Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HS74L_HUMAN

GO
G2C
SynGO

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HS74L_HUMAN
GO:0043168 anion binding 34.2105 4 yes
GO:0000166 nucleotide binding 32.8947 4 yes
GO:0017076 purine nucleotide binding 32.8947 5 yes
GO:0032555 purine ribonucleotide binding 32.8947 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 32.8947 4 yes
GO:0005524 ATP binding 30.2632 5 yes
GO:0030554 adenyl nucleotide binding 30.2632 6 yes
GO:0032559 adenyl ribonucleotide binding 30.2632 5 yes
GO:0043169 cation binding 27.6316 4 no
GO:0046872 metal ion binding 27.6316 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in HS74L_HUMAN
GO:0060255 regulation of macromolecule metabolic process 61.8421 4 no
GO:0080090 regulation of primary metabolic process 60.5263 4 no
GO:0048523 negative regulation of cellular process 59.2105 4 no
GO:0048522 positive regulation of cellular process 57.8947 4 no
GO:0031323 regulation of cellular metabolic process 57.8947 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 48.6842 4 no
GO:0031326 regulation of cellular biosynthetic process 48.6842 5 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0010468 regulation of gene expression 46.0526 6 no
GO:0009893 positive regulation of metabolic process 43.4211 4 no
GO:0009966 regulation of signal transduction 43.4211 4 no
GO:0010646 regulation of cell communication 43.4211 4 no
GO:0009892 negative regulation of metabolic process 43.4211 4 no
GO:0051246 regulation of protein metabolic process 43.4211 5 no
GO:0010604 positive regulation of macromolecule metabolic process 40.7895 5 no
GO:0010605 negative regulation of macromolecule metabolic process 40.7895 5 no
GO:0031324 negative regulation of cellular metabolic process 38.1579 5 no
GO:1902531 regulation of intracellular signal transduction 35.5263 5 no
GO:0031325 positive regulation of cellular metabolic process 34.2105 5 no
GO:0006996 organelle organization 34.2105 4 no
GO:0022607 cellular component assembly 34.2105 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.8947 5 no
GO:0031399 regulation of protein modification process 32.8947 6 no
GO:0008104 protein localization 32.8947 4 no
GO:0051252 regulation of RNA metabolic process 31.5789 5 no
GO:0043412 macromolecule modification 30.2632 4 no
GO:0006355 regulation of DNA-templated transcription 30.2632 7 no
GO:0009890 negative regulation of biosynthetic process 30.2632 5 no
GO:0051247 positive regulation of protein metabolic process 30.2632 6 no
GO:2001141 regulation of RNA biosynthetic process 30.2632 6 no
GO:0036211 protein modification process 28.9474 4 no
GO:0042981 regulation of apoptotic process 28.9474 5 no
GO:0043067 regulation of programmed cell death 28.9474 4 no
GO:0048584 positive regulation of response to stimulus 28.9474 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.9474 6 no
GO:0031327 negative regulation of cellular biosynthetic process 28.9474 6 no
GO:0010647 positive regulation of cell communication 27.6316 5 no
GO:0023056 positive regulation of signaling 27.6316 4 no
GO:0051049 regulation of transport 27.6316 4 no
GO:0042127 regulation of cell population proliferation 26.3158 4 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0009967 positive regulation of signal transduction 26.3158 5 no
GO:0030334 regulation of cell migration 26.3158 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.3158 6 no
GO:0048585 negative regulation of response to stimulus 26.3158 4 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0071310 cellular response to organic substance 26.3158 4 no
GO:2000145 regulation of cell motility 26.3158 4 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0009968 negative regulation of signal transduction 23.6842 5 no
GO:0010648 negative regulation of cell communication 23.6842 5 no
GO:0023057 negative regulation of signaling 23.6842 4 no
GO:1901701 cellular response to oxygen-containing compound 23.6842 4 no
GO:0001932 regulation of protein phosphorylation 23.6842 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.6842 6 no
GO:0031344 regulation of cell projection organization 22.3684 5 no
GO:0051240 positive regulation of multicellular organismal process 22.3684 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.3684 6 no
GO:1902533 positive regulation of intracellular signal transduction 22.3684 6 no
GO:0045595 regulation of cell differentiation 22.3684 4 no
GO:0051338 regulation of transferase activity 22.3684 4 no
GO:0071702 organic substance transport 22.3684 4 no
GO:0009894 regulation of catabolic process 22.3684 4 no
GO:0033043 regulation of organelle organization 22.3684 5 no
GO:0080134 regulation of response to stress 21.0526 4 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.0526 8 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:2000026 regulation of multicellular organismal development 21.0526 4 no
GO:0051129 negative regulation of cellular component organization 21.0526 5 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0043933 protein-containing complex organization 21.0526 4 no
GO:0006986 response to unfolded protein 11.8421 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
MSRA_HUMAN [view interactions] Low throughput no no
GRP1_HUMAN [view interactions] High throughput no no
CCAR1_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
RNF43_HUMAN [view interactions] High throughput no yes
ARMC5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RUFY1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
KKCC2_HUMAN [view entry] [view interactions] High throughput yes yes
GCSP_HUMAN [view interactions] High throughput no yes
CL16A_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
NU188_HUMAN [view interactions] High throughput no yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
DIAP1_HUMAN [view interactions] High throughput no yes
NUBP2_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
LC7L2_HUMAN [view interactions] High throughput no yes
2ABA_HUMAN [view interactions] High throughput no yes
RANB3_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PUS7_HUMAN [view interactions] High throughput no yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA4_HUMAN [view interactions] High throughput no yes
DJC10_HUMAN [view interactions] High throughput no yes
DNJC9_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
DNJC2_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FKB14_HUMAN [view interactions] High throughput no yes
GRPE1_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
RCN1_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
UBL7_HUMAN [view interactions] High throughput no yes
PAIP1_HUMAN [view interactions] High throughput no yes
PP1RB_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
TTC4_HUMAN [view interactions] High throughput no yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV2_HUMAN [view interactions] High throughput no yes
ELAV3_HUMAN [view interactions] High throughput no yes
RT4I1_HUMAN [view interactions] High throughput no yes
SELO_HUMAN [view interactions] High throughput no yes
GET3_HUMAN [view interactions] High throughput no yes
FMC1_HUMAN [view interactions] High throughput no no
UBA6_HUMAN [view interactions] High throughput no no
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
OGA_HUMAN [view interactions] High throughput no yes
CLU_HUMAN [view interactions] High throughput no yes
PARN_HUMAN [view entry] [view interactions] High throughput yes yes
SAP_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
ERF3A_HUMAN [view interactions] High throughput no yes
DNLI1_HUMAN [view interactions] High throughput no yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
OSBP1_HUMAN [view interactions] High throughput no yes
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
NFYA_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
CEBPG_HUMAN [view interactions] High throughput no yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MO4L2_HUMAN [view interactions] High throughput no yes
ELOB_HUMAN [view interactions] High throughput no no
GRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RN213_HUMAN [view interactions] High throughput no yes
TFG_HUMAN [view interactions] High throughput no yes
ARHG1_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
UBAC1_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
TEX2_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
HSF1_HUMAN [view interactions] High throughput no yes
SGTA_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TTC1_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
MGN2_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
SCLT1_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
SRF_HUMAN [view interactions] High throughput no yes
PEBB_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ZN283_HUMAN [view interactions] High throughput no no
ZN304_HUMAN [view interactions] High throughput no yes
ZN546_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK1_HUMAN [view interactions] High throughput no yes
LATS2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CREB1_HUMAN [view interactions] High throughput no yes
HNF1A_HUMAN [view interactions] High throughput no no
GLI2_HUMAN [view interactions] High throughput no yes
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
KLF16_HUMAN [view interactions] High throughput no yes
KLF8_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROS1_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
TUSC2_HUMAN [view interactions] High throughput no no
USF2_HUMAN [view interactions] High throughput no no
IF6_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
DOK2_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
TIMP2_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TAB1_HUMAN [view interactions] High throughput no yes
SMYD2_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHAA_HUMAN [view interactions] High throughput no yes
EPHA8_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI1_HUMAN [view interactions] High throughput no no
TCAL1_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
MT21A_HUMAN [view interactions] High throughput no yes
KS6B2_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
WDTC1_HUMAN [view interactions] High throughput no yes
PTPRR_HUMAN [view interactions] High throughput no yes
EDEM3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
STK40_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TXNIP_HUMAN [view interactions] High throughput no no
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
NR2C2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
MPIP3_HUMAN [view interactions] High throughput no yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
PTN12_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHG4_HUMAN [view interactions] High throughput no no
ARGAL_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
STA13_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes