Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DUS10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003078 DOC_MAPK_JIP1_4 DOC 19 25 -
ELMI003078 DOC_MAPK_JIP1_4 DOC 19 25 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DUS10_HUMAN
GO:0043168 anion binding 41.3793 4 no
GO:0000166 nucleotide binding 37.9310 4 no
GO:0017076 purine nucleotide binding 37.9310 5 no
GO:0032555 purine ribonucleotide binding 37.9310 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.9310 4 no
GO:0005524 ATP binding 34.4828 5 no
GO:0030554 adenyl nucleotide binding 34.4828 6 no
GO:0032559 adenyl ribonucleotide binding 34.4828 5 no
GO:0019900 kinase binding 31.0345 4 yes
GO:0016301 kinase activity 24.1379 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.6897 4 no
GO:0043169 cation binding 20.6897 4 no
GO:0046872 metal ion binding 20.6897 5 no
GO:0016791 phosphatase activity 17.2414 5 yes
GO:0019901 protein kinase binding 17.2414 5 yes
GO:0042578 phosphoric ester hydrolase activity 17.2414 4 yes
GO:0004722 protein serine/threonine phosphatase activity 13.7931 4 yes
GO:0004725 protein tyrosine phosphatase activity 10.3448 4 yes
GO:0017018 myosin phosphatase activity 10.3448 5 yes
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 6.8966 4 yes
GO:0008330 protein tyrosine/threonine phosphatase activity 6.8966 4 yes
GO:0008432 JUN kinase binding 6.8966 6 yes
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 6.8966 5 yes
GO:0033549 MAP kinase phosphatase activity 6.8966 4 yes
GO:0033550 MAP kinase tyrosine phosphatase activity 6.8966 5 yes
GO:0048273 mitogen-activated protein kinase p38 binding 6.8966 7 yes
GO:0051019 mitogen-activated protein kinase binding 6.8966 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DUS10_HUMAN
GO:0048522 positive regulation of cellular process 75.8621 4 yes
GO:0048523 negative regulation of cellular process 62.0690 4 yes
GO:0010646 regulation of cell communication 58.6207 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.6207 4 yes
GO:0080090 regulation of primary metabolic process 58.6207 4 yes
GO:0009966 regulation of signal transduction 55.1724 4 yes
GO:0031323 regulation of cellular metabolic process 55.1724 4 yes
GO:0051128 regulation of cellular component organization 51.7241 4 no
GO:0051246 regulation of protein metabolic process 44.8276 5 yes
GO:1902531 regulation of intracellular signal transduction 41.3793 5 yes
GO:0009889 regulation of biosynthetic process 41.3793 4 no
GO:0009893 positive regulation of metabolic process 41.3793 4 no
GO:0031326 regulation of cellular biosynthetic process 41.3793 5 no
GO:0051130 positive regulation of cellular component organization 41.3793 5 no
GO:0042127 regulation of cell population proliferation 37.9310 4 yes
GO:0048585 negative regulation of response to stimulus 37.9310 4 yes
GO:0048584 positive regulation of response to stimulus 37.9310 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.9310 5 no
GO:0022607 cellular component assembly 37.9310 4 no
GO:0008104 protein localization 37.9310 4 no
GO:0051049 regulation of transport 37.9310 4 no
GO:0001932 regulation of protein phosphorylation 34.4828 7 yes
GO:0006796 phosphate-containing compound metabolic process 34.4828 4 yes
GO:0009968 negative regulation of signal transduction 34.4828 5 yes
GO:0010648 negative regulation of cell communication 34.4828 5 yes
GO:0019220 regulation of phosphate metabolic process 34.4828 6 yes
GO:0023057 negative regulation of signaling 34.4828 4 yes
GO:0031399 regulation of protein modification process 34.4828 6 yes
GO:0042325 regulation of phosphorylation 34.4828 7 yes
GO:0051174 regulation of phosphorus metabolic process 34.4828 5 yes
GO:0051240 positive regulation of multicellular organismal process 34.4828 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 34.4828 5 no
GO:0010647 positive regulation of cell communication 34.4828 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.4828 5 no
GO:0023056 positive regulation of signaling 34.4828 4 no
GO:0031325 positive regulation of cellular metabolic process 34.4828 5 no
GO:0010468 regulation of gene expression 34.4828 6 no
GO:0060341 regulation of cellular localization 34.4828 4 no
GO:0009892 negative regulation of metabolic process 31.0345 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 31.0345 5 yes
GO:0045595 regulation of cell differentiation 31.0345 4 yes
GO:2000145 regulation of cell motility 31.0345 4 yes
GO:0009967 positive regulation of signal transduction 31.0345 5 no
GO:0033043 regulation of organelle organization 31.0345 5 no
GO:0008285 negative regulation of cell population proliferation 27.5862 5 yes
GO:0030155 regulation of cell adhesion 27.5862 4 yes
GO:0030334 regulation of cell migration 27.5862 5 yes
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 yes
GO:0036211 protein modification process 27.5862 4 yes
GO:0043408 regulation of MAPK cascade 27.5862 6 yes
GO:0043412 macromolecule modification 27.5862 4 yes
GO:0051094 positive regulation of developmental process 27.5862 4 yes
GO:0051338 regulation of transferase activity 27.5862 4 yes
GO:2000026 regulation of multicellular organismal development 27.5862 4 yes
GO:0042981 regulation of apoptotic process 27.5862 5 no
GO:0043067 regulation of programmed cell death 27.5862 4 no
GO:0006355 regulation of DNA-templated transcription 27.5862 7 no
GO:0051252 regulation of RNA metabolic process 27.5862 5 no
GO:2001141 regulation of RNA biosynthetic process 27.5862 6 no
GO:0032880 regulation of protein localization 27.5862 5 no
GO:0006996 organelle organization 27.5862 4 no
GO:0043549 regulation of kinase activity 24.1379 5 yes
GO:0045596 negative regulation of cell differentiation 24.1379 5 yes
GO:0045859 regulation of protein kinase activity 24.1379 6 yes
GO:0051093 negative regulation of developmental process 24.1379 4 yes
GO:0080134 regulation of response to stress 24.1379 4 yes
GO:0141124 intracellular signaling cassette 24.1379 4 yes
GO:1902532 negative regulation of intracellular signal transduction 24.1379 6 yes
GO:0009891 positive regulation of biosynthetic process 24.1379 5 no
GO:0030030 cell projection organization 24.1379 4 no
GO:0031328 positive regulation of cellular biosynthetic process 24.1379 6 no
GO:0051726 regulation of cell cycle 24.1379 4 no
GO:0051247 positive regulation of protein metabolic process 24.1379 6 no
GO:0051493 regulation of cytoskeleton organization 24.1379 6 no
GO:0044087 regulation of cellular component biogenesis 24.1379 4 no
GO:0034762 regulation of transmembrane transport 24.1379 4 no
GO:0002684 positive regulation of immune system process 20.6897 4 yes
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 yes
GO:0051248 negative regulation of protein metabolic process 20.6897 6 yes
GO:0060284 regulation of cell development 20.6897 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 20.6897 7 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 20.6897 4 no
GO:0008284 positive regulation of cell population proliferation 20.6897 5 no
GO:0010564 regulation of cell cycle process 20.6897 5 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 20.6897 6 no
GO:0071310 cellular response to organic substance 20.6897 4 no
GO:0043933 protein-containing complex organization 20.6897 4 no
GO:0051050 positive regulation of transport 20.6897 4 no
GO:0006915 apoptotic process 20.6897 4 no
GO:0034329 cell junction assembly 20.6897 5 no
GO:0034330 cell junction organization 20.6897 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.6897 6 no
GO:0044089 positive regulation of cellular component biogenesis 20.6897 5 no
GO:0050804 modulation of chemical synaptic transmission 20.6897 5 no
GO:0099177 regulation of trans-synaptic signaling 20.6897 4 no
GO:1902414 protein localization to cell junction 20.6897 5 no
GO:0022898 regulation of transmembrane transporter activity 20.6897 4 no
GO:0043269 regulation of monoatomic ion transport 20.6897 5 no
GO:0000165 MAPK cascade 17.2414 5 yes
GO:0010720 positive regulation of cell development 17.2414 6 yes
GO:0032101 regulation of response to external stimulus 17.2414 4 yes
GO:0043409 negative regulation of MAPK cascade 17.2414 7 yes
GO:0045597 positive regulation of cell differentiation 17.2414 5 yes
GO:0050678 regulation of epithelial cell proliferation 17.2414 5 yes
GO:0050776 regulation of immune response 17.2414 4 yes
GO:0051960 regulation of nervous system development 17.2414 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 17.2414 7 yes
GO:0001933 negative regulation of protein phosphorylation 13.7931 8 yes
GO:0002694 regulation of leukocyte activation 13.7931 4 yes
GO:0006470 protein dephosphorylation 13.7931 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 13.7931 6 yes
GO:0010721 negative regulation of cell development 13.7931 6 yes
GO:0016311 dephosphorylation 13.7931 5 yes
GO:0022407 regulation of cell-cell adhesion 13.7931 5 yes
GO:0031400 negative regulation of protein modification process 13.7931 7 yes
GO:0040013 negative regulation of locomotion 13.7931 4 yes
GO:0042326 negative regulation of phosphorylation 13.7931 8 yes
GO:0043086 negative regulation of catalytic activity 13.7931 4 yes
GO:0045785 positive regulation of cell adhesion 13.7931 5 yes
GO:0045926 negative regulation of growth 13.7931 4 yes
GO:0045936 negative regulation of phosphate metabolic process 13.7931 7 yes
GO:0046328 regulation of JNK cascade 13.7931 7 yes
GO:0050680 negative regulation of epithelial cell proliferation 13.7931 6 yes
GO:0050767 regulation of neurogenesis 13.7931 6 yes
GO:0050768 negative regulation of neurogenesis 13.7931 6 yes
GO:0050863 regulation of T cell activation 13.7931 6 yes
GO:0050865 regulation of cell activation 13.7931 4 yes
GO:0051249 regulation of lymphocyte activation 13.7931 5 yes
GO:0051961 negative regulation of nervous system development 13.7931 5 yes
GO:1902105 regulation of leukocyte differentiation 13.7931 5 yes
GO:1902107 positive regulation of leukocyte differentiation 13.7931 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 13.7931 6 yes
GO:1903706 regulation of hemopoiesis 13.7931 4 yes
GO:1903708 positive regulation of hemopoiesis 13.7931 5 yes
GO:2000146 negative regulation of cell motility 13.7931 5 yes
GO:0002683 negative regulation of immune system process 10.3448 4 yes
GO:0002696 positive regulation of leukocyte activation 10.3448 5 yes
GO:0010001 glial cell differentiation 10.3448 4 yes
GO:0014013 regulation of gliogenesis 10.3448 7 yes
GO:0014014 negative regulation of gliogenesis 10.3448 7 yes
GO:0022409 positive regulation of cell-cell adhesion 10.3448 6 yes
GO:0030336 negative regulation of cell migration 10.3448 6 yes
GO:0031098 stress-activated protein kinase signaling cascade 10.3448 4 yes
GO:0032102 negative regulation of response to external stimulus 10.3448 5 yes
GO:0033993 response to lipid 10.3448 4 yes
GO:0035970 peptidyl-threonine dephosphorylation 10.3448 6 yes
GO:0043405 regulation of MAP kinase activity 10.3448 8 yes
GO:0045580 regulation of T cell differentiation 10.3448 7 yes
GO:0045582 positive regulation of T cell differentiation 10.3448 8 yes
GO:0045619 regulation of lymphocyte differentiation 10.3448 6 yes
GO:0045621 positive regulation of lymphocyte differentiation 10.3448 7 yes
GO:0045685 regulation of glial cell differentiation 10.3448 5 yes
GO:0048638 regulation of developmental growth 10.3448 4 yes
GO:0050867 positive regulation of cell activation 10.3448 5 yes
GO:0050870 positive regulation of T cell activation 10.3448 7 yes
GO:0051251 positive regulation of lymphocyte activation 10.3448 6 yes
GO:0051403 stress-activated MAPK cascade 10.3448 5 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 10.3448 8 yes
GO:1900744 regulation of p38MAPK cascade 10.3448 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 10.3448 7 yes
GO:1903753 negative regulation of p38MAPK cascade 10.3448 8 yes
GO:0002237 response to molecule of bacterial origin 6.8966 4 yes
GO:0002697 regulation of immune effector process 6.8966 4 yes
GO:0002698 negative regulation of immune effector process 6.8966 5 yes
GO:0002819 regulation of adaptive immune response 6.8966 5 yes
GO:0002831 regulation of response to biotic stimulus 6.8966 4 yes
GO:0002832 negative regulation of response to biotic stimulus 6.8966 5 yes
GO:0006469 negative regulation of protein kinase activity 6.8966 7 yes
GO:0010632 regulation of epithelial cell migration 6.8966 4 yes
GO:0010633 negative regulation of epithelial cell migration 6.8966 5 yes
GO:0031347 regulation of defense response 6.8966 5 yes
GO:0031348 negative regulation of defense response 6.8966 5 yes
GO:0032496 response to lipopolysaccharide 6.8966 4 yes
GO:0033673 negative regulation of kinase activity 6.8966 6 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 6.8966 6 yes
GO:0043407 negative regulation of MAP kinase activity 6.8966 8 yes
GO:0043506 regulation of JUN kinase activity 6.8966 9 yes
GO:0043508 negative regulation of JUN kinase activity 6.8966 9 yes
GO:0045088 regulation of innate immune response 6.8966 5 yes
GO:0045589 regulation of regulatory T cell differentiation 6.8966 8 yes
GO:0045591 positive regulation of regulatory T cell differentiation 6.8966 9 yes
GO:0045598 regulation of fat cell differentiation 6.8966 5 yes
GO:0045686 negative regulation of glial cell differentiation 6.8966 6 yes
GO:0045824 negative regulation of innate immune response 6.8966 6 yes
GO:0046329 negative regulation of JNK cascade 6.8966 8 yes
GO:0048640 negative regulation of developmental growth 6.8966 5 yes
GO:0048709 oligodendrocyte differentiation 6.8966 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 6.8966 6 yes
GO:0048715 negative regulation of oligodendrocyte differentiation 6.8966 7 yes
GO:0050727 regulation of inflammatory response 6.8966 5 yes
GO:0050728 negative regulation of inflammatory response 6.8966 6 yes
GO:0050777 negative regulation of immune response 6.8966 5 yes
GO:0051348 negative regulation of transferase activity 6.8966 5 yes
GO:0060263 regulation of respiratory burst 6.8966 4 yes
GO:0060264 regulation of respiratory burst involved in inflammatory response 6.8966 4 yes
GO:0060266 negative regulation of respiratory burst involved in inflammatory response 6.8966 5 yes
GO:0060268 negative regulation of respiratory burst 6.8966 5 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 6.8966 8 yes
GO:0090335 regulation of brown fat cell differentiation 6.8966 6 yes
GO:1905041 regulation of epithelium regeneration 6.8966 5 yes
GO:1905042 negative regulation of epithelium regeneration 6.8966 6 yes
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 6.8966 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DUS10_HUMAN [view entry] [view interactions] Low throughput yes yes
MK09_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
SKI2_HUMAN [view interactions] High throughput no yes
SORL_HUMAN [view interactions] High throughput no yes
SPRR3_HUMAN [view interactions] High throughput no no
TCOF_HUMAN [view interactions] High throughput no yes
SKI3_HUMAN [view interactions] High throughput no yes
TXND9_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
SKI8_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
CNKR1_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
SLX1_HUMAN [view interactions] High throughput no yes
CKLF6_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTA_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
EFHD1_HUMAN [view interactions] High throughput no no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
HXA1_HUMAN [view interactions] High throughput no no
KRA32_HUMAN [view interactions] High throughput no no
CRYAA_HUMAN [view interactions] High throughput no no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR3_HUMAN [view interactions] High throughput no yes
NMDE3_HUMAN [view entry] [view interactions] High throughput yes no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
BACE2_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
FND3B_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
MK10_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
CE022_HUMAN [view interactions] High throughput no yes
CDC45_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DJC10_HUMAN [view interactions] High throughput no yes
ECI1_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
FBN2_HUMAN [view interactions] High throughput no no
FBX3_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
HPBP1_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
LRP1_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
MPDZ_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
MRE11_HUMAN [view interactions] High throughput no yes
NU205_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
2ABA_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
PRUN1_HUMAN [view interactions] High throughput no no
RAD50_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes