Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HS74L_HUMAN

GO
G2C
SynGO

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HS74L_HUMAN
GO:0017076 purine nucleotide binding 43.3333 4 yes
GO:0030554 adenyl nucleotide binding 41.6667 5 yes
GO:0032555 purine ribonucleotide binding 38.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.3333 4 yes
GO:0005524 ATP binding 36.6667 5 yes
GO:0032559 adenyl ribonucleotide binding 36.6667 5 yes
GO:0044389 ubiquitin-like protein ligase binding 30.0000 4 no
GO:0031625 ubiquitin protein ligase binding 28.3333 5 no
GO:0019900 kinase binding 21.6667 4 no
GO:0016462 pyrophosphatase activity 20.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.0000 6 yes
GO:0016887 ATP hydrolysis activity 18.3333 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HS74L_HUMAN
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 65.0000 4 no
GO:0080090 regulation of primary metabolic process 65.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 63.3333 4 no
GO:0031323 regulation of cellular metabolic process 61.6667 4 no
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0009893 positive regulation of metabolic process 51.6667 4 no
GO:0051246 regulation of protein metabolic process 51.6667 5 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0009892 negative regulation of metabolic process 48.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 46.6667 5 no
GO:0051128 regulation of cellular component organization 46.6667 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 45.0000 5 no
GO:0010468 regulation of gene expression 43.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 43.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:1902531 regulation of intracellular signal transduction 38.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 38.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 38.3333 5 no
GO:0051247 positive regulation of protein metabolic process 36.6667 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.6667 5 no
GO:0010941 regulation of cell death 36.6667 4 no
GO:0051248 negative regulation of protein metabolic process 35.0000 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 31.6667 5 no
GO:0010648 negative regulation of cell communication 31.6667 5 no
GO:0023057 negative regulation of signaling 31.6667 4 no
GO:0044087 regulation of cellular component biogenesis 31.6667 4 no
GO:0006355 regulation of DNA-templated transcription 30.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 30.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0006996 organelle organization 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0009968 negative regulation of signal transduction 30.0000 5 no
GO:0048585 negative regulation of response to stimulus 30.0000 4 no
GO:0032880 regulation of protein localization 28.3333 5 no
GO:0043549 regulation of kinase activity 28.3333 5 no
GO:0060341 regulation of cellular localization 28.3333 4 no
GO:0042127 regulation of cell population proliferation 28.3333 4 no
GO:0080134 regulation of response to stress 26.6667 4 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0031401 positive regulation of protein modification process 26.6667 7 no
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0010647 positive regulation of cell communication 26.6667 5 no
GO:0023056 positive regulation of signaling 26.6667 4 no
GO:0048584 positive regulation of response to stimulus 26.6667 4 no
GO:0051049 regulation of transport 26.6667 4 no
GO:0006986 response to unfolded protein 26.6667 4 yes
GO:0022607 cellular component assembly 26.6667 4 no
GO:0051129 negative regulation of cellular component organization 26.6667 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.3333 6 no
GO:0042327 positive regulation of phosphorylation 23.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.3333 7 no
GO:0051347 positive regulation of transferase activity 23.3333 5 no
GO:0045859 regulation of protein kinase activity 23.3333 6 no
GO:0071705 nitrogen compound transport 23.3333 4 no
GO:0016192 vesicle-mediated transport 23.3333 4 no
GO:0043066 negative regulation of apoptotic process 23.3333 7 no
GO:0043069 negative regulation of programmed cell death 23.3333 6 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 21.6667 7 no
GO:0051130 positive regulation of cellular component organization 21.6667 5 no
GO:0015031 protein transport 21.6667 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.6667 6 no
GO:0010243 response to organonitrogen compound 21.6667 4 no
GO:0014070 response to organic cyclic compound 21.6667 4 no
GO:1901701 cellular response to oxygen-containing compound 21.6667 4 no
GO:0031396 regulation of protein ubiquitination 21.6667 8 no
GO:0042176 regulation of protein catabolic process 21.6667 5 no

Disease

Term Name % Distance from top the of the tree Annotated in HS74L_HUMAN
DOID:0050686 organ system cancer 3.3333 3 no
DOID:120 female reproductive organ cancer 3.3333 5 no
DOID:193 reproductive organ cancer 3.3333 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
MSRA_HUMAN [view interactions] Low throughput no no
DNJA4_HUMAN [view interactions] High throughput no yes
DJC10_HUMAN [view interactions] High throughput no yes
DNJC9_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
DNJC2_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FKB14_HUMAN [view interactions] High throughput no yes
GRPE1_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
RCN1_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
UBL7_HUMAN [view interactions] High throughput no yes
PAIP1_HUMAN [view interactions] High throughput no yes
PP1RB_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
TTC4_HUMAN [view interactions] High throughput no yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV2_HUMAN [view interactions] High throughput no yes
ELAV3_HUMAN [view interactions] High throughput no yes
RT4I1_HUMAN [view interactions] High throughput no yes
SELO_HUMAN [view interactions] High throughput no yes
GET3_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMC1_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
HSF1_HUMAN [view interactions] High throughput no yes
SGTA_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TTC1_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
MGN2_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
SCLT1_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
SRF_HUMAN [view interactions] High throughput no yes
PEBB_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HNF1A_HUMAN [view interactions] High throughput no no
CREB1_HUMAN [view interactions] High throughput no yes
GLI2_HUMAN [view interactions] High throughput no yes
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
KLF16_HUMAN [view interactions] High throughput no yes
KLF8_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROS1_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
TUSC2_HUMAN [view interactions] High throughput no no
USF2_HUMAN [view interactions] High throughput no no
IF6_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
DOK2_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
TIMP2_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
TAB1_HUMAN [view interactions] High throughput no yes
SMYD2_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHAA_HUMAN [view interactions] High throughput no yes
EPHA8_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI1_HUMAN [view interactions] High throughput no no
TCAL1_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
MT21A_HUMAN [view interactions] High throughput no yes
KS6B2_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
PTPRR_HUMAN [view interactions] High throughput no yes
EDEM3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
STK40_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TXNIP_HUMAN [view interactions] High throughput no no
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
NR2C2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
MPIP3_HUMAN [view interactions] High throughput no yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
PTN12_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHG4_HUMAN [view interactions] High throughput no no
ARGAL_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
STA13_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
GRP1_HUMAN [view interactions] High throughput no no
CCAR1_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
NU188_HUMAN [view interactions] High throughput no yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
DIAP1_HUMAN [view interactions] High throughput no yes
NUBP2_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
LC7L2_HUMAN [view interactions] High throughput no yes
2ABA_HUMAN [view interactions] High throughput no yes
RANB3_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PUS7_HUMAN [view interactions] High throughput no yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
NUP62_HUMAN [view interactions] Computational no yes
BAG4_HUMAN [view interactions] Computational no yes
NUP43_HUMAN [view interactions] Computational no yes
PO210_HUMAN [view interactions] Computational no yes
NUP54_HUMAN [view interactions] Computational no yes
HS90B_HUMAN [view entry] [view interactions] Computational yes yes
HS105_HUMAN [view entry] [view interactions] Computational yes yes
RAE1L_HUMAN [view interactions] Computational no no
HS71B_HUMAN [view entry] [view interactions] Computational yes yes
HS71A_HUMAN [view entry] [view interactions] Computational yes yes
NU160_HUMAN [view interactions] Computational no no
NUP98_HUMAN [view interactions] Computational no no
NU153_HUMAN [view interactions] Computational no yes
NUP37_HUMAN [view interactions] Computational no yes
HS12B_HUMAN [view interactions] Computational no yes
F10A1_HUMAN [view interactions] Computational no yes
P121C_HUMAN [view interactions] Computational no yes
BAG3_HUMAN [view entry] [view interactions] Computational yes no
NUP93_HUMAN [view interactions] Computational no yes
NUP85_HUMAN [view interactions] Computational no yes
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
NU107_HUMAN [view interactions] Computational no no
DNJA3_HUMAN [view entry] [view interactions] Computational yes yes
NU133_HUMAN [view interactions] Computational no yes
P121A_HUMAN [view interactions] Computational no yes
NUP35_HUMAN [view interactions] Computational no yes
NUP88_HUMAN [view interactions] Computational no yes
NU205_HUMAN [view interactions] Computational no no
AHSA1_HUMAN [view entry] [view interactions] Computational yes yes
NUP42_HUMAN [view interactions] Computational no no
SEH1_HUMAN [view interactions] Computational no no
NU214_HUMAN [view interactions] Computational no no
SEC13_HUMAN [view entry] [view interactions] Computational yes yes
HS12A_HUMAN [view entry] [view interactions] Computational yes yes
DNJB6_HUMAN [view entry] [view interactions] Computational yes yes
NU155_HUMAN [view interactions] Computational no yes
AAAS_HUMAN [view interactions] Computational no yes
HPBP1_HUMAN [view interactions] Computational no yes
TPR_HUMAN [view interactions] Computational no yes
RBP2_HUMAN [view interactions] Computational no yes
HS71L_HUMAN [view entry] [view interactions] Computational yes no
NUP58_HUMAN [view interactions] Computational no yes
NUP50_HUMAN [view interactions] Computational no yes
BAG5_HUMAN [view entry] [view interactions] Computational yes no
BAG2_HUMAN [view entry] [view interactions] Computational yes no
NDC1_HUMAN [view interactions] Computational no yes