Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DUS10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003078 DOC_MAPK_JIP1_4 DOC 19 25 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DUS10_HUMAN
GO:0017076 purine nucleotide binding 41.9355 4 no
GO:0032555 purine ribonucleotide binding 41.9355 4 no
GO:0035639 purine ribonucleoside triphosphate binding 41.9355 4 no
GO:0005524 ATP binding 38.7097 5 no
GO:0030554 adenyl nucleotide binding 38.7097 5 no
GO:0032559 adenyl ribonucleotide binding 38.7097 5 no
GO:0019900 kinase binding 25.8065 4 yes
GO:0016301 kinase activity 25.8065 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 22.5806 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.5806 4 no
GO:0019901 protein kinase binding 19.3548 5 yes
GO:0016791 phosphatase activity 12.9032 5 yes
GO:0042578 phosphoric ester hydrolase activity 12.9032 4 yes
GO:0004722 protein serine/threonine phosphatase activity 9.6774 4 yes
GO:0004725 protein tyrosine phosphatase activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DUS10_HUMAN
GO:0048522 positive regulation of cellular process 70.9677 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.7419 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 61.2903 4 yes
GO:0080090 regulation of primary metabolic process 61.2903 4 yes
GO:0031323 regulation of cellular metabolic process 54.8387 4 yes
GO:0048523 negative regulation of cellular process 54.8387 4 yes
GO:0010646 regulation of cell communication 51.6129 4 yes
GO:0051246 regulation of protein metabolic process 48.3871 5 yes
GO:0009893 positive regulation of metabolic process 48.3871 4 no
GO:0010468 regulation of gene expression 48.3871 5 no
GO:0051128 regulation of cellular component organization 48.3871 4 no
GO:0009966 regulation of signal transduction 45.1613 4 yes
GO:0019220 regulation of phosphate metabolic process 45.1613 6 yes
GO:0042325 regulation of phosphorylation 45.1613 7 yes
GO:0051174 regulation of phosphorus metabolic process 45.1613 5 yes
GO:0001932 regulation of protein phosphorylation 41.9355 7 yes
GO:0031399 regulation of protein modification process 41.9355 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.9355 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.9355 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.9355 5 no
GO:0051338 regulation of transferase activity 38.7097 4 yes
GO:0009889 regulation of biosynthetic process 38.7097 4 no
GO:0031325 positive regulation of cellular metabolic process 38.7097 5 no
GO:0031326 regulation of cellular biosynthetic process 38.7097 5 no
GO:0051130 positive regulation of cellular component organization 38.7097 5 no
GO:0051049 regulation of transport 38.7097 4 no
GO:0060341 regulation of cellular localization 38.7097 4 no
GO:0042127 regulation of cell population proliferation 35.4839 4 yes
GO:1902531 regulation of intracellular signal transduction 35.4839 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.4839 5 no
GO:0022607 cellular component assembly 35.4839 4 no
GO:0010647 positive regulation of cell communication 35.4839 5 no
GO:0023056 positive regulation of signaling 35.4839 4 no
GO:0048584 positive regulation of response to stimulus 35.4839 4 no
GO:0009892 negative regulation of metabolic process 32.2581 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 32.2581 5 yes
GO:0043549 regulation of kinase activity 32.2581 5 yes
GO:0048585 negative regulation of response to stimulus 32.2581 4 yes
GO:0006355 regulation of DNA-templated transcription 32.2581 6 no
GO:0043085 positive regulation of catalytic activity 32.2581 4 no
GO:0051247 positive regulation of protein metabolic process 32.2581 6 no
GO:0051252 regulation of RNA metabolic process 32.2581 5 no
GO:1903506 regulation of nucleic acid-templated transcription 32.2581 7 no
GO:2001141 regulation of RNA biosynthetic process 32.2581 6 no
GO:0008104 protein localization 32.2581 4 no
GO:0016192 vesicle-mediated transport 32.2581 4 no
GO:0009968 negative regulation of signal transduction 29.0323 5 yes
GO:0010648 negative regulation of cell communication 29.0323 5 yes
GO:0023057 negative regulation of signaling 29.0323 4 yes
GO:0036211 protein modification process 29.0323 4 yes
GO:0043408 regulation of MAPK cascade 29.0323 6 yes
GO:0043412 macromolecule modification 29.0323 4 yes
GO:2000145 regulation of cell motility 29.0323 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 29.0323 6 no
GO:0042327 positive regulation of phosphorylation 29.0323 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.0323 7 no
GO:0051347 positive regulation of transferase activity 29.0323 5 no
GO:0032880 regulation of protein localization 29.0323 5 no
GO:0006996 organelle organization 29.0323 4 no
GO:0009967 positive regulation of signal transduction 29.0323 5 no
GO:0033043 regulation of organelle organization 29.0323 5 no
GO:0006796 phosphate-containing compound metabolic process 25.8065 4 yes
GO:0008285 negative regulation of cell population proliferation 25.8065 5 yes
GO:0030334 regulation of cell migration 25.8065 5 yes
GO:0045859 regulation of protein kinase activity 25.8065 6 yes
GO:0051240 positive regulation of multicellular organismal process 25.8065 4 yes
GO:0080134 regulation of response to stress 25.8065 4 yes
GO:0001934 positive regulation of protein phosphorylation 25.8065 8 no
GO:0031401 positive regulation of protein modification process 25.8065 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.8065 6 no
GO:0071310 cellular response to organic substance 25.8065 4 no
GO:0010941 regulation of cell death 25.8065 4 no
GO:0051493 regulation of cytoskeleton organization 25.8065 6 no
GO:0045595 regulation of cell differentiation 22.5806 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 22.5806 5 yes
GO:0080135 regulation of cellular response to stress 22.5806 4 yes
GO:0033674 positive regulation of kinase activity 22.5806 6 no
GO:0051726 regulation of cell cycle 22.5806 4 no
GO:0043269 regulation of ion transport 22.5806 5 no
GO:1905475 regulation of protein localization to membrane 22.5806 6 no
GO:0030030 cell projection organization 22.5806 4 no
GO:0051050 positive regulation of transport 22.5806 4 no
GO:0010638 positive regulation of organelle organization 22.5806 6 no
GO:0042981 regulation of apoptotic process 22.5806 6 no
GO:0043067 regulation of programmed cell death 22.5806 5 no
GO:0009891 positive regulation of biosynthetic process 22.5806 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5806 6 no
GO:0030155 regulation of cell adhesion 19.3548 4 yes
GO:0031324 negative regulation of cellular metabolic process 19.3548 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 19.3548 6 yes
GO:0051094 positive regulation of developmental process 19.3548 4 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 19.3548 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 19.3548 7 yes
GO:2000026 regulation of multicellular organismal development 19.3548 4 yes
GO:0002684 positive regulation of immune system process 16.1290 4 yes
GO:0032101 regulation of response to external stimulus 16.1290 4 yes
GO:0045596 negative regulation of cell differentiation 16.1290 5 yes
GO:0051093 negative regulation of developmental process 16.1290 4 yes
GO:0051248 negative regulation of protein metabolic process 16.1290 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 16.1290 7 yes
GO:1902532 negative regulation of intracellular signal transduction 16.1290 6 yes
GO:0001933 negative regulation of protein phosphorylation 12.9032 8 yes
GO:0010563 negative regulation of phosphorus metabolic process 12.9032 6 yes
GO:0031400 negative regulation of protein modification process 12.9032 7 yes
GO:0042326 negative regulation of phosphorylation 12.9032 8 yes
GO:0043409 negative regulation of MAPK cascade 12.9032 7 yes
GO:0045936 negative regulation of phosphate metabolic process 12.9032 7 yes
GO:0050678 regulation of epithelial cell proliferation 12.9032 5 yes
GO:0050776 regulation of immune response 12.9032 4 yes
GO:0051241 negative regulation of multicellular organismal process 12.9032 4 yes
GO:0051960 regulation of nervous system development 12.9032 5 yes
GO:0006470 protein dephosphorylation 9.6774 5 yes
GO:0010001 glial cell differentiation 9.6774 4 yes
GO:0010721 negative regulation of cell development 9.6774 6 yes
GO:0016311 dephosphorylation 9.6774 5 yes
GO:0040013 negative regulation of locomotion 9.6774 4 yes
GO:0043086 negative regulation of catalytic activity 9.6774 4 yes
GO:0043405 regulation of MAP kinase activity 9.6774 8 yes
GO:0045597 positive regulation of cell differentiation 9.6774 5 yes
GO:0045926 negative regulation of growth 9.6774 4 yes
GO:0046328 regulation of JNK cascade 9.6774 7 yes
GO:0050680 negative regulation of epithelial cell proliferation 9.6774 6 yes
GO:0050767 regulation of neurogenesis 9.6774 6 yes
GO:0050768 negative regulation of neurogenesis 9.6774 6 yes
GO:0051961 negative regulation of nervous system development 9.6774 5 yes
GO:0060284 regulation of cell development 9.6774 5 yes
GO:2000146 negative regulation of cell motility 9.6774 5 yes
GO:0002683 negative regulation of immune system process 6.4516 4 yes
GO:0002694 regulation of leukocyte activation 6.4516 4 yes
GO:0002831 regulation of response to biotic stimulus 6.4516 4 yes
GO:0014013 regulation of gliogenesis 6.4516 7 yes
GO:0014014 negative regulation of gliogenesis 6.4516 7 yes
GO:0022407 regulation of cell-cell adhesion 6.4516 5 yes
GO:0030336 negative regulation of cell migration 6.4516 6 yes
GO:0031347 regulation of defense response 6.4516 5 yes
GO:0032102 negative regulation of response to external stimulus 6.4516 5 yes
GO:0032873 negative regulation of stress-activated MAPK cascade 6.4516 7 yes
GO:0033993 response to lipid 6.4516 4 yes
GO:0035970 peptidyl-threonine dephosphorylation 6.4516 6 yes
GO:0043506 regulation of JUN kinase activity 6.4516 9 yes
GO:0045685 regulation of glial cell differentiation 6.4516 5 yes
GO:0045785 positive regulation of cell adhesion 6.4516 5 yes
GO:0048638 regulation of developmental growth 6.4516 4 yes
GO:0050863 regulation of T cell activation 6.4516 6 yes
GO:0050865 regulation of cell activation 6.4516 4 yes
GO:0051249 regulation of lymphocyte activation 6.4516 5 yes
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 6.4516 6 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 6.4516 8 yes
GO:1900744 regulation of p38MAPK cascade 6.4516 7 yes
GO:1902105 regulation of leukocyte differentiation 6.4516 5 yes
GO:1902107 positive regulation of leukocyte differentiation 6.4516 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 6.4516 6 yes
GO:1903706 regulation of hemopoiesis 6.4516 4 yes
GO:1903708 positive regulation of hemopoiesis 6.4516 5 yes
GO:1903753 negative regulation of p38MAPK cascade 6.4516 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in DUS10_HUMAN
DOID:331 central nervous system disease 6.4516 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK09_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
FHL2_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
SLX1_HUMAN [view interactions] High throughput no yes
CKLF6_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD1_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
OTUD4_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
HXA1_HUMAN [view interactions] High throughput no no
KRA32_HUMAN [view interactions] High throughput no no
CRYAA_HUMAN [view interactions] High throughput no no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR3_HUMAN [view interactions] High throughput no yes
NMDE3_HUMAN [view entry] [view interactions] High throughput yes no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
BACE2_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
FND3B_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
MK10_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
CE022_HUMAN [view interactions] High throughput no yes
CDC45_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DJC10_HUMAN [view interactions] High throughput no yes
ECI1_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
FBN2_HUMAN [view interactions] High throughput no no
FBX3_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
HPBP1_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
LRP1_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
MPDZ_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
MRE11_HUMAN [view interactions] High throughput no yes
NU205_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
2ABA_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
PRUN1_HUMAN [view interactions] High throughput no no
RAD50_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
SKIV2_HUMAN [view entry] [view interactions] High throughput yes yes
SORL_HUMAN [view interactions] High throughput no yes
SPRR3_HUMAN [view interactions] High throughput no no
TCOF_HUMAN [view interactions] High throughput no yes
TTC37_HUMAN [view entry] [view interactions] High throughput yes yes
TXND9_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
WDR61_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
CNKR1_HUMAN [view interactions] High throughput no no
MK13_HUMAN [view interactions] Computational no yes
MK12_HUMAN [view interactions] Computational no no
MK11_HUMAN [view interactions] Computational no yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes