AP2S1_HUMAN
Evidence for PS localization
Functions
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif . May also play a role in extracellular calcium homeostasis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 15 | Arg | Cys | Hypocalciurichypercalcemia,familial3(HHC3) | - |
| 15 | Arg | His | Hypocalciurichypercalcemia,familial3(HHC3) | - |
| 15 | Arg | Leu | Hypocalciurichypercalcemia,familial3(HHC3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP2S1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 21.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.6667 | 4 | no |
| GO:0043168 | anion binding | 21.6667 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP2S1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | no |
| GO:0008104 | protein localization | 43.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.3333 | 4 | yes |
| GO:0071702 | organic substance transport | 43.3333 | 4 | yes |
| GO:0098657 | import into cell | 43.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 41.6667 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.3333 | 4 | no |
| GO:0006996 | organelle organization | 38.3333 | 4 | no |
| GO:0051049 | regulation of transport | 36.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 36.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 35.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.6667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0006886 | intracellular protein transport | 26.6667 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 25.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.3333 | 6 | no |
| GO:0036211 | protein modification process | 23.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 23.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.3333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.6667 | 5 | no |
| GO:0030100 | regulation of endocytosis | 21.6667 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 21.6667 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 18.3333 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 16.6667 | 4 | yes |
| GO:0031623 | receptor internalization | 15.0000 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 15.0000 | 5 | yes |
| GO:0098884 | postsynaptic neurotransmitter receptor internalization | 11.6667 | 4 | yes |
| GO:0140239 | postsynaptic endocytosis | 11.6667 | 4 | yes |
| GO:0048268 | clathrin coat assembly | 6.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AAGAB_HUMAN | [view interactions] | Low throughput | no | yes |
| NECP2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD4_HUMAN | [view interactions] | Low throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TDGF1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| KHK_HUMAN | [view interactions] | High throughput | no | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| DPOLQ_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| CCD32_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA25_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| MANF_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX29_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NACAM_HUMAN | [view interactions] | High throughput | no | no |
| PCNP_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| TAB3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |