of cellular biosynthetic process	26.6667	5	no

Showing 1 to 25 of 52 entries

Disease

No data found.

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Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
A16L1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AAGAB_HUMAN	[view interactions]	Low throughput	no	yes
AAK1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ACACA_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AGO2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AMPH_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ANS1B_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP1B1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP1G1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AP2A1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AP2A2_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AP2B1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AP2M1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AP2S1_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
ARFG1_HUMAN	[view interactions]	High throughput	no	no
ARHG1_HUMAN	[view interactions]	High throughput	no	no
ATG5_HUMAN	[view entry] [view interactions]	High throughput	yes	no
BAG2_HUMAN	[view entry] [view interactions]	High throughput	yes	no
BASI_HUMAN	[view entry] [view interactions]	High throughput	yes	no
BCAR1_HUMAN	[view interactions]	High throughput	no	yes
BMI1_HUMAN	[view interactions]	High throughput	no	yes
BMP2K_HUMAN	[view interactions]	High throughput	no	yes
CCD32_HUMAN	[view interactions]	High throughput	no	yes
CD4_HUMAN	[view interactions]	Low throughput	no	no
CE128_HUMAN	[view interactions]	High throughput	no	yes

Showing 1 to 25 of 145 entries

AP2S1_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

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Molecular function

Biological process

Disease

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